More than 300 homologs were found in PanDaTox collection
for query gene Mbur_0399 on replicon NC_007955
Organism: Methanococcoides burtonii DSM 6242



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_007955  Mbur_0399  MCP methyltransferase, CheR-type  100 
 
 
820 aa  1669    Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_013173  Dbac_1410  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  47.24 
 
 
1120 aa  776    Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.132886  n/a   
 
 
-
 
NC_013205  Aaci_0673  signal transduction histidine kinase with CheB and CheR activity  37.23 
 
 
1215 aa  593  1e-168  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_008609  Ppro_3165  signal transduction histidine kinase with CheB and CheR activity  39.64 
 
 
1306 aa  594  1e-168  Pelobacter propionicus DSM 2379  Bacteria  normal  n/a   
 
 
-
 
NC_009712  Mboo_0327  putative PAS/PAC sensor protein  37.14 
 
 
1008 aa  577  1.0000000000000001e-163  Candidatus Methanoregula boonei 6A8  Archaea  normal  normal 
 
 
-
 
NC_013440  Hoch_3250  signal transduction histidine kinase with CheB and CheR activity  38.07 
 
 
1348 aa  574  1.0000000000000001e-162  Haliangium ochraceum DSM 14365  Bacteria  normal  0.534329  normal  0.0270765 
 
 
-
 
NC_007908  Rfer_2355  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  38.4 
 
 
1008 aa  574  1.0000000000000001e-162  Rhodoferax ferrireducens T118  Bacteria  normal  0.71741  n/a   
 
 
-
 
NC_011832  Mpal_2460  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  36.17 
 
 
971 aa  570  1e-161  Methanosphaerula palustris E1-9c  Archaea  normal  normal 
 
 
-
 
NC_013061  Phep_3913  PAS sensor protein  39.38 
 
 
1337 aa  566  1e-160  Pedobacter heparinus DSM 2366  Bacteria  normal  0.290527  normal  0.28306 
 
 
-
 
NC_011060  Ppha_1653  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  37.38 
 
 
993 aa  565  1.0000000000000001e-159  Pelodictyon phaeoclathratiforme BU-1  Bacteria  normal  n/a   
 
 
-
 
NC_007912  Sde_3046  hypothetical protein  38.9 
 
 
1010 aa  562  1.0000000000000001e-159  Saccharophagus degradans 2-40  Bacteria  normal  hitchhiker  0.00164382 
 
 
-
 
NC_007517  Gmet_0780  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  37.13 
 
 
887 aa  560  1e-158  Geobacter metallireducens GS-15  Bacteria  normal  normal 
 
 
-
 
NC_013132  Cpin_7206  signal transduction histidine kinase with CheB and CheR activity  37.89 
 
 
1499 aa  561  1e-158  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal 
 
 
-
 
NC_008576  Mmc1_3390  MCP methyltransferase, CheR-type  49.56 
 
 
617 aa  562  1e-158  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_008639  Cpha266_1788  putative PAS/PAC sensor protein  37.29 
 
 
998 aa  556  1e-157  Chlorobium phaeobacteroides DSM 266  Bacteria  normal  n/a   
 
 
-
 
NC_008709  Ping_2549  fused CheR-type MCP methyltransferase and PAS sensor protein  38.83 
 
 
1006 aa  557  1e-157  Psychromonas ingrahamii 37  Bacteria  normal  normal 
 
 
-
 
NC_007298  Daro_2045  CheB methylesterase:MCP methyltransferase, CheR-type  37.42 
 
 
868 aa  555  1e-156  Dechloromonas aromatica RCB  Bacteria  normal  normal 
 
 
-
 
NC_011060  Ppha_0229  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  37.28 
 
 
1138 aa  552  1e-156  Pelodictyon phaeoclathratiforme BU-1  Bacteria  normal  n/a   
 
 
-
 
NC_010803  Clim_1600  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  36.49 
 
