More than 300 homologs were found in PanDaTox collection
for query gene M446_2198 on replicon NC_010511
Organism: Methylobacterium sp. 4-46



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_010511  M446_2198  response regulator receiver protein  100 
 
 
127 aa  248  3e-65  Methylobacterium sp. 4-46  Bacteria  normal  0.16592  normal  0.62826 
 
 
-
 
NC_011894  Mnod_1157  response regulator receiver protein  92.13 
 
 
127 aa  229  8.000000000000001e-60  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.116971  n/a   
 
 
-
 
NC_010505  Mrad2831_3997  response regulator receiver protein  86.78 
 
 
121 aa  209  9e-54  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal  0.0883649 
 
 
-
 
NC_010725  Mpop_2980  response regulator receiver protein  85.95 
 
 
121 aa  209  1e-53  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_011757  Mchl_3086  response regulator receiver protein  85.95 
 
 
121 aa  208  3e-53  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.342425  normal 
 
 
-
 
NC_010172  Mext_2860  response regulator receiver  85.95 
 
 
121 aa  208  3e-53  Methylobacterium extorquens PA1  Bacteria  normal  0.388237  normal 
 
 
-
 
NC_011004  Rpal_5220  response regulator receiver protein  65.08 
 
 
126 aa  162  1.0000000000000001e-39  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.472283  n/a   
 
 
-
 
NC_007958  RPD_0941  response regulator receiver  63.71 
 
 
125 aa  159  1e-38  Rhodopseudomonas palustris BisB5  Bacteria  normal  normal 
 
 
-
 
NC_007406  Nwi_0574  response regulator receiver  63.93 
 
 
130 aa  159  2e-38  Nitrobacter winogradskyi Nb-255  Bacteria  normal  0.4385  normal 
 
 
-
 
NC_009485  BBta_1174  putative two-component response regulator  60.32 
 
 
126 aa  155  1e-37  Bradyrhizobium sp. BTAi1  Bacteria  normal  0.289144  normal  0.876478 
 
 
-
 
NC_007778  RPB_0832  response regulator receiver domain-containing protein  67.86 
 
 
125 aa  154  3e-37  Rhodopseudomonas palustris HaA2  Bacteria  normal  0.155773  normal  0.875827 
 
 
-
 
NC_007964  Nham_0665  response regulator receiver domain-containing protein  63.64 
 
 
127 aa  152  1e-36  Nitrobacter hamburgensis X14  Bacteria  normal  0.709306  n/a   
 
 
-
 
NC_007925  RPC_4869  response regulator receiver domain-containing protein  62.5 
 
 
123 aa  143  1e-33  Rhodopseudomonas palustris BisB18  Bacteria  normal  0.337506  normal  0.697748 
 
 
-
 
NC_008254  Meso_3094  response regulator receiver protein  55.37 
 
 
121 aa  127  4.0000000000000003e-29  Chelativorans sp. BNC1  Bacteria  normal  n/a   
 
 
-
 
NC_011369  Rleg2_3569  response regulator receiver protein  53.72 
 
 
119 aa  126  9.000000000000001e-29  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.146165 
 
 
-
 
NC_012850  Rleg_3862  response regulator receiver protein  52.89 
 
 
119 aa  126  1.0000000000000001e-28  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.762525  normal  0.105944 
 
 
-
 
NC_011989  Avi_4023  two component response regulator  53.72 
 
 
119 aa  124  5e-28  Agrobacterium vitis S4  Bacteria  normal  n/a   
 
 
-
 
NC_009719  Plav_1598  response regulator receiver protein  51.16 
 
 
127 aa  116  9.999999999999999e-26  Parvibaculum lavamentivorans DS-1  Bacteria  normal  normal 
 
 
-
 
NC_009636  Smed_2540  response regulator receiver protein  54.55 
 
 
119 aa  114  6e-25  Sinorhizobium medicae WSM419  Bacteria  normal  0.676292  normal 
 
 
-
 
NC_007760  Adeh_0504  two component, sigma54 specific, Fis family transcriptional regulator  40 
 
 
443 aa  90.9  5e-18  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_011145  AnaeK_0537  two component, sigma54 specific, transcriptional regulator, Fis family  40 
 
 
446 aa  89.7  1e-17  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_011891  A2cp1_0533  two component, sigma54 specific, transcriptional regulator, Fis family  40 
 
 
443 aa  89.7  1e-17  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  0.141325  n/a   
 
