More than 300 homologs were found in PanDaTox collection
for query gene CCC13826_0894 on replicon NC_009802
Organism: Campylobacter concisus 13826



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_009802  CCC13826_0894  putative outer membrane component of efflux system  100 
 
 		 211 aa  432  1e-120  Campylobacter concisus 13826  Bacteria  hitchhiker  0.00401485  n/a   
 
 
-
 
NC_009715  CCV52592_0166  transcriptional regulator, LuxR family protein  68.25 
 
 		 207 aa  284  5.999999999999999e-76  Campylobacter curvus 525.92  Bacteria  hitchhiker  0.00243136  n/a   
 
 
-
 
NC_013512  Sdel_0795  regulatory protein LuxR  34.95 
 
 		 202 aa  144  8.000000000000001e-34  Sulfurospirillum deleyianum DSM 6946  Bacteria  hitchhiker  0.0000492678  n/a   
 
 
-
 
NC_007520  Tcr_0205  LuxR family transcriptional regulator  35.97 
 
 		 205 aa  92.4  5e-18  Thiomicrospira crunogena XCL-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_009654  Mmwyl1_2822  response regulator receiver protein  31.82 
 
 		 211 aa  87.8  1e-16  Marinomonas sp. MWYL1  Bacteria  normal  1  normal  0.473652 
 
 
-
 
NC_007908  Rfer_3768  LuxR family transcriptional regulator  27.22 
 
 		 231 aa  78.2  0.00000000000009  Rhodoferax ferrireducens T118  Bacteria  normal  1  n/a   
 
 
-
 
NC_008228  Patl_4028  two component LuxR family transcriptional regulator  27.89 
 
 		 212 aa  77  0.0000000000002  Pseudoalteromonas atlantica T6c  Bacteria  normal  1  n/a   
 
 
-
 
NC_007298  Daro_3200  LuxR family transcriptional regulator  27.62 
 
 		 205 aa  76.3  0.0000000000003  Dechloromonas aromatica RCB  Bacteria  normal  0.618751  normal  0.891545 
 
 
-
 
NC_011658  BCAH187_A5591  DNA-binding response regulator  30.34 
 
 		 215 aa  75.1  0.0000000000008  Bacillus cereus AH187  Bacteria  normal  1  n/a   
 
 
-
 
NC_009441  Fjoh_1987  two component LuxR family transcriptional regulator  35.66 
 
 		 213 aa  74.7  0.0000000000009  Flavobacterium johnsoniae UW101  Bacteria  normal  0.429674  n/a   
 
 
-
 
NC_011725  BCB4264_A5535  DNA-binding response regulator  30.71 
 
 		 215 aa  74.3  0.000000000001  Bacillus cereus B4264  Bacteria  normal  1  n/a   
 
 
-
 
NC_013889  TK90_1314  transcriptional regulator, LuxR family  24.17 
 
 		 204 aa  73.9  0.000000000001  Thioalkalivibrio sp. K90mix  Bacteria  normal  0.404844  normal  1 
 
 
-
 
NC_010184  BcerKBAB4_5205  two component LuxR family transcriptional regulator  29.66 
 
 		 215 aa  73.9  0.000000000001  Bacillus weihenstephanensis KBAB4  Bacteria  normal  1  n/a   
 
 
-
 
NC_003909  BCE_5540  DNA-binding response regulator  29.66 
 
 		 215 aa  73.6  0.000000000002  Bacillus cereus ATCC 10987  Bacteria  normal  1  n/a   
 
 
-
 
NC_011772  BCG9842_B5417  DNA-binding response regulator  29.66 
 
 		 215 aa  73.2  0.000000000003  Bacillus cereus G9842  Bacteria  normal  1  normal  1 
 
 
-
 
NC_005945  BAS5263  DNA-binding response regulator  28.97 
 
 		 215 aa  71.2  0.00000000001  Bacillus anthracis str. Sterne  Bacteria  normal  0.24037  n/a   
 
 
-
 
NC_005957  BT9727_5091  response regulator  28.97 
 
 		 215 aa  71.2  0.00000000001  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  normal  1  n/a   
 
 
-
 
NC_006274  BCZK5108  response regulator  28.97 
 
 		 215 aa  71.2  0.00000000001  Bacillus cereus E33L  Bacteria  decreased coverage  0.00235048  n/a   
 
 
-
 
NC_011773  BCAH820_5506  DNA-binding response regulator  28.97 
 
 		 215 aa  71.2  0.00000000001  Bacillus cereus AH820  Bacteria  n/a    normal  1 
 
 
-
 
NC_007530  GBAA_5661  DNA-binding response regulator  28.97 
 
 		 215 aa  71.2  0.00000000001  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  normal  1  n/a   
 
