More than 300 homologs were found in PanDaTox collection
for query gene Tpau_1000 on replicon NC_014158
Organism: Tsukamurella paurometabola DSM 20162



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_014158  Tpau_1000  binding-protein-dependent transport systems inner membrane component  100 
 
 
306 aa  601  1.0000000000000001e-171  Tsukamurella paurometabola DSM 20162  Bacteria  normal  0.0937011  n/a   
 
 
-
 
NC_014211  Ndas_4907  binding-protein-dependent transport systems inner membrane component  60.77 
 
 
323 aa  378  1e-104  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  0.939574  normal 
 
 
-
 
NC_009664  Krad_3468  binding-protein-dependent transport systems inner membrane component  53.62 
 
 
321 aa  343  2e-93  Kineococcus radiotolerans SRS30216  Bacteria  normal  normal 
 
 
-
 
NC_013131  Caci_7921  binding-protein-dependent transport systems inner membrane component  48.36 
 
 
334 aa  286  2.9999999999999996e-76  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.376076  normal 
 
 
-
 
NC_013093  Amir_0615  binding-protein-dependent transport systems inner membrane component  53.33 
 
 
302 aa  284  1.0000000000000001e-75  Actinosynnema mirum DSM 43827  Bacteria  normal  n/a   
 
 
-
 
NC_011886  Achl_3170  binding-protein-dependent transport systems inner membrane component  52.58 
 
 
323 aa  273  2.0000000000000002e-72  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal  0.380301 
 
 
-
 
NC_008541  Arth_3380  binding-protein-dependent transport systems inner membrane component  50.32 
 
 
323 aa  270  2.9999999999999997e-71  Arthrobacter sp. FB24  Bacteria  normal  n/a   
 
 
-
 
NC_012669  Bcav_0941  binding-protein-dependent transport systems inner membrane component  38.51 
 
 
313 aa  177  2e-43  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal  0.737632 
 
 
-
 
NC_008709  Ping_2010  ABC transporter substrate binding inner membrane protein  33.23 
 
 
318 aa  169  4e-41  Psychromonas ingrahamii 37  Bacteria  normal  0.360583  normal 
 
 
-
 
NC_011899  Hore_20510  binding-protein-dependent transport systems inner membrane component  35.89 
 
 
290 aa  167  2e-40  Halothermothrix orenii H 168  Bacteria  normal  0.0790749  n/a   
 
 
-
 
NC_008543  Bcen2424_5659  binding-protein-dependent transport systems inner membrane component  35.03 
 
 
313 aa  164  1.0000000000000001e-39  Burkholderia cenocepacia HI2424  Bacteria  normal  0.308138  normal  0.32687 
 
 
-
 
NC_008061  Bcen_5200  binding-protein-dependent transport systems inner membrane component  35.03 
 
 
313 aa  164  2.0000000000000002e-39  Burkholderia cenocepacia AU 1054  Bacteria  normal  n/a   
 
 
-
 
NC_010515  Bcenmc03_4576  binding-protein-dependent transport systems inner membrane component  35.03 
 
 
314 aa  163  3e-39  Burkholderia cenocepacia MC0-3  Bacteria  normal  hitchhiker  0.00748515 
 
 
-
 
NC_008391  Bamb_4933  binding-protein-dependent transport systems inner membrane component  35.54 
 
 
314 aa  160  2e-38  Burkholderia ambifaria AMMD  Bacteria  normal  normal  0.103484 
 
 
-
 
NC_010552  BamMC406_5488  binding-protein-dependent transport systems inner membrane component  35.19 
 
 
319 aa  158  9e-38  Burkholderia ambifaria MC40-6  Bacteria  normal  0.80176  hitchhiker  0.000205378 
 
 
-
 
NC_009718  Fnod_0627  binding-protein-dependent transport systems inner membrane component  32.75 
 
