More than 300 homologs were found in PanDaTox collection
for query gene M446_2047 on replicon NC_010511
Organism: Methylobacterium sp. 4-46



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_010511  M446_2047  response regulator receiver protein  100 
 
 
127 aa  244  2e-64  Methylobacterium sp. 4-46  Bacteria  normal  hitchhiker  0.000802297 
 
 
-
 
NC_011894  Mnod_0768  response regulator receiver protein  85.04 
 
 
127 aa  191  3e-48  Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_010338  Caul_3300  response regulator receiver protein  64.29 
 
 
127 aa  151  4e-36  Caulobacter sp. K31  Bacteria  normal  normal  0.420279 
 
 
-
 
NC_007925  RPC_4605  response regulator receiver domain-containing protein  57.14 
 
 
149 aa  145  2.0000000000000003e-34  Rhodopseudomonas palustris BisB18  Bacteria  normal  normal 
 
 
-
 
NC_008576  Mmc1_2284  response regulator receiver protein  43.24 
 
 
121 aa  99.8  1e-20  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_011666  Msil_3910  response regulator receiver protein  41.88 
 
 
132 aa  87.4  6e-17  Methylocella silvestris BL2  Bacteria  n/a    normal  0.867729 
 
 
-
 
NC_007908  Rfer_1889  response regulator receiver domain-containing protein  38.53 
 
 
153 aa  82  0.000000000000002  Rhodoferax ferrireducens T118  Bacteria  normal  n/a   
 
 
-
 
NC_007643  Rru_A1277  Hpt sensor hybrid histidine kinase  37.72 
 
 
811 aa  68.9  0.00000000002  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  n/a   
 
 
-
 
NC_010571  Oter_1551  two component LuxR family transcriptional regulator  42.11 
 
 
229 aa  68.9  0.00000000002  Opitutus terrae PB90-1  Bacteria  normal  normal  0.460798 
 
 
-
 
NC_009439  Pmen_3725  CheC, inhibitor of MCP methylation  40.78 
 
 
333 aa  68.6  0.00000000003  Pseudomonas mendocina ymp  Bacteria  normal  normal 
 
 
-
 
NC_009943  Dole_1977  response regulator receiver protein  35.58 
 
 
265 aa  67.8  0.00000000004  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_009664  Krad_0325  response regulator receiver protein  33.94 
 
 
298 aa  65.5  0.0000000002  Kineococcus radiotolerans SRS30216  Bacteria  normal  0.314809  normal  0.535249 
 
 
-
 
NC_007005  Psyr_0063  response regulator receiver:LytTr DNA-binding region  40.54 
 
 
248 aa  65.5  0.0000000002  Pseudomonas syringae pv. syringae B728a  Bacteria  normal  normal 
 
 
-
 
NC_007575  Suden_1034  response regulator receiver domain-containing protein  45.24 
 
 
120 aa  65.9  0.0000000002  Sulfurimonas denitrificans DSM 1251  Bacteria  normal  0.114962  n/a   
 
 
-
 
NC_013521  Sked_30870  response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains  37.38 
 
 
119 aa  65.9  0.0000000002  Sanguibacter keddieii DSM 10542  Bacteria  normal  normal 
 
 
-
 
NC_008576  Mmc1_0647  PAS/PAC sensor hybrid histidine kinase  34.91 
 
 
1064 aa  65.1  0.0000000003  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_011146  Gbem_3845  response regulator receiver protein  36.97 
 
 
120 aa  64.3  0.0000000006  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_007650  BTH_II1587  response regulator  34.96 
 
 
122 aa  64.3  0.0000000006  Burkholderia thailandensis E264  Bacteria  normal  0.458847  n/a   
 
 
-
 
NC_004578  PSPTO_0127  alginate biosynthesis regulatory protein AlgR  39.64 
 
 
248 aa  63.9  0.0000000007  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  n/a   
 
 
-
 
NC_013456  VEA_003520  chemotaxis protein CheC -- inhibitor of MCP methylation  35.51 
 
 
344 aa  63.9  0.0000000008  Vibrio sp. Ex25  Bacteria  hitchhiker  0.000479337  n/a   
 
 
-
 
NC_009656  PSPA7_6007  alginate biosynthesis regulatory protein AlgR  40.34 
 
 
248 aa  63.2  0.000000001  Pseudomonas aeruginosa PA7  Bacteria  normal  0.404994  n/a   
 
