72 homologs were found in PanDaTox collection
for query gene Hlac_2019 on replicon NC_012029
Organism: Halorubrum lacusprofundi ATCC 49239



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_012029  Hlac_2019  3-hydroxy-3-methylglutaryl Coenzyme A reductase  100 
 
 		 407 aa  804    Halorubrum lacusprofundi ATCC 49239  Archaea  normal  1  normal  0.439309 
 
 
-
 
NC_013922  Nmag_2929  3-hydroxy-3-methylglutaryl Coenzyme A reductase  72.26 
 
 		 410 aa  550  1e-155  Natrialba magadii ATCC 43099  Archaea  normal  0.342818  n/a   
 
 
-
 
NC_013202  Hmuk_1499  3-hydroxy-3-methylglutaryl Coenzyme A reductase  73.43 
 
 		 403 aa  546  1e-154  Halomicrobium mukohataei DSM 12286  Archaea  normal  0.398419  normal  1 
 
 
-
 
NC_013743  Htur_0537  3-hydroxy-3-methylglutaryl Coenzyme A reductase  72.17 
 
 		 408 aa  542  1e-153  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_013158  Huta_0276  3-hydroxy-3-methylglutaryl Coenzyme A reductase  66.67 
 
 		 403 aa  515  1.0000000000000001e-145  Halorhabdus utahensis DSM 12940  Archaea  normal  1  n/a   
 
 
-
 
NC_008942  Mlab_1655  3-hydroxy-3-methylglutaryl-coenzyme A reductase  53.03 
 
 		 404 aa  402  1e-111  Methanocorpusculum labreanum Z  Archaea  normal  1  hitchhiker  0.0000342006 
 
 
-
 
NC_009975  MmarC6_0860  3-hydroxy-3-methylglutaryl coenzyme A reductase  49.14 
 
 		 408 aa  389  1e-107  Methanococcus maripaludis C6  Archaea  normal  0.187348  n/a   
 
 
-
 
NC_010525  Tneu_1359  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.42 
 
 		 395 aa  391  1e-107  Thermoproteus neutrophilus V24Sta  Archaea  normal  1  normal  1 
 
 
-
 
NC_009637  MmarC7_1086  3-hydroxy-3-methylglutaryl coenzyme A reductase  48.89 
 
 		 408 aa  389  1e-107  Methanococcus maripaludis C7  Archaea  normal  1  normal  1 
 
 
-
 
CP001800  Ssol_1610  3-hydroxy-3-methylglutaryl Coenzyme A reductase  47.38 
 
 		 409 aa  387  1e-106  Sulfolobus solfataricus 98/2  Archaea  normal  1  n/a   
 
 
-
 
NC_007955  Mbur_1098  3-hydroxy-3-methylglutaryl-coenzyme A reductase  51.37 
 
 		 414 aa  386  1e-106  Methanococcoides burtonii DSM 6242  Archaea  normal  1  n/a   
 
 
-
 
NC_009135  MmarC5_1589  3-hydroxy-3-methylglutaryl-coenzyme A reductase  48.4 
 
 		 408 aa  386  1e-106  Methanococcus maripaludis C5  Archaea  normal  0.346816  n/a   
 
 
-
 
NC_009634  Mevan_1099  3-hydroxy-3-methylglutaryl coenzyme A reductase  47.9 
 
 		 411 aa  382  1e-105  Methanococcus vannielii SB  Archaea  normal  1  n/a   
 
 
-
 
NC_009954  Cmaq_0412  3-hydroxy-3-methylglutaryl coenzyme A reductase  51.39 
 
 		 410 aa  378  1e-104  Caldivirga maquilingensis IC-167  Archaea  normal  1  normal  1 
 
 
-
 
NC_009635  Maeo_0718  3-hydroxy-3-methylglutaryl coenzyme A reductase  46.08 
 
 		 418 aa  376  1e-103  Methanococcus aeolicus Nankai-3  Archaea  normal  1  n/a   
 
 
-
 
NC_007796  Mhun_3004  3-hydroxy-3-methylglutaryl coenzyme A reductase  50.51 
 
 		 401 aa  375  1e-103  Methanospirillum hungatei JF-1  Archaea  normal  1  normal  1 
 
 
-
 
NC_009440  Msed_1649  3-hydroxy-3-methylglutaryl-coenzyme A reductase  49.13 
 
 		 410 aa  372  1e-102  Metallosphaera sedula DSM 5348  Archaea  normal  0.982475  normal  1 
 