 
294 aa  156  3e-37  Fervidobacterium nodosum Rt17-B1  Bacteria  hitchhiker  0.0000000558297  n/a   
 
 
-
 
NC_014212  Mesil_2392  binding-protein-dependent transport systems inner membrane component  31.03 
 
 
318 aa  153  2.9999999999999998e-36  Meiothermus silvanus DSM 9946  Bacteria  normal  0.488692  normal 
 
 
-
 
NC_010622  Bphy_2350  binding-protein-dependent transport systems inner membrane component  32.2 
 
 
317 aa  152  5.9999999999999996e-36  Burkholderia phymatum STM815  Bacteria  normal  normal  0.143445 
 
 
-
 
NC_010086  Bmul_3195  binding-protein-dependent transport systems inner membrane component  35.64 
 
 
312 aa  150  3e-35  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal  0.142654 
 
 
-
 
NC_010676  Bphyt_4587  binding-protein-dependent transport systems inner membrane component  32.88 
 
 
325 aa  149  4e-35  Burkholderia phytofirmans PsJN  Bacteria  normal  0.351015  normal 
 
 
-
 
NC_010557  BamMC406_6025  binding-protein-dependent transport systems inner membrane component  34.85 
 
 
305 aa  146  3e-34  Burkholderia ambifaria MC40-6  Bacteria  normal  0.584937  normal 
 
 
-
 
NC_008392  Bamb_6325  binding-protein-dependent transport systems inner membrane component  35.79 
 
 
305 aa  146  6e-34  Burkholderia ambifaria AMMD  Bacteria  normal  normal 
 
 
-
 
NC_008043  TM1040_3484  binding-protein-dependent transport systems inner membrane component  32.13 
 
 
275 aa  145  9e-34  Ruegeria sp. TM1040  Bacteria  normal  normal 
 
 
-
 
NC_011988  Avi_5738  ABC transporter membrane spanning protein (sugar)  32.66 
 
 
302 aa  144  1e-33  Agrobacterium vitis S4  Bacteria  normal  0.0678785  n/a   
 
 
-
 
NC_008061  Bcen_4879  binding-protein-dependent transport systems inner membrane component  35.49 
 
 
305 aa  144  2e-33  Burkholderia cenocepacia AU 1054  Bacteria  normal  0.825826  n/a   
 
 
-
 
NC_008543  Bcen2424_3286  binding-protein-dependent transport systems inner membrane component  35.49 
 
 
305 aa  144  2e-33  Burkholderia cenocepacia HI2424  Bacteria  normal  normal 
 
 
-
 
NC_013595  Sros_8235  ABC transporter, permease protein  30.9 
 
 
306 aa  144  2e-33  Streptosporangium roseum DSM 43021  Bacteria  normal  normal 
 
 
-
 
NC_009952  Dshi_1247  binding-protein-dependent transport systems inner membrane component  32.59 
 
 
308 aa  142  6e-33  Dinoroseobacter shibae DFL 12  Bacteria  normal  normal  0.732084 
 
 
-
 
NC_009654  Mmwyl1_2009  binding-protein-dependent transport systems inner membrane component  32.22 
 
 
291 aa  141  9.999999999999999e-33  Marinomonas sp. MWYL1  Bacteria  normal  normal 
 
 
-
 
NC_013526  Tter_2000  binding-protein-dependent transport systems inner membrane component  31.33 
 
 
319 aa  140  3e-32  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_009664  Krad_0295  binding-protein-dependent transport systems inner membrane component  32.65 
 
 
306 aa  139  4.999999999999999e-32  Kineococcus radiotolerans SRS30216  Bacteria  normal  normal  0.0472746 
 
 
-
 
NC_007802  Jann_3837  binding-protein-dependent transport systems inner membrane component  35.63 
 
 
350 aa  139  6e-32  Jannaschia sp. CCS1  Bacteria  normal  0.344745  normal 
 
 
-
 
NC_014165  Tbis_2414  binding-protein-dependent transporter inner membrane component  31.23 
 