 
-
 
NC_013757  Gobs_4999  response regulator receiver protein  36.11 
 
 
120 aa  63.2  0.000000001  Geodermatophilus obscurus DSM 43160  Bacteria  normal  n/a   
 
 
-
 
NC_012918  GM21_3929  response regulator receiver protein  36.13 
 
 
120 aa  63.2  0.000000001  Geobacter sp. M21  Bacteria  n/a    normal  0.0321819 
 
 
-
 
NC_008463  PA14_69470  alginate biosynthesis regulatory protein AlgR  40.34 
 
 
248 aa  63.2  0.000000001  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  0.184834  normal 
 
 
-
 
NC_014148  Plim_2329  response regulator receiver  30.43 
 
 
301 aa  62.8  0.000000002  Planctomyces limnophilus DSM 3776  Bacteria  normal  0.25746  n/a   
 
 
-
 
NC_011769  DvMF_2550  multi-sensor signal transduction histidine kinase  37.5 
 
 
685 aa  62.8  0.000000002  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal 
 
 
-
 
NC_008639  Cpha266_1834  multi-sensor signal transduction histidine kinase  32.11 
 
 
681 aa  62.4  0.000000002  Chlorobium phaeobacteroides DSM 266  Bacteria  normal  n/a   
 
 
-
 
NC_013411  GYMC61_0410  two component transcriptional regulator, AraC family  32.71 
 
 
233 aa  61.6  0.000000003  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_013093  Amir_2317  response regulator receiver protein  34.26 
 
 
120 aa  61.6  0.000000003  Actinosynnema mirum DSM 43827  Bacteria  normal  0.357454  n/a   
 
 
-
 
NC_008709  Ping_2985  fused histidine kinase sensor/response regulator  33.33 
 
 
1121 aa  61.6  0.000000003  Psychromonas ingrahamii 37  Bacteria  normal  normal  0.446873 
 
 
-
 
NC_006349  BMAA0678  response regulator  33.33 
 
 
122 aa  61.6  0.000000004  Burkholderia mallei ATCC 23344  Bacteria  normal  n/a   
 
 
-
 
NC_010571  Oter_2328  LytTR family two component transcriptional regulator  40.87 
 
 
255 aa  61.2  0.000000004  Opitutus terrae PB90-1  Bacteria  normal  0.261765  decreased coverage  0.00199939 
 
 
-
 
NC_009075  BURPS668_A1201  response regulator  33.33 
 
 
122 aa  61.6  0.000000004  Burkholderia pseudomallei 668  Bacteria  normal  n/a   
 
 
-
 
NC_008835  BMA10229_0787  response regulator  33.33 
 
 
122 aa  61.6  0.000000004  Burkholderia mallei NCTC 10229  Bacteria  normal  0.54167  n/a   
 
 
-
 
NC_008699  Noca_3595  response regulator receiver  34.26 
 
 
120 aa  61.2  0.000000004  Nocardioides sp. JS614  Bacteria  normal  0.682594  n/a   
 
 
-
 
NC_008726  Mvan_2840  response regulator receiver/ANTAR domain-containing protein  38.83 
 
 
213 aa  61.2  0.000000005  Mycobacterium vanbaalenii PYR-1  Bacteria  normal  0.0401204  normal 
 
 
-
 
NC_013223  Dret_1438  response regulator receiver protein  34.26 
 
 
118 aa  60.8  0.000000006  Desulfohalobium retbaense DSM 5692  Bacteria  normal  0.0726214  normal  0.0482802 
 
 
-
 
NC_013037  Dfer_5142  two component transcriptional regulator, LytTR family  35.19 
 
 
244 aa  60.8  0.000000006  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.546377  normal 
 
 
-
 
NC_010571  Oter_2329  LytTR family two component transcriptional regulator  41.67 
 
 
255 aa  60.8  0.000000007  Opitutus terrae PB90-1  Bacteria  normal  0.0531557  decreased coverage  0.00207881 
 
 
-
 
NC_009078  BURPS1106A_A1124  response regulator  33.33 
 
 
122 aa  60.5  0.000000007  Burkholderia pseudomallei 1106a  Bacteria  normal  0.706224  n/a   
 
 
-
 
NC_007435  BURPS1710b_A2404  response regulator  33.33 
 
 
122 aa  60.5  0.000000007  Burkholderia pseudomallei 1710b  Bacteria  normal  n/a   
 
 
-
 
NC_011894  Mnod_1691  CheA signal transduction histidine kinase  37.5 
 
 
878 aa  60.5  0.000000008  Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_009783  VIBHAR_02240  hypothetical protein  34.58 
 
