65 homologs were found in PanDaTox collection
for query gene Mbar_A1972 on replicon NC_007355
Organism: Methanosarcina barkeri str. Fusaro



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_007355  Mbar_A1972  hydroxymethylglutaryl-CoA reductase (NADPH)  100 
 
 		 418 aa  857    Methanosarcina barkeri str. Fusaro  Archaea  normal  1  normal  1 
 
 
-
 
NC_007955  Mbur_1098  3-hydroxy-3-methylglutaryl-coenzyme A reductase  68.95 
 
 		 414 aa  561  1.0000000000000001e-159  Methanococcoides burtonii DSM 6242  Archaea  normal  1  n/a   
 
 
-
 
NC_009712  Mboo_0137  3-hydroxy-3-methylglutaryl coenzyme A reductase  53.94 
 
 		 426 aa  419  1e-116  Candidatus Methanoregula boonei 6A8  Archaea  normal  1  normal  1 
 
 
-
 
NC_009635  Maeo_0718  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.21 
 
 		 418 aa  415  9.999999999999999e-116  Methanococcus aeolicus Nankai-3  Archaea  normal  1  n/a   
 
 
-
 
NC_011832  Mpal_2647  3-hydroxy-3-methylglutaryl Coenzyme A reductase  54.45 
 
 		 407 aa  416  9.999999999999999e-116  Methanosphaerula palustris E1-9c  Archaea  normal  0.259986  normal  0.338347 
 
 
-
 
NC_007796  Mhun_3004  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.5 
 
 		 401 aa  406  1.0000000000000001e-112  Methanospirillum hungatei JF-1  Archaea  normal  1  normal  1 
 
 
-
 
NC_008942  Mlab_1655  3-hydroxy-3-methylglutaryl-coenzyme A reductase  51.99 
 
 		 404 aa  401  9.999999999999999e-111  Methanocorpusculum labreanum Z  Archaea  normal  1  hitchhiker  0.0000342006 
 
 
-
 
NC_009634  Mevan_1099  3-hydroxy-3-methylglutaryl coenzyme A reductase  51.35 
 
 		 411 aa  401  9.999999999999999e-111  Methanococcus vannielii SB  Archaea  normal  1  n/a   
 
 
-
 
NC_009975  MmarC6_0860  3-hydroxy-3-methylglutaryl coenzyme A reductase  50.86 
 
 		 408 aa  399  9.999999999999999e-111  Methanococcus maripaludis C6  Archaea  normal  0.187348  n/a   
 
 
-
 
NC_009637  MmarC7_1086  3-hydroxy-3-methylglutaryl coenzyme A reductase  50.37 
 
 		 408 aa  395  1e-109  Methanococcus maripaludis C7  Archaea  normal  1  normal  1 
 
 
-
 
NC_010525  Tneu_1359  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.39 
 
 		 395 aa  394  1e-108  Thermoproteus neutrophilus V24Sta  Archaea  normal  1  normal  1 
 
 
-
 
NC_009135  MmarC5_1589  3-hydroxy-3-methylglutaryl-coenzyme A reductase  50.12 
 
 		 408 aa  392  1e-108  Methanococcus maripaludis C5  Archaea  normal  0.346816  n/a   
 
 
-
 
NC_009051  Memar_2365  3-hydroxy-3-methylglutaryl coenzyme A reductase  54.36 
 
 		 402 aa  392  1e-108  Methanoculleus marisnigri JR1  Archaea  normal  1  n/a   
 
 
-
 
NC_013158  Huta_0276  3-hydroxy-3-methylglutaryl Coenzyme A reductase  49.63 
 
 		 403 aa  389  1e-107  Halorhabdus utahensis DSM 12940  Archaea  normal  1  n/a   
 
 
-
 
CP001800  Ssol_1610  3-hydroxy-3-methylglutaryl Coenzyme A reductase  46.65 
 
 		 409 aa  382  1e-105  Sulfolobus solfataricus 98/2  Archaea  normal  1  n/a   
 
 
-
 
NC_013202  Hmuk_1499  3-hydroxy-3-methylglutaryl Coenzyme A reductase  51.37 
 
 		 403 aa  382  1e-105  Halomicrobium mukohataei DSM 12286  Archaea  normal  0.398419  normal  1 
 