 
294 aa  137  2e-31  Thermobispora bispora DSM 43833  Bacteria  normal  normal 
 
 
-
 
NC_009636  Smed_3328  binding-protein-dependent transport systems inner membrane component  31.08 
 
 
318 aa  136  3.0000000000000003e-31  Sinorhizobium medicae WSM419  Bacteria  normal  0.670475  normal  0.953703 
 
 
-
 
NC_003909  BCE_1900  sugar ABC transporter, permease protein, putative  33.19 
 
 
314 aa  136  4e-31  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
NC_006274  BCZK1635  sugar ABC transporter, permease  33.19 
 
 
314 aa  136  4e-31  Bacillus cereus E33L  Bacteria  normal  n/a   
 
 
-
 
NC_013131  Caci_6970  binding-protein-dependent transport systems inner membrane component  30.17 
 
 
305 aa  136  4e-31  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.0388505  normal 
 
 
-
 
NC_012669  Bcav_0146  binding-protein-dependent transport systems inner membrane component  32.25 
 
 
292 aa  135  6.0000000000000005e-31  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.0896196  normal 
 
 
-
 
NC_012848  Rleg_4750  binding-protein-dependent transport systems inner membrane component  28.48 
 
 
299 aa  135  8e-31  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.62916  normal  0.701692 
 
 
-
 
NC_013131  Caci_3588  binding-protein-dependent transport systems inner membrane component  32.74 
 
 
338 aa  134  1.9999999999999998e-30  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.786552  normal 
 
 
-
 
NC_011899  Hore_09500  binding-protein-dependent transport systems inner membrane component  33.09 
 
 
296 aa  134  1.9999999999999998e-30  Halothermothrix orenii H 168  Bacteria  decreased coverage  0.00000000000000144721  n/a   
 
 
-
 
NC_007435  BURPS1710b_A1183  ABC transporter, permease protein  31.27 
 
 
307 aa  133  3e-30  Burkholderia pseudomallei 1710b  Bacteria  normal  0.101432  n/a   
 
 
-
 
NC_009078  BURPS1106A_A2817  putative carbohydrate ABC transporter, permease protein  31.27 
 
 
307 aa  133  3e-30  Burkholderia pseudomallei 1106a  Bacteria  normal  n/a   
 
 
-
 
NC_012850  Rleg_2651  binding-protein-dependent transport systems inner membrane component  31.77 
 
 
294 aa  133  3e-30  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.493427  normal 
 
 
-
 
NC_012034  Athe_0615  binding-protein-dependent transport systems inner membrane component  28.77 
 
 
296 aa  133  3.9999999999999996e-30  Anaerocellum thermophilum DSM 6725  Bacteria  normal  n/a   
 
 
-
 
NC_011368  Rleg2_4663  binding-protein-dependent transport systems inner membrane component  28.38 
 
 
299 aa  132  5e-30  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.456499 
 
 
-
 
NC_008541  Arth_1946  binding-protein-dependent transport systems inner membrane component  28.01 
 
 
320 aa  132  6.999999999999999e-30  Arthrobacter sp. FB24  Bacteria  normal  0.305055  n/a   
 
 
-
 
NC_010816  BLD_1875  MalF-type ABC sugar transport systems permease component  34.31 
 
 
350 aa  132  6.999999999999999e-30  Bifidobacterium longum DJO10A  Bacteria  normal  0.0432685  n/a   
 
 
-
 
NC_011369  Rleg2_2326  binding-protein-dependent transport systems inner membrane component  32.89 
 
 
294 aa  132  7.999999999999999e-30  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  0.180469  normal 
 
 
-
 
NC_012850  Rleg_4345  binding-protein-dependent transport systems inner membrane component  29.68 
 
 
319 aa  130  2.0000000000000002e-29  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  hitchhiker  0.0000915897 
 