 
-
 
NC_009712  Mboo_0137  3-hydroxy-3-methylglutaryl coenzyme A reductase  49.38 
 
 		 426 aa  369  1e-101  Candidatus Methanoregula boonei 6A8  Archaea  normal  1  normal  1 
 
 
-
 
NC_011832  Mpal_2647  3-hydroxy-3-methylglutaryl Coenzyme A reductase  52.19 
 
 		 407 aa  369  1e-101  Methanosphaerula palustris E1-9c  Archaea  normal  0.259986  normal  0.338347 
 
 
-
 
NC_009376  Pars_0796  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.93 
 
 		 398 aa  367  1e-100  Pyrobaculum arsenaticum DSM 13514  Archaea  normal  1  normal  1 
 
 
-
 
NC_009073  Pcal_1085  3-hydroxy-3-methylglutaryl-coenzyme A reductase  53.18 
 
 		 399 aa  367  1e-100  Pyrobaculum calidifontis JCM 11548  Archaea  n/a    normal  1 
 
 
-
 
NC_007355  Mbar_A1972  hydroxymethylglutaryl-CoA reductase (NADPH)  49.88 
 
 		 418 aa  359  4e-98  Methanosarcina barkeri str. Fusaro  Archaea  normal  1  normal  1 
 
 
-
 
NC_008701  Pisl_0814  3-hydroxy-3-methylglutaryl coenzyme A reductase  51.65 
 
 		 399 aa  359  4e-98  Pyrobaculum islandicum DSM 4184  Archaea  normal  1  hitchhiker  0.00207544 
 
 
-
 
NC_009051  Memar_2365  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.39 
 
 		 402 aa  358  9.999999999999999e-98  Methanoculleus marisnigri JR1  Archaea  normal  1  n/a   
 
 
-
 
NC_011697  PHATRDRAFT_16870  predicted protein  49.24 
 
 		 367 aa  305  1.0000000000000001e-81  Phaeodactylum tricornutum CCAP 1055/1  Eukaryota  normal  1  n/a   
 
 
-
 
NC_009046  PICST_72872  3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA)  41.77 
 
 		 1047 aa  292  7e-78  Scheffersomyces stipitis CBS 6054  Eukaryota  normal  1  normal  1 
 
 
-
 
NC_006691  CNF04830  hydroxymethylglutaryl-CoA reductase (NADPH), putative  42.22 
 
 		 1283 aa  286  4e-76  Cryptococcus neoformans var. neoformans JEC21  Eukaryota  normal  1  n/a   
 
 
-
 
NC_013457  VEA_000087  hydroxymethylglutaryl-CoA reductase  45.6 
 
 		 420 aa  286  4e-76  Vibrio sp. Ex25  Bacteria  normal  1  n/a   
 
 
-
 
BN001302  ANIA_03817  hypothetical protein similar to HMG-CoA reductase (Eurofung)  42.57 
 
 		 1125 aa  286  5e-76  Aspergillus nidulans FGSC A4  Eukaryota  normal  1  normal  1 
 
 
-
 
BN001307  ANIA_01593  conserved hypothetical protein  43.73 
 
 		 416 aa  281  1e-74  Aspergillus nidulans FGSC A4  Eukaryota  normal  1  normal  1 
 
 
-
 
NC_009784  VIBHAR_05704  3-hydroxy-3-methylglutaryl CoA reductase  44.15 
 
 		 420 aa  273  4.0000000000000004e-72  Vibrio harveyi ATCC BAA-1116  Bacteria  n/a    n/a   
 
 
-
 
NC_011138  MADE_03398  Hydroxymethylglutaryl-coenzyme A reductase  39.57 
 
 		 396 aa  264  2e-69  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  1  n/a   
 
 
-
 
NC_009456  VC0395_0662  hydroxymethylglutaryl-coenzyme A reductase  44.19 
 
 		 420 aa  261  1e-68  Vibrio cholerae O395  Bacteria  normal  1  n/a   
 
 
-
 
NC_011313  VSAL_II0253  putative 3-hydroxy-3-methylglutaryl coenzyme a reductase  44.7 
 
 		 419 aa  258  2e-67  Aliivibrio salmonicida LFI1238  Bacteria  normal  0.0262386  n/a   
 
 
-
 
NC_008228  Patl_0427  hydroxymethylglutaryl-CoA reductase (NADPH)  38.18 
 
 		 395 aa  252  7e-66  Pseudoalteromonas atlantica T6c  Bacteria  normal  0.601953  n/a   
 