 
-
 
NC_007333  Tfu_2950  LuxR response regulator receiver  28.49 
 
 		 221 aa  70.1  0.00000000002  Thermobifida fusca YX  Bacteria  normal  1  n/a   
 
 
-
 
NC_007347  Reut_A3419  LuxR response regulator receiver  25.35 
 
 		 231 aa  70.5  0.00000000002  Ralstonia eutropha JMP134  Bacteria  normal  0.393456  n/a   
 
 
-
 
NC_012669  Bcav_1049  two component transcriptional regulator, LuxR family  29.87 
 
 		 222 aa  70.1  0.00000000002  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.661499  normal  0.245945 
 
 
-
 
NC_013131  Caci_0094  two component transcriptional regulator, LuxR family  28.12 
 
 		 233 aa  69.7  0.00000000003  Catenulispora acidiphila DSM 44928  Bacteria  normal  1  normal  0.0277195 
 
 
-
 
NC_013170  Ccur_06630  response regulator containing a CheY-like receiver domain protein and an HTH DNA-binding domain protein  33.33 
 
 		 215 aa  69.3  0.00000000004  Cryptobacterium curtum DSM 15641  Bacteria  normal  0.252447  normal  0.303532 
 
 
-
 
NC_013131  Caci_2656  two component transcriptional regulator, LuxR family  28.38 
 
 		 226 aa  68.9  0.00000000005  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.161573  normal  1 
 
 
-
 
NC_009636  Smed_1980  two component LuxR family transcriptional regulator  26.8 
 
 		 226 aa  68.9  0.00000000005  Sinorhizobium medicae WSM419  Bacteria  normal  0.893627  normal  1 
 
 
-
 
NC_011899  Hore_21820  two component transcriptional regulator, LuxR family  29.45 
 
 		 211 aa  68.6  0.00000000006  Halothermothrix orenii H 168  Bacteria  normal  1  n/a   
 
 
-
 
NC_009523  RoseRS_3421  two component LuxR family transcriptional regulator  27.39 
 
 		 223 aa  68.6  0.00000000007  Roseiflexus sp. RS-1  Bacteria  normal  1  normal  0.0556432 
 
 
-
 
NC_011138  MADE_02155  putative regulator in two-component regulatory system ; LuxR family protein  25.74 
 
 		 211 aa  68.2  0.00000000008  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  1  n/a   
 
 
-
 
NC_013131  Caci_6963  two component transcriptional regulator, LuxR family  27.5 
 
 		 225 aa  67.4  0.0000000001  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.029709  normal  1 
 
 
-
 
NC_009921  Franean1_4062  two component LuxR family transcriptional regulator  30.07 
 
 		 216 aa  67.4  0.0000000001  Frankia sp. EAN1pec  Bacteria  normal  0.0448793  normal  0.300284 
 
 
-
 
NC_013132  Cpin_1732  two component transcriptional regulator, LuxR family  31.29 
 
 		 211 aa  68.2  0.0000000001  Chitinophaga pinensis DSM 2588  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013947  Snas_1740  two component transcriptional regulator, LuxR family  29.06 
 
 		 228 aa  67.8  0.0000000001  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  1  normal  1 
 
 
-
 
NC_007948  Bpro_0302  LuxR family transcriptional regulator  24 
 
 		 227 aa  67.8  0.0000000001  Polaromonas sp. JS666  Bacteria  normal  1  normal  1 
 
 
-
 
NC_008346  Swol_0186  response regulator receiver protein  30.43 
 
 		 213 aa  67.8  0.0000000001  Syntrophomonas wolfei subsp. wolfei str. Goettingen  Bacteria  decreased coverage  0.00000327076  n/a   
 
 
-
 
NC_013739  Cwoe_3988  two component transcriptional regulator, LuxR family  31.94 
 
 		 228 aa  67.4  0.0000000001  Conexibacter woesei DSM 14684  Bacteria  normal  0.0354189  normal  0.736565 
 
 
-
 
NC_013595  Sros_1446  response regulator receiver protein  27.34 
 
 		 209 aa  67.4  0.0000000001  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0167897  normal  0.0778626 
 
 
-
 
NC_011729  PCC7424_0807  two component transcriptional regulator, LuxR family  35.78 
 
 		 228 aa  66.6  0.0000000002  Cyanothece sp. PCC 7424  Bacteria  n/a    normal  0.218712 
 
