81 decreased-coverage genes were found for selected organism/s



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Locus tag

Gene type

Replicon accession

From

To

Strand

Gene Length

Product

Protein accession

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Organism name

Kingdom

Coverage Plot

PanDaTox homologs

Experimental validation
Msed_0017  CDS  NC_009440  14526  15524  999  5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase  YP_001190118  normal  0.117033  decreased coverage  0.00153786  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0018  CDS  NC_009440  15575  16951  1377  adenylosuccinate lyase  YP_001190119  normal  0.146335  decreased coverage  0.000415583  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0019  CDS  NC_009440  17075  18016  942  AIR synthase-like protein  YP_001190120  normal  0.213041  decreased coverage  0.00139533  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0020  CDS  NC_009440  18084  19829  1746  radical SAM domain-containing protein  YP_001190121  normal  decreased coverage  0.00170872  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0034  CDS  NC_009440  32163  34823  2661  DNA-directed RNA polymerase subunit A'  YP_001190135  decreased coverage  2.87475e-06  normal  0.0408299  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0168  CDS  NC_009440  135558  136409  852  L-2-aminoadipate N-acetyltransferase  YP_001190269  decreased coverage  1.51287e-08  normal  0.111818  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0185  CDS  NC_009440  149378  150253  876  ribokinase  YP_001190286  decreased coverage  6.9064e-07  normal  0.0609987  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0212  CDS  NC_009440  173908  174810  903  flap endonuclease-1  YP_001190313  normal  0.022826  decreased coverage  0.0048464  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0217  CDS  NC_009440  178945  179817  873  porphobilinogen deaminase  YP_001190318  decreased coverage  3.56603e-08  normal  0.0285906  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0218  CDS  NC_009440  179798  180472  675  uroporphyrinogen III synthase HEM4  YP_001190319  decreased coverage  1.44428e-08  normal  0.0267075  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0219  CDS  NC_009440  180465  180728  264  hypothetical protein  YP_001190320  decreased coverage  2.54454e-09  normal  0.0235176  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0224  CDS  NC_009440  186289  186675  387  hypothetical protein  YP_001190325  normal  0.166196  decreased coverage  0.00859524  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0225  CDS  NC_009440  186748  187167  420  hypothetical protein  YP_001190326  normal  0.73932  decreased coverage  0.00846992  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0226  CDS  NC_009440  187323  187802  480  hypothetical protein  YP_001190327  normal  decreased coverage  0.00895097  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0227  CDS  NC_009440  187807  188490  684  orotidine 5'-phosphate decarboxylase  YP_001190328  normal  decreased coverage  0.0096121  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0229  CDS  NC_009440  190140  190472  333  regulatory protein, ArsR  YP_001190330  normal  decreased coverage  0.00808889  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0230  CDS  NC_009440  190549  190812  264  like-Sm ribonucleoprotein, core  YP_001190331  normal  decreased coverage  0.00778138  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0231  CDS  NC_009440  190846  192063  1218  S-adenosylmethionine synthetase  YP_001190332  normal  decreased coverage  0.00947715  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0268  CDS  NC_009440  226367  226792  426  hypothetical protein  YP_001190369  decreased coverage  0.00125281  normal  0.120379  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0269  CDS  NC_009440  226793  227290  498  hypothetical protein  YP_001190370  decreased coverage  0.000709024  normal  0.121609  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0270  CDS  NC_009440  227300  228475  1176  acetyl-CoA acetyltransferase  YP_001190371  decreased coverage  0.00178908  normal  0.140204  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0465  CDS  NC_009440  420319  421287  969  formamidase  YP_001190566  decreased coverage  5.77809e-05  normal  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0511  CDS  NC_009440  467281  468381  1101  radical SAM domain-containing protein  YP_001190610  hitchhiker  0.00485755  decreased coverage  0.00020138  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0660  CDS  NC_009440  604176  604871  696  hypothetical protein  YP_001190759  decreased coverage  2.58046e-08  normal  0.0100764  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0661  CDS  NC_009440  604868  605494  627  ribonuclease HII  YP_001190760  decreased coverage  1.81972e-08  hitchhiker  0.00940331  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0687  CDS  NC_009440  627777  628766  990  FAD dependent oxidoreductase  YP_001190786  decreased coverage  3.30964e-08  unclonable  3.00742e-07  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0762  CDS  NC_009440  695187  697763  