 
-
 
NC_013517  Sterm_1947  hydroxymethylglutaryl-coenzyme A reductase  35.87 
 
 		 424 aa  230  3e-59  Sebaldella termitidis ATCC 33386  Bacteria  normal  1  n/a   
 
 
-
 
NC_007520  Tcr_1717  hydroxymethylglutaryl-CoA reductase (NADPH)  38.08 
 
 		 352 aa  221  9.999999999999999e-57  Thiomicrospira crunogena XCL-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_011138  MADE_03508  Hydroxymethylglutaryl-coenzyme A reductase  38.5 
 
 		 514 aa  206  5e-52  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  1  n/a   
 
 
-
 
NC_010117  COXBURSA331_A0723  hydroxymethylglutaryl-CoA reductase (NADPH)  38.82 
 
 		 355 aa  204  3e-51  Coxiella burnetii RSA 331  Bacteria  hitchhiker  0.000000000015079  n/a   
 
 
-
 
NC_009727  CBUD_0622  3-hydroxy-3-methylglutaryl-coenzyme A reductase  38.82 
 
 		 357 aa  204  3e-51  Coxiella burnetii Dugway 5J108-111  Bacteria  hitchhiker  0.000221084  n/a   
 
 
-
 
NC_010117  COXBURSA331_A2174  hydroxymethylglutaryl-coenzyme A reductase  35.07 
 
 		 395 aa  202  9e-51  Coxiella burnetii RSA 331  Bacteria  normal  0.0352988  n/a   
 
 
-
 
NC_009727  CBUD_0151  3-hydroxy-3-methylglutaryl-coenzyme A reductase  32.17 
 
 		 364 aa  165  1.0000000000000001e-39  Coxiella burnetii Dugway 5J108-111  Bacteria  normal  1  n/a   
 
 
-
 
NC_008553  Mthe_0936  hydroxymethylglutaryl-CoA reductase, degradative  27.23 
 
 		 419 aa  70.9  0.00000000004  Methanosaeta thermophila PT  Archaea  normal  1  n/a   
 
 
-
 
NC_009972  Haur_3539  hydroxymethylglutaryl-CoA reductase, degradative  26.17 
 
 		 441 aa  64.7  0.000000003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.0777406  n/a   
 
 
-
 
NC_002976  SERP2121  hydroxymethylglutaryl-CoA reductase, degradative  24.54 
 
 		 425 aa  63.5  0.000000006  Staphylococcus epidermidis RP62A  Bacteria  normal  1  n/a   
 
 
-
 
NC_009767  Rcas_0981  hydroxymethylglutaryl-CoA reductase, degradative  25.62 
 
 		 444 aa  59.7  0.0000001  Roseiflexus castenholzii DSM 13941  Bacteria  normal  1  normal  1 
 
 
-
 
NC_008527  LACR_1664  3-hydroxy-3-methylglutaryl-coenzyme A reductase  23.29 
 
 		 410 aa  58.5  0.0000002  Lactococcus lactis subsp. cremoris SK11  Bacteria  hitchhiker  0.0024632  n/a   
 
 
-
 
NC_008528  OEOE_1799  3-hydroxy-3-methylglutaryl-coenzyme A reductase  24.59 
 
 		 363 aa  57.8  0.0000003  Oenococcus oeni PSU-1  Bacteria  normal  1  n/a   
 
 
-
 
NC_009523  RoseRS_0431  hydroxymethylglutaryl-CoA reductase, degradative  24.79 
 
 		 456 aa  57  0.0000006  Roseiflexus sp. RS-1  Bacteria  normal  1  normal  0.316381 
 
 
-
 
NC_009487  SaurJH9_2568  hydroxymethylglutaryl-CoA reductase, degradative  25.18 
 
 		 425 aa  53.5  0.000006  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  1  n/a   
 
 
-
 
NC_009632  SaurJH1_2621  hydroxymethylglutaryl-CoA reductase, degradative  25.18 
 
 		 425 aa  53.5  0.000006  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  1  n/a   
 
 
-
 
NC_013515  Smon_1290  hydroxymethylglutaryl-CoA reductase, degradative  23.38 
 
 		 406 aa  53.1  0.000008  Streptobacillus moniliformis DSM 12112  Bacteria  n/a    n/a   
 
 
-
 
NC_008530  LGAS_1373  hydroxymethylglutaryl-CoA reductase  21.88 
 
 		 429 aa  50.8  0.00004  Lactobacillus gasseri ATCC 33323  Bacteria  normal  1  hitchhiker  0.0000000000375721 
 
 
-
 
NC_008532  STER_0620  3-hydroxy-3-methylglutaryl-coenzyme A reductase  23.77 
 
 		 423 aa  50.8  0.00004  Streptococcus thermophilus LMD-9  Bacteria  normal  1  n/a   
 