 
-
 
NC_009511  Swit_0513  multi-sensor hybrid histidine kinase  39.02 
 
 
803 aa  88.2  4e-17  Sphingomonas wittichii RW1  Bacteria  normal  0.883754  normal 
 
 
-
 
NC_008347  Mmar10_2507  response regulator receiver protein  42.15 
 
 
121 aa  87  7e-17  Maricaulis maris MCS10  Bacteria  normal  normal 
 
 
-
 
NC_014212  Mesil_0142  two component transcriptional regulator, winged helix family  39.37 
 
 
221 aa  84  6e-16  Meiothermus silvanus DSM 9946  Bacteria  normal  normal  0.709604 
 
 
-
 
NC_009719  Plav_1998  response regulator receiver protein  48 
 
 
120 aa  82  0.000000000000002  Parvibaculum lavamentivorans DS-1  Bacteria  hitchhiker  0.00000230643  normal 
 
 
-
 
NC_009485  BBta_5491  cell cycle control histidine kinase CckA  36.36 
 
 
892 aa  80.1  0.00000000000001  Bradyrhizobium sp. BTAi1  Bacteria  normal  0.606378  normal 
 
 
-
 
NC_011146  Gbem_3634  response regulator receiver sensor signal transduction histidine kinase  38.02 
 
 
379 aa  79.7  0.00000000000001  Geobacter bemidjiensis Bem  Bacteria  normal  0.0261897  n/a   
 
 
-
 
NC_007406  Nwi_1138  Signal transduction histidine kinase  37.82 
 
 
888 aa  79.3  0.00000000000002  Nitrobacter winogradskyi Nb-255  Bacteria  normal  0.408537  normal 
 
 
-
 
NC_008048  Sala_1727  periplasmic sensor hybrid histidine kinase  37.3 
 
 
793 aa  79.3  0.00000000000002  Sphingopyxis alaskensis RB2256  Bacteria  normal  normal 
 
 
-
 
NC_007794  Saro_1446  multi-sensor hybrid histidine kinase  36.44 
 
 
811 aa  78.2  0.00000000000003  Novosphingobium aromaticivorans DSM 12444  Bacteria  normal  n/a   
 
 
-
 
NC_012918  GM21_3739  response regulator receiver sensor signal transduction histidine kinase  38.02 
 
 
379 aa  78.2  0.00000000000003  Geobacter sp. M21  Bacteria  n/a    normal 
 
 
-
 
NC_008783  BARBAKC583_0853  sensor histidine kinase/reponse regulator  33.05 
 
 
845 aa  78.6  0.00000000000003  Bartonella bacilliformis KC583  Bacteria  decreased coverage  0.00134282  n/a   
 
 
-
 
NC_010338  Caul_0863  response regulator receiver protein  40.5 
 
 
118 aa  78.2  0.00000000000004  Caulobacter sp. K31  Bacteria  normal  normal  0.385882 
 
 
-
 
NC_013501  Rmar_0513  two component transcriptional regulator, winged helix family  36.61 
 
 
228 aa  78.2  0.00000000000004  Rhodothermus marinus DSM 4252  Bacteria  normal  0.985837  n/a   
 
 
-
 
NC_008554  Sfum_0719  response regulator receiver modulated diguanylate cyclase  37.72 
 
 
307 aa  77.8  0.00000000000004  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_007406  Nwi_0114  Signal transduction histidine kinase  40 
 
 
939 aa  77.4  0.00000000000006  Nitrobacter winogradskyi Nb-255  Bacteria  normal  normal  0.153209 
 
 
-
 
NC_009675  Anae109_2379  two component, sigma54 specific, Fis family transcriptional regulator  39.83 
 
 
446 aa  77.4  0.00000000000006  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  0.373235  normal  0.0399931 
 
 
-
 
NC_012034  Athe_0080  two component transcriptional regulator, winged helix family  33.33 
 
 
230 aa  77.4  0.00000000000007  Anaerocellum thermophilum DSM 6725  Bacteria  normal  n/a   
 
 
-
 
NC_013440  Hoch_3222  two component, sigma54 specific, transcriptional regulator, Fis family  37.5 
 
 
447 aa  76.3  0.0000000000001  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0905113 
 
 
-
 
NC_007912  Sde_3108  response regulator receiver domain-containing protein  39.34 
 
 
120 aa  75.5  0.0000000000002  Saccharophagus degradans 2-40  Bacteria  normal  normal 
 
 
-
 
NC_007925  RPC_1524  multi-sensor hybrid histidine kinase  37.29 
 
 
853 aa  75.5  0.0000000000002  Rhodopseudomonas palustris BisB18  Bacteria  normal  normal  0.334346 
 
