More than 300 homologs were found in PanDaTox collection
for query gene Amir_2052 on replicon NC_013093
Organism: Actinosynnema mirum DSM 43827



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_013093  Amir_2052  binding-protein-dependent transport systems inner membrane component  100 
 
 
216 aa  410  1e-114  Actinosynnema mirum DSM 43827  Bacteria  normal  n/a   
 
 
-
 
NC_013159  Svir_00630  ABC-type proline/glycine betaine transport system, permease component  75.81 
 
 
215 aa  321  6e-87  Saccharomonospora viridis DSM 43017  Bacteria  normal  0.0471054  normal 
 
 
-
 
NC_013947  Snas_5181  binding-protein-dependent transport systems inner membrane component  55.61 
 
 
215 aa  240  1e-62  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  normal 
 
 
-
 
NC_009077  Mjls_2529  binding-protein-dependent transport systems inner membrane component  57.75 
 
 
217 aa  223  1e-57  Mycobacterium sp. JLS  Bacteria  normal  normal  0.194108 
 
 
-
 
NC_009338  Mflv_3108  binding-protein-dependent transport systems inner membrane component  58.22 
 
 
215 aa  222  4e-57  Mycobacterium gilvum PYR-GCK  Bacteria  normal  normal  0.915347 
 
 
-
 
NC_008146  Mmcs_2492  binding-protein-dependent transport systems inner membrane component  57.28 
 
 
217 aa  221  6e-57  Mycobacterium sp. MCS  Bacteria  normal  0.33067  n/a   
 
 
-
 
NC_008705  Mkms_2537  binding-protein-dependent transport systems inner membrane component  57.28 
 
 
217 aa  221  6e-57  Mycobacterium sp. KMS  Bacteria  normal  0.043837  normal  0.575038 
 
 
-
 
NC_009953  Sare_1623  binding-protein-dependent transport systems inner membrane component  54.33 
 
 
242 aa  213  1.9999999999999998e-54  Salinispora arenicola CNS-205  Bacteria  normal  normal  0.733782 
 
 
-
 
NC_009380  Strop_1636  binding-protein-dependent transport systems inner membrane component  53.85 
 
 
242 aa  209  2e-53  Salinispora tropica CNB-440  Bacteria  normal  normal  0.537762 
 
 
-
 
NC_013441  Gbro_1556  binding-protein-dependent transport systems inner membrane component  43.66 
 
 
214 aa  177  1e-43  Gordonia bronchialis DSM 43247  Bacteria  normal  n/a   
 
 
-
 
NC_012803  Mlut_15750  ABC-type proline/glycine betaine transport system, permease component  48.1 
 
 
213 aa  162  5.0000000000000005e-39  Micrococcus luteus NCTC 2665  Bacteria  normal  n/a   
 
 
-
 
NC_014158  Tpau_4152  binding-protein-dependent transport systems inner membrane component  48.83 
 
 
214 aa  139  1.9999999999999998e-32  Tsukamurella paurometabola DSM 20162  Bacteria  normal  n/a   
 
 
-
 
NC_010320  Teth514_1202  binding-protein-dependent transport systems inner membrane component  36.45 
 
 
212 aa  139  1.9999999999999998e-32  Thermoanaerobacter sp. X514  Bacteria  normal  n/a   
 
 
-
 
NC_002976  SERP2357  amino acid ABC transporter, permease protein  35.24 
 
 
211 aa  134  9.999999999999999e-31  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_013730  Slin_0317  binding-protein-dependent transport systems inner membrane component  40.1 
 
 
519 aa  134  9.999999999999999e-31  Spirosoma linguale DSM 74  Bacteria  normal  normal  0.417886 
 
 
-
 
NC_009621  Smed_5106  binding-protein-dependent transport systems inner membrane component  38.46 
 
 
220 aa  132  3e-30  Sinorhizobium medicae WSM419  Bacteria  normal  0.485727  normal  0.10095 
 