2577  SMC domain-containing protein  YP_001190861  normal  0.0108669  decreased coverage  0.00239369  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0763  CDS  NC_009440  697760  698755  996  hypothetical protein  YP_001190862  normal  0.413008  decreased coverage  0.00447816  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0764  CDS  NC_009440  698963  699562  600  methyltransferase type 11  YP_001190863  normal  0.855881  decreased coverage  0.00371896  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0962  CDS  NC_009440  889304  890020  717  phosphoadenosine phosphosulfate reductase  YP_001191057  decreased coverage  1.10311e-09  normal  0.512598  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_0993  CDS  NC_009440  916253  917746  1494  major facilitator transporter  YP_001191085  decreased coverage  0.000427964  normal  0.0333525  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1004  CDS  NC_009440  924826  925434  609  isoprenylcysteine carboxyl methyltransferase  YP_001191096  decreased coverage  0.00191791  normal  0.0260384  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1010  CDS  NC_009440  929560  931158  1599  phosphoesterase  YP_001191102  normal  decreased coverage  0.00457541  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1011  CDS  NC_009440  931210  932085  876  undecaprenyl pyrophosphate phosphatase  YP_001191103  normal  decreased coverage  0.00382837  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1012  CDS  NC_009440  932156  933088  933  peptidase M48, Ste24p  YP_001191104  normal  decreased coverage  0.00402297  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1013  CDS  NC_009440  933229  934542  1314  major facilitator transporter  YP_001191105  normal  decreased coverage  0.00471133  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1014  CDS  NC_009440  934653  935186  534  hypothetical protein  YP_001191106  normal  decreased coverage  0.0038833  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1015  CDS  NC_009440  935268  936764  1497  AMP-dependent synthetase and ligase  YP_001191107  normal  decreased coverage  0.00519801  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1163  CDS  NC_009440  1126688  1129348  2661  hypothetical protein  YP_001191248  normal  decreased coverage  0.00163358  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1324  CDS  NC_009440  1303026  1304453  1428  flagella assembly protein J-like protein  YP_001191406  decreased coverage  1.49145e-06  normal  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1353  CDS  NC_009440  1323783  1325777  1995  acetyl-CoA synthetase  YP_001191435  decreased coverage  2.52998e-06  normal  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1384  CDS  NC_009440  1360505  1360918  414  hypothetical protein  YP_001191466  decreased coverage  0.00709714  hitchhiker  4.01191e-05  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1386  CDS  NC_009440  1361397  1361627  231  hypothetical protein  YP_001191468  decreased coverage  0.00544804  hitchhiker  4.71619e-06  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1387  CDS  NC_009440  1361760  1362335  576  xanthine and Co dehydrogenase maturation factor  YP_001191469  decreased coverage  0.0079429  hitchhiker  5.98776e-06  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1413  CDS  NC_009440  1380335  1380844  510  hypothetical protein  YP_001191495  decreased coverage  1.04505e-06  hitchhiker  0.000761829  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1414  CDS  NC_009440  1380888  1381994  1107  D-proline dehydrogenase  YP_001191496  decreased coverage  8.36219e-06  hitchhiker  0.0027626  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1575  CDS  NC_009440  1524514  1525482  969  phosphomevalonate kinase  YP_001191654  normal  decreased coverage  0.00534382  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1576  CDS  NC_009440  1525466  1526437  972  diphosphomevalonate decarboxylase  YP_001191655  normal  decreased coverage  0.00467699  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1577  CDS  NC_009440  1526471  1527694  1224  metal dependent phosphohydrolase  YP_001191656  normal  decreased coverage  0.00516026  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1578  CDS  NC_009440  1527694  1528410  717  purine phosphorylase family 1  YP_001191657  normal  decreased coverage  0.00464289  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1579  CDS  NC_009440  1528520  1529062  543  hypothetical protein  YP_001191658  normal  0.257545  decreased coverage  0.00474591  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1580  CDS  NC_009440  1529118  1529336  219  hypothetical protein  YP_001191659  normal  0.13914  decreased coverage  0.00408256  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1581  CDS  NC_009440  1529339  1530130  792  succinyl-CoA synthetase (ADP-forming) alpha subunit  YP_001191660  normal  0.144732  decreased coverage  0.00457541  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1582  CDS  NC_009440  1530193  1531206  1014  succinyl-CoA synthetase (ADP-forming) beta subunit  YP_001191661  normal  0.0310843  decreased coverage  0.00561469  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1583  