 
1000 aa  544  1e-153  Chlorobium limicola DSM 245  Bacteria  normal  n/a   
 
 
-
 
NC_013173  Dbac_2162  MCP methyltransferase/methylesterase, CheR/CheB  35.64 
 
 
879 aa  544  1e-153  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  n/a   
 
 
-
 
NC_007514  Cag_0563  putative PAS/PAC sensor protein  36.65 
 
 
1035 aa  536  1e-151  Chlorobium chlorochromatii CaD3  Bacteria  normal  n/a   
 
 
-
 
NC_010814  Glov_2975  diguanylate cyclase with PAS/PAC sensor  45.59 
 
 
1084 aa  537  1e-151  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_014248  Aazo_2376  signal transduction histidine kinase with CheB and CheR activity  36.98 
 
 
1407 aa  538  1e-151  'Nostoc azollae' 0708  Bacteria  normal  n/a   
 
 
-
 
NC_008709  Ping_1840  MCP methyltransferase, CheR-type  37.58 
 
 
840 aa  538  1e-151  Psychromonas ingrahamii 37  Bacteria  normal  0.59391  normal  0.603716 
 
 
-
 
NC_008709  Ping_3128  MCP methyltransferase, CheR-type  38.23 
 
 
840 aa  536  1e-151  Psychromonas ingrahamii 37  Bacteria  normal  normal 
 
 
-
 
NC_007355  Mbar_A2183  hypothetical protein  37.51 
 
 
980 aa  534  1e-150  Methanosarcina barkeri str. Fusaro  Archaea  normal  normal  0.850093 
 
 
-
 
NC_007413  Ava_0314  Signal transduction histidine kinase (STHK) with CheB and CheR activity  35.84 
 
 
1399 aa  535  1e-150  Anabaena variabilis ATCC 29413  Bacteria  normal  normal 
 
 
-
 
NC_007908  Rfer_3013  MCP methyltransferase, CheR-type  35.36 
 
 
877 aa  526  1e-148  Rhodoferax ferrireducens T118  Bacteria  normal  0.404945  n/a   
 
 
-
 
NC_008340  Mlg_1118  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  35.61 
 
 
852 aa  514  1e-144  Alkalilimnicola ehrlichii MLHE-1  Bacteria  normal  normal  0.742809 
 
 
-
 
NC_009620  Smed_4278  putative PAS/PAC sensor protein  34.89 
 
 
1027 aa  511  1e-143  Sinorhizobium medicae WSM419  Bacteria  normal  normal 
 
 
-
 
NC_008789  Hhal_1716  MCP methyltransferase, CheR-type  32.66 
 
 
856 aa  509  1e-143  Halorhodospira halophila SL1  Bacteria  normal  0.92135  n/a   
 
 
-
 
NC_014230  CA2559_12648  Signal Transduction Histidine Kinase (STHK) with CheB and CheRactivity  37.36 
 
 
1200 aa  510  1e-143  Croceibacter atlanticus HTCC2559  Bacteria  normal  n/a   
 
 
-
 
NC_007643  Rru_A1500  Signal transduction histidine kinase (STHK) with CheB and CheR activity  33.73 
 
 
1483 aa  504  1e-141  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  n/a   
 
 
-
 
NC_008255  CHU_1237  chemotaxis response regulator (methyltransferase)  37.15 
 
 
1618 aa  503  1e-141  Cytophaga hutchinsonii ATCC 33406  Bacteria  normal  normal 
 
 
-
 
NC_010625  Bphy_6399  signal transduction histidine kinase with CheB and CheR activity  32.17 
 
 
1361 aa  501  1e-140  Burkholderia phymatum STM815  Bacteria  normal  0.191888  normal 
 
 
-
 
NC_008781  Pnap_1703  signal transduction histidine kinase with CheB and CheR activity  33.06 
 
 
1408 aa  496  1e-139  Polaromonas naphthalenivorans CJ2  Bacteria  normal  0.433463  normal 
 
 
-
 
NC_013440  Hoch_4639  signal transduction histidine kinase with CheB and CheR activity  35.42 
 
 
1453 aa  495  9.999999999999999e-139  Haliangium ochraceum DSM 14365  Bacteria  normal  0.432269  normal 
 
 
-
 
NC_007348  Reut_B4915  PAS  32.55 
 
 
1384 aa  489  1e-136  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_009467  Acry_3169  signal transduction histidine kinase with CheB and CheR activity  33.73 
 