 
-
 
NC_009921  Franean1_6933  two component LuxR family transcriptional regulator  30.07 
 
 		 244 aa  67.4  0.0000000002  Frankia sp. EAN1pec  Bacteria  normal  1  normal  0.322421 
 
 
-
 
NC_013235  Namu_3387  two component transcriptional regulator, LuxR family  29.33 
 
 		 223 aa  66.2  0.0000000003  Nakamurella multipartita DSM 44233  Bacteria  hitchhiker  0.0000386408  hitchhiker  0.000570848 
 
 
-
 
NC_009620  Smed_3954  two component LuxR family transcriptional regulator  24.4 
 
 		 229 aa  66.2  0.0000000003  Sinorhizobium medicae WSM419  Bacteria  normal  1  normal  1 
 
 
-
 
NC_014165  Tbis_3390  LuxR family two component transcriptional regulator  29.09 
 
 		 228 aa  65.9  0.0000000004  Thermobispora bispora DSM 43833  Bacteria  normal  0.269937  normal  1 
 
 
-
 
NC_014165  Tbis_3505  LuxR family two component transcriptional regulator  28.87 
 
 		 213 aa  66.2  0.0000000004  Thermobispora bispora DSM 43833  Bacteria  normal  0.345096  normal  1 
 
 
-
 
NC_002976  SERP1981  transcriptional regulatory protein DegU, putative  34.01 
 
 		 218 aa  65.9  0.0000000005  Staphylococcus epidermidis RP62A  Bacteria  normal  1  n/a   
 
 
-
 
NC_013521  Sked_03540  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  25.38 
 
 		 226 aa  65.9  0.0000000005  Sanguibacter keddieii DSM 10542  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013093  Amir_3314  two component transcriptional regulator, LuxR family  30.33 
 
 		 222 aa  65.9  0.0000000005  Actinosynnema mirum DSM 43827  Bacteria  hitchhiker  0.00833126  n/a   
 
 
-
 
NC_011071  Smal_2061  two component transcriptional regulator, LuxR family  23.93 
 
 		 224 aa  65.5  0.0000000006  Stenotrophomonas maltophilia R551-3  Bacteria  normal  0.737796  normal  1 
 
 
-
 
NC_009921  Franean1_1971  two component LuxR family transcriptional regulator  29.68 
 
 		 216 aa  65.5  0.0000000006  Frankia sp. EAN1pec  Bacteria  normal  0.356635  normal  0.773651 
 
 
-
 
NC_010320  Teth514_2042  two component LuxR family transcriptional regulator  35.25 
 
 		 208 aa  65.5  0.0000000006  Thermoanaerobacter sp. X514  Bacteria  normal  1  n/a   
 
 
-
 
NC_011901  Tgr7_2171  two component transcriptional regulator, LuxR family  32.2 
 
 		 227 aa  65.5  0.0000000006  Thioalkalivibrio sp. HL-EbGR7  Bacteria  normal  1  n/a   
 
 
-
 
NC_013525  Tter_1125  two component transcriptional regulator, LuxR family  27.82 
 
 		 225 aa  65.1  0.0000000007  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_012034  Athe_2627  two component transcriptional regulator, LuxR family  36.17 
 
 		 211 aa  65.1  0.0000000008  Anaerocellum thermophilum DSM 6725  Bacteria  normal  1  n/a   
 
 
-
 
NC_013739  Cwoe_0356  two component transcriptional regulator, LuxR family  25.75 
 
 		 220 aa  64.7  0.0000000009  Conexibacter woesei DSM 14684  Bacteria  normal  0.165726  normal  0.0985551 
 
 
-
 
NC_010718  Nther_0747  two component transcriptional regulator, LuxR family  29.51 
 
 		 232 aa  64.3  0.000000001  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  0.643618  normal  0.38139 
 
 
-
 
NC_013161  Cyan8802_1954  two component transcriptional regulator, LuxR family  29.31 
 
 		 221 aa  64.3  0.000000001  Cyanothece sp. PCC 8802  Bacteria  normal  1  normal  0.682063 
 
 
-
 
NC_013204  Elen_1743  two component transcriptional regulator, LuxR family  33.33 
 
 		 214 aa  64.3  0.000000001  Eggerthella lenta DSM 2243  Bacteria  normal  0.370009  normal  0.039988 
 
 
-
 
NC_007614  Nmul_A2674  two component LuxR family transcriptional regulator  28.87 
 
 		 203 aa  64.3  0.000000001  Nitrosospira multiformis ATCC 25196  Bacteria  normal  0.125422  n/a   
 
 
-
 
NC_007777  Francci3_1487  two component LuxR family transcriptional regulator  29.66 
 
