More than 300 homologs were found in PanDaTox collection
for query gene TBFG_10197 on replicon NC_009565
Organism: Mycobacterium tuberculosis F11



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_009565  TBFG_10197  LuxR family two component transcriptional regulator  100 
 
 		 232 aa  469  1.0000000000000001e-131  Mycobacterium tuberculosis F11  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013131  Caci_4395  transcriptional regulator, LuxR family  33.81 
 
 		 208 aa  105  5e-22  Catenulispora acidiphila DSM 44928  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009953  Sare_4852  LuxR family transcriptional regulator  32.85 
 
 		 207 aa  103  3e-21  Salinispora arenicola CNS-205  Bacteria  normal  1  normal  0.0262091 
 
 
-
 
NC_013093  Amir_5376  transcriptional regulator, LuxR family  32.54 
 
 		 213 aa  99.8  3e-20  Actinosynnema mirum DSM 43827  Bacteria  normal  0.416669  n/a   
 
 
-
 
NC_014151  Cfla_2255  transcriptional regulator, LuxR family  36.36 
 
 		 207 aa  99.8  4e-20  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.0543436  hitchhiker  0.000519578 
 
 
-
 
NC_013235  Namu_1891  transcriptional regulator, LuxR family  34.62 
 
 		 230 aa  99.4  4e-20  Nakamurella multipartita DSM 44233  Bacteria  hitchhiker  0.00164243  normal  0.142555 
 
 
-
 
NC_009077  Mjls_0940  response regulator receiver protein  40.14 
 
 		 207 aa  97.4  2e-19  Mycobacterium sp. JLS  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009953  Sare_0350  LuxR family transcriptional regulator  32.85 
 
 		 202 aa  90.1  3e-17  Salinispora arenicola CNS-205  Bacteria  normal  0.204823  normal  0.0810275 
 
 
-
 
NC_009921  Franean1_3808  LuxR family transcriptional regulator  35.5 
 
 		 268 aa  88.2  9e-17  Frankia sp. EAN1pec  Bacteria  normal  0.0706178  normal  0.229787 
 
 
-
 
NC_013093  Amir_2952  transcriptional regulator, LuxR family  38.51 
 
 		 207 aa  85.9  5e-16  Actinosynnema mirum DSM 43827  Bacteria  normal  0.0281323  n/a   
 
 
-
 
NC_013093  Amir_2930  transcriptional regulator, LuxR family  29.81 
 
 		 208 aa  85.1  9e-16  Actinosynnema mirum DSM 43827  Bacteria  normal  0.757677  n/a   
 
 
-
 
NC_013093  Amir_3574  transcriptional regulator, LuxR family  35.1 
 
 		 206 aa  80.5  0.00000000000002  Actinosynnema mirum DSM 43827  Bacteria  normal  1  n/a   
 
 
-
 
NC_013093  Amir_3573  transcriptional regulator, LuxR family  33.33 
 
 		 189 aa  80.1  0.00000000000003  Actinosynnema mirum DSM 43827  Bacteria  normal  1  n/a   
 
 
-
 
NC_009953  Sare_0351  LuxR family transcriptional regulator  33.81 
 
 		 195 aa  79  0.00000000000005  Salinispora arenicola CNS-205  Bacteria  normal  0.147651  normal  0.0771656 
 
 
-
 
NC_014151  Cfla_2886  transcriptional regulator, LuxR family  34.59 
 
 		 252 aa  78.6  0.00000000000008  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.197544  normal  0.152863 
 
 
-
 
NC_013595  Sros_4468  response regulator receiver protein  35.22 
 
 		 219 aa  77.8  0.0000000000001  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0876299  normal  0.32237 
 
 
-
 
NC_013159  Svir_26840  response regulator containing a CheY-like receiver domain protein and an HTH DNA-binding domain protein  34.72 
 
 		 239 aa  77.4  0.0000000000002  Saccharomonospora viridis DSM 43017  Bacteria  normal  0.274056  normal  0.228776 
 
 
-
 
NC_009953  Sare_4860  two component LuxR family transcriptional regulator  34.72 
 
 		 219 aa  75.9  0.0000000000005  Salinispora arenicola CNS-205  Bacteria  normal  0.452521  normal  0.0798716 
 
 
-
 
NC_009664  Krad_2599  two component transcriptional regulator, LuxR family  35.62 
 
