More than 300 homologs were found in PanDaTox collection
for query gene Mchl_0516 on replicon NC_011757
Organism: Methylobacterium chloromethanicum CM4



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_011757  Mchl_0516  response regulator receiver protein  100 
 
 
124 aa  247  3e-65  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.131947  normal 
 
 
-
 
NC_010725  Mpop_0095  response regulator receiver protein  65.32 
 
 
123 aa  148  3e-35  Methylobacterium populi BJ001  Bacteria  normal  0.898425  normal 
 
 
-
 
NC_010725  Mpop_1475  response regulator receiver protein  59.68 
 
 
124 aa  142  1e-33  Methylobacterium populi BJ001  Bacteria  normal  0.292646  normal  0.101486 
 
 
-
 
NC_010511  M446_6418  response regulator receiver protein  62.5 
 
 
126 aa  136  8.999999999999999e-32  Methylobacterium sp. 4-46  Bacteria  normal  normal 
 
 
-
 
NC_010172  Mext_3363  response regulator receiver  55.83 
 
 
126 aa  136  8.999999999999999e-32  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_010172  Mext_4112  response regulator receiver  66.39 
 
 
128 aa  134  4e-31  Methylobacterium extorquens PA1  Bacteria  normal  0.576276  normal  0.834365 
 
 
-
 
NC_011757  Mchl_4480  response regulator receiver protein  66.39 
 
 
128 aa  134  4e-31  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.361856  normal 
 
 
-
 
NC_010172  Mext_1895  response regulator receiver  60.71 
 
 
126 aa  134  6.0000000000000005e-31  Methylobacterium extorquens PA1  Bacteria  normal  0.208302  normal 
 
 
-
 
NC_010511  M446_4214  response regulator receiver protein  55.74 
 
 
130 aa  128  3e-29  Methylobacterium sp. 4-46  Bacteria  normal  0.843954  normal  0.213428 
 
 
-
 
NC_010725  Mpop_4593  response regulator receiver protein  59.68 
 
 
129 aa  125  2.0000000000000002e-28  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_007778  RPB_4041  response regulator receiver domain-containing protein  56 
 
 
124 aa  111  3e-24  Rhodopseudomonas palustris HaA2  Bacteria  normal  0.0979956  normal 
 
 
-
 
NC_007958  RPD_3796  response regulator receiver  52.38 
 
 
124 aa  108  2.0000000000000002e-23  Rhodopseudomonas palustris BisB5  Bacteria  normal  normal  0.787937 
 
 
-
 
NC_011004  Rpal_1668  response regulator receiver protein  54.29 
 
 
131 aa  109  2.0000000000000002e-23  Rhodopseudomonas palustris TIE-1  Bacteria  normal  n/a   
 
 
-
 
NC_007958  RPD_0328  response regulator receiver  44.25 
 
 
147 aa  105  2e-22  Rhodopseudomonas palustris BisB5  Bacteria  normal  0.0634669  normal 
 
 
-
 
NC_007778  RPB_0497  response regulator receiver domain-containing protein  44.64 
 
 
125 aa  103  1e-21  Rhodopseudomonas palustris HaA2  Bacteria  normal  0.0614776  normal 
 
 
-
 
NC_011666  Msil_0850  response regulator receiver protein  45.9 
 
 
131 aa  100  5e-21  Methylocella silvestris BL2  Bacteria  n/a    normal  0.886181 
 
 
-
 
NC_007925  RPC_1228  response regulator receiver domain-containing protein  48.18 
 
 
124 aa  99.4  1e-20  Rhodopseudomonas palustris BisB18  Bacteria  normal  hitchhiker  0.0000969205 
 
 
-
 
NC_010725  Mpop_3346  response regulator receiver protein  45.97 
 
 
128 aa  98.2  3e-20  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_009511  Swit_4398  response regulator receiver protein  48.18 
 
 
127 aa  98.6  3e-20  Sphingomonas wittichii RW1  Bacteria  normal  0.481257  normal 
 
 
-
 
NC_010172  Mext_3150  response regulator receiver  45.97 
 
 
128 aa  98.2  4e-20  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_011757  Mchl_3474  response regulator receiver protein  45.97 
 
