More than 300 homologs were found in PanDaTox collection
for query gene Amir_4433 on replicon NC_013093
Organism: Actinosynnema mirum DSM 43827



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_013093  Amir_4433  two component transcriptional regulator, LuxR family  100 
 
 		 215 aa  421  1e-117  Actinosynnema mirum DSM 43827  Bacteria  normal  1  n/a   
 
 
-
 
NC_013739  Cwoe_2472  two component transcriptional regulator, LuxR family  57.27 
 
 		 221 aa  213  9.999999999999999e-55  Conexibacter woesei DSM 14684  Bacteria  normal  0.0113125  hitchhiker  0.00367669 
 
 
-
 
NC_014151  Cfla_2842  two component transcriptional regulator, LuxR family  52.02 
 
 		 226 aa  201  5e-51  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.622781  decreased coverage  0.00305681 
 
 
-
 
NC_008726  Mvan_5522  two component LuxR family transcriptional regulator  53.52 
 
 		 219 aa  201  7e-51  Mycobacterium vanbaalenii PYR-1  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013595  Sros_2533  response regulator receiver protein  50.23 
 
 		 220 aa  201  8e-51  Streptosporangium roseum DSM 43021  Bacteria  normal  1  normal  0.495874 
 
 
-
 
NC_008699  Noca_1020  response regulator receiver  51.64 
 
 		 218 aa  199  1.9999999999999998e-50  Nocardioides sp. JS614  Bacteria  normal  0.648692  n/a   
 
 
-
 
NC_013159  Svir_26840  response regulator containing a CheY-like receiver domain protein and an HTH DNA-binding domain protein  52.04 
 
 		 239 aa  198  3.9999999999999996e-50  Saccharomonospora viridis DSM 43017  Bacteria  normal  0.274056  normal  0.228776 
 
 
-
 
NC_013093  Amir_2737  two component transcriptional regulator, LuxR family  51.13 
 
 		 227 aa  197  9e-50  Actinosynnema mirum DSM 43827  Bacteria  normal  0.418014  n/a   
 
 
-
 
NC_009664  Krad_1350  two component transcriptional regulator, LuxR family  50.22 
 
 		 249 aa  197  1.0000000000000001e-49  Kineococcus radiotolerans SRS30216  Bacteria  normal  0.691965  normal  1 
 
 
-
 
NC_014165  Tbis_1846  LuxR family two component transcriptional regulator  50.45 
 
 		 226 aa  197  1.0000000000000001e-49  Thermobispora bispora DSM 43833  Bacteria  normal  0.699471  normal  1 
 
 
-
 
NC_013595  Sros_5905  response regulator receiver protein  48.9 
 
 		 227 aa  196  2.0000000000000003e-49  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0252894  normal  0.145246 
 
 
-
 
NC_009380  Strop_1796  response regulator receiver  51.82 
 
 		 230 aa  194  9e-49  Salinispora tropica CNB-440  Bacteria  normal  1  normal  1 
 
 
-
 
NC_014210  Ndas_1477  two component transcriptional regulator, LuxR family  50.23 
 
 		 234 aa  192  3e-48  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  0.594471  normal  1 
 
 
-
 
NC_013510  Tcur_2302  two component transcriptional regulator, LuxR family  47.51 
 
 		 226 aa  191  8e-48  Thermomonospora curvata DSM 43183  Bacteria  normal  0.0191252  n/a   
 
 
-
 
NC_013441  Gbro_3475  response regulator receiver  52.58 
 
 		 228 aa  191  9e-48  Gordonia bronchialis DSM 43247  Bacteria  normal  0.849127  n/a   
 
 
-
 
NC_013595  Sros_3244  response regulator receiver protein  51.39 
 
 		 218 aa  191  9e-48  Streptosporangium roseum DSM 43021  Bacteria  hitchhiker  0.000568428  normal  0.332742 
 
 
-
 
NC_009921  Franean1_6427  two component LuxR family transcriptional regulator  53.39 
 
 		 238 aa  189  2e-47  Frankia sp. EAN1pec  Bacteria  normal  0.140089  normal  0.356444 
 
 
-
 
NC_009953  Sare_1782  two component LuxR family transcriptional regulator  52.27 
 
 		 230 aa  190  2e-47  Salinispora arenicola CNS-205  Bacteria  normal  1  hitchhiker  0.0025253 
 
 
-
 
NC_013521  Sked_03540  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  50 
 
 		 226 aa  189  2e-47  Sanguibacter keddieii DSM 10542  Bacteria  normal  1  normal  1 
 