 
-
 
NC_013037  Dfer_1250  binding-protein-dependent transport systems inner membrane component  42.62 
 
 
525 aa  132  3.9999999999999996e-30  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.615651  normal  0.522042 
 
 
-
 
NC_013745  Htur_4757  binding-protein-dependent transport systems inner membrane component  38.5 
 
 
228 aa  131  6e-30  Haloterrigena turkmenica DSM 5511  Archaea  normal  n/a   
 
 
-
 
NC_013132  Cpin_4963  binding-protein-dependent transport systems inner membrane component  41.84 
 
 
522 aa  128  6e-29  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.0875398  normal  0.252786 
 
 
-
 
NC_011898  Ccel_3333  Substrate-binding region of ABC-type glycine betaine transport system  34.95 
 
 
524 aa  125  4.0000000000000003e-28  Clostridium cellulolyticum H10  Bacteria  hitchhiker  0.0000937167  n/a   
 
 
-
 
NC_013517  Sterm_1515  Substrate-binding region of ABC-type glycine betaine transport system  35.86 
 
 
526 aa  125  4.0000000000000003e-28  Sebaldella termitidis ATCC 33386  Bacteria  normal  0.0692577  n/a   
 
 
-
 
NC_009632  SaurJH1_0763  substrate-binding region of ABC-type glycine betaine transport system  41.29 
 
 
504 aa  120  9.999999999999999e-27  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  0.458546  n/a   
 
 
-
 
NC_009487  SaurJH9_0746  substrate-binding region of ABC-type glycine betaine transport system  41.29 
 
 
504 aa  120  9.999999999999999e-27  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  n/a   
 
 
-
 
NC_009632  SaurJH1_2522  binding-protein-dependent transport systems inner membrane component  30.48 
 
 
211 aa  120  1.9999999999999998e-26  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  0.241712  n/a   
 
 
-
 
NC_009487  SaurJH9_2474  binding-protein-dependent transport systems inner membrane component  30.48 
 
 
211 aa  120  1.9999999999999998e-26  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  0.13842  n/a   
 
 
-
 
NC_010001  Cphy_0119  substrate-binding region of ABC-type glycine betaine transport system  34.57 
 
 
523 aa  120  1.9999999999999998e-26  Clostridium phytofermentans ISDg  Bacteria  hitchhiker  0.000124345  n/a   
 
 
-
 
NC_007963  Csal_2353  binding-protein-dependent transport systems inner membrane component  38.79 
 
 
220 aa  119  3e-26  Chromohalobacter salexigens DSM 3043  Bacteria  normal  n/a   
 
 
-
 
NC_002976  SERP2030  amino acid ABC transporter, permease protein  30.14 
 
 
211 aa  119  3.9999999999999996e-26  Staphylococcus epidermidis RP62A  Bacteria  normal  0.207242  n/a   
 
 
-
 
NC_013223  Dret_0770  binding-protein-dependent transport systems inner membrane component  37.56 
 
 
222 aa  118  6e-26  Desulfohalobium retbaense DSM 5692  Bacteria  normal  normal 
 
 
-
 
NC_010512  Bcenmc03_6583  binding-protein-dependent transport systems inner membrane component  36.94 
 
 
217 aa  118  7.999999999999999e-26  Burkholderia cenocepacia MC0-3  Bacteria  normal  0.0902932  normal  0.0101515 
 
 
-
 
NC_013204  Elen_0084  Substrate-binding region of ABC-type glycine betaine transport system  40 
 
 
528 aa  117  1.9999999999999998e-25  Eggerthella lenta DSM 2243  Bacteria  normal  0.689632  normal 
 
 
-
 
NC_004116  SAG0243  amino acid ABC transporter, permease protein  37.91 
 
 
211 aa  116  3e-25  Streptococcus agalactiae 2603V/R  Bacteria  normal  n/a   
 
 
-
 
NC_012793  GWCH70_0296  binding-protein-dependent transport systems inner membrane component  35.05 
 