 
-
 
NC_011369  Rleg2_4016  binding-protein-dependent transport systems inner membrane component  29.68 
 
 
319 aa  130  3e-29  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal 
 
 
-
 
NC_013172  Bfae_28370  carbohydrate ABC transporter membrane protein  32.22 
 
 
287 aa  129  4.0000000000000003e-29  Brachybacterium faecium DSM 4810  Bacteria  normal  0.096742  n/a   
 
 
-
 
NC_013093  Amir_2984  binding-protein-dependent transport systems inner membrane component  31.25 
 
 
305 aa  129  5.0000000000000004e-29  Actinosynnema mirum DSM 43827  Bacteria  normal  n/a   
 
 
-
 
NC_002977  MCA1942  sugar ABC transporter, permease protein  32.49 
 
 
287 aa  129  7.000000000000001e-29  Methylococcus capsulatus str. Bath  Bacteria  normal  n/a   
 
 
-
 
NC_013595  Sros_4987  binding-protein-dependent transport systems inner membrane component  34.8 
 
 
292 aa  128  1.0000000000000001e-28  Streptosporangium roseum DSM 43021  Bacteria  normal  0.753078  normal 
 
 
-
 
NC_011369  Rleg2_1219  binding-protein-dependent transport systems inner membrane component  36.44 
 
 
297 aa  127  2.0000000000000002e-28  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal 
 
 
-
 
NC_008262  CPR_0477  ABC tranporter, permease protein  31.06 
 
 
315 aa  127  3e-28  Clostridium perfringens SM101  Bacteria  normal  n/a   
 
 
-
 
NC_012850  Rleg_1307  binding-protein-dependent transport systems inner membrane component  36.44 
 
 
297 aa  127  3e-28  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  normal 
 
 
-
 
NC_011898  Ccel_0201  binding-protein-dependent transport systems inner membrane component  29.5 
 
 
294 aa  126  4.0000000000000003e-28  Clostridium cellulolyticum H10  Bacteria  normal  n/a   
 
 
-
 
NC_014151  Cfla_1127  binding-protein-dependent transport systems inner membrane component  27.65 
 
 
328 aa  125  9e-28  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.190953  hitchhiker  0.00155627 
 
 
-
 
NC_011886  Achl_3567  binding-protein-dependent transport systems inner membrane component  32.4 
 
 
309 aa  124  2e-27  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal 
 
 
-
 
NC_008781  Pnap_0229  binding-protein-dependent transport systems inner membrane component  30.86 
 
 
312 aa  124  2e-27  Polaromonas naphthalenivorans CJ2  Bacteria  normal  0.772545  normal  0.492978 
 
 
-
 
NC_010001  Cphy_3408  binding-protein-dependent transport systems inner membrane component  30.45 
 
 
293 aa  124  2e-27  Clostridium phytofermentans ISDg  Bacteria  hitchhiker  0.00259426  n/a   
 
 
-
 
NC_013131  Caci_2784  binding-protein-dependent transport systems inner membrane component  29.77 
 
 
306 aa  123  3e-27  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.390449  normal 
 
 
-
 
NC_009565  TBFG_12077  sugar ABC transporter membrane protein  30.62 
 
 
300 aa  124  3e-27  Mycobacterium tuberculosis F11  Bacteria  normal  normal 
 
 
-
 
NC_009654  Mmwyl1_0024  binding-protein-dependent transport systems inner membrane component  25.74 
 
 
320 aa  122  6e-27  Marinomonas sp. MWYL1  Bacteria  normal  0.227719  normal  0.433481 
 
 
-
 
NC_008541  Arth_2946  binding-protein-dependent transport systems inner membrane component  31.27 
 
 
316 aa  122  7e-27  Arthrobacter sp. FB24  Bacteria  normal  n/a   
 
 
-
 
NC_011992  Dtpsy_2658  binding-protein-dependent transport systems inner membrane component  36.51 
 