 
-
 
NC_013946  Mrub_1260  response regulator receiver protein  38.71 
 
 
331 aa  75.9  0.0000000000002  Meiothermus ruber DSM 1279  Bacteria  normal  0.208704  normal 
 
 
-
 
NC_013223  Dret_1848  two component transcriptional regulator, winged helix family  39.81 
 
 
236 aa  75.9  0.0000000000002  Desulfohalobium retbaense DSM 5692  Bacteria  hitchhiker  0.0065624  normal 
 
 
-
 
NC_011989  Avi_3746  chemotaxis response regulator  41.53 
 
 
121 aa  75.1  0.0000000000003  Agrobacterium vitis S4  Bacteria  normal  0.193057  n/a   
 
 
-
 
NC_009720  Xaut_2816  response regulator receiver protein  38.84 
 
 
120 aa  75.1  0.0000000000003  Xanthobacter autotrophicus Py2  Bacteria  normal  0.101903  normal  0.104606 
 
 
-
 
NC_009767  Rcas_1273  multi-sensor signal transduction histidine kinase  35.83 
 
 
556 aa  75.1  0.0000000000003  Roseiflexus castenholzii DSM 13941  Bacteria  normal  0.12815  normal  0.758765 
 
 
-
 
NC_009483  Gura_0224  response regulator receiver sensor signal transduction histidine kinase  36.36 
 
 
379 aa  75.1  0.0000000000003  Geobacter uraniireducens Rf4  Bacteria  normal  n/a   
 
 
-
 
NC_009972  Haur_1267  response regulator receiver sensor signal transduction histidine kinase  38.33 
 
 
542 aa  75.1  0.0000000000003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_009636  Smed_2719  response regulator receiver protein  40 
 
 
120 aa  74.3  0.0000000000005  Sinorhizobium medicae WSM419  Bacteria  normal  0.0959171  normal 
 
 
-
 
NC_008609  Ppro_2957  two component transcriptional regulator  36.28 
 
 
223 aa  74.3  0.0000000000005  Pelobacter propionicus DSM 2379  Bacteria  unclonable  0.000000000406961  n/a   
 
 
-
 
NC_008686  Pden_0595  multi-sensor hybrid histidine kinase  38.84 
 
 
680 aa  74.3  0.0000000000005  Paracoccus denitrificans PD1222  Bacteria  normal  normal 
 
 
-
 
NC_009972  Haur_3458  multi-sensor signal transduction histidine kinase  35.54 
 
 
958 aa  73.9  0.0000000000006  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_010511  M446_0878  integral membrane sensor hybrid histidine kinase  39.47 
 
 
754 aa  74.3  0.0000000000006  Methylobacterium sp. 4-46  Bacteria  normal  0.307069  normal 
 
 
-
 
NC_007802  Jann_1984  PAS/PAC sensor hybrid histidine kinase  34.48 
 
 
752 aa  73.9  0.0000000000006  Jannaschia sp. CCS1  Bacteria  normal  normal  0.684295 
 
 
-
 
NC_009523  RoseRS_0520  multi-sensor signal transduction histidine kinase  35.83 
 
 
556 aa  73.9  0.0000000000007  Roseiflexus sp. RS-1  Bacteria  normal  0.936608  normal  0.731504 
 
 
-
 
NC_009719  Plav_2576  multi-sensor hybrid histidine kinase  36.36 
 
 
840 aa  73.9  0.0000000000007  Parvibaculum lavamentivorans DS-1  Bacteria  normal  normal  0.0149194 
 
 
-
 
NC_010338  Caul_0611  response regulator receiver protein  38.52 
 
 
121 aa  73.9  0.0000000000007  Caulobacter sp. K31  Bacteria  normal  normal 
 
 
-
 
NC_007964  Nham_1398  multi-sensor hybrid histidine kinase  35.9 
 
 
853 aa  73.6  0.0000000000008  Nitrobacter hamburgensis X14  Bacteria  normal  n/a   
 
 
-
 
NC_013739  Cwoe_5905  two component transcriptional regulator, winged helix family  36.21 
 
 
237 aa  73.6  0.0000000000008  Conexibacter woesei DSM 14684  Bacteria  normal  normal 
 
 
-
 
NC_009943  Dole_0867  PAS/PAC sensor hybrid histidine kinase  37.5 
 
 
905 aa  73.6  0.0000000000008  Desulfococcus oleovorans Hxd3  Bacteria  normal  0.768776  n/a   
 