 
211 aa  116  3e-25  Geobacillus sp. WCH70  Bacteria  normal  0.4946  n/a   
 
 
-
 
NC_007347  Reut_A2494  binding-protein dependent transport system inner membrane protein  37.44 
 
 
216 aa  115  3.9999999999999997e-25  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_007492  Pfl01_0804  binding-protein dependent transport system inner membrane protein  37.9 
 
 
217 aa  115  6e-25  Pseudomonas fluorescens Pf0-1  Bacteria  normal  0.141523  normal  0.643445 
 
 
-
 
NC_007509  Bcep18194_C7552  ABC glycinebetaine/carnitine/choline transporter, inner membrane subunit  36.04 
 
 
217 aa  115  6e-25  Burkholderia sp. 383  Bacteria  normal  normal  0.542589 
 
 
-
 
NC_008062  Bcen_5737  binding-protein-dependent transport systems inner membrane component  36.04 
 
 
217 aa  114  7.999999999999999e-25  Burkholderia cenocepacia AU 1054  Bacteria  normal  n/a   
 
 
-
 
NC_008544  Bcen2424_6101  binding-protein-dependent transport systems inner membrane component  36.04 
 
 
217 aa  114  7.999999999999999e-25  Burkholderia cenocepacia HI2424  Bacteria  normal  normal 
 
 
-
 
NC_007973  Rmet_0801  binding-protein-dependent transport systems inner membrane component  36.99 
 
 
216 aa  114  8.999999999999998e-25  Cupriavidus metallidurans CH34  Bacteria  normal  normal  0.435209 
 
 
-
 
NC_010117  COXBURSA331_A0267  quaternary amine ABC transporter periplasmic substrate-binding protein  38.19 
 
 
526 aa  114  1.0000000000000001e-24  Coxiella burnetii RSA 331  Bacteria  normal  n/a   
 
 
-
 
NC_013457  VEA_001529  probable inner-membrane permease  40.21 
 
 
199 aa  114  1.0000000000000001e-24  Vibrio sp. Ex25  Bacteria  normal  0.90895  n/a   
 
 
-
 
NC_011830  Dhaf_2803  binding-protein-dependent transport systems inner membrane component  40.24 
 
 
218 aa  114  2.0000000000000002e-24  Desulfitobacterium hafniense DCB-2  Bacteria  hitchhiker  0.000000135531  n/a   
 
 
-
 
NC_009727  CBUD_1923  glycine betaine transport system permease protein  38.19 
 
 
526 aa  112  5e-24  Coxiella burnetii Dugway 5J108-111  Bacteria  normal  n/a   
 
 
-
 
NC_002976  SERP0386  ABC transporter, permease protein  40.13 
 
 
504 aa  111  7.000000000000001e-24  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_004578  PSPTO_4576  glycine betaine/choline OpuC ABC transporter, permease protein  36.07 
 
 
217 aa  111  8.000000000000001e-24  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  0.28564  n/a   
 
 
-
 
NC_007005  Psyr_4250  binding-protein dependent transport system inner membrane protein  36.07 
 
 
217 aa  111  8.000000000000001e-24  Pseudomonas syringae pv. syringae B728a  Bacteria  normal  normal 
 
 
-
 
NC_013517  Sterm_3032  Substrate-binding region of ABC-type glycine betaine transport system  33.33 
 
 
531 aa  111  1.0000000000000001e-23  Sebaldella termitidis ATCC 33386  Bacteria  normal  0.367999  n/a   
 
 
-
 
NC_010003  Pmob_1127  binding-protein-dependent transport systems inner membrane component  33.48 
 
 
216 aa  110  2.0000000000000002e-23  Petrotoga mobilis SJ95  Bacteria  normal  0.721959  n/a   
 
 
-
 
NC_008688  Pden_4885  binding-protein-dependent transport systems inner membrane component  39.9 
 