 
128 aa  98.2  4e-20  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.212338  normal 
 
 
-
 
NC_011666  Msil_3741  response regulator receiver protein  46.02 
 
 
127 aa  96.3  1e-19  Methylocella silvestris BL2  Bacteria  n/a    normal 
 
 
-
 
NC_010511  M446_2634  response regulator receiver protein  48 
 
 
135 aa  95.5  2e-19  Methylobacterium sp. 4-46  Bacteria  normal  0.873964  normal  0.0480327 
 
 
-
 
NC_011894  Mnod_4811  response regulator receiver protein  48.18 
 
 
140 aa  95.1  3e-19  Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_007778  RPB_2945  response regulator receiver domain-containing protein  39.29 
 
 
124 aa  94.7  4e-19  Rhodopseudomonas palustris HaA2  Bacteria  normal  0.161273  normal  0.393497 
 
 
-
 
NC_010172  Mext_0144  hypothetical protein  55.06 
 
 
118 aa  94.7  4e-19  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_010505  Mrad2831_0691  response regulator receiver protein  46.34 
 
 
128 aa  94.4  5e-19  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.852187  normal  0.378672 
 
 
-
 
NC_012858  Rleg_6937  response regulator receiver protein  47.92 
 
 
133 aa  93.6  8e-19  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.0671376  normal 
 
 
-
 
NC_011989  Avi_1195  Two component sensor kinase/response regulator hybrid protein  42.73 
 
 
130 aa  92.8  1e-18  Agrobacterium vitis S4  Bacteria  normal  n/a   
 
 
-
 
NC_012850  Rleg_0771  response regulator receiver protein  41.07 
 
 
130 aa  90.9  5e-18  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  normal 
 
 
-
 
NC_011757  Mchl_4665  response regulator receiver protein  42.48 
 
 
127 aa  90.9  6e-18  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal  0.191751 
 
 
-
 
NC_011984  Avi_9028  two component sensor kinase/response regulator hybrid  39.13 
 
 
123 aa  89.7  1e-17  Agrobacterium vitis S4  Bacteria  normal  n/a   
 
 
-
 
NC_010725  Mpop_4814  response regulator receiver protein  42.48 
 
 
127 aa  88.2  3e-17  Methylobacterium populi BJ001  Bacteria  normal  0.24379  normal  0.163877 
 
 
-
 
NC_011004  Rpal_4537  response regulator receiver protein  39.52 
 
 
125 aa  88.6  3e-17  Rhodopseudomonas palustris TIE-1  Bacteria  normal  n/a   
 
 
-
 
NC_007958  RPD_2510  response regulator receiver  39.29 
 
 
124 aa  87.4  6e-17  Rhodopseudomonas palustris BisB5  Bacteria  normal  normal  0.294916 
 
 
-
 
NC_009507  Swit_5396  response regulator receiver protein  43.12 
 
 
132 aa  86.7  9e-17  Sphingomonas wittichii RW1  Bacteria  normal  0.476573  normal 
 
 
-
 
NC_010510  Mrad2831_5790  response regulator receiver protein  41.03 
 
 
122 aa  86.3  1e-16  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.0889979  normal  0.112489 
 
 
-
 
NC_010505  Mrad2831_5535  response regulator receiver protein  45.22 
 
 
130 aa  85.9  2e-16  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.591914  decreased coverage  0.00892468 
 
 
-
 
NC_010172  Mext_4296  response regulator receiver  41.28 
 
 
115 aa  85.5  3e-16  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_012850  Rleg_2931  response regulator receiver protein  42.48 
 
 
122 aa  84.7  4e-16  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.139057  normal 
 
 
-
 
NC_011369  Rleg2_2670  response regulator receiver protein  40.71 
 
 
122 aa  83.2  0.000000000000001  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  0.313891  normal 
 
 
-
 
NC_010505  Mrad2831_5605  response regulator receiver protein  44.72 
 
 
198 aa  82.8  0.000000000000001  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.469743  normal 
 