CDS  NC_009440  1531209  1531874  666  DNA-3-methyladenine glycosylase III  YP_001191662  hitchhiker  0.00807235  decreased coverage  0.00557129  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1584  CDS  NC_009440  1531867  1532817  951  glycosyltransferase family 28 protein  YP_001191663  normal  0.0306453  decreased coverage  0.00652045  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1585  CDS  NC_009440  1532863  1534488  1626  threonyl-tRNA synthetase  YP_001191664  decreased coverage  0.000347084  normal  0.0207238  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1586  CDS  NC_009440  1534489  1534959  471  methylated-DNA--protein-cysteine methyltransferase  YP_001191665  decreased coverage  0.000118285  normal  0.0148554  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1587  CDS  NC_009440  1535132  1535329  198  hypothetical protein  YP_001191666  decreased coverage  0.000137654  normal  0.013276  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1589  CDS  NC_009440  1536160  1536582  423  UspA domain-containing protein  YP_001191668  decreased coverage  0.000251397  normal  0.0131871  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1590  CDS  NC_009440  1536899  1538305  1407  glycosyl transferase, group 1  YP_001191669  hitchhiker  0.00816719  decreased coverage  0.0063014  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1628  CDS  NC_009440  1572065  1572736  672  translation initiation factor IF-6  YP_001191707  decreased coverage  8.60601e-07  normal  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1670  CDS  NC_009440  1611723  1612442  720  hypothetical protein  YP_001191749  decreased coverage  0.000279655  normal  0.985366  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1687  CDS  NC_009440  1625666  1626928  1263  anthranilate synthase component I  YP_001191766  decreased coverage  0.00216782  normal  0.0764877  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1752  CDS  NC_009440  1687634  1689016  1383  hypothetical protein  YP_001191831  decreased coverage  5.73149e-07  normal  0.0520768  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1774  CDS  NC_009440  1716239  1717681  1443  aldehyde dehydrogenase  YP_001191853  decreased coverage  0.00658035  normal  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1847    NC_009440  1793363  1793775  413      decreased coverage  2.02031e-06  normal  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1899  CDS  NC_009440  1842791  1843300  510  NADH dehydrogenase subunit I  YP_001191963  decreased coverage  0.00550248  normal  0.26939  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1900  CDS  NC_009440  1843281  1843781  501  NADH-ubiquinone/plastoquinone oxidoreductase, chain 6  YP_001191964  decreased coverage  0.00282958  normal  0.084057  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1915  CDS  NC_009440  1863022  1863312  291  vacuolar H+-transporting two-sector ATPase, F subunit  YP_001191979  decreased coverage  1.62336e-06  normal  0.61793  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1916  CDS  NC_009440  1863317  1863895  579  H+-transporting two-sector ATPase, E subunit  YP_001191980  decreased coverage  7.77149e-07  normal  0.663872  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_1917  CDS  NC_009440  1863896  1865671  1776  V-type ATP synthase subunit A  YP_001191981  decreased coverage  5.35851e-05  normal  0.804968  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2129  CDS  NC_009440  2048480  2049646  1167  metal dependent phosphohydrolase  YP_001192192  decreased coverage  8.00981e-08  hitchhiker  7.61992e-05  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2130  CDS  NC_009440  2049643  2050311  669  SPP-like hydrolase  YP_001192193  decreased coverage  1.13582e-09  hitchhiker  5.79549e-05  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2135  CDS  NC_009440  2055499  2056482  984  geranyltranstransferase  YP_001192198  normal  0.0551821  decreased coverage  9.78796e-06  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2136  CDS  NC_009440  2056482  2057582  1101  isopentenyl pyrophosphate isomerase  YP_001192199  normal  0.163315  decreased coverage  9.69261e-06  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2137  CDS  NC_009440  2057579  2058253  675  aspartate/glutamate/uridylate kinase  YP_001192200  normal  0.0520229  decreased coverage  7.87981e-06  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2189  CDS  NC_009440  2100279  2101697  1419  hypothetical protein  YP_001192252  decreased coverage  9.70823e-05  hitchhiker  7.55051e-05  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_2190  CDS  NC_009440  2101742  2103610  1869  AAA ATPase  YP_001192253  decreased coverage  0.0020112  hitchhiker  7.68998e-05  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_R0001  tRNA  NC_009440  16975  17060  86  tRNA-Thr    normal  0.526231  decreased coverage  0.00115585  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
Msed_R0017  tRNA  NC_009440  1538335  1538424  90  tRNA-Ala    normal  0.0717588  decreased coverage  0.00491532  Metallosphaera sedula DSM 5348  Archaea 
 
 
-
 
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