 		 231 aa  63.9  0.000000001  Frankia sp. CcI3  Bacteria  normal  0.0122618  normal  0.753042 
 
 
-
 
NC_014210  Ndas_1125  two component transcriptional regulator, LuxR family  29.51 
 
 		 229 aa  64.3  0.000000001  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  1  normal  0.306134 
 
 
-
 
NC_013521  Sked_26900  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  30.95 
 
 		 247 aa  64.7  0.000000001  Sanguibacter keddieii DSM 10542  Bacteria  hitchhiker  0.00793239  normal  0.935402 
 
 
-
 
NC_014210  Ndas_4254  two component transcriptional regulator, LuxR family  27.59 
 
 		 225 aa  64.3  0.000000001  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  0.867992  normal  0.287586 
 
 
-
 
NC_008726  Mvan_1646  two component LuxR family transcriptional regulator  25.4 
 
 		 219 aa  64.7  0.000000001  Mycobacterium vanbaalenii PYR-1  Bacteria  normal  1  normal  0.92254 
 
 
-
 
NC_011662  Tmz1t_1311  two component transcriptional regulator, LuxR family  27.78 
 
 		 226 aa  64.7  0.000000001  Thauera sp. MZ1T  Bacteria  normal  0.165019  n/a   
 
 
-
 
NC_011726  PCC8801_1927  two component transcriptional regulator, LuxR family  29.31 
 
 		 221 aa  64.3  0.000000001  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_009921  Franean1_6351  two component LuxR family transcriptional regulator  31.9 
 
 		 244 aa  64.3  0.000000001  Frankia sp. EAN1pec  Bacteria  normal  1  normal  1 
 
 
-
 
NC_007492  Pfl01_3957  two component LuxR family transcriptional regulator  27.16 
 
 		 219 aa  63.5  0.000000002  Pseudomonas fluorescens Pf0-1  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011884  Cyan7425_1401  two component transcriptional regulator, LuxR family  28.28 
 
 		 217 aa  63.5  0.000000002  Cyanothece sp. PCC 7425  Bacteria  normal  1  normal  0.482316 
 
 
-
 
NC_013595  Sros_6032  response regulator receiver protein  28.92 
 
 		 218 aa  63.9  0.000000002  Streptosporangium roseum DSM 43021  Bacteria  normal  0.53611  normal  1 
 
 
-
 
NC_011831  Cagg_1769  two component transcriptional regulator, LuxR family  25.48 
 
 		 219 aa  63.9  0.000000002  Chloroflexus aggregans DSM 9485  Bacteria  normal  0.221401  normal  0.0578747 
 
 
-
 
NC_009523  RoseRS_4275  two component LuxR family transcriptional regulator  26.42 
 
 		 226 aa  63.5  0.000000002  Roseiflexus sp. RS-1  Bacteria  normal  0.798613  normal  0.287125 
 
 
-
 
NC_004578  PSPTO_4027  DNA-binding response regulator, LuxR family  21.89 
 
 		 215 aa  63.2  0.000000003  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  1  n/a   
 
 
-
 
NC_013510  Tcur_0154  two component transcriptional regulator, LuxR family  27.06 
 
 		 244 aa  63.2  0.000000003  Thermomonospora curvata DSM 43183  Bacteria  normal  1  n/a   
 
 
-
 
NC_009767  Rcas_1142  two component LuxR family transcriptional regulator  25.81 
 
 		 222 aa  63.2  0.000000003  Roseiflexus castenholzii DSM 13941  Bacteria  normal  0.661777  normal  1 
 
 
-
 
NC_013131  Caci_0683  two component transcriptional regulator, LuxR family  28.7 
 
 		 234 aa  62.8  0.000000003  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.344925  normal  1 
 
 
-
 
NC_013132  Cpin_1440  two component transcriptional regulator, LuxR family  31.98 
 
 		 208 aa  62.8  0.000000003  Chitinophaga pinensis DSM 2588  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013739  Cwoe_4976  two component transcriptional regulator, LuxR family  25.73 
 
 		 218 aa  63.2  0.000000003  Conexibacter woesei DSM 14684  Bacteria  normal  0.289575  normal  0.034027 
 
 
-
 
NC_009380  Strop_4132  response regulator receiver  27.86 
 
 		 235 aa  63.2  0.000000003  Salinispora tropica CNB-440  Bacteria  normal  0.232221  normal  1 
 
 
-
 
NC_009487  SaurJH9_2415  two component LuxR family transcriptional regulator  31.91 
 