 
-
 
NC_011365  Gdia_2320  response regulator receiver protein  44.23 
 
 
127 aa  82.8  0.000000000000002  Gluconacetobacter diazotrophicus PAl 5  Bacteria  normal  normal  0.632565 
 
 
-
 
NC_010172  Mext_4573  response regulator receiver  38.52 
 
 
134 aa  81.3  0.000000000000004  Methylobacterium extorquens PA1  Bacteria  normal  normal  0.546072 
 
 
-
 
NC_011757  Mchl_5033  response regulator receiver protein  38.52 
 
 
134 aa  81.3  0.000000000000004  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.649741  normal  0.0493927 
 
 
-
 
NC_010725  Mpop_5091  response regulator receiver protein  40.35 
 
 
134 aa  80.5  0.000000000000006  Methylobacterium populi BJ001  Bacteria  normal  0.947919  normal 
 
 
-
 
NC_011368  Rleg2_5228  response regulator receiver protein  39.62 
 
 
135 aa  80.9  0.000000000000006  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  0.0214459  normal  0.509013 
 
 
-
 
NC_010511  M446_6328  response regulator receiver protein  37.3 
 
 
141 aa  80.1  0.000000000000009  Methylobacterium sp. 4-46  Bacteria  normal  hitchhiker  0.00633094 
 
 
-
 
NC_011894  Mnod_7165  response regulator receiver protein  37.3 
 
 
143 aa  79.3  0.00000000000001  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.272897  n/a   
 
 
-
 
NC_010505  Mrad2831_2499  response regulator receiver protein  40.71 
 
 
136 aa  79.7  0.00000000000001  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.353166  normal 
 
 
-
 
NC_009485  BBta_7425  putative response regulator receiver (CheY-like protein)  43.27 
 
 
133 aa  80.1  0.00000000000001  Bradyrhizobium sp. BTAi1  Bacteria  normal  normal  0.0404716 
 
 
-
 
NC_012853  Rleg_5645  response regulator receiver protein  40.71 
 
 
182 aa  79.7  0.00000000000001  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.633042  normal 
 
 
-
 
NC_010511  M446_6442  multi-sensor hybrid histidine kinase  39.09 
 
 
688 aa  78.6  0.00000000000003  Methylobacterium sp. 4-46  Bacteria  normal  0.381857  normal 
 
 
-
 
NC_012856  Rpic12D_0024  PAS/PAC sensor hybrid histidine kinase  42.59 
 
 
734 aa  77  0.00000000000008  Ralstonia pickettii 12D  Bacteria  normal  normal 
 
 
-
 
NC_011894  Mnod_7092  response regulator receiver protein  42.16 
 
 
196 aa  76.3  0.0000000000001  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.08524  n/a   
 
 
-
 
NC_006349  BMAA0137  sensory box histidine kinase/response regulator  43.75 
 
 
611 aa  75.5  0.0000000000002  Burkholderia mallei ATCC 23344  Bacteria  normal  n/a   
 
 
-
 
NC_007435  BURPS1710b_A1041  sensory box histidine kinase/response regulator  43.75 
 
 
611 aa  75.5  0.0000000000002  Burkholderia pseudomallei 1710b  Bacteria  normal  n/a   
 
 
-
 
NC_008784  BMASAVP1_1307  sensory box histidine kinase/response regulator  43.75 
 
 
611 aa  75.5  0.0000000000002  Burkholderia mallei SAVP1  Bacteria  normal  n/a   
 
 
-
 
NC_009075  BURPS668_A2778  Signal transduction histidine kinase  43.75 
 
 
611 aa  75.9  0.0000000000002  Burkholderia pseudomallei 668  Bacteria  normal  n/a   
 
 
-
 
NC_009078  BURPS1106A_A2635  sensory box histidine kinase/response regulator  43.75 
 
 
611 aa  75.5  0.0000000000002  Burkholderia pseudomallei 1106a  Bacteria  normal  n/a   
 
 
-
 
NC_010505  Mrad2831_2732  response regulator receiver protein  36.89 
 
 
151 aa  75.9  0.0000000000002  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal  0.169998 
 
 
-
 
NC_009079  BMA10247_A0163  sensory box histidine kinase/response regulator  43.75 
 