 
1445 aa  489  1e-136  Acidiphilium cryptum JF-5  Bacteria  normal  n/a   
 
 
-
 
NC_010581  Bind_0707  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  35.55 
 
 
1190 aa  481  1e-134  Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  normal 
 
 
-
 
NC_007760  Adeh_3183  signal transduction histidine kinase  32.7 
 
 
1279 aa  481  1e-134  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_007961  Nham_4605  MCP methyltransferase, CheR-type  35.01 
 
 
1092 aa  476  1e-133  Nitrobacter hamburgensis X14  Bacteria  normal  0.315944  n/a   
 
 
-
 
NC_011891  A2cp1_3377  signal transduction histidine kinase with CheB and CheR activity  32.22 
 
 
1242 aa  474  1e-132  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_011145  AnaeK_0372  signal transduction histidine kinase with CheB and CheR activity  32.22 
 
 
1233 aa  471  1.0000000000000001e-131  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_013037  Dfer_5571  signal transduction histidine kinase with CheB and CheR activity  32.37 
 
 
1218 aa  468  9.999999999999999e-131  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.273526  normal 
 
 
-
 
NC_011004  Rpal_3739  MCP methyltransferase, CheR-type  34.37 
 
 
1045 aa  468  9.999999999999999e-131  Rhodopseudomonas palustris TIE-1  Bacteria  normal  n/a   
 
 
-
 
NC_008751  Dvul_2487  signal transduction histidine kinase with CheB and CheR activity  33.76 
 
 
1535 aa  466  9.999999999999999e-131  Desulfovibrio vulgaris DP4  Bacteria  normal  0.162467  normal  0.455724 
 
 
-
 
NC_013440  Hoch_5252  signal transduction histidine kinase with CheB and CheR activity  31.68 
 
 
1698 aa  466  9.999999999999999e-131  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_013132  Cpin_4422  signal transduction histidine kinase with CheB and CheR activity  33.25 
 
 
1274 aa  463  1e-129  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.381764  normal 
 
 
-
 
NC_010725  Mpop_0310  MCP methyltransferase, CheR-type  32.32 
 
 
1149 aa  462  1e-129  Methylobacterium populi BJ001  Bacteria  normal  0.512157  normal 
 
 
-
 
NC_008752  Aave_2417  signal transduction histidine kinase with CheB and CheR activity  31.1 
 
 
1535 aa  464  1e-129  Acidovorax citrulli AAC00-1  Bacteria  normal  0.117494  normal 
 
 
-
 
NC_009621  Smed_5776  putative PAS/PAC sensor protein  33.69 
 
 
1160 aa  459  9.999999999999999e-129  Sinorhizobium medicae WSM419  Bacteria  normal  0.491611  normal  0.0137055 
 
 
-
 
NC_007493  RSP_2229  methylesterase CheB/methylase CheR  33.77 
 
 
1170 aa  461  9.999999999999999e-129  Rhodobacter sphaeroides 2.4.1  Bacteria  normal  0.840236  n/a   
 
 
-
 
NC_009049  Rsph17029_0905  putative PAS/PAC sensor protein  33.77 
 
 
1170 aa  461  9.999999999999999e-129  Rhodobacter sphaeroides ATCC 17029  Bacteria  normal  normal  0.968727 
 
 
-
 
NC_007484  Noc_1601  CheB methylesterase, CheR methyltransferase, hybrid histidine kinase  33.06 
 
 
1222 aa  458  1e-127  Nitrosococcus oceani ATCC 19707  Bacteria  normal  0.472526  n/a   
 
 
-
 
NC_013037  Dfer_5176  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  33.01 
 
 
1404 aa  458  1e-127  Dyadobacter fermentans DSM 18053  Bacteria  normal  normal  0.190634 
 
 
-
 
NC_010322  PputGB1_3018  signal transduction histidine kinase with CheB and CheR activity  31.96 
 
 
1371 aa  459  1e-127  Pseudomonas putida GB-1  Bacteria  normal  normal  0.980757 
 
 
-
 
NC_010580  Bind_3835  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  33.18 
 
 
1167 aa  453  1.0000000000000001e-126  Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  normal 
 