 
-
 
NC_013743  Htur_0537  3-hydroxy-3-methylglutaryl Coenzyme A reductase  49.88 
 
 		 408 aa  379  1e-104  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_009376  Pars_0796  3-hydroxy-3-methylglutaryl coenzyme A reductase  53 
 
 		 398 aa  375  1e-103  Pyrobaculum arsenaticum DSM 13514  Archaea  normal  1  normal  1 
 
 
-
 
NC_008701  Pisl_0814  3-hydroxy-3-methylglutaryl coenzyme A reductase  52.39 
 
 		 399 aa  370  1e-101  Pyrobaculum islandicum DSM 4184  Archaea  normal  1  hitchhiker  0.00207544 
 
 
-
 
NC_009073  Pcal_1085  3-hydroxy-3-methylglutaryl-coenzyme A reductase  53.4 
 
 		 399 aa  368  1e-100  Pyrobaculum calidifontis JCM 11548  Archaea  n/a    normal  1 
 
 
-
 
NC_013922  Nmag_2929  3-hydroxy-3-methylglutaryl Coenzyme A reductase  48.4 
 
 		 410 aa  366  1e-100  Natrialba magadii ATCC 43099  Archaea  normal  0.342818  n/a   
 
 
-
 
NC_009954  Cmaq_0412  3-hydroxy-3-methylglutaryl coenzyme A reductase  49.12 
 
 		 410 aa  359  6e-98  Caldivirga maquilingensis IC-167  Archaea  normal  1  normal  1 
 
 
-
 
NC_009440  Msed_1649  3-hydroxy-3-methylglutaryl-coenzyme A reductase  48.27 
 
 		 410 aa  353  2.9999999999999997e-96  Metallosphaera sedula DSM 5348  Archaea  normal  0.982475  normal  1 
 
 
-
 
NC_012029  Hlac_2019  3-hydroxy-3-methylglutaryl Coenzyme A reductase  49.88 
 
 		 407 aa  330  3e-89  Halorubrum lacusprofundi ATCC 49239  Archaea  normal  1  normal  0.439309 
 
 
-
 
NC_006691  CNF04830  hydroxymethylglutaryl-CoA reductase (NADPH), putative  41.35 
 
 		 1283 aa  304  2.0000000000000002e-81  Cryptococcus neoformans var. neoformans JEC21  Eukaryota  normal  1  n/a   
 
 
-
 
NC_011697  PHATRDRAFT_16870  predicted protein  48.61 
 
 		 367 aa  301  1e-80  Phaeodactylum tricornutum CCAP 1055/1  Eukaryota  normal  1  n/a   
 
 
-
 
NC_009046  PICST_72872  3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA)  41.12 
 
 		 1047 aa  291  1e-77  Scheffersomyces stipitis CBS 6054  Eukaryota  normal  1  normal  1 
 
 
-
 
BN001302  ANIA_03817  hypothetical protein similar to HMG-CoA reductase (Eurofung)  41.49 
 
 		 1125 aa  291  2e-77  Aspergillus nidulans FGSC A4  Eukaryota  normal  1  normal  1 
 
 
-
 
NC_008228  Patl_0427  hydroxymethylglutaryl-CoA reductase (NADPH)  40.4 
 
 		 395 aa  290  5.0000000000000004e-77  Pseudoalteromonas atlantica T6c  Bacteria  normal  0.601953  n/a   
 
 
-
 
NC_009456  VC0395_0662  hydroxymethylglutaryl-coenzyme A reductase  42.72 
 
 		 420 aa  284  2.0000000000000002e-75  Vibrio cholerae O395  Bacteria  normal  1  n/a   
 
 
-
 
NC_013457  VEA_000087  hydroxymethylglutaryl-CoA reductase  44.56 
 
 		 420 aa  280  3e-74  Vibrio sp. Ex25  Bacteria  normal  1  n/a   
 
 
-
 
BN001307  ANIA_01593  conserved hypothetical protein  41.91 
 
 		 416 aa  273  6e-72  Aspergillus nidulans FGSC A4  Eukaryota  normal  1  normal  1 
 