 
300 aa  122  7e-27  Acidovorax ebreus TPSY  Bacteria  decreased coverage  0.00312349  n/a   
 
 
-
 
NC_010483  TRQ2_0115  binding-protein-dependent transport systems inner membrane component  28.82 
 
 
300 aa  122  8e-27  Thermotoga sp. RQ2  Bacteria  normal  n/a   
 
 
-
 
NC_008751  Dvul_0223  binding-protein-dependent transport systems inner membrane component  32.17 
 
 
293 aa  122  8e-27  Desulfovibrio vulgaris DP4  Bacteria  normal  normal 
 
 
-
 
NC_009486  Tpet_0117  binding-protein-dependent transport systems inner membrane component  28.82 
 
 
300 aa  122  8e-27  Thermotoga petrophila RKU-1  Bacteria  normal  n/a   
 
 
-
 
NC_013526  Tter_2292  binding-protein-dependent transport systems inner membrane component  34.43 
 
 
306 aa  122  9e-27  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_011661  Dtur_0549  binding-protein-dependent transport systems inner membrane component  26.42 
 
 
297 aa  122  9e-27  Dictyoglomus turgidum DSM 6724  Bacteria  decreased coverage  0.0000488765  n/a   
 
 
-
 
NC_010001  Cphy_1390  binding-protein-dependent transport systems inner membrane component  27.4 
 
 
308 aa  122  9.999999999999999e-27  Clostridium phytofermentans ISDg  Bacteria  normal  n/a   
 
 
-
 
NC_009939  Dgeo_2918  ABC-type sugar transport system, permease component  28.94 
 
 
305 aa  121  9.999999999999999e-27  Deinococcus geothermalis DSM 11300  Bacteria  n/a    n/a   
 
 
-
 
NC_013739  Cwoe_4453  binding-protein-dependent transport systems inner membrane component  34.32 
 
 
319 aa  120  1.9999999999999998e-26  Conexibacter woesei DSM 14684  Bacteria  normal  normal 
 
 
-
 
NC_014151  Cfla_3051  binding-protein-dependent transport systems inner membrane component  33.46 
 
 
338 aa  120  3e-26  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.335951  normal  0.466485 
 
 
-
 
NC_008782  Ajs_3305  binding-protein-dependent transport systems inner membrane component  35.68 
 
 
300 aa  120  3e-26  Acidovorax sp. JS42  Bacteria  normal  0.980927  normal 
 
 
-
 
NC_013411  GYMC61_0532  binding-protein-dependent transport systems inner membrane component  31.3 
 
 
311 aa  120  3e-26  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_013743  Htur_1814  binding-protein-dependent transport systems inner membrane component  28.78 
 
 
329 aa  119  3.9999999999999996e-26  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_013521  Sked_11550  carbohydrate ABC transporter membrane protein  28.67 
 
 
354 aa  120  3.9999999999999996e-26  Sanguibacter keddieii DSM 10542  Bacteria  normal  0.151535  normal  0.0144146 
 
 
-
 
NC_011831  Cagg_0728  binding-protein-dependent transport systems inner membrane component  29.1 
 
 
313 aa  120  3.9999999999999996e-26  Chloroflexus aggregans DSM 9485  Bacteria  hitchhiker  0.000239391  normal 
 
 
-
 
NC_010003  Pmob_1923  binding-protein-dependent transport systems inner membrane component  27.3 
 
 
307 aa  119  4.9999999999999996e-26  Petrotoga mobilis SJ95  Bacteria  normal  0.372981  n/a   
 
 
-
 
NC_009616  Tmel_0819  binding-protein-dependent transport systems inner membrane component  29.82 
 
 
306 aa  119  4.9999999999999996e-26  Thermosipho melanesiensis BI429  Bacteria  normal  n/a   
 