 
-
 
NC_010086  Bmul_3193  signal transduction histidine kinase with CheB and CheR activity  30.92 
 
 
1380 aa  455  1.0000000000000001e-126  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal  0.112764 
 
 
-
 
NC_009428  Rsph17025_2264  putative PAS/PAC sensor protein  32.93 
 
 
1165 aa  452  1e-125  Rhodobacter sphaeroides ATCC 17025  Bacteria  normal  0.620072  normal  0.0600346 
 
 
-
 
NC_008044  TM1040_1028  signal transduction histidine kinase with CheB and CheR activity  33.26 
 
 
1248 aa  452  1e-125  Ruegeria sp. TM1040  Bacteria  normal  normal  0.507304 
 
 
-
 
NC_013440  Hoch_1404  signal transduction histidine kinase with CheB and CheR activity  32.49 
 
 
1759 aa  447  1.0000000000000001e-124  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_010505  Mrad2831_4430  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  31.23 
 
 
1158 aa  433  1e-120  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_007953  Bxe_C0521  multi sensor hybrid histidine kinase  32.26 
 
 
1344 aa  424  1e-117  Burkholderia xenovorans LB400  Bacteria  normal  normal 
 
 
-
 
NC_008044  TM1040_2227  MCP methyltransferase, CheR-type  32.18 
 
 
824 aa  409  1e-113  Ruegeria sp. TM1040  Bacteria  normal  normal 
 
 
-
 
NC_013730  Slin_3102  signal transduction histidine kinase with CheB and CheR activity  33.13 
 
 
1418 aa  411  1e-113  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_010505  Mrad2831_5709  MCP methyltransferase, CheR-type  30.94 
 
 
853 aa  402  1e-111  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal  0.729466 
 
 
-
 
NC_007952  Bxe_B1520  signal transduction histidine kinase (STHK) with CheB and CheR activity  30.94 
 
 
1303 aa  397  1e-109  Burkholderia xenovorans LB400  Bacteria  normal  0.124967  normal 
 
 
-
 
NC_010725  Mpop_1297  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  30.19 
 
 
1168 aa  395  1e-108  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_010510  Mrad2831_6264  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  30.82 
 
 
1163 aa  387  1e-106  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_3278  signal transduction histidine kinase with CheB and CheR activity  30.36 
 
 
2468 aa  386  1e-106  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0267066 
 
 
-
 
NC_010623  Bphy_5175  MCP methyltransferase, CheR-type  30.58 
 
 
823 aa  386  1e-105  Burkholderia phymatum STM815  Bacteria  normal  normal  0.367936 
 
 
-
 
NC_010511  M446_6211  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  30.4 
 
 
1061 aa  383  1e-105  Methylobacterium sp. 4-46  Bacteria  normal  0.820077  normal  0.703655 
 
 
-
 
NC_008044  TM1040_0460  MCP methyltransferase, CheR-type  31.68 
 
 
837 aa  384  1e-105  Ruegeria sp. TM1040  Bacteria  normal  0.604812  normal 
 
 
-
 
NC_011894  Mnod_3755  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  29.35 
 
 
1063 aa  377  1e-103  Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_007802  Jann_2564  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  29.99 
 
 
1089 aa  373  1e-102  Jannaschia sp. CCS1  Bacteria  normal  normal 
 
 
-
 
NC_011368  Rleg2_5237  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  29.01 
 
 
1324 aa  363  6e-99  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.395635 
 
 
-
 
NC_008789  Hhal_0370  protein-glutamate O-methyltransferase  34.34 
 
 
639 aa  361  2e-98  Halorhodospira halophila SL1  Bacteria  normal  0.181962  n/a   
 
 
-
 
NC_007348  Reut_B5191  CheB methylesterase:MCP methyltransferase, CheR-type  29.72 
 
 
813 aa  353  5e-96  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_007964  Nham_3990  MCP methyltransferase, CheR-type  39.7 
 
 
432 aa  330  9e-89  Nitrobacter hamburgensis X14  Bacteria  normal  n/a   
 
 
-
 
NC_010086  Bmul_4696  signal transduction histidine kinase with CheB and CheR activity  27.48 
 
