More than 300 homologs were found in PanDaTox collection
for query gene M446_5294 on replicon NC_010511
Organism: Methylobacterium sp. 4-46



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_010511  M446_5294  response regulator receiver protein  100 
 
 
130 aa  254  4e-67  Methylobacterium sp. 4-46  Bacteria  normal  0.0717946  normal  0.338735 
 
 
-
 
NC_010511  M446_2799  response regulator receiver protein  78.4 
 
 
132 aa  195  1.0000000000000001e-49  Methylobacterium sp. 4-46  Bacteria  normal  normal 
 
 
-
 
NC_010511  M446_0185  response regulator receiver protein  74.6 
 
 
132 aa  186  1e-46  Methylobacterium sp. 4-46  Bacteria  normal  normal 
 
 
-
 
NC_010505  Mrad2831_5658  response regulator receiver protein  67.69 
 
 
132 aa  174  4e-43  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.483341  normal 
 
 
-
 
NC_013730  Slin_5022  response regulator receiver protein  51.67 
 
 
126 aa  116  9e-26  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_013037  Dfer_1111  response regulator receiver protein  48.21 
 
 
123 aa  109  1.0000000000000001e-23  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.0272953  normal  0.304596 
 
 
-
 
NC_010505  Mrad2831_5657  adenylate/guanylate cyclase  49.18 
 
 
421 aa  97.8  4e-20  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.517681  normal 
 
 
-
 
NC_013730  Slin_4603  response regulator receiver protein  46.79 
 
 
132 aa  95.1  2e-19  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_013037  Dfer_1110  adenylate/guanylate cyclase  40.31 
 
 
348 aa  92.4  2e-18  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.0224811  normal  0.236606 
 
 
-
 
NC_010511  M446_5293  adenylate/guanylate cyclase  45.38 
 
 
421 aa  92  2e-18  Methylobacterium sp. 4-46  Bacteria  normal  0.0545376  normal  0.227088 
 
 
-
 
NC_013730  Slin_5021  adenylate/guanylate cyclase  41.03 
 
 
348 aa  92  2e-18  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_010511  M446_2796  adenylate/guanylate cyclase  44.54 
 
 
447 aa  91.3  5e-18  Methylobacterium sp. 4-46  Bacteria  normal  normal 
 
 
-
 
NC_013730  Slin_6047  response regulator receiver sensor hybrid histidine kinase  42.02 
 
 
677 aa  85.5  2e-16  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_013730  Slin_4604  histidine kinase  38.21 
 
 
663 aa  83.6  9e-16  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_008312  Tery_0615  response regulator receiver sensor signal transduction histidine kinase  40 
 
 
395 aa  80.9  0.000000000000005  Trichodesmium erythraeum IMS101  Bacteria  normal  hitchhiker  0.00858549 
 
 
-
 
NC_013730  Slin_1905  response regulator receiver sensor hybrid histidine kinase  36.97 
 
 
668 aa  79  0.00000000000002  Spirosoma linguale DSM 74  Bacteria  normal  0.0295515  normal  0.210974 
 
 
-
 
NC_007947  Mfla_0911  two component, sigma54 specific, Fis family transcriptional regulator  38.98 
 
 
456 aa  75.5  0.0000000000002  Methylobacillus flagellatus KT  Bacteria  normal  normal 
 
 
-
 
NC_007947  Mfla_1055  two component, sigma54 specific, Fis family transcriptional regulator  38.98 
 
 
456 aa  75.5  0.0000000000002  Methylobacillus flagellatus KT  Bacteria  normal  0.523432  normal 
 
 
-
 
NC_013440  Hoch_2281  response regulator receiver protein  38.26 
 
 
128 aa  73.9  0.0000000000007  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.498531 
 
 
-
 
NC_002620  TC0753  sigma-54 dependent response regulator  35.4 
 
 
387 aa  72  0.000000000002  Chlamydia muridarum Nigg  Bacteria  normal  n/a   
 
 
-
 
NC_007492  Pfl01_4840  two-component response regulator PilR  37.76 
 
 
448 aa  72  0.000000000003  Pseudomonas fluorescens Pf0-1  Bacteria  normal  0.43512  normal  0.760188 
 
 
-
 
NC_013440  Hoch_4621  adenylate/guanylate cyclase  35.4 
 
 
687 aa  71.6  0.000000000003  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.828122 
 
 
-
 
NC_008740  Maqu_1999  two component, sigma54 specific, Fis family transcriptional regulator  37.6 
 