 		 217 aa  63.2  0.000000003  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  1  n/a   
 
 
-
 
NC_009632  SaurJH1_2463  response regulator receiver  31.91 
 
 		 217 aa  63.2  0.000000003  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  1  n/a   
 
 
-
 
NC_009921  Franean1_2449  two component LuxR family transcriptional regulator  27.5 
 
 		 211 aa  62.8  0.000000004  Frankia sp. EAN1pec  Bacteria  normal  1  normal  0.265588 
 
 
-
 
NC_009972  Haur_1104  two component LuxR family transcriptional regulator  28.77 
 
 		 218 aa  62.4  0.000000005  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.348687  n/a   
 
 
-
 
NC_009767  Rcas_1355  two component LuxR family transcriptional regulator  27.65 
 
 		 230 aa  62.4  0.000000005  Roseiflexus castenholzii DSM 13941  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013510  Tcur_0500  two component transcriptional regulator, LuxR family  26.06 
 
 		 226 aa  62.4  0.000000005  Thermomonospora curvata DSM 43183  Bacteria  normal  1  n/a   
 
 
-
 
NC_013947  Snas_5644  two component transcriptional regulator, LuxR family  27.12 
 
 		 225 aa  62  0.000000006  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  1  normal  0.114252 
 
 
-
 
NC_007005  Psyr_1384  LuxR response regulator receiver  23.45 
 
 		 215 aa  62  0.000000006  Pseudomonas syringae pv. syringae B728a  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013739  Cwoe_4937  two component transcriptional regulator, LuxR family  27.7 
 
 		 224 aa  62  0.000000006  Conexibacter woesei DSM 14684  Bacteria  normal  0.570807  normal  0.210467 
 
 
-
 
NC_014210  Ndas_4749  two component transcriptional regulator, LuxR family  26.16 
 
 		 223 aa  62  0.000000006  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013131  Caci_7105  two component transcriptional regulator, LuxR family  26.14 
 
 		 241 aa  62  0.000000007  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.106023  normal  0.469545 
 
 
-
 
NC_007519  Dde_2674  two component LuxR family transcriptional regulator  27.27 
 
 		 215 aa  62  0.000000007  Desulfovibrio desulfuricans subsp. desulfuricans str. G20  Bacteria  normal  0.721789  n/a   
 
 
-
 
NC_009972  Haur_0983  two component LuxR family transcriptional regulator  27.01 
 
 		 213 aa  61.6  0.000000007  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  1  n/a   
 
 
-
 
NC_013159  Svir_38420  response regulator containing a CheY-like receiver domain protein and an HTH DNA-binding domain protein  26.49 
 
 		 226 aa  61.6  0.000000008  Saccharomonospora viridis DSM 43017  Bacteria  normal  1  normal  1 
 
 
-
 
NC_012793  GWCH70_3043  two component transcriptional regulator, LuxR family  28.92 
 
 		 225 aa  61.6  0.000000008  Geobacillus sp. WCH70  Bacteria  decreased coverage  0.0000000652561  n/a   
 
 
-
 
NC_011901  Tgr7_0272  two component transcriptional regulator, LuxR family  23.33 
 
 		 218 aa  61.6  0.000000008  Thioalkalivibrio sp. HL-EbGR7  Bacteria  normal  0.353555  n/a   
 
 
-
 
NC_009620  Smed_4344  two component LuxR family transcriptional regulator  27.71 
 
 		 219 aa  61.6  0.000000008  Sinorhizobium medicae WSM419  Bacteria  normal  1  normal  0.218307 
 
 
-
 
NC_013757  Gobs_0707  two component transcriptional regulator, LuxR family  25.18 
 
 		 270 aa  61.6  0.000000009  Geodermatophilus obscurus DSM 43160  Bacteria  normal  1  n/a   
 
 
-
 
NC_010571  Oter_2496  two component LuxR family transcriptional regulator  29.01 
 
 		 212 aa  60.8  0.00000001  Opitutus terrae PB90-1  Bacteria  normal  1  normal  0.996792 
 
 
-
 
NC_009675  Anae109_3355  two component LuxR family transcriptional regulator  27.21 
 
 		 232 aa  61.2  0.00000001  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009720  Xaut_0991  two component LuxR family transcriptional regulator  29.55 
 
 		 210 aa  61.2  0.00000001  Xanthobacter autotrophicus Py2  Bacteria  normal  1  normal  1 
 
 
-
 
NC_008463  PA14_06950  LuxR family transcriptional regulator  27.97 
 
 		 496 aa  60.8  0.00000001  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  0.490761  normal  1 
 
 
-
 
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