 
216 aa  110  2.0000000000000002e-23  Paracoccus denitrificans PD1222  Bacteria  normal  normal  0.694048 
 
 
-
 
NC_010322  PputGB1_0913  binding-protein-dependent transport systems inner membrane component  41.11 
 
 
217 aa  110  2.0000000000000002e-23  Pseudomonas putida GB-1  Bacteria  normal  0.0471991  normal  0.178829 
 
 
-
 
NC_008786  Veis_2914  binding-protein-dependent transport systems inner membrane component  37.43 
 
 
220 aa  109  4.0000000000000004e-23  Verminephrobacter eiseniae EF01-2  Bacteria  normal  normal  0.208767 
 
 
-
 
NC_010003  Pmob_1125  binding-protein-dependent transport systems inner membrane component  35.2 
 
 
218 aa  108  9.000000000000001e-23  Petrotoga mobilis SJ95  Bacteria  normal  n/a   
 
 
-
 
NC_008061  Bcen_3223  binding-protein-dependent transport systems inner membrane component  41.95 
 
 
255 aa  108  9.000000000000001e-23  Burkholderia cenocepacia AU 1054  Bacteria  normal  0.362528  n/a   
 
 
-
 
NC_010515  Bcenmc03_5138  binding-protein-dependent transport systems inner membrane component  41.95 
 
 
255 aa  108  9.000000000000001e-23  Burkholderia cenocepacia MC0-3  Bacteria  normal  0.316717  normal 
 
 
-
 
NC_008543  Bcen2424_5144  binding-protein-dependent transport systems inner membrane component  41.95 
 
 
255 aa  108  9.000000000000001e-23  Burkholderia cenocepacia HI2424  Bacteria  normal  0.0793163  normal 
 
 
-
 
NC_007511  Bcep18194_B0496  ABC proline/glycine betaine transporter, inner membrane subunit  42.53 
 
 
255 aa  107  1e-22  Burkholderia sp. 383  Bacteria  normal  0.792199  normal 
 
 
-
 
NC_013411  GYMC61_1174  binding-protein-dependent transport systems inner membrane component  35.38 
 
 
209 aa  107  2e-22  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_009512  Pput_0899  binding-protein-dependent transport systems inner membrane component  40.56 
 
 
217 aa  106  2e-22  Pseudomonas putida F1  Bacteria  normal  normal  0.334865 
 
 
-
 
NC_008391  Bamb_4538  binding-protein-dependent transport systems inner membrane component  40 
 
 
255 aa  107  2e-22  Burkholderia ambifaria AMMD  Bacteria  normal  0.52595  normal 
 
 
-
 
NC_002947  PP_0869  binding-protein-dependent transport systems inner membrane component  40.56 
 
 
217 aa  106  3e-22  Pseudomonas putida KT2440  Bacteria  normal  0.476701  normal 
 
 
-
 
NC_010552  BamMC406_5062  binding-protein-dependent transport systems inner membrane component  41.9 
 
 
255 aa  106  3e-22  Burkholderia ambifaria MC40-6  Bacteria  normal  0.646466  normal 
 
 
-
 
NC_010086  Bmul_3510  binding-protein-dependent transport systems inner membrane component  43.1 
 
 
263 aa  105  4e-22  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal 
 
 
-
 
NC_010501  PputW619_4309  binding-protein-dependent transport systems inner membrane component  40.56 
 
 
217 aa  105  4e-22  Pseudomonas putida W619  Bacteria  normal  0.473063  normal  0.447957 
 
 
-
 
NC_009436  Ent638_1922  binding-protein-dependent transport systems inner membrane component  35.16 
 
 
215 aa  105  5e-22  Enterobacter sp. 638  Bacteria  normal  normal 
 
 
-
 
NC_009972  Haur_0352  binding-protein-dependent transport systems inner membrane component  36.56 
 