 		 211 aa  74.3  0.000000000001  Kineococcus radiotolerans SRS30216  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009380  Strop_2458  response regulator receiver  35.14 
 
 		 220 aa  73.6  0.000000000002  Salinispora tropica CNB-440  Bacteria  normal  0.0554598  normal  1 
 
 
-
 
NC_013530  Xcel_1619  two component transcriptional regulator, LuxR family  35.51 
 
 		 234 aa  72.8  0.000000000004  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  1  n/a   
 
 
-
 
NC_013093  Amir_2811  two component transcriptional regulator, LuxR family  35.81 
 
 		 217 aa  73.2  0.000000000004  Actinosynnema mirum DSM 43827  Bacteria  normal  0.206772  n/a   
 
 
-
 
NC_013947  Snas_3359  two component transcriptional regulator, LuxR family  30.37 
 
 		 219 aa  72.4  0.000000000005  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.0172663  normal  1 
 
 
-
 
NC_013946  Mrub_0806  two component LuxR family transcriptional regulator  33.06 
 
 		 216 aa  70.9  0.00000000001  Meiothermus ruber DSM 1279  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009674  Bcer98_0214  two component LuxR family transcriptional regulator  28.11 
 
 		 220 aa  71.6  0.00000000001  Bacillus cytotoxicus NVH 391-98  Bacteria  normal  1  n/a   
 
 
-
 
NC_013947  Snas_2469  two component transcriptional regulator, LuxR family  34.03 
 
 		 214 aa  70.5  0.00000000002  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.126163  normal  1 
 
 
-
 
NC_013595  Sros_0279  response regulator receiver protein  33.57 
 
 		 216 aa  70.9  0.00000000002  Streptosporangium roseum DSM 43021  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013172  Bfae_11600  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  33.1 
 
 		 225 aa  70.1  0.00000000003  Brachybacterium faecium DSM 4810  Bacteria  decreased coverage  0.00120804  n/a   
 
 
-
 
NC_009664  Krad_1198  two component transcriptional regulator, LuxR family  29.28 
 
 		 225 aa  69.7  0.00000000003  Kineococcus radiotolerans SRS30216  Bacteria  normal  0.109916  normal  0.0247339 
 
 
-
 
NC_012669  Bcav_0236  two component transcriptional regulator, LuxR family  30.28 
 
 		 224 aa  69.3  0.00000000004  Beutenbergia cavernae DSM 12333  Bacteria  normal  1  normal  1 
 
 
-
 
NC_014210  Ndas_4652  two component transcriptional regulator, LuxR family  31.74 
 
 		 219 aa  69.3  0.00000000005  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  0.0949639  normal  1 
 
 
-
 
NC_007951  Bxe_A1815  two component LuxR family transcriptional regulator  39.68 
 
 		 213 aa  68.6  0.00000000007  Burkholderia xenovorans LB400  Bacteria  normal  0.922696  normal  0.34679 
 
 
-
 
NC_013595  Sros_5905  response regulator receiver protein  33.79 
 
 		 227 aa  68.6  0.00000000008  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0252894  normal  0.145246 
 
 
-
 
NC_013947  Snas_1903  two component transcriptional regulator, LuxR family  28.74 
 
 		 225 aa  67  0.0000000002  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.202425  normal  0.182857 
 
 
-
 
NC_014165  Tbis_1846  LuxR family two component transcriptional regulator  32.67 
 
 		 226 aa  67.4  0.0000000002  Thermobispora bispora DSM 43833  Bacteria  normal  0.699471  normal  1 
 
 
-
 
NC_008699  Noca_1438  response regulator receiver  29.37 
 
 		 213 aa  67.4  0.0000000002  Nocardioides sp. JS614  Bacteria  normal  0.494689  n/a   
 
 
-
 
NC_013131  Caci_7415  two component transcriptional regulator, LuxR family  30.77 
 
 		 228 aa  66.6  0.0000000003  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.933403  normal  1 
 
 
-
 
NC_011729  PCC7424_0164  two component transcriptional regulator, LuxR family  27.73 
 
 		 234 aa  66.6  0.0000000003  Cyanothece sp. PCC 7424  Bacteria  n/a    normal  0.0441129 
 
 
-
 
NC_014165  Tbis_0228  LuxR family two component transcriptional regulator  29.17 
 
 		 206 aa  66.2  0.0000000004  Thermobispora bispora DSM 43833  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013159  Svir_39510  response regulator containing a CheY-like receiver domain protein and an HTH DNA-binding domain protein  27.44 
 