 
481 aa  71.6  0.000000000003  Marinobacter aquaeolei VT8  Bacteria  normal  n/a   
 
 
-
 
NC_009439  Pmen_0965  two-component response regulator PilR  41.88 
 
 
446 aa  70.1  0.000000000009  Pseudomonas mendocina ymp  Bacteria  normal  0.25964  normal 
 
 
-
 
NC_007298  Daro_1804  two component, sigma54 specific, Fis family transcriptional regulator  38.84 
 
 
469 aa  69.7  0.00000000001  Dechloromonas aromatica RCB  Bacteria  normal  0.0358984  normal  0.379225 
 
 
-
 
NC_009656  PSPA7_5187  two-component response regulator PilR  41.03 
 
 
445 aa  68.9  0.00000000002  Pseudomonas aeruginosa PA7  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_0986  response regulator receiver protein  29.27 
 
 
143 aa  68.2  0.00000000003  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal 
 
 
-
 
NC_009972  Haur_0852  GAF sensor hybrid histidine kinase  35.9 
 
 
1055 aa  68.6  0.00000000003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_008463  PA14_60260  two-component response regulator PilR  41.03 
 
 
445 aa  68.6  0.00000000003  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  hitchhiker  0.000000831057 
 
 
-
 
NC_009972  Haur_2161  adenylate/guanylate cyclase with GAF sensor(s)  37.61 
 
 
1020 aa  67.4  0.00000000006  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.0428251  n/a   
 
 
-
 
NC_010814  Glov_3076  two component, sigma54 specific, transcriptional regulator, Fis family  34.11 
 
 
454 aa  67  0.00000000008  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_007519  Dde_0324  response regulator receiver domain-containing protein  33.88 
 
 
127 aa  66.2  0.0000000001  Desulfovibrio desulfuricans subsp. desulfuricans str. G20  Bacteria  normal  0.581793  n/a   
 
 
-
 
NC_010322  PputGB1_3932  two component, sigma54 specific, Fis family transcriptional regulator  37.8 
 
 
451 aa  66.6  0.0000000001  Pseudomonas putida GB-1  Bacteria  normal  0.215439  normal 
 
 
-
 
NC_011831  Cagg_3065  response regulator receiver protein  36.75 
 
 
128 aa  66.2  0.0000000001  Chloroflexus aggregans DSM 9485  Bacteria  normal  0.735156  hitchhiker  0.0000890784 
 
 
-
 
NC_011830  Dhaf_4841  response regulator receiver protein  38.6 
 
 
118 aa  65.5  0.0000000002  Desulfitobacterium hafniense DCB-2  Bacteria  normal  0.202718  n/a   
 
 
-
 
NC_004578  PSPTO_0823  type 4 fimbriae expression regulatory protein pilR  36 
 
 
446 aa  65.5  0.0000000002  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  n/a   
 
 
-
 
NC_007005  Psyr_0722  helix-turn-helix, Fis-type  36 
 
 
445 aa  65.9  0.0000000002  Pseudomonas syringae pv. syringae B728a  Bacteria  normal  normal 
 
 
-
 
NC_011901  Tgr7_2618  two component, sigma54 specific, transcriptional regulator, Fis family  35 
 
 
453 aa  66.2  0.0000000002  Thioalkalivibrio sp. HL-EbGR7  Bacteria  normal  0.153552  n/a   
 
 
-
 
NC_007484  Noc_0723  two component, sigma-54 specific, Fis family transcriptional regulator  32.79 
 
 
444 aa  65.5  0.0000000002  Nitrosococcus oceani ATCC 19707  Bacteria  hitchhiker  0.00153946  n/a   
 
 
-
 
NC_012918  GM21_1165  diguanylate cyclase  35.65 
 
 
459 aa  65.9  0.0000000002  Geobacter sp. M21  Bacteria  n/a    hitchhiker  0.000192138 
 
 
-
 
NC_011769  DvMF_2550  multi-sensor signal transduction histidine kinase  41.59 
 
 
685 aa  65.5  0.0000000002  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal 
 
 
-
 
NC_008321  Shewmr4_2685  two component, sigma54 specific, Fis family transcriptional regulator  36.97 
 
 
425 aa  65.5  0.0000000002  Shewanella sp. MR-4  Bacteria  normal  0.501083  normal  0.0990314 
 
 
-
 
NC_011146  Gbem_3097  diguanylate cyclase  35.65 
 
 
458 aa  66.2  0.0000000002  Geobacter bemidjiensis Bem  Bacteria  normal  0.948135  n/a   
 