 
-
 
NC_013131  Caci_7905  binding-protein-dependent transport systems inner membrane component  32.38 
 
 
336 aa  119  6e-26  Catenulispora acidiphila DSM 44928  Bacteria  normal  normal 
 
 
-
 
NC_013739  Cwoe_3982  binding-protein-dependent transport systems inner membrane component  30.77 
 
 
316 aa  119  6e-26  Conexibacter woesei DSM 14684  Bacteria  normal  normal 
 
 
-
 
NC_013595  Sros_3537  ABC transporter membrane spanning protein (galacturonic acid)  34.76 
 
 
322 aa  119  6e-26  Streptosporangium roseum DSM 43021  Bacteria  normal  0.601194  normal 
 
 
-
 
NC_013739  Cwoe_5440  binding-protein-dependent transport systems inner membrane component  31.8 
 
 
329 aa  119  7.999999999999999e-26  Conexibacter woesei DSM 14684  Bacteria  normal  0.811614  normal 
 
 
-
 
NC_008578  Acel_1361  binding-protein-dependent transport systems inner membrane component  33.01 
 
 
315 aa  119  9e-26  Acidothermus cellulolyticus 11B  Bacteria  normal  0.193472  normal  0.165724 
 
 
-
 
NC_011071  Smal_2682  binding-protein-dependent transport systems inner membrane component  32.03 
 
 
293 aa  118  9.999999999999999e-26  Stenotrophomonas maltophilia R551-3  Bacteria  normal  0.990678  normal 
 
 
-
 
NC_014165  Tbis_3250  binding-protein-dependent transporter inner membrane component  32.59 
 
 
310 aa  118  9.999999999999999e-26  Thermobispora bispora DSM 43833  Bacteria  normal  normal 
 
 
-
 
NC_010483  TRQ2_0971  binding-protein-dependent transport systems inner membrane component  27.53 
 
 
293 aa  117  1.9999999999999998e-25  Thermotoga sp. RQ2  Bacteria  normal  0.0994152  n/a   
 
 
-
 
NC_010577  XfasM23_1549  binding-protein-dependent transport systems inner membrane component  29.89 
 
 
293 aa  118  1.9999999999999998e-25  Xylella fastidiosa M23  Bacteria  normal  0.563461  n/a   
 
 
-
 
NC_008261  CPF_1114  sugar ABC transporter, permease protein  29.18 
 
 
301 aa  117  1.9999999999999998e-25  Clostridium perfringens ATCC 13124  Bacteria  normal  0.212611  n/a   
 
 
-
 
NC_012854  Rleg_6533  binding-protein-dependent transport systems inner membrane component  29.83 
 
 
292 aa  117  1.9999999999999998e-25  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.824779  normal  0.0156091 
 
 
-
 
NC_012669  Bcav_1656  binding-protein-dependent transport systems inner membrane component  30.19 
 
 
318 aa  117  1.9999999999999998e-25  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.152531  normal  0.26367 
 
 
-
 
NC_010513  Xfasm12_1606  ABC transporter sugar permease  29.89 
 
 
293 aa  117  1.9999999999999998e-25  Xylella fastidiosa M12  Bacteria  normal  n/a   
 
 
-
 
NC_013172  Bfae_01490  carbohydrate ABC transporter membrane protein  28.67 
 
 
324 aa  117  1.9999999999999998e-25  Brachybacterium faecium DSM 4810  Bacteria  normal  0.659857  n/a   
 
 
-
 
NC_013172  Bfae_29890  carbohydrate ABC transporter membrane protein  29.75 
 
 
333 aa  117  1.9999999999999998e-25  Brachybacterium faecium DSM 4810  Bacteria  normal  n/a   
 
 
-
 
NC_012669  Bcav_0311  binding-protein-dependent transport systems inner membrane component  29.25 
 
 
321 aa  117  1.9999999999999998e-25  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal 
 
 
-
 
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