 		 216 aa  66.2  0.0000000004  Saccharomonospora viridis DSM 43017  Bacteria  normal  1  normal  0.657091 
 
 
-
 
NC_009674  Bcer98_1160  two component LuxR family transcriptional regulator  25.93 
 
 		 210 aa  66.2  0.0000000004  Bacillus cytotoxicus NVH 391-98  Bacteria  normal  1  n/a   
 
 
-
 
NC_007954  Sden_3055  response regulator receiver  28.24 
 
 		 219 aa  65.9  0.0000000005  Shewanella denitrificans OS217  Bacteria  normal  1  n/a   
 
 
-
 
NC_014212  Mesil_2510  two component transcriptional regulator, LuxR family  32.26 
 
 		 217 aa  65.9  0.0000000005  Meiothermus silvanus DSM 9946  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013525  Tter_0300  two component transcriptional regulator, LuxR family  26.82 
 
 		 224 aa  65.9  0.0000000005  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_009921  Franean1_6933  two component LuxR family transcriptional regulator  32.52 
 
 		 244 aa  65.9  0.0000000005  Frankia sp. EAN1pec  Bacteria  normal  1  normal  0.322421 
 
 
-
 
NC_009921  Franean1_4062  two component LuxR family transcriptional regulator  32.52 
 
 		 216 aa  65.9  0.0000000005  Frankia sp. EAN1pec  Bacteria  normal  0.0448793  normal  0.300284 
 
 
-
 
NC_008322  Shewmr7_1222  two component LuxR family transcriptional regulator  28.24 
 
 		 225 aa  65.9  0.0000000006  Shewanella sp. MR-7  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013093  Amir_2737  two component transcriptional regulator, LuxR family  29.22 
 
 		 227 aa  65.9  0.0000000006  Actinosynnema mirum DSM 43827  Bacteria  normal  0.418014  n/a   
 
 
-
 
NC_010571  Oter_3231  two component LuxR family transcriptional regulator  31.43 
 
 		 209 aa  65.1  0.0000000008  Opitutus terrae PB90-1  Bacteria  normal  0.229823  normal  0.0283688 
 
 
-
 
NC_013757  Gobs_4064  two component transcriptional regulator, LuxR family  37.01 
 
 		 217 aa  65.5  0.0000000008  Geodermatophilus obscurus DSM 43160  Bacteria  normal  1  n/a   
 
 
-
 
NC_013441  Gbro_3238  regulatory protein LuxR  30.16 
 
 		 228 aa  64.7  0.000000001  Gordonia bronchialis DSM 43247  Bacteria  normal  1  n/a   
 
 
-
 
NC_013510  Tcur_2302  two component transcriptional regulator, LuxR family  28.44 
 
 		 226 aa  64.7  0.000000001  Thermomonospora curvata DSM 43183  Bacteria  normal  0.0191252  n/a   
 
 
-
 
NC_013595  Sros_1417  response regulator receiver protein  31.51 
 
 		 234 aa  65.1  0.000000001  Streptosporangium roseum DSM 43021  Bacteria  normal  1  normal  0.0224272 
 
 
-
 
NC_013521  Sked_32990  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  32.12 
 
 		 217 aa  64.3  0.000000001  Sanguibacter keddieii DSM 10542  Bacteria  normal  1  normal  0.227707 
 
 
-
 
CP001509  ECD_02120  DNA-binding response regulator in two-component regulatory system with NarQ or NarX  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli BL21(DE3)  Bacteria  normal  1  n/a   
 
 
-
 
CP001637  EcDH1_1466  two component transcriptional regulator, LuxR family  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli DH1  Bacteria  normal  0.25338  n/a   
 
 
-
 
NC_013739  Cwoe_4937  two component transcriptional regulator, LuxR family  34.62 
 
 		 224 aa  64.3  0.000000002  Conexibacter woesei DSM 14684  Bacteria  normal  0.570807  normal  0.210467 
 
 
-
 
NC_010468  EcolC_1457  transcriptional regulator NarP  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli ATCC 8739  Bacteria  normal  1  normal  0.956805 
 
 
-
 
NC_010498  EcSMS35_2341  transcriptional regulator NarP  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli SMS-3-5  Bacteria  normal  1  normal  0.277554 
 