 
-
 
NC_009784  VIBHAR_05704  3-hydroxy-3-methylglutaryl CoA reductase  47.14 
 
 		 420 aa  273  6e-72  Vibrio harveyi ATCC BAA-1116  Bacteria  n/a    n/a   
 
 
-
 
NC_011313  VSAL_II0253  putative 3-hydroxy-3-methylglutaryl coenzyme a reductase  40.34 
 
 		 419 aa  273  6e-72  Aliivibrio salmonicida LFI1238  Bacteria  normal  0.0262386  n/a   
 
 
-
 
NC_011138  MADE_03398  Hydroxymethylglutaryl-coenzyme A reductase  39.74 
 
 		 396 aa  268  2e-70  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  1  n/a   
 
 
-
 
NC_011138  MADE_03508  Hydroxymethylglutaryl-coenzyme A reductase  40.26 
 
 		 514 aa  242  9e-63  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  1  n/a   
 
 
-
 
NC_013517  Sterm_1947  hydroxymethylglutaryl-coenzyme A reductase  41.21 
 
 		 424 aa  223  7e-57  Sebaldella termitidis ATCC 33386  Bacteria  normal  1  n/a   
 
 
-
 
NC_007520  Tcr_1717  hydroxymethylglutaryl-CoA reductase (NADPH)  36.99 
 
 		 352 aa  221  1.9999999999999999e-56  Thiomicrospira crunogena XCL-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_009727  CBUD_0622  3-hydroxy-3-methylglutaryl-coenzyme A reductase  38.57 
 
 		 357 aa  218  1e-55  Coxiella burnetii Dugway 5J108-111  Bacteria  hitchhiker  0.000221084  n/a   
 
 
-
 
NC_010117  COXBURSA331_A0723  hydroxymethylglutaryl-CoA reductase (NADPH)  38.57 
 
 		 355 aa  218  1e-55  Coxiella burnetii RSA 331  Bacteria  hitchhiker  0.000000000015079  n/a   
 
 
-
 
NC_010117  COXBURSA331_A2174  hydroxymethylglutaryl-coenzyme A reductase  33.07 
 
 		 395 aa  204  2e-51  Coxiella burnetii RSA 331  Bacteria  normal  0.0352988  n/a   
 
 
-
 
NC_009727  CBUD_0151  3-hydroxy-3-methylglutaryl-coenzyme A reductase  30.49 
 
 		 364 aa  166  1.0000000000000001e-39  Coxiella burnetii Dugway 5J108-111  Bacteria  normal  1  n/a   
 
 
-
 
NC_013926  Aboo_1461  hydroxymethylglutaryl-CoA reductase, degradative  25.74 
 
 		 420 aa  64.7  0.000000003  Aciduliprofundum boonei T469  Archaea  normal  0.478544  n/a   
 
 
-
 
NC_013515  Smon_1290  hydroxymethylglutaryl-CoA reductase, degradative  25.62 
 
 		 406 aa  59.3  0.0000001  Streptobacillus moniliformis DSM 12112  Bacteria  n/a    n/a   
 
 
-
 
NC_011831  Cagg_1141  hydroxymethylglutaryl-CoA reductase, degradative  25.22 
 
 		 440 aa  58.5  0.0000002  Chloroflexus aggregans DSM 9485  Bacteria  normal  1  hitchhiker  0.00353445 
 
 
-
 
NC_002976  SERP2121  hydroxymethylglutaryl-CoA reductase, degradative  23.39 
 
 		 425 aa  53.9  0.000005  Staphylococcus epidermidis RP62A  Bacteria  normal  1  n/a   
 
 
-
 
NC_008531  LEUM_0335  hydroxymethylglutaryl-CoA reductase  24.55 
 
 		 401 aa  52.4  0.00001  Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293  Bacteria  normal  1  n/a   
 
 
-
 
NC_008527  LACR_1664  3-hydroxy-3-methylglutaryl-coenzyme A reductase  21.88 
 
 		 410 aa  52  0.00002  Lactococcus lactis subsp. cremoris SK11  Bacteria  hitchhiker  0.0024632  n/a   
 