 
-
 
NC_014165  Tbis_0951  LuxR family two component transcriptional regulator  50 
 
 		 221 aa  189  2.9999999999999997e-47  Thermobispora bispora DSM 43833  Bacteria  normal  0.392411  normal  0.343359 
 
 
-
 
NC_014158  Tpau_1410  two component transcriptional regulator, LuxR family  52.56 
 
 		 222 aa  189  2.9999999999999997e-47  Tsukamurella paurometabola DSM 20162  Bacteria  normal  0.46664  n/a   
 
 
-
 
NC_013093  Amir_7009  two component transcriptional regulator, LuxR family  48.86 
 
 		 218 aa  188  5e-47  Actinosynnema mirum DSM 43827  Bacteria  normal  0.0896567  n/a   
 
 
-
 
NC_013595  Sros_5499  response regulator receiver protein  49.54 
 
 		 213 aa  188  5e-47  Streptosporangium roseum DSM 43021  Bacteria  decreased coverage  0.00659712  normal  0.108677 
 
 
-
 
NC_013131  Caci_8900  two component transcriptional regulator, LuxR family  52.56 
 
 		 221 aa  188  5.999999999999999e-47  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.967084  normal  1 
 
 
-
 
NC_013131  Caci_0956  two component transcriptional regulator, LuxR family  48.4 
 
 		 221 aa  187  7e-47  Catenulispora acidiphila DSM 44928  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013947  Snas_2557  two component transcriptional regulator, LuxR family  48.86 
 
 		 224 aa  187  7e-47  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.231398  normal  0.0978001 
 
 
-
 
NC_011886  Achl_2270  two component transcriptional regulator, LuxR family  49.13 
 
 		 242 aa  187  8e-47  Arthrobacter chlorophenolicus A6  Bacteria  n/a    hitchhiker  0.000000000113212 
 
 
-
 
NC_013739  Cwoe_3768  two component transcriptional regulator, LuxR family  49.77 
 
 		 223 aa  187  1e-46  Conexibacter woesei DSM 14684  Bacteria  normal  0.28303  normal  0.763501 
 
 
-
 
NC_013595  Sros_5304  response regulator receiver protein  50 
 
 		 220 aa  187  1e-46  Streptosporangium roseum DSM 43021  Bacteria  normal  0.128918  normal  1 
 
 
-
 
NC_013510  Tcur_4491  two component transcriptional regulator, LuxR family  51.79 
 
 		 225 aa  187  1e-46  Thermomonospora curvata DSM 43183  Bacteria  normal  1  n/a   
 
 
-
 
NC_013947  Snas_1903  two component transcriptional regulator, LuxR family  49.08 
 
 		 225 aa  185  4e-46  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.202425  normal  0.182857 
 
 
-
 
NC_013510  Tcur_0110  two component transcriptional regulator, LuxR family  49.54 
 
 		 222 aa  185  4e-46  Thermomonospora curvata DSM 43183  Bacteria  normal  1  n/a   
 
 
-
 
NC_013093  Amir_4051  two component transcriptional regulator, LuxR family  49.31 
 
 		 225 aa  185  5e-46  Actinosynnema mirum DSM 43827  Bacteria  decreased coverage  0.00308286  n/a   
 
 
-
 
NC_013235  Namu_0523  two component transcriptional regulator, LuxR family  51.61 
 
 		 230 aa  184  8e-46  Nakamurella multipartita DSM 44233  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009767  Rcas_1142  two component LuxR family transcriptional regulator  46.4 
 
 		 222 aa  184  9e-46  Roseiflexus castenholzii DSM 13941  Bacteria  normal  0.661777  normal  1 
 
 
-
 
NC_013595  Sros_7301  response regulator receiver protein  48.39 
 
 		 220 aa  184  1.0000000000000001e-45  Streptosporangium roseum DSM 43021  Bacteria  normal  1  normal  1 
 
 
-
 
NC_012669  Bcav_2822  two component transcriptional regulator, LuxR family  49.55 
 
 		 231 aa  183  1.0000000000000001e-45  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.311075  normal  1 
 
 
-
 
NC_013093  Amir_6235  two component transcriptional regulator, LuxR family  51.61 
 
 		 215 aa  183  1.0000000000000001e-45  Actinosynnema mirum DSM 43827  Bacteria  normal  0.502704  n/a   
 
 
-
 
NC_009664  Krad_1198  two component transcriptional regulator, LuxR family  47.95 
 