 
322 aa  60.5  0.000000009  Vibrio harveyi ATCC BAA-1116  Bacteria  n/a    n/a   
 
 
-
 
NC_010086  Bmul_3168  response regulator receiver protein  38.6 
 
 
122 aa  60.1  0.00000001  Burkholderia multivorans ATCC 17616  Bacteria  hitchhiker  0.000557514  normal  0.634749 
 
 
-
 
NC_009943  Dole_0913  response regulator receiver protein  36.89 
 
 
301 aa  59.7  0.00000001  Desulfococcus oleovorans Hxd3  Bacteria  normal  0.348072  n/a   
 
 
-
 
NC_007404  Tbd_2464  two component LuxR family transcriptional regulator  37.01 
 
 
221 aa  59.7  0.00000001  Thiobacillus denitrificans ATCC 25259  Bacteria  normal  normal 
 
 
-
 
NC_009439  Pmen_0279  two-component response regulator AlgR  39.64 
 
 
248 aa  60.1  0.00000001  Pseudomonas mendocina ymp  Bacteria  normal  normal 
 
 
-
 
NC_013501  Rmar_1797  two component, sigma54 specific, transcriptional regulator, Fis family  33.02 
 
 
461 aa  60.1  0.00000001  Rhodothermus marinus DSM 4252  Bacteria  normal  0.774224  n/a   
 
 
-
 
NC_007908  Rfer_2738  response regulator receiver domain-containing protein  32.41 
 
 
194 aa  60.1  0.00000001  Rhodoferax ferrireducens T118  Bacteria  hitchhiker  0.000186206  n/a   
 
 
-
 
NC_011832  Mpal_2247  response regulator receiver protein  32.76 
 
 
119 aa  60.1  0.00000001  Methanosphaerula palustris E1-9c  Archaea  normal  0.135382  normal  0.142459 
 
 
-
 
NC_010730  SYO3AOP1_0930  response regulator receiver protein  33.94 
 
 
130 aa  60.1  0.00000001  Sulfurihydrogenibium sp. YO3AOP1  Bacteria  hitchhiker  0.000000284085  n/a   
 
 
-
 
NC_009616  Tmel_1263  response regulator receiver protein  30.63 
 
 
197 aa  58.9  0.00000002  Thermosipho melanesiensis BI429  Bacteria  normal  n/a   
 
 
-
 
NC_010676  Bphyt_6235  two component transcriptional regulator, LuxR family  35.71 
 
 
210 aa  58.9  0.00000002  Burkholderia phytofirmans PsJN  Bacteria  normal  normal  0.612124 
 
 
-
 
NC_009455  DehaBAV1_0849  two component LuxR family transcriptional regulator  34 
 
 
209 aa  59.3  0.00000002  Dehalococcoides sp. BAV1  Bacteria  normal  n/a   
 
 
-
 
NC_007492  Pfl01_5488  two-component response regulator AlgR  37.5 
 
 
248 aa  58.9  0.00000002  Pseudomonas fluorescens Pf0-1  Bacteria  normal  normal 
 
 
-
 
NC_010717  PXO_02404  transcriptional regulator LuxR/uhpA family  32.76 
 
 
218 aa  59.3  0.00000002  Xanthomonas oryzae pv. oryzae PXO99A  Bacteria  normal  n/a   
 
 
-
 
NC_007912  Sde_3668  two-component response regulator AlgR  40.74 
 
 
243 aa  59.3  0.00000002  Saccharophagus degradans 2-40  Bacteria  decreased coverage  0.00827536  normal  0.334671 
 
 
-
 
NC_011312  VSAL_I1157  autoinducer regulatory protein AinR  27.78 
 
 
822 aa  59.3  0.00000002  Aliivibrio salmonicida LFI1238  Bacteria  normal  n/a   
 
 
-
 
NC_009338  Mflv_3575  response regulator receiver/ANTAR domain-containing protein  37.86 
 
 
229 aa  59.3  0.00000002  Mycobacterium gilvum PYR-GCK  Bacteria  normal  0.10936  normal  0.0183031 
 
 
-
 
NC_010511  M446_0247  PAS/PAC sensor hybrid histidine kinase  35.14 
 
 
640 aa  58.5  0.00000003  Methylobacterium sp. 4-46  Bacteria  normal  normal  0.0678153 
 
 
-
 
NC_009565  TBFG_11642  two component system transcriptional regulator  36.89 
 
 
205 aa  58.5  0.00000003  Mycobacterium tuberculosis F11  Bacteria  normal  0.0378541  normal  0.634495 
 
