More than 300 homologs were found in PanDaTox collection
for query gene Acid345_0154 on replicon NC_008009
Organism: Candidatus Koribacter versatilis Ellin345



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_008009  Acid345_0154  biotin/lipoyl attachment  100 
 
 
167 aa  333  5e-91  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  0.560413  hitchhiker  0.00148686 
 
 
-
 
NC_009675  Anae109_0280  biotin/lipoyl attachment domain-containing protein  40.38 
 
 
170 aa  99.4  2e-20  Anaeromyxobacter sp. Fw109-5  Bacteria  hitchhiker  0.000162076  normal  0.138469 
 
 
-
 
NC_011891  A2cp1_0280  biotin/lipoyl attachment domain-containing protein  39.33 
 
 
170 aa  92.8  2e-18  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  0.0253037  n/a   
 
 
-
 
NC_011145  AnaeK_0269  biotin/lipoyl attachment domain-containing protein  39.33 
 
 
170 aa  92.4  2e-18  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_007760  Adeh_0258  biotin/lipoyl attachment protein  46.67 
 
 
170 aa  89  3e-17  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  0.63102  n/a   
 
 
-
 
NC_009523  RoseRS_2909  biotin/lipoyl attachment domain-containing protein  33.73 
 
 
164 aa  79.3  0.00000000000002  Roseiflexus sp. RS-1  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_6688  biotin/lipoyl attachment domain-containing protein  37.25 
 
 
169 aa  77.4  0.00000000000009  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_013522  Taci_0293  biotin/lipoyl attachment domain-containing protein  50 
 
 
133 aa  72.4  0.000000000003  Thermanaerovibrio acidaminovorans DSM 6589  Bacteria  normal  n/a   
 
 
-
 
NC_009767  Rcas_2883  biotin/lipoyl attachment domain-containing protein  31.95 
 
 
164 aa  72  0.000000000004  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_009720  Xaut_1855  carbamoyl-phosphate synthase L chain ATP-binding  33.33 
 
 
666 aa  70.5  0.000000000009  Xanthobacter autotrophicus Py2  Bacteria  normal  0.181486  normal 
 
 
-
 
NC_007925  RPC_3352  carbamoyl-phosphate synthase L chain, ATP-binding  34.04 
 
 
671 aa  69.7  0.00000000002  Rhodopseudomonas palustris BisB18  Bacteria  normal  0.124303  normal 
 
 
-
 
NC_010718  Nther_0631  Conserved carboxylase region  34.03 
 
 
633 aa  68.9  0.00000000003  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  normal 
 
 
-
 
NC_013216  Dtox_1343  biotin/lipoyl attachment domain-containing protein  52.17 
 
 
142 aa  69.3  0.00000000003  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  normal  0.166002 
 
 
-
 
NC_009718  Fnod_1319  biotin/lipoyl attachment domain-containing protein  43.37 
 
 
147 aa  68.6  0.00000000004  Fervidobacterium nodosum Rt17-B1  Bacteria  normal  n/a   
 
 
-
 
NC_010184  BcerKBAB4_3773  pyruvate carboxylase  43.66 
 
 
1148 aa  68.6  0.00000000004  Bacillus weihenstephanensis KBAB4  Bacteria  normal  0.333  n/a   
 
 
-
 
NC_010718  Nther_1491  biotin/lipoyl attachment domain-containing protein  50 
 
 
144 aa  68.2  0.00000000005  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  normal  0.0157118 
 
 
-
 
NC_008347  Mmar10_1142  pyruvate carboxylase  31.54 
 
 
1146 aa  67.8  0.00000000006  Maricaulis maris MCS10  Bacteria  normal  0.0248368  normal  0.044238 
 
 
-
 
NC_009674  Bcer98_2649  pyruvate carboxylase  41.33 
 
 
1148 aa  67.8  0.00000000007  Bacillus cytotoxicus NVH 391-98  Bacteria  decreased coverage  0.00733169  n/a   
 
 
-
 
NC_009634  Mevan_1350  pyruvate carboxylase subunit B  33.33 
 
 
568 aa  67.8  0.00000000008  Methanococcus vannielii SB  Archaea  normal  n/a   
 
 
-
 
NC_006274  BCZK3707  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000008  Bacillus cereus E33L  Bacteria  normal  0.863258  n/a   
 
 
-
 
NC_011658  BCAH187_A4065  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000008  Bacillus cereus AH187  Bacteria  normal  0.0164116  n/a   
 
 
-
 
NC_011773  BCAH820_3962  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000008  Bacillus cereus AH820  Bacteria  n/a    normal 
 
 
-
 
NC_003909  BCE_3994  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000009  Bacillus cereus ATCC 10987  Bacteria  normal  0.882525  n/a   
 
 
-
 
NC_011772  BCG9842_B1190  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000009  Bacillus cereus G9842  Bacteria  normal  normal 
 
 
-
 
NC_005945  BAS3859  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000009  Bacillus anthracis str. Sterne  Bacteria  normal  n/a   
 
 
-
 
NC_005957  BT9727_3690  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000009  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  normal  n/a   
 
 
-
 
NC_011725  BCB4264_A4050  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000009  Bacillus cereus B4264  Bacteria  normal  0.898796  n/a   
 
 
-
 
NC_007530  GBAA_4157  pyruvate carboxylase  42.25 
 
 
1148 aa  67.4  0.00000000009  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  normal  0.820084  n/a   
 
 
-
 
NC_007347  Reut_A1463  3-methylcrotonoyl-CoA carboxylase, alpha subunit  36.84 
 
 
674 aa  67  0.0000000001  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_013061  Phep_4063  biotin/lipoyl attachment domain-containing protein  31.48 
 
 
165 aa  66.6  0.0000000001  Pedobacter heparinus DSM 2366  Bacteria  normal  normal 
 
 
-
 
NC_009565  TBFG_12523  acetyl-/propionyl-coenzyme A carboxylase subunit alpha  34.04 
 
 
654 aa  65.9  0.0000000002  Mycobacterium tuberculosis F11  Bacteria  normal  normal  0.881887 
 
 
-
 
NC_009077  Mjls_3213  carbamoyl-phosphate synthase L chain, ATP-binding  31.94 
 
 
677 aa  65.1  0.0000000004  Mycobacterium sp. JLS  Bacteria  normal  normal 
 
 
-
 
NC_007435  BURPS1710b_A0468  biotin carboxylase subunit of acetyl-CoA carboxylase  46.05 
 
 
666 aa  65.1  0.0000000004  Burkholderia pseudomallei 1710b  Bacteria  normal  n/a   
 
 
-
 
NC_009637  MmarC7_1341  pyruvate carboxylase subunit B  42.11 
 
 
569 aa  65.5  0.0000000004  Methanococcus maripaludis C7  Archaea  normal  normal  0.421509 
 
 
-
 
NC_009135  MmarC5_1334  pyruvate carboxylase subunit B  43.42 
 
 
569 aa  65.1  0.0000000004  Methanococcus maripaludis C5  Archaea  normal  n/a   
 
 
-
 
NC_009078  BURPS1106A_A1956  putative acetyl-CoA carboxylase, biotin carboxylase  46.05 