 		 225 aa  183  2.0000000000000003e-45  Kineococcus radiotolerans SRS30216  Bacteria  normal  0.109916  normal  0.0247339 
 
 
-
 
NC_012669  Bcav_0236  two component transcriptional regulator, LuxR family  48.42 
 
 		 224 aa  182  3e-45  Beutenbergia cavernae DSM 12333  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009664  Krad_1981  two component transcriptional regulator, LuxR family  47.14 
 
 		 230 aa  182  5.0000000000000004e-45  Kineococcus radiotolerans SRS30216  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013521  Sked_21600  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  46.82 
 
 		 222 aa  182  5.0000000000000004e-45  Sanguibacter keddieii DSM 10542  Bacteria  normal  0.49613  normal  1 
 
 
-
 
NC_013739  Cwoe_0262  two component transcriptional regulator, LuxR family  48.39 
 
 		 225 aa  181  9.000000000000001e-45  Conexibacter woesei DSM 14684  Bacteria  normal  0.0721339  normal  0.623073 
 
 
-
 
NC_013235  Namu_0480  two component transcriptional regulator, LuxR family  52.09 
 
 		 214 aa  180  1e-44  Nakamurella multipartita DSM 44233  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013530  Xcel_1619  two component transcriptional regulator, LuxR family  47.66 
 
 		 234 aa  179  2e-44  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  1  n/a   
 
 
-
 
NC_013721  HMPREF0424_0644  response regulator receiver domain protein  38.74 
 
 		 261 aa  179  2e-44  Gardnerella vaginalis 409-05  Bacteria  n/a    normal  0.520039 
 
 
-
 
NC_013739  Cwoe_1616  two component transcriptional regulator, LuxR family  47.35 
 
 		 229 aa  180  2e-44  Conexibacter woesei DSM 14684  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009921  Franean1_3185  two component LuxR family transcriptional regulator  48.89 
 
 		 223 aa  180  2e-44  Frankia sp. EAN1pec  Bacteria  normal  0.704721  normal  1 
 
 
-
 
NC_014151  Cfla_0278  two component transcriptional regulator, LuxR family  48.86 
 
 		 225 aa  179  2.9999999999999997e-44  Cellulomonas flavigena DSM 20109  Bacteria  normal  1  hitchhiker  0.000789071 
 
 
-
 
NC_011886  Achl_3912  two component transcriptional regulator, LuxR family  45.7 
 
 		 230 aa  179  2.9999999999999997e-44  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal  1 
 
 
-
 
NC_013172  Bfae_11600  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  49.31 
 
 		 225 aa  179  4e-44  Brachybacterium faecium DSM 4810  Bacteria  decreased coverage  0.00120804  n/a   
 
 
-
 
NC_013739  Cwoe_0356  two component transcriptional regulator, LuxR family  48.2 
 
 		 220 aa  178  4.999999999999999e-44  Conexibacter woesei DSM 14684  Bacteria  normal  0.165726  normal  0.0985551 
 
 
-
 
NC_009523  RoseRS_3421  two component LuxR family transcriptional regulator  47.42 
 
 		 223 aa  178  5.999999999999999e-44  Roseiflexus sp. RS-1  Bacteria  normal  1  normal  0.0556432 
 
 
-
 
NC_008541  Arth_4134  two component LuxR family transcriptional regulator  43.57 
 
 		 250 aa  177  8e-44  Arthrobacter sp. FB24  Bacteria  normal  1  n/a   
 
 
-
 
NC_012669  Bcav_2449  two component transcriptional regulator, LuxR family  49.11 
 
 		 220 aa  177  1e-43  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.729355  normal  1 
 
 
-
 
NC_013595  Sros_1523  response regulator receiver protein  46.05 
 
 		 215 aa  177  1e-43  Streptosporangium roseum DSM 43021  Bacteria  normal  0.894169  normal  0.0152488 
 
 
-
 
NC_013595  Sros_1746  response regulator receiver protein  51.39 
 
 		 217 aa  177  1e-43  Streptosporangium roseum DSM 43021  Bacteria  normal  0.59096  normal  0.157721 
 
 
-
 
NC_013739  Cwoe_0549  two component transcriptional regulator, LuxR family  47.47 
 
 		 220 aa  176  2e-43  Conexibacter woesei DSM 14684  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013947  Snas_2037  two component transcriptional regulator, LuxR family  47.71 
 