 
212 aa  104  9e-22  Herpetosiphon aurantiacus ATCC 23779  Bacteria  hitchhiker  0.00133912  n/a   
 
 
-
 
NC_010718  Nther_0118  binding-protein-dependent transport systems inner membrane component  36.78 
 
 
216 aa  104  9e-22  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  normal 
 
 
-
 
NC_011145  AnaeK_3299  Substrate-binding region of ABC-type glycine betaine transport system  37.8 
 
 
490 aa  104  1e-21  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_011891  A2cp1_3373  Substrate-binding region of ABC-type glycine betaine transport system  37.75 
 
 
489 aa  103  2e-21  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_013739  Cwoe_3264  binding-protein-dependent transport systems inner membrane component  34.31 
 
 
243 aa  103  2e-21  Conexibacter woesei DSM 14684  Bacteria  normal  normal  0.0145709 
 
 
-
 
NC_007952  Bxe_B2993  ABC glycine betaine/L-proline transporter, inner membrane subunit  34.7 
 
 
217 aa  102  4e-21  Burkholderia xenovorans LB400  Bacteria  normal  normal 
 
 
-
 
NC_013745  Htur_4755  binding-protein-dependent transport systems inner membrane component  32.08 
 
 
224 aa  102  5e-21  Haloterrigena turkmenica DSM 5511  Archaea  normal  n/a   
 
 
-
 
NC_008347  Mmar10_1070  substrate-binding region of ABC-type glycine betaine transport system  40.48 
 
 
525 aa  102  6e-21  Maricaulis maris MCS10  Bacteria  normal  0.019749  normal 
 
 
-
 
NC_007484  Noc_0540  ABC transporter inner membrane/substrate-binding proteins  36.1 
 
 
501 aa  100  2e-20  Nitrosococcus oceani ATCC 19707  Bacteria  normal  n/a   
 
 
-
 
NC_007963  Csal_2946  binding-protein-dependent transport systems inner membrane component  39.39 
 
 
255 aa  99.8  3e-20  Chromohalobacter salexigens DSM 3043  Bacteria  normal  0.0159646  n/a   
 
 
-
 
NC_003295  RSc2516  putative lipoprotein transmembrane  42.31 
 
 
520 aa  99  5e-20  Ralstonia solanacearum GMI1000  Bacteria  normal  0.2714  hitchhiker  0.00948908 
 
 
-
 
NC_010465  YPK_2862  binding-protein-dependent transport systems inner membrane component  40.8 
 
 
278 aa  98.6  7e-20  Yersinia pseudotuberculosis YPIII  Bacteria  normal  0.01956  n/a   
 
 
-
 
NC_009708  YpsIP31758_2783  quaternary amine ABC transporter permease  40.8 
 
 
278 aa  98.6  7e-20  Yersinia pseudotuberculosis IP 31758  Bacteria  normal  n/a   
 
 
-
 
NC_008463  PA14_13590  ABC transporter permease  34.55 
 
 
220 aa  98.6  7e-20  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  normal 
 
 
-
 
NC_009656  PSPA7_1216  ABC transporter permease  34.09 
 
 
220 aa  98.2  9e-20  Pseudomonas aeruginosa PA7  Bacteria  normal  n/a   
 
 
-
 
NC_009708  YpsIP31758_2785  quaternary amine ABC transporter permease  34 
 
 
384 aa  97.8  1e-19  Yersinia pseudotuberculosis IP 31758  Bacteria  normal  n/a   
 
 
-
 
NC_010465  YPK_2864  binding-protein-dependent transport systems inner membrane component  34 
 
 
384 aa  97.8  1e-19  Yersinia pseudotuberculosis YPIII  Bacteria  normal  n/a   
 
 
-
 
NC_011369  Rleg2_0144  binding-protein-dependent transport systems inner membrane component  39.39 
 
 
388 aa  97.4  1e-19  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.0628663 
 
 
-
 
NC_011729  PCC7424_1223  Substrate-binding region of ABC-type glycine betaine transport system  43.17 
 