 
-
 
NC_012669  Bcav_0717  two component transcriptional regulator, LuxR family  28.24 
 
 		 209 aa  63.9  0.000000002  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.854815  normal  0.189113 
 
 
-
 
NC_008025  Dgeo_0315  two component LuxR family transcriptional regulator  30.65 
 
 		 214 aa  63.9  0.000000002  Deinococcus geothermalis DSM 11300  Bacteria  normal  1  hitchhiker  0.0084678 
 
 
-
 
NC_014165  Tbis_0775  LuxR family two component transcriptional regulator  32.19 
 
 		 234 aa  63.9  0.000000002  Thermobispora bispora DSM 43833  Bacteria  normal  1  normal  0.336237 
 
 
-
 
NC_008531  LEUM_1141  DNA-binding response regulator  27.62 
 
 		 210 aa  64.3  0.000000002  Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293  Bacteria  normal  0.780315  n/a   
 
 
-
 
NC_008699  Noca_3643  two component LuxR family transcriptional regulator  30.73 
 
 		 215 aa  63.5  0.000000002  Nocardioides sp. JS614  Bacteria  normal  0.516516  n/a   
 
 
-
 
NC_011663  Sbal223_3070  two component transcriptional regulator, LuxR family  27.98 
 
 		 216 aa  64.3  0.000000002  Shewanella baltica OS223  Bacteria  decreased coverage  0.000689776  unclonable  0.00000000000283062 
 
 
-
 
NC_013131  Caci_8900  two component transcriptional regulator, LuxR family  31.03 
 
 		 221 aa  64.3  0.000000002  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.967084  normal  1 
 
 
-
 
NC_012892  B21_02079  hypothetical protein  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli BL21  Bacteria  normal  1  n/a   
 
 
-
 
NC_009800  EcHS_A2331  transcriptional regulator NarP  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli HS  Bacteria  normal  1  n/a   
 
 
-
 
NC_009801  EcE24377A_2492  transcriptional regulator NarP  34.78 
 
 		 215 aa  63.9  0.000000002  Escherichia coli E24377A  Bacteria  normal  1  n/a   
 
 
-
 
NC_010658  SbBS512_E0748  transcriptional regulator NarP  34.78 
 
 		 215 aa  63.9  0.000000002  Shigella boydii CDC 3083-94  Bacteria  normal  0.251733  n/a   
 
 
-
 
NC_007412  Ava_C0116  two component LuxR family transcriptional regulator  30.99 
 
 		 209 aa  63.2  0.000000003  Anabaena variabilis ATCC 29413  Bacteria  normal  1  normal  1 
 
 
-
 
NC_007794  Saro_1627  two component LuxR family transcriptional regulator  32.12 
 
 		 244 aa  63.2  0.000000003  Novosphingobium aromaticivorans DSM 12444  Bacteria  normal  0.0484719  n/a   
 
 
-
 
NC_009052  Sbal_1241  two component LuxR family transcriptional regulator  27.98 
 
 		 216 aa  63.2  0.000000003  Shewanella baltica OS155  Bacteria  decreased coverage  0.0000399601  n/a   
 
 
-
 
NC_013947  Snas_2557  two component transcriptional regulator, LuxR family  25.81 
 
 		 224 aa  63.5  0.000000003  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.231398  normal  0.0978001 
 
 
-
 
NC_009972  Haur_3654  two component LuxR family transcriptional regulator  35.04 
 
 		 221 aa  63.5  0.000000003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  hitchhiker  0.0000210563  n/a   
 
 
-
 
NC_009665  Shew185_1285  two component LuxR family transcriptional regulator  27.98 
 
 		 216 aa  63.5  0.000000003  Shewanella baltica OS185  Bacteria  decreased coverage  0.000337392  n/a   
 
 
-
 
NC_011353  ECH74115_3330  transcriptional regulator NarP  32.61 
 
 		 215 aa  62.8  0.000000004  Escherichia coli O157:H7 str. EC4115  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013947  Snas_0625  two component transcriptional regulator, LuxR family  31.48 
 
 		 216 aa  62.8  0.000000004  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.732521  normal  1 
 
 
-
 
NC_010505  Mrad2831_4608  two component LuxR family transcriptional regulator  29.93 
 
 		 275 aa  63.2  0.000000004  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.313635  normal  1 
 