 
-
 
NC_009767  Rcas_0981  hydroxymethylglutaryl-CoA reductase, degradative  23.62 
 
 		 444 aa  50.4  0.00005  Roseiflexus castenholzii DSM 13941  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009523  RoseRS_0431  hydroxymethylglutaryl-CoA reductase, degradative  22.86 
 
 		 456 aa  50.1  0.00007  Roseiflexus sp. RS-1  Bacteria  normal  1  normal  0.316381 
 
 
-
 
NC_009441  Fjoh_1418  hydroxymethylglutaryl-CoA reductase, degradative  24.57 
 
 		 437 aa  49.7  0.0001  Flavobacterium johnsoniae UW101  Bacteria  normal  0.984667  n/a   
 
 
-
 
NC_006369  lpl2030  hypothetical protein  22.61 
 
 		 432 aa  48.1  0.0003  Legionella pneumophila str. Lens  Bacteria  n/a    n/a   
 
 
-
 
NC_008530  LGAS_1373  hydroxymethylglutaryl-CoA reductase  23.04 
 
 		 429 aa  48.1  0.0003  Lactobacillus gasseri ATCC 33323  Bacteria  normal  1  hitchhiker  0.0000000000375721 
 
 
-
 
NC_006368  lpp2035  hypothetical protein  21.78 
 
 		 432 aa  48.1  0.0003  Legionella pneumophila str. Paris  Bacteria  n/a    n/a   
 
 
-
 
NC_008528  OEOE_1799  3-hydroxy-3-methylglutaryl-coenzyme A reductase  22.84 
 
 		 363 aa  47.8  0.0004  Oenococcus oeni PSU-1  Bacteria  normal  1  n/a   
 
 
-
 
NC_008553  Mthe_0936  hydroxymethylglutaryl-CoA reductase, degradative  23.96 
 
 		 419 aa  47.8  0.0004  Methanosaeta thermophila PT  Archaea  normal  1  n/a   
 
 
-
 
NC_008698  Tpen_0927  hydroxymethylglutaryl-CoA reductase, degradative  24.52 
 
 		 428 aa  47.4  0.0005  Thermofilum pendens Hrk 5  Archaea  normal  1  n/a   
 
 
-
 
NC_009632  SaurJH1_2621  hydroxymethylglutaryl-CoA reductase, degradative  23.38 
 
 		 425 aa  47  0.0006  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  1  n/a   
 
 
-
 
NC_009487  SaurJH9_2568  hydroxymethylglutaryl-CoA reductase, degradative  23.38 
 
 		 425 aa  47  0.0006  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  1  n/a   
 
 
-
 
NC_011728  BbuZS7_0705  hydroxymethylglutaryl-CoA reductase, degradative  27.88 
 
 		 422 aa  47  0.0007  Borrelia burgdorferi ZS7  Bacteria  normal  1  n/a   
 
 
-
 
NC_009513  Lreu_0206  3-hydroxy-3-methylglutaryl-coenzyme A reductase  22.49 
 
 		 420 aa  46.6  0.0009  Lactobacillus reuteri DSM 20016  Bacteria  normal  1  n/a   
 
 
-
 
NC_010002  Daci_0287  hydroxymethylglutaryl-CoA reductase, degradative  23.73 
 
 		 429 aa  46.2  0.001  Delftia acidovorans SPH-1  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009972  Haur_3539  hydroxymethylglutaryl-CoA reductase, degradative  23.47 
 
 		 441 aa  44.7  0.003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.0777406  n/a   
 
 
-
 
NC_008532  STER_0620  3-hydroxy-3-methylglutaryl-coenzyme A reductase  21.41 
 
 		 423 aa  44.7  0.003  Streptococcus thermophilus LMD-9  Bacteria  normal  1  n/a   
 
 
-
 
NC_014230  CA2559_04185  3-hydroxy-3-methylglutaryl-coenzyme A reductase  22.65 
 
 		 436 aa  43.5  0.007  Croceibacter atlanticus HTCC2559  Bacteria  normal  1  n/a   
 
 
-
 
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