 
611 aa  75.1  0.0000000000003  Burkholderia mallei NCTC 10247  Bacteria  normal  n/a   
 
 
-
 
NC_010511  M446_6212  response regulator receiver protein  38.05 
 
 
177 aa  75.5  0.0000000000003  Methylobacterium sp. 4-46  Bacteria  normal  0.0392664  normal  0.598992 
 
 
-
 
NC_010676  Bphyt_5841  PAS/PAC sensor hybrid histidine kinase  38.4 
 
 
887 aa  75.1  0.0000000000003  Burkholderia phytofirmans PsJN  Bacteria  normal  normal  0.111175 
 
 
-
 
NC_010682  Rpic_0029  PAS/PAC sensor hybrid histidine kinase  41.67 
 
 
732 aa  74.7  0.0000000000004  Ralstonia pickettii 12J  Bacteria  normal  normal  0.598305 
 
 
-
 
NC_002947  PP_3969  response regulator  34.86 
 
 
120 aa  74.3  0.0000000000005  Pseudomonas putida KT2440  Bacteria  normal  normal  0.13044 
 
 
-
 
NC_010172  Mext_1882  response regulator receiver  43.96 
 
 
108 aa  73.9  0.0000000000006  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_011666  Msil_2794  response regulator receiver protein  38.05 
 
 
125 aa  73.9  0.0000000000006  Methylocella silvestris BL2  Bacteria  n/a    normal 
 
 
-
 
NC_011757  Mchl_2780  response regulator receiver protein  43.36 
 
 
173 aa  74.3  0.0000000000006  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal 
 
 
-
 
NC_010172  Mext_1672  PAS sensor protein  33.33 
 
 
695 aa  73.9  0.0000000000006  Methylobacterium extorquens PA1  Bacteria  normal  0.487392  normal 
 
 
-
 
NC_011757  Mchl_1990  multi-sensor hybrid histidine kinase  33.33 
 
 
695 aa  73.9  0.0000000000006  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal 
 
 
-
 
NC_011004  Rpal_0495  multi-sensor hybrid histidine kinase  38.89 
 
 
1076 aa  74.3  0.0000000000006  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.359716  n/a   
 
 
-
 
NC_010552  BamMC406_5047  PAS/PAC sensor hybrid histidine kinase  40.68 
 
 
589 aa  73.6  0.0000000000008  Burkholderia ambifaria MC40-6  Bacteria  normal  0.153925  normal 
 
 
-
 
NC_010725  Mpop_2071  response regulator receiver protein  36.29 
 
 
124 aa  73.6  0.0000000000009  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_010172  Mext_2557  response regulator receiver  43.36 
 
 
194 aa  73.6  0.0000000000009  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_010511  M446_3963  response regulator receiver protein  38.53 
 
 
133 aa  73.2  0.000000000001  Methylobacterium sp. 4-46  Bacteria  normal  normal  0.150847 
 
 
-
 
NC_011757  Mchl_4788  histidine kinase  36.67 
 
 
685 aa  73.2  0.000000000001  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal 
 
 
-
 
NC_011757  Mchl_3366  histidine kinase  36.67 
 
 
580 aa  73.6  0.000000000001  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal 
 
 
-
 
NC_010622  Bphy_0135  multi-sensor hybrid histidine kinase  40.87 
 
 
1631 aa  72.8  0.000000000001  Burkholderia phymatum STM815  Bacteria  normal  normal 
 
 
-
 
NC_008391  Bamb_4524  PAS/PAC sensor hybrid histidine kinase  40.68 
 
 
589 aa  73.2  0.000000000001  Burkholderia ambifaria AMMD  Bacteria  normal  normal 
 
 
-
 
NC_010322  PputGB1_2989  response regulator receiver protein  36.19 
 
 
120 aa  73.2  0.000000000001  Pseudomonas putida GB-1  Bacteria  normal  normal  0.319214 
 
 
-
 
NC_007778  RPB_3596  multi-sensor hybrid histidine kinase  39.84 
 
 
926 aa  72.4  0.000000000002  Rhodopseudomonas palustris HaA2  Bacteria  normal  normal 
 