 		 225 aa  176  2e-43  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  1  normal  0.137578 
 
 
-
 
NC_013530  Xcel_2601  two component transcriptional regulator, LuxR family  48.44 
 
 		 234 aa  176  2e-43  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  0.1212  n/a   
 
 
-
 
NC_013739  Cwoe_4937  two component transcriptional regulator, LuxR family  47.49 
 
 		 224 aa  176  2e-43  Conexibacter woesei DSM 14684  Bacteria  normal  0.570807  normal  0.210467 
 
 
-
 
NC_013739  Cwoe_3988  two component transcriptional regulator, LuxR family  46.88 
 
 		 228 aa  176  2e-43  Conexibacter woesei DSM 14684  Bacteria  normal  0.0354189  normal  0.736565 
 
 
-
 
NC_013521  Sked_08490  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  46.67 
 
 		 236 aa  176  2e-43  Sanguibacter keddieii DSM 10542  Bacteria  normal  0.199706  normal  0.526513 
 
 
-
 
NC_014151  Cfla_2391  two component transcriptional regulator, LuxR family  47.92 
 
 		 239 aa  176  3e-43  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.0696687  hitchhiker  0.00128542 
 
 
-
 
NC_014151  Cfla_0857  two component transcriptional regulator, LuxR family  49.31 
 
 		 219 aa  176  3e-43  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.0762303  normal  1 
 
 
-
 
NC_013172  Bfae_20460  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  46.85 
 
 		 229 aa  175  4e-43  Brachybacterium faecium DSM 4810  Bacteria  normal  0.0212792  n/a   
 
 
-
 
NC_008699  Noca_3643  two component LuxR family transcriptional regulator  46.79 
 
 		 215 aa  174  6e-43  Nocardioides sp. JS614  Bacteria  normal  0.516516  n/a   
 
 
-
 
NC_013595  Sros_5619  response regulator receiver protein  48.17 
 
 		 226 aa  174  6e-43  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0556461  normal  0.802866 
 
 
-
 
NC_008697  Noca_4896  response regulator receiver  47.42 
 
 		 215 aa  174  7e-43  Nocardioides sp. JS614  Bacteria  normal  0.446448  normal  0.220667 
 
 
-
 
NC_013093  Amir_4260  two component transcriptional regulator, LuxR family  46.98 
 
 		 217 aa  174  9e-43  Actinosynnema mirum DSM 43827  Bacteria  normal  1  n/a   
 
 
-
 
NC_013595  Sros_3251  response regulator receiver protein  44.39 
 
 		 221 aa  174  9e-43  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0793449  normal  1 
 
 
-
 
NC_012803  Mlut_21900  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  47.51 
 
 		 230 aa  174  9e-43  Micrococcus luteus NCTC 2665  Bacteria  hitchhiker  0.00486265  n/a   
 
 
-
 
NC_013530  Xcel_2717  two component transcriptional regulator, LuxR family  45 
 
 		 223 aa  174  9.999999999999999e-43  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  1  n/a   
 
 
-
 
NC_012669  Bcav_1049  two component transcriptional regulator, LuxR family  45.95 
 
 		 222 aa  173  9.999999999999999e-43  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.661499  normal  0.245945 
 
 
-
 
NC_013947  Snas_4575  two component transcriptional regulator, LuxR family  49.33 
 
 		 224 aa  173  1.9999999999999998e-42  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.703378  normal  0.112036 
 
 
-
 
NC_009012  Cthe_1267  two component LuxR family transcriptional regulator  38.97 
 
 		 216 aa  173  1.9999999999999998e-42  Clostridium thermocellum ATCC 27405  Bacteria  normal  1  n/a   
 
 
-
 
NC_013595  Sros_8793  response regulator receiver protein  45.87 
 
 		 221 aa  172  1.9999999999999998e-42  Streptosporangium roseum DSM 43021  Bacteria  normal  0.321987  normal  1 
 
 
-
 
NC_012669  Bcav_0102  two component transcriptional regulator, LuxR family  46.82 
 
 		 221 aa  173  1.9999999999999998e-42  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.0637251  normal  1 
 
 
-
 
NC_013131  Caci_7105  two component transcriptional regulator, LuxR family  44.39 
 
 		 241 aa  173  1.9999999999999998e-42  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.106023  normal  0.469545 
 
 
-
 
NC_013131  Caci_1951  two component transcriptional regulator, LuxR family  47.3 
 
 		 226 aa  172  2.9999999999999996e-42  Catenulispora acidiphila DSM 44928  Bacteria  normal  1  normal  0.0924411 
 