 
-
 
NC_013205  Aaci_0516  two component transcriptional regulator, LuxR family  31.82 
 
 
231 aa  58.5  0.00000003  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_010511  M446_2799  response regulator receiver protein  39.32 
 
 
132 aa  58.5  0.00000003  Methylobacterium sp. 4-46  Bacteria  normal  normal 
 
 
-
 
NC_010682  Rpic_3358  multi-sensor hybrid histidine kinase  38.02 
 
 
1436 aa  58.5  0.00000003  Ralstonia pickettii 12J  Bacteria  normal  0.504651  normal 
 
 
-
 
NC_011894  Mnod_0214  two component, sigma54 specific, transcriptional regulator, Fis family  38.94 
 
 
495 aa  58.2  0.00000004  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.308761  n/a   
 
 
-
 
NC_007517  Gmet_0660  response regulator receiver/ANTAR domain-containing protein  35.78 
 
 
202 aa  58.2  0.00000004  Geobacter metallireducens GS-15  Bacteria  normal  0.132289  normal  0.0166929 
 
 
-
 
NC_010524  Lcho_0901  two component LuxR family transcriptional regulator  33.71 
 
 
235 aa  58.2  0.00000004  Leptothrix cholodnii SP-6  Bacteria  n/a    normal 
 
 
-
 
NC_011769  DvMF_0215  two component, sigma54 specific, transcriptional regulator, Fis family  31.48 
 
 
528 aa  58.2  0.00000004  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal  0.0571306 
 
 
-
 
NC_007908  Rfer_2735  response regulator receiver domain-containing protein  35.29 
 
 
242 aa  58.2  0.00000004  Rhodoferax ferrireducens T118  Bacteria  normal  0.284606  n/a   
 
 
-
 
NC_007952  Bxe_B1771  periplasmic sensor hybrid histidine kinase  38.05 
 
 
613 aa  58.2  0.00000004  Burkholderia xenovorans LB400  Bacteria  normal  hitchhiker  0.00000228361 
 
 
-
 
NC_012856  Rpic12D_3011  PAS/PAC sensor hybrid histidine kinase  38.02 
 
 
1436 aa  58.2  0.00000004  Ralstonia pickettii 12D  Bacteria  normal  0.701044  normal 
 
 
-
 
NC_010002  Daci_1576  CheA signal transduction histidine kinase  34.45 
 
 
2137 aa  58.2  0.00000004  Delftia acidovorans SPH-1  Bacteria  normal  0.167147  normal  0.557453 
 
 
-
 
NC_013124  Afer_0217  response regulator receiver protein  33.33 
 
 
122 aa  58.2  0.00000004  Acidimicrobium ferrooxidans DSM 10331  Bacteria  normal  0.410028  n/a   
 
 
-
 
NC_004578  PSPTO_1039  response regulator  40.54 
 
 
334 aa  57.8  0.00000005  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  n/a   
 
 
-
 
NC_007517  Gmet_1243  histidine kinase  36.21 
 
 
654 aa  57.8  0.00000005  Geobacter metallireducens GS-15  Bacteria  normal  normal  0.0706231 
 
 
-
 
NC_002939  GSU2822  response regulator  37.61 
 
 
191 aa  57.4  0.00000006  Geobacter sulfurreducens PCA  Bacteria  normal  n/a   
 
 
-
 
NC_009483  Gura_2678  two component, sigma-54 specific, Fis family transcriptional regulator  31.93 
 
 
457 aa  57.4  0.00000006  Geobacter uraniireducens Rf4  Bacteria  normal  n/a   
 
 
-
 
NC_007434  BURPS1710b_2224  putative two-component regulatory system, sensor kinase protein  37.27 
 
 
1082 aa  57.4  0.00000006  Burkholderia pseudomallei 1710b  Bacteria  normal  n/a   
 
 
-
 
NC_009483  Gura_4220  response regulator receiver protein  34.23 
 
 
120 aa  57.4  0.00000006  Geobacter uraniireducens Rf4  Bacteria  normal  n/a   
 
 
-
 
NC_009074  BURPS668_2021  Hpt sensor hybrid histidine kinase  37.27 
 
 
1082 aa  57.4  0.00000006  Burkholderia pseudomallei 668  Bacteria  normal  n/a   
 
 
-
 
NC_007963  Csal_1062  Hpt sensor hybrid histidine kinase  32.26 
 
 
695 aa  57.4  0.00000006  Chromohalobacter salexigens DSM 3043  Bacteria  normal  n/a   
 