 
-
 
NC_010725  Mpop_2488  response regulator receiver protein  42.98 
 
 
173 aa  72.4  0.000000000002  Methylobacterium populi BJ001  Bacteria  normal  0.365206  normal  0.13004 
 
 
-
 
NC_011369  Rleg2_2043  PAS/PAC sensor hybrid histidine kinase  41.32 
 
 
691 aa  70.9  0.000000000005  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  0.10086  normal 
 
 
-
 
NC_011894  Mnod_3607  response regulator receiver protein  37.61 
 
 
135 aa  70.9  0.000000000006  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.621989  n/a   
 
 
-
 
NC_007952  Bxe_B0221  GAF sensor hybrid histidine kinase  35.88 
 
 
1651 aa  70.9  0.000000000006  Burkholderia xenovorans LB400  Bacteria  normal  normal 
 
 
-
 
NC_012850  Rleg_1290  histidine kinase  41.07 
 
 
573 aa  70.5  0.000000000007  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.163396  normal 
 
 
-
 
NC_007958  RPD_1872  sensor histidine kinase  40 
 
 
936 aa  70.1  0.000000000009  Rhodopseudomonas palustris BisB5  Bacteria  normal  0.291512  normal  0.670925 
 
 
-
 
NC_010505  Mrad2831_3211  PAS/PAC sensor hybrid histidine kinase  35.78 
 
 
696 aa  70.1  0.000000000009  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.7085  normal 
 
 
-
 
NC_010515  Bcenmc03_5170  PAS/PAC sensor hybrid histidine kinase  43.52 
 
 
588 aa  69.7  0.00000000001  Burkholderia cenocepacia MC0-3  Bacteria  normal  normal  0.0474386 
 
 
-
 
NC_009621  Smed_5576  histidine kinase  40.71 
 
 
529 aa  70.1  0.00000000001  Sinorhizobium medicae WSM419  Bacteria  normal  0.44664  normal  0.0252292 
 
 
-
 
NC_011757  Mchl_4092  response regulator receiver protein  35.9 
 
 
161 aa  70.1  0.00000000001  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal 
 
 
-
 
NC_008061  Bcen_3257  PAS/PAC sensor hybrid histidine kinase  43.52 
 
 
589 aa  69.7  0.00000000001  Burkholderia cenocepacia AU 1054  Bacteria  normal  n/a   
 
 
-
 
NC_008543  Bcen2424_5111  PAS/PAC sensor hybrid histidine kinase  43.52 
 
 
589 aa  69.7  0.00000000001  Burkholderia cenocepacia HI2424  Bacteria  normal  normal 
 
 
-
 
NC_010511  M446_1292  integral membrane sensor hybrid histidine kinase  40.52 
 
 
686 aa  69.7  0.00000000001  Methylobacterium sp. 4-46  Bacteria  normal  0.21073  normal  0.829403 
 
 
-
 
NC_010676  Bphyt_7104  multi-sensor hybrid histidine kinase  35.11 
 
 
1646 aa  68.9  0.00000000002  Burkholderia phytofirmans PsJN  Bacteria  normal  normal 
 
 
-
 
NC_009719  Plav_3491  PAS/PAC sensor hybrid histidine kinase  37.29 
 
 
966 aa  68.9  0.00000000002  Parvibaculum lavamentivorans DS-1  Bacteria  normal  normal  0.691252 
 
 
-
 
NC_007492  Pfl01_3529  response regulator receiver domain-containing protein  38.05 
 
 
137 aa  68.9  0.00000000002  Pseudomonas fluorescens Pf0-1  Bacteria  normal  0.440569  normal  0.421617 
 
 
-
 
NC_011894  Mnod_6162  PAS/PAC sensor hybrid histidine kinase  43.69 
 
 
673 aa  68.9  0.00000000002  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.30079  n/a   
 
 
-
 
NC_012850  Rleg_2267  PAS/PAC sensor hybrid histidine kinase  39.67 
 
 
721 aa  68.2  0.00000000003  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.0115994  normal  0.0775846 
 
 
-
 
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