 
-
 
NC_009441  Fjoh_1418  hydroxymethylglutaryl-CoA reductase, degradative  23.34 
 
 		 437 aa  49.7  0.00008  Flavobacterium johnsoniae UW101  Bacteria  normal  0.984667  n/a   
 
 
-
 
NC_007650  BTH_II1513  hypothetical protein  32.94 
 
 		 270 aa  48.5  0.0002  Burkholderia thailandensis E264  Bacteria  normal  0.175272  n/a   
 
 
-
 
NC_013440  Hoch_3406  hydroxymethylglutaryl-CoA reductase, degradative  26.65 
 
 		 443 aa  47.8  0.0004  Haliangium ochraceum DSM 14365  Bacteria  normal  0.121756  normal  0.0808381 
 
 
-
 
NC_011831  Cagg_1141  hydroxymethylglutaryl-CoA reductase, degradative  25.49 
 
 		 440 aa  47.4  0.0005  Chloroflexus aggregans DSM 9485  Bacteria  normal  1  hitchhiker  0.00353445 
 
 
-
 
NC_008698  Tpen_0927  hydroxymethylglutaryl-CoA reductase, degradative  24.66 
 
 		 428 aa  46.2  0.001  Thermofilum pendens Hrk 5  Archaea  normal  1  n/a   
 
 
-
 
NC_008784  BMASAVP1_0333  hypothetical protein  31.76 
 
 		 282 aa  45.1  0.002  Burkholderia mallei SAVP1  Bacteria  normal  1  n/a   
 
 
-
 
NC_008835  BMA10229_0611  hypothetical protein  31.76 
 
 		 282 aa  45.1  0.002  Burkholderia mallei NCTC 10229  Bacteria  normal  1  n/a   
 
 
-
 
NC_009075  BURPS668_A1291  hypothetical protein  31.76 
 
 		 282 aa  45.1  0.002  Burkholderia pseudomallei 668  Bacteria  normal  0.132365  n/a   
 
 
-
 
NC_009078  BURPS1106A_A1219  hypothetical protein  31.76 
 
 		 282 aa  45.1  0.002  Burkholderia pseudomallei 1106a  Bacteria  normal  0.264003  n/a   
 
 
-
 
NC_009079  BMA10247_A0958  hypothetical protein  31.76 
 
 		 282 aa  45.1  0.002  Burkholderia mallei NCTC 10247  Bacteria  normal  1  n/a   
 
 
-
 
NC_007435  BURPS1710b_A2482  hypothetical protein  31.76 
 
 		 273 aa  45.1  0.002  Burkholderia pseudomallei 1710b  Bacteria  normal  1  n/a   
 
 
-
 
NC_006349  BMAA1348  hypothetical protein  31.76 
 
 		 273 aa  45.4  0.002  Burkholderia mallei ATCC 23344  Bacteria  normal  1  n/a   
 
 
-
 
NC_013926  Aboo_1461  hydroxymethylglutaryl-CoA reductase, degradative  24.94 
 
 		 420 aa  45.4  0.002  Aciduliprofundum boonei T469  Archaea  normal  0.478544  n/a   
 
 
-
 
NC_008543  Bcen2424_3505  hydroxymethylglutaryl-CoA reductase, degradative  26.12 
 
 		 428 aa  45.1  0.003  Burkholderia cenocepacia HI2424  Bacteria  normal  1  normal  1 
 
 
-
 
NC_010515  Bcenmc03_4013  hydroxymethylglutaryl-CoA reductase, degradative  26.12 
 
 		 428 aa  45.1  0.003  Burkholderia cenocepacia MC0-3  Bacteria  normal  1  normal  0.316182 
 
 
-
 
NC_011728  BbuZS7_0705  hydroxymethylglutaryl-CoA reductase, degradative  26.25 
 
 		 422 aa  43.1  0.008  Borrelia burgdorferi ZS7  Bacteria  normal  1  n/a   
 
 
-
 
NC_013162  Coch_1037  hydroxymethylglutaryl-CoA reductase, degradative  23.56 
 
 		 436 aa  43.1  0.008  Capnocytophaga ochracea DSM 7271  Bacteria  normal  1  n/a   
 
 
-
 
NC_014230  CA2559_04185  3-hydroxy-3-methylglutaryl-coenzyme A reductase  20.97 
 
 		 436 aa  43.5  0.008  Croceibacter atlanticus HTCC2559  Bacteria  normal  1  n/a   
 
 
-
 
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