 
1214 aa  327  7e-88  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal 
 
 
-
 
NC_010508  Bcenmc03_1302  signal transduction histidine kinase with CheB and CheR activity  26.94 
 
 
1220 aa  324  3e-87  Burkholderia cenocepacia MC0-3  Bacteria  normal  normal  0.772751 
 
 
-
 
NC_002977  MCA1246  methyltransferase CheR, putative  28.66 
 
 
1378 aa  318  3e-85  Methylococcus capsulatus str. Bath  Bacteria  normal  0.271052  n/a   
 
 
-
 
NC_010814  Glov_0566  MCP methyltransferase, CheR-type with PAS/PAC sensor  30.24 
 
 
1193 aa  308  3e-82  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_3640  MCP methyltransferase, CheR-type with PAS/PAC sensor  33.22 
 
 
1303 aa  295  2e-78  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal  0.581797 
 
 
-
 
NC_013730  Slin_1989  MCP methyltransferase, CheR-type with PAS/PAC sensor  31.81 
 
 
1110 aa  291  4e-77  Spirosoma linguale DSM 74  Bacteria  normal  0.175442  normal  0.013335 
 
 
-
 
NC_009622  Smed_6341  putative PAS/PAC sensor protein  30.92 
 
 
629 aa  277  5e-73  Sinorhizobium medicae WSM419  Bacteria  normal  0.433344  normal  0.230755 
 
 
-
 
NC_010717  PXO_03023  methyltransferase  33.17 
 
 
604 aa  256  2.0000000000000002e-66  Xanthomonas oryzae pv. oryzae PXO99A  Bacteria  normal  0.361036  n/a   
 
 
-
 
NC_011884  Cyan7425_3121  MCP methyltransferase, CheR-type with PAS/PAC sensor  27.42 
 
 
617 aa  227  7e-58  Cyanothece sp. PCC 7425  Bacteria  normal  0.0152355  normal  0.805919 
 
 
-
 
NC_013440  Hoch_3427  MCP methyltransferase, CheR-type with PAS/PAC sensor  24.64 
 
 
2031 aa  215  2.9999999999999995e-54  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0889636 
 
 
-
 
NC_014248  Aazo_0227  MCP methyltransferase  28.13 
 
 
631 aa  213  1e-53  'Nostoc azollae' 0708  Bacteria  normal  0.993793  n/a   
 
 
-
 
NC_008576  Mmc1_3393  putative PAS/PAC sensor protein  45.32 
 
 
545 aa  206  2e-51  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_009622  Smed_6342  CheB methylesterase  39.86 
 
 
336 aa  203  9.999999999999999e-51  Sinorhizobium medicae WSM419  Bacteria  normal  0.582664  normal  0.191496 
 
 
-
 
NC_011729  PCC7424_0433  MCP methyltransferase, CheR-type with PAS/PAC sensor  26.63 
 
 
618 aa  200  1.0000000000000001e-49  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_008576  Mmc1_2113  MCP methyltransferase, CheR-type  26.68 
 
 
565 aa  159  2e-37  Magnetococcus sp. MC-1  Bacteria  normal  0.982588  normal 
 
 
-
 
NC_009637  MmarC7_0177  protein-glutamate O-methyltransferase  34.15 
 
 
270 aa  157  1e-36  Methanococcus maripaludis C7  Archaea  normal  normal 
 
 
-
 
NC_011146  Gbem_0626  MCP methyltransferase, CheR-type  32.83 
 
 
277 aa  154  5e-36  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_009135  MmarC5_0737  protein-glutamate O-methyltransferase  35.87 
 
 
270 aa  153  1e-35  Methanococcus maripaludis C5  Archaea  normal  0.730545  n/a   
 
 
-
 
NC_009975  MmarC6_1725  MCP methyltransferase, CheR-type  33.74 
 
 
270 aa  150  8e-35  Methanococcus maripaludis C6  Archaea  normal  n/a   
 
 
-
 
NC_013132  Cpin_6403  CheB methylesterase  42.86 
 
 
203 aa  150  8e-35  Chitinophaga pinensis DSM 2588  Bacteria  hitchhiker  0.00116583  normal 
 
 
-
 
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