 
-
 
NC_013385  Adeg_0532  two component, sigma54 specific, transcriptional regulator, Fis family  35.71 
 
 
470 aa  65.9  0.0000000002  Ammonifex degensii KC4  Bacteria  hitchhiker  0.00706375  n/a   
 
 
-
 
NC_009512  Pput_1496  two component, sigma54 specific, Fis family transcriptional regulator  34.65 
 
 
451 aa  65.1  0.0000000003  Pseudomonas putida F1  Bacteria  normal  0.190196  normal  0.699272 
 
 
-
 
NC_010814  Glov_2298  two component, sigma54 specific, transcriptional regulator, Fis family  37.19 
 
 
452 aa  65.1  0.0000000003  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_008789  Hhal_1340  two component, sigma54 specific, Fis family transcriptional regulator  36.07 
 
 
457 aa  65.5  0.0000000003  Halorhodospira halophila SL1  Bacteria  normal  n/a   
 
 
-
 
NC_007912  Sde_2555  two-component response regulator PilR  33.91 
 
 
459 aa  65.5  0.0000000003  Saccharophagus degradans 2-40  Bacteria  normal  0.822177  normal  0.0698623 
 
 
-
 
NC_009483  Gura_1886  diguanylate cyclase  35.9 
 
 
462 aa  65.1  0.0000000003  Geobacter uraniireducens Rf4  Bacteria  normal  n/a   
 
 
-
 
NC_011831  Cagg_1830  response regulator receiver modulated diguanylate cyclase  42.02 
 
 
941 aa  65.1  0.0000000003  Chloroflexus aggregans DSM 9485  Bacteria  normal  normal 
 
 
-
 
NC_007796  Mhun_1438  putative PAS/PAC sensor protein  37.5 
 
 
393 aa  64.7  0.0000000004  Methanospirillum hungatei JF-1  Archaea  normal  normal  0.92182 
 
 
-
 
NC_011206  Lferr_0029  two component, sigma54 specific, transcriptional regulator, Fis family  38.05 
 
 
455 aa  64.7  0.0000000004  Acidithiobacillus ferrooxidans ATCC 53993  Bacteria  normal  0.59486  normal  0.125276 
 
 
-
 
NC_008322  Shewmr7_2753  two component, sigma54 specific, Fis family transcriptional regulator  37.82 
 
 
425 aa  64.7  0.0000000004  Shewanella sp. MR-7  Bacteria  decreased coverage  0.00792223  normal 
 
 
-
 
NC_011761  AFE_0027  sigma-54 dependent transcriptional regulator/response regulator  38.05 
 
 
455 aa  64.7  0.0000000004  Acidithiobacillus ferrooxidans ATCC 23270  Bacteria  normal  n/a   
 
 
-
 
NC_008825  Mpe_A3216  type IV pilus expression regulatory protein  36.51 
 
 
537 aa  64.3  0.0000000005  Methylibium petroleiphilum PM1  Bacteria  normal  normal  0.422678 
 
 
-
 
NC_008554  Sfum_2806  two component, sigma54 specific, Fis family transcriptional regulator  36.36 
 
 
450 aa  64.3  0.0000000005  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_009523  RoseRS_4041  response regulator receiver protein  34.78 
 
 
127 aa  64.3  0.0000000006  Roseiflexus sp. RS-1  Bacteria  normal  0.557093  normal 
 
 
-
 
NC_002947  PP_4371  two component, sigma54 specific, transcriptional regulator, Fis family  33.86 
 
 
451 aa  64.3  0.0000000006  Pseudomonas putida KT2440  Bacteria  normal  0.109269  normal  0.91149 
 
 
-
 
NC_009972  Haur_3092  response regulator receiver protein  34.43 
 
 
128 aa  64.3  0.0000000006  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.0109887  n/a   
 
 
-
 
NC_007298  Daro_2585  helix-turn-helix, Fis-type  32 
 
 
468 aa  63.9  0.0000000007  Dechloromonas aromatica RCB  Bacteria  normal  0.023304  normal  0.859939 
 
 
-
 
NC_010524  Lcho_0380  two component, sigma54 specific, Fis family transcriptional regulator  35.9 
 
 
522 aa  63.9  0.0000000007  Leptothrix cholodnii SP-6  Bacteria  n/a    normal  0.0200588 
 
 
-
 
NC_012918  GM21_1811  response regulator receiver modulated metal dependent phosphohydrolase  39.09 
 
 
347 aa  62.8  0.000000001  Geobacter sp. M21  Bacteria  n/a    hitchhiker  0.00843757 
 