 
-
 
NC_013170  Ccur_01320  response regulator containing a CheY-like receiver domain protein and an HTH DNA-binding domain protein  43.84 
 
 		 261 aa  172  3.9999999999999995e-42  Cryptobacterium curtum DSM 15641  Bacteria  normal  1  normal  1 
 
 
-
 
NC_010816  BLD_0671  putative response regulator  41.39 
 
 		 248 aa  171  5e-42  Bifidobacterium longum DJO10A  Bacteria  normal  0.248332  n/a   
 
 
-
 
NC_008697  Noca_4902  response regulator receiver  43.06 
 
 		 216 aa  171  6.999999999999999e-42  Nocardioides sp. JS614  Bacteria  normal  0.443208  normal  0.676579 
 
 
-
 
NC_013530  Xcel_0239  two component transcriptional regulator, LuxR family  45 
 
 		 230 aa  171  6.999999999999999e-42  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  1  n/a   
 
 
-
 
NC_013131  Caci_2656  two component transcriptional regulator, LuxR family  46.12 
 
 		 226 aa  170  1e-41  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.161573  normal  1 
 
 
-
 
NC_013595  Sros_4468  response regulator receiver protein  47.44 
 
 		 219 aa  170  1e-41  Streptosporangium roseum DSM 43021  Bacteria  normal  0.0876299  normal  0.32237 
 
 
-
 
NC_009921  Franean1_7161  two component LuxR family transcriptional regulator  46.08 
 
 		 225 aa  170  1e-41  Frankia sp. EAN1pec  Bacteria  normal  0.0588186  normal  0.118819 
 
 
-
 
NC_013131  Caci_8412  two component transcriptional regulator, LuxR family  46.33 
 
 		 239 aa  171  1e-41  Catenulispora acidiphila DSM 44928  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013757  Gobs_4064  two component transcriptional regulator, LuxR family  48.06 
 
 		 217 aa  171  1e-41  Geodermatophilus obscurus DSM 43160  Bacteria  normal  1  n/a   
 
 
-
 
NC_013947  Snas_2469  two component transcriptional regulator, LuxR family  46.61 
 
 		 214 aa  170  2e-41  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.126163  normal  1 
 
 
-
 
NC_013174  Jden_1873  two component transcriptional regulator, LuxR family  43.42 
 
 		 233 aa  169  3e-41  Jonesia denitrificans DSM 20603  Bacteria  normal  0.145213  normal  0.385799 
 
 
-
 
NC_009664  Krad_1998  two component transcriptional regulator, LuxR family  47.51 
 
 		 225 aa  169  3e-41  Kineococcus radiotolerans SRS30216  Bacteria  normal  0.12496  normal  1 
 
 
-
 
NC_009664  Krad_4217  two component transcriptional regulator, LuxR family  48.67 
 
 		 225 aa  169  3e-41  Kineococcus radiotolerans SRS30216  Bacteria  decreased coverage  0.000816589  normal  0.757819 
 
 
-
 
NC_013947  Snas_0625  two component transcriptional regulator, LuxR family  45.16 
 
 		 216 aa  169  3e-41  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.732521  normal  1 
 
 
-
 
NC_012669  Bcav_3028  two component transcriptional regulator, LuxR family  46.73 
 
 		 225 aa  169  3e-41  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.211566  decreased coverage  0.0000266978 
 
 
-
 
NC_013947  Snas_3359  two component transcriptional regulator, LuxR family  45.79 
 
 		 219 aa  169  4e-41  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.0172663  normal  1 
 
 
-
 
NC_013947  Snas_4479  two component transcriptional regulator, LuxR family  44.95 
 
 		 224 aa  168  5e-41  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.518456  normal  0.598935 
 
 
-
 
NC_013595  Sros_4115  response regulator receiver protein  49.05 
 
 		 216 aa  168  5e-41  Streptosporangium roseum DSM 43021  Bacteria  normal  0.071707  normal  0.0608108 
 
 
-
 
NC_013521  Sked_16860  response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  47.3 
 
 		 258 aa  168  6e-41  Sanguibacter keddieii DSM 10542  Bacteria  normal  0.85724  normal  0.036031 
 
 
-
 
NC_013595  Sros_0199  response regulator receiver protein  47.39 
 
 		 213 aa  168  7e-41  Streptosporangium roseum DSM 43021  Bacteria  normal  1  normal  1 
 
 
-
 
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