 
-
 
NC_011899  Hore_21640  two component transcriptional regulator, winged helix family  31.3 
 
 
226 aa  73.6  0.0000000000008  Halothermothrix orenii H 168  Bacteria  hitchhiker  0.0000000000176926  n/a   
 
 
-
 
NC_007517  Gmet_2453  two component, sigma54 specific, Fis family transcriptional regulator  37.07 
 
 
461 aa  73.6  0.0000000000009  Geobacter metallireducens GS-15  Bacteria  hitchhiker  0.0000196128  normal 
 
 
-
 
NC_013440  Hoch_5989  two component, sigma54 specific, transcriptional regulator, Fis family  38.28 
 
 
459 aa  73.6  0.0000000000009  Haliangium ochraceum DSM 14365  Bacteria  normal  0.999422  normal 
 
 
-
 
NC_009636  Smed_1525  multi-sensor hybrid histidine kinase  37.82 
 
 
872 aa  73.6  0.0000000000009  Sinorhizobium medicae WSM419  Bacteria  normal  0.40409  normal 
 
 
-
 
NC_010814  Glov_1745  response regulator receiver sensor signal transduction histidine kinase  37.29 
 
 
417 aa  73.6  0.0000000000009  Geobacter lovleyi SZ  Bacteria  normal  0.0330192  n/a   
 
 
-
 
NC_014212  Mesil_2980  response regulator receiver protein  37.61 
 
 
138 aa  72.8  0.000000000001  Meiothermus silvanus DSM 9946  Bacteria  normal  normal 
 
 
-
 
NC_013946  Mrub_0302  two component transcriptional regulator, winged helix family  36.07 
 
 
221 aa  73.6  0.000000000001  Meiothermus ruber DSM 1279  Bacteria  normal  normal 
 
 
-
 
NC_011989  Avi_2463  two component sensor kinase  36.36 
 
 
872 aa  73.6  0.000000000001  Agrobacterium vitis S4  Bacteria  normal  0.899501  n/a   
 
 
-
 
NC_007517  Gmet_0202  response regulator receiver sensor signal transduction histidine kinase  37.4 
 
 
374 aa  72.8  0.000000000001  Geobacter metallireducens GS-15  Bacteria  normal  hitchhiker  0.00101669 
 
 
-
 
NC_014158  Tpau_3286  two component transcriptional regulator, winged helix family  39.52 
 
 
228 aa  72.8  0.000000000001  Tsukamurella paurometabola DSM 20162  Bacteria  normal  0.167791  n/a   
 
 
-
 
NC_009523  RoseRS_0338  response regulator receiver modulated metal dependent phosphohydrolase  35.04 
 
 
513 aa  72.8  0.000000000001  Roseiflexus sp. RS-1  Bacteria  normal  normal  0.102838 
 
 
-
 
NC_007794  Saro_1287  response regulator receiver domain-containing protein  39.5 
 
 
127 aa  73.6  0.000000000001  Novosphingobium aromaticivorans DSM 12444  Bacteria  normal  0.442215  n/a   
 
 
-
 
NC_009523  RoseRS_2625  two component transcriptional regulator  34.43 
 
 
231 aa  73.2  0.000000000001  Roseiflexus sp. RS-1  Bacteria  normal  0.983258  normal 
 
 
-
 
NC_008009  Acid345_0311  two component transcriptional regulator  38.14 
 
 
232 aa  72.8  0.000000000001  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  normal  0.280613 
 
 
-
 
NC_008820  P9303_26531  two-component response regulator  36.75 
 
 
248 aa  72.8  0.000000000001  Prochlorococcus marinus str. MIT 9303  Bacteria  n/a    normal 
 
 
-
 
NC_009767  Rcas_2599  two component transcriptional regulator  36.45 
 
 
232 aa  72.4  0.000000000002  Roseiflexus castenholzii DSM 13941  Bacteria  normal  0.268704  normal 
 
 
-
 
NC_012918  GM21_0227  two component transcriptional regulator, winged helix family  42.11 
 
 
224 aa  72.4  0.000000000002  Geobacter sp. M21  Bacteria  n/a    normal 
 
 
-
 
NC_012850  Rleg_3624  response regulator receiver protein  39.83 
 
 
120 aa  72.4  0.000000000002  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  normal 
 
 
-
 
NC_011369  Rleg2_3325  response regulator receiver protein  39.83 
 
 
120 aa  72.4  0.000000000002  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.745241 
 