 
-
 
NC_009921  Franean1_6351  two component LuxR family transcriptional regulator  30.09 
 
 		 244 aa  62.8  0.000000004  Frankia sp. EAN1pec  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009012  Cthe_1267  two component LuxR family transcriptional regulator  24.88 
 
 		 216 aa  63.2  0.000000004  Clostridium thermocellum ATCC 27405  Bacteria  normal  1  n/a   
 
 
-
 
NC_011772  BCG9842_B3849  DNA-binding response regulator  25.12 
 
 		 210 aa  62.8  0.000000004  Bacillus cereus G9842  Bacteria  decreased coverage  0.0000000308683  hitchhiker  0.000000000350245 
 
 
-
 
NC_007413  Ava_2028  two component LuxR family transcriptional regulator  33.33 
 
 		 219 aa  62.8  0.000000005  Anabaena variabilis ATCC 29413  Bacteria  normal  0.515359  normal  1 
 
 
-
 
NC_008726  Mvan_2836  two component LuxR family transcriptional regulator  28.37 
 
 		 207 aa  62.8  0.000000005  Mycobacterium vanbaalenii PYR-1  Bacteria  normal  0.644859  normal  1 
 
 
-
 
NC_009972  Haur_2171  two component LuxR family transcriptional regulator  29.93 
 
 		 218 aa  62.4  0.000000005  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.0762379  n/a   
 
 
-
 
NC_013093  Amir_4051  two component transcriptional regulator, LuxR family  28.44 
 
 		 225 aa  62.8  0.000000005  Actinosynnema mirum DSM 43827  Bacteria  decreased coverage  0.00308286  n/a   
 
 
-
 
NC_003909  BCE_1563  DNA-binding response regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus cereus ATCC 10987  Bacteria  hitchhiker  0.0000000942452  n/a   
 
 
-
 
NC_005945  BAS1348  DNA-binding response regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus anthracis str. Sterne  Bacteria  hitchhiker  0.0000440829  n/a   
 
 
-
 
NC_005957  BT9727_1322  response regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  decreased coverage  7.30192e-17  n/a   
 
 
-
 
NC_006274  BCZK1321  response regulator  29.2 
 
 		 210 aa  62.4  0.000000006  Bacillus cereus E33L  Bacteria  hitchhiker  0.00000332221  n/a   
 
 
-
 
NC_010184  BcerKBAB4_1363  two component LuxR family transcriptional regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus weihenstephanensis KBAB4  Bacteria  hitchhiker  0.0039551  n/a   
 
 
-
 
NC_007530  GBAA_1457  DNA-binding response regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  hitchhiker  0.0000538049  n/a   
 
 
-
 
NC_011658  BCAH187_A1601  DNA-binding response regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus cereus AH187  Bacteria  unclonable  0.00000000136266  n/a   
 
 
-
 
NC_011725  BCB4264_A1495  DNA-binding response regulator  25.12 
 
 		 210 aa  62.4  0.000000006  Bacillus cereus B4264  Bacteria  unclonable  0.0000174821  n/a   
 
 
-
 
NC_013595  Sros_3244  response regulator receiver protein  29.66 
 
 		 218 aa  62.4  0.000000006  Streptosporangium roseum DSM 43021  Bacteria  hitchhiker  0.000568428  normal  0.332742 
 
 
-
 
NC_009664  Krad_4217  two component transcriptional regulator, LuxR family  34.44 
 
 		 225 aa  62.4  0.000000006  Kineococcus radiotolerans SRS30216  Bacteria  decreased coverage  0.000816589  normal  0.757819 
 
 
-
 
NC_013131  Caci_0175  two component transcriptional regulator, LuxR family  28.5 
 
 		 222 aa  62  0.000000007  Catenulispora acidiphila DSM 44928  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013205  Aaci_0516  two component transcriptional regulator, LuxR family  29.71 
 
 		 231 aa  62  0.000000008  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  1  n/a   
 
 
-
 
NC_009338  Mflv_3579  two component LuxR family transcriptional regulator  26.95 
 
 		 217 aa  61.6  0.000000009  Mycobacterium gilvum PYR-GCK  Bacteria  normal  0.393396  normal  0.0540104 
 
 
-
 
NC_014210  Ndas_1477  two component transcriptional regulator, LuxR family  33.58 
 
 		 234 aa  62  0.000000009  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  0.594471  normal  1 
 
 
-
 
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