 
-
 
NC_008752  Aave_3002  two component transcriptional regulator  35.59 
 
 
230 aa  62.8  0.000000001  Acidovorax citrulli AAC00-1  Bacteria  normal  0.67465  normal  0.369251 
 
 
-
 
NC_009943  Dole_1361  response regulator receiver protein  34.96 
 
 
147 aa  62.8  0.000000001  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_009719  Plav_2050  two component, sigma54 specific, Fis family transcriptional regulator  33.93 
 
 
511 aa  63.2  0.000000001  Parvibaculum lavamentivorans DS-1  Bacteria  normal  0.155124  hitchhiker  0.000156568 
 
 
-
 
NC_011146  Gbem_2407  response regulator receiver modulated metal dependent phosphohydrolase  39.09 
 
 
347 aa  62.8  0.000000001  Geobacter bemidjiensis Bem  Bacteria  normal  0.21688  n/a   
 
 
-
 
NC_007912  Sde_2191  diguanylate cyclase/phosphodiesterase  33.59 
 
 
497 aa  62.8  0.000000001  Saccharophagus degradans 2-40  Bacteria  normal  normal 
 
 
-
 
NC_010814  Glov_1760  response regulator receiver modulated diguanylate cyclase  33.94 
 
 
473 aa  63.2  0.000000001  Geobacter lovleyi SZ  Bacteria  normal  0.554911  n/a   
 
 
-
 
NC_011149  SeAg_B4418  transcriptional regulatory protein ZraR  32.26 
 
 
441 aa  63.2  0.000000001  Salmonella enterica subsp. enterica serovar Agona str. SL483  Bacteria  normal  0.298897  n/a   
 
 
-
 
NC_008609  Ppro_1179  two component, sigma54 specific, Fis family transcriptional regulator  34.21 
 
 
457 aa  63.2  0.000000001  Pelobacter propionicus DSM 2379  Bacteria  normal  0.655382  n/a   
 
 
-
 
NC_011831  Cagg_1597  adenylate/guanylate cyclase with GAF sensor(s)  35.09 
 
 
981 aa  62  0.000000002  Chloroflexus aggregans DSM 9485  Bacteria  unclonable  0.000711164  normal 
 
 
-
 
NC_009767  Rcas_3669  response regulator receiver protein  34.78 
 
 
127 aa  62.4  0.000000002  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_6827  response regulator receiver protein  31.75 
 
 
389 aa  62.4  0.000000002  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_007908  Rfer_2738  response regulator receiver domain-containing protein  35.65 
 
 
194 aa  62.8  0.000000002  Rhodoferax ferrireducens T118  Bacteria  hitchhiker  0.000186206  n/a   
 
 
-
 
NC_007908  Rfer_2982  nitrogen metabolism transcriptional regulator, NtrC, Fis family  39.82 
 
 
520 aa  62.8  0.000000002  Rhodoferax ferrireducens T118  Bacteria  normal  0.980884  n/a   
 
 
-
 
NC_008312  Tery_3155  adenylate/guanylate cyclase  33.88 
 
 
1172 aa  62  0.000000002  Trichodesmium erythraeum IMS101  Bacteria  normal  0.386213  hitchhiker  0.00095291 
 
 
-
 
NC_013223  Dret_0097  two component, sigma54 specific, transcriptional regulator, Fis family  33.03 
 
 
448 aa  61.6  0.000000003  Desulfohalobium retbaense DSM 5692  Bacteria  normal  normal 
 
 
-
 
NC_010498  EcSMS35_4454  transcriptional regulatory protein ZraR  32.54 
 
 
441 aa  61.6  0.000000003  Escherichia coli SMS-3-5  Bacteria  normal  0.209341  hitchhiker  0.000519331 
 
 
-
 
NC_009801  EcE24377A_4549  transcriptional regulatory protein ZraR  32.54 
 
 
441 aa  61.6  0.000000003  Escherichia coli E24377A  Bacteria  hitchhiker  0.000369022  n/a   
 
 
-
 
NC_008751  Dvul_2403  two component, sigma54 specific, Fis family transcriptional regulator  34.71 
 
 
467 aa  61.6  0.000000003  Desulfovibrio vulgaris DP4  Bacteria  normal  normal  0.32958 
 
 
-
 
NC_007517  Gmet_2034  two component, sigma54 specific, Fis family transcriptional regulator  31.36 
 
 
449 aa  61.6  0.000000003  Geobacter metallireducens GS-15  Bacteria  normal  0.0792682  normal  0.101595 
 