 
-
 
NC_014212  Mesil_2802  two component transcriptional regulator, winged helix family  32.8 
 
 
219 aa  72.8  0.000000000002  Meiothermus silvanus DSM 9946  Bacteria  normal  normal  0.204502 
 
 
-
 
NC_007517  Gmet_2924  two component, sigma54 specific, Fis family transcriptional regulator  35 
 
 
470 aa  72  0.000000000002  Geobacter metallireducens GS-15  Bacteria  normal  0.777319  hitchhiker  0.0000000000564278 
 
 
-
 
NC_013093  Amir_2464  two component transcriptional regulator, winged helix family  39.37 
 
 
229 aa  72  0.000000000002  Actinosynnema mirum DSM 43827  Bacteria  normal  n/a   
 
 
-
 
NC_011831  Cagg_3502  two component transcriptional regulator, winged helix family  36.45 
 
 
232 aa  72.4  0.000000000002  Chloroflexus aggregans DSM 9485  Bacteria  normal  normal 
 
 
-
 
NC_011831  Cagg_1351  two component transcriptional regulator, winged helix family  36.72 
 
 
225 aa  72.8  0.000000000002  Chloroflexus aggregans DSM 9485  Bacteria  hitchhiker  0.00188361  unclonable  0.0000000206018 
 
 
-
 
NC_011004  Rpal_4405  multi-sensor hybrid histidine kinase  35.83 
 
 
880 aa  72  0.000000000002  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.0198095  n/a   
 
 
-
 
NC_008554  Sfum_3112  putative PAS/PAC sensor protein  32.48 
 
 
733 aa  72.8  0.000000000002  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_008554  Sfum_3738  response regulator receiver modulated metal dependent phosphohydrolase  35.96 
 
 
384 aa  72.4  0.000000000002  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_011146  Gbem_0243  two component transcriptional regulator, winged helix family  42.11 
 
 
224 aa  72  0.000000000002  Geobacter bemidjiensis Bem  Bacteria  hitchhiker  0.000226454  n/a   
 
 
-
 
NC_013216  Dtox_1377  two component transcriptional regulator, winged helix family  36.43 
 
 
225 aa  72.8  0.000000000002  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  hitchhiker  0.0000000301655 
 
 
-
 
NC_009943  Dole_3264  PAS/PAC sensor hybrid histidine kinase  38.98 
 
 
1134 aa  72  0.000000000002  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_009511  Swit_0135  response regulator receiver protein  42.74 
 
 
124 aa  72.8  0.000000000002  Sphingomonas wittichii RW1  Bacteria  normal  normal 
 
 
-
 
NC_012918  GM21_2359  CheA signal transduction histidine kinase  40 
 
 
756 aa  71.6  0.000000000003  Geobacter sp. M21  Bacteria  n/a    normal 
 
 
-
 
NC_007575  Suden_1530  CheA signal transduction histidine kinases  32.77 
 
 
803 aa  71.6  0.000000000003  Sulfurimonas denitrificans DSM 1251  Bacteria  normal  n/a   
 
 
-
 
NC_009831  Ssed_2316  response regulator receiver protein  37.84 
 
 
226 aa  72  0.000000000003  Shewanella sediminis HAW-EB3  Bacteria  decreased coverage  0.00000147543  hitchhiker  0.000888492 
 
 
-
 
NC_007908  Rfer_2738  response regulator receiver domain-containing protein  34.71 
 
 
194 aa  71.6  0.000000000003  Rhodoferax ferrireducens T118  Bacteria  hitchhiker  0.000186206  n/a   
 
 
-
 
NC_009511  Swit_3901  integral membrane sensor hybrid histidine kinase  38.46 
 
 
661 aa  71.6  0.000000000003  Sphingomonas wittichii RW1  Bacteria  normal  0.0390399  normal 
 
 
-
 
NC_013131  Caci_0904  two component transcriptional regulator, winged helix family  42.31 
 
 
254 aa  71.6  0.000000000003  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.936287  normal  0.32173 
 
 
-
 
NC_010623  Bphy_3962  two component heavy metal response transcriptional regulator  38.26 
 
 
225 aa  71.6  0.000000000003  Burkholderia phymatum STM815  Bacteria  normal  normal 
 
 
-
 
NC_013385  Adeg_0173  two component, sigma54 specific, transcriptional regulator, Fis family  34.15 
 
 
463 aa  71.6  0.000000000003  Ammonifex degensii KC4  Bacteria  normal  0.127235  n/a   
 
 
-
 
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