 
512 aa  97.4  1e-19  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_010159  YpAngola_A1330  quaternary amine ABC transporter permease  34 
 
 
384 aa  97.8  1e-19  Yersinia pestis Angola  Bacteria  normal  normal 
 
 
-
 
NC_012850  Rleg_0150  binding-protein-dependent transport systems inner membrane component  39.39 
 
 
388 aa  97.8  1e-19  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  normal 
 
 
-
 
NC_010682  Rpic_2784  Substrate-binding region of ABC-type glycine betaine transport system  40.22 
 
 
504 aa  97.8  1e-19  Ralstonia pickettii 12J  Bacteria  normal  normal 
 
 
-
 
NC_008254  Meso_2980  binding-protein-dependent transport systems inner membrane component  42.55 
 
 
211 aa  97.4  1e-19  Chelativorans sp. BNC1  Bacteria  normal  n/a   
 
 
-
 
NC_007347  Reut_A1451  binding-protein dependent transport system inner membrane protein  45.1 
 
 
493 aa  97.1  2e-19  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_007643  Rru_A2382  binding-protein dependent transport system inner membrane protein  40.83 
 
 
260 aa  97.1  2e-19  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  0.813569  n/a   
 
 
-
 
NC_011353  ECH74115_3253  ABC transporter, quaternary amine uptake (QAT) family, permease protein  38.5 
 
 
243 aa  96.3  3e-19  Escherichia coli O157:H7 str. EC4115  Bacteria  normal  hitchhiker  0.000564908 
 
 
-
 
NC_009505  BOV_0213  ABC transporter, permease protein  36.49 
 
 
248 aa  96.3  3e-19  Brucella ovis ATCC 25840  Bacteria  normal  n/a   
 
 
-
 
NC_012892  B21_02016  hypothetical protein  38.5 
 
 
243 aa  96.3  3e-19  Escherichia coli BL21  Bacteria  normal  n/a   
 
 
-
 
NC_004310  BR0222  ABC transporter, permease protein  36.49 
 
 
248 aa  96.3  3e-19  Brucella suis 1330  Bacteria  normal  n/a   
 
 
-
 
NC_010658  SbBS512_E0845  ABC transporter, quaternary amine uptake (QAT) family, permease protein  38.5 
 
 
243 aa  96.3  3e-19  Shigella boydii CDC 3083-94  Bacteria  normal  n/a   
 
 
-
 
NC_010468  EcolC_1519  binding-protein-dependent transport systems inner membrane component  38.5 
 
 
243 aa  96.3  3e-19  Escherichia coli ATCC 8739  Bacteria  normal  normal 
 
 
-
 
NC_009801  EcE24377A_2416  quaternary amine ABC transporter permease  38.5 
 
 
243 aa  96.3  3e-19  Escherichia coli E24377A  Bacteria  normal  n/a   
 
 
-
 
NC_011353  ECH74115_3255  ABC transporter, quaternary amine uptake (QAT) family, permease protein  37 
 
 
385 aa  96.3  3e-19  Escherichia coli O157:H7 str. EC4115  Bacteria  normal  hitchhiker  0.000687244 
 
 
-
 
NC_008261  CPF_0538  glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein  34.12 
 
 
517 aa  96.7  3e-19  Clostridium perfringens ATCC 13124  Bacteria  normal  0.863672  n/a   
 
 
-
 
NC_008262  CPR_0522  glycine betaine/carnitine/choline ABC transporter, permease/substrate-binding protein  34.12 
 
 
517 aa  96.7  3e-19  Clostridium perfringens SM101  Bacteria  normal  0.271995  n/a   
 
 
-
 
NC_008531  LEUM_1017  ABC-type proline/glycine betaine transport systems, permease and substrate binding protein  42.01 
 
 
508 aa  96.7  3e-19  Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293  Bacteria  unclonable  0.00355742  n/a   
 
 
-
 
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