 
-
 
NC_010338  Caul_0621  two component LuxR family transcriptional regulator  40.38 
 
 
212 aa  57.8  0.00000006  Caulobacter sp. K31  Bacteria  normal  normal  0.881689 
 
 
-
 
NC_009076  BURPS1106A_2077  sensor histidine kinase/response regulator  37.27 
 
 
1082 aa  57.4  0.00000006  Burkholderia pseudomallei 1106a  Bacteria  normal  0.981024  n/a   
 
 
-
 
NC_009943  Dole_3263  PAS/PAC sensor hybrid histidine kinase  30.56 
 
 
639 aa  57.4  0.00000006  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_010552  BamMC406_5511  response regulator receiver protein  38.26 
 
 
122 aa  57.4  0.00000007  Burkholderia ambifaria MC40-6  Bacteria  normal  normal  0.0318397 
 
 
-
 
NC_010717  PXO_00070  Two-component system response regulator RpfG  33.62 
 
 
353 aa  57.4  0.00000007  Xanthomonas oryzae pv. oryzae PXO99A  Bacteria  normal  0.0844737  n/a   
 
 
-
 
NC_008391  Bamb_4958  response regulator receiver protein  38.26 
 
 
122 aa  57.4  0.00000007  Burkholderia ambifaria AMMD  Bacteria  normal  0.382884  normal  0.0760928 
 
 
-
 
NC_011662  Tmz1t_3355  two component transcriptional regulator, LuxR family  36.11 
 
 
208 aa  57  0.00000008  Thauera sp. MZ1T  Bacteria  normal  0.687232  n/a   
 
 
-
 
NC_011071  Smal_2061  two component transcriptional regulator, LuxR family  35.16 
 
 
224 aa  57  0.00000008  Stenotrophomonas maltophilia R551-3  Bacteria  normal  0.737796  normal 
 
 
-
 
NC_008061  Bcen_5173  response regulator receiver protein  38.26 
 
 
122 aa  57  0.00000009  Burkholderia cenocepacia AU 1054  Bacteria  hitchhiker  0.00428361  n/a   
 
 
-
 
NC_010424  Daud_0469  response regulator receiver protein  36.7 
 
 
254 aa  57  0.00000009  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  n/a   
 
 
-
 
NC_010515  Bcenmc03_4549  response regulator receiver protein  38.26 
 
 
122 aa  57  0.00000009  Burkholderia cenocepacia MC0-3  Bacteria  normal  0.0252334  normal  0.61339 
 
 
-
 
NC_008543  Bcen2424_5686  response regulator receiver protein  38.26 
 
 
122 aa  57  0.00000009  Burkholderia cenocepacia HI2424  Bacteria  normal  0.280105  decreased coverage  0.000257331 
 
 
-
 
NC_002939  GSU0403  chemotaxis protein CheY  32.73 
 
 
120 aa  56.2  0.0000001  Geobacter sulfurreducens PCA  Bacteria  normal  0.286627  n/a   
 
 
-
 
NC_009049  Rsph17029_0243  two component, sigma54 specific, Fis family transcriptional regulator  34.48 
 
 
485 aa  56.2  0.0000001  Rhodobacter sphaeroides ATCC 17029  Bacteria  normal  normal 
 
 
-
 
NC_011769  DvMF_1223  anti-sigma-factor antagonist  35.29 
 
 
271 aa  56.2  0.0000001  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal  0.068542 
 
 
-
 
NC_007493  RSP_1590  two component, sigma54 specific, Fis family transcriptional regulator  34.48 
 
 
485 aa  56.6  0.0000001  Rhodobacter sphaeroides 2.4.1  Bacteria  normal  0.0352913  n/a   
 
 
-
 
NC_007908  Rfer_2786  two component, sigma54 specific, Fis family transcriptional regulator  34.29 
 
 
477 aa  56.2  0.0000001  Rhodoferax ferrireducens T118  Bacteria  normal  n/a   
 
 
-
 
NC_010681  Bphyt_2130  two component transcriptional regulator, LuxR family  34.58 
 
 
239 aa  56.6  0.0000001  Burkholderia phytofirmans PsJN  Bacteria  normal  normal 
 
 
-
 
NC_007963  Csal_0246  nitrogen metabolism transcriptional regulator, NtrC, Fis family  36.27 
 
 
469 aa  56.2  0.0000001  Chromohalobacter salexigens DSM 3043  Bacteria  normal  0.487777  n/a   
 
 
-
 
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