 
-
 
NC_009767  Rcas_1114  response regulator receiver modulated serine phosphatase  37.5 
 
 
391 aa  62  0.000000003  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_009654  Mmwyl1_1086  response regulator receiver modulated metal dependent phosphohydrolase  40.54 
 
 
331 aa  62  0.000000003  Marinomonas sp. MWYL1  Bacteria  normal  0.226857  hitchhiker  0.0000000112469 
 
 
-
 
NC_007947  Mfla_0214  two component, sigma54 specific, Fis family transcriptional regulator  37.3 
 
 
455 aa  62  0.000000003  Methylobacillus flagellatus KT  Bacteria  normal  normal  0.662344 
 
 
-
 
NC_011205  SeD_A4581  transcriptional regulatory protein ZraR  32.26 
 
 
441 aa  61.6  0.000000003  Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853  Bacteria  normal  normal 
 
 
-
 
NC_009972  Haur_4156  two component transcriptional regulator  37.04 
 
 
232 aa  62  0.000000003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  decreased coverage  0.0000307056  n/a   
 
 
-
 
NC_011080  SNSL254_A4507  transcriptional regulatory protein ZraR  32.26 
 
 
441 aa  61.6  0.000000003  Salmonella enterica subsp. enterica serovar Newport str. SL254  Bacteria  normal  normal  0.0570238 
 
 
-
 
NC_011094  SeSA_A4385  transcriptional regulatory protein ZraR  32.26 
 
 
441 aa  61.6  0.000000003  Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633  Bacteria  normal  normal  0.712665 
 
 
-
 
CP001637  EcDH1_3989  two component, sigma54 specific, transcriptional regulator, Fis family  32.54 
 
 
441 aa  61.6  0.000000004  Escherichia coli DH1  Bacteria  normal  0.716922  n/a   
 
 
-
 
NC_008752  Aave_1445  nitrogen metabolism transcriptional regulator, NtrC, Fis family  35.71 
 
 
549 aa  61.6  0.000000004  Acidovorax citrulli AAC00-1  Bacteria  normal  normal 
 
 
-
 
NC_010658  SbBS512_E4497  transcriptional regulatory protein ZraR  32.54 
 
 
441 aa  61.6  0.000000004  Shigella boydii CDC 3083-94  Bacteria  hitchhiker  0.0000279415  n/a   
 
 
-
 
NC_010814  Glov_1745  response regulator receiver sensor signal transduction histidine kinase  37.7 
 
 
417 aa  61.2  0.000000004  Geobacter lovleyi SZ  Bacteria  normal  0.0330192  n/a   
 
 
-
 
NC_007519  Dde_3715  multi-sensor signal transduction histidine kinase  38.21 
 
 
653 aa  61.6  0.000000004  Desulfovibrio desulfuricans subsp. desulfuricans str. G20  Bacteria  normal  n/a   
 
 
-
 
NC_009800  EcHS_A4238  transcriptional regulatory protein ZraR  32.54 
 
 
441 aa  61.6  0.000000004  Escherichia coli HS  Bacteria  normal  0.020936  n/a   
 
 
-
 
NC_007948  Bpro_1117  two component, sigma54 specific, Fis family transcriptional regulator  37.01 
 
 
466 aa  61.6  0.000000004  Polaromonas sp. JS666  Bacteria  normal  normal 
 
 
-
 
NC_012791  Vapar_0965  putative two component, sigma54 specific, transcriptional regulator, Fis family  36.29 
 
 
462 aa  61.6  0.000000004  Variovorax paradoxus S110  Bacteria  normal  n/a   
 
 
-
 
NC_011206  Lferr_0364  two component, sigma54 specific, transcriptional regulator, Fis family  37.29 
 
 
451 aa  61.2  0.000000005  Acidithiobacillus ferrooxidans ATCC 53993  Bacteria  normal  normal  0.48055 
 
 
-
 
NC_007947  Mfla_0716  two component transcriptional regulator  36.7 
 
 
233 aa  60.8  0.000000005  Methylobacillus flagellatus KT  Bacteria  normal  normal 
 
 
-
 
NC_012892  B21_03834  hypothetical protein  32.54 
 
 
441 aa  61.2  0.000000005  Escherichia coli BL21  Bacteria  normal  0.0118236  n/a   
 
 
-
 
NC_010468  EcolC_4021  transcriptional regulatory protein ZraR  32.54 
 
 
441 aa  61.2  0.000000005  Escherichia coli ATCC 8739  Bacteria  normal  0.0128092  normal  0.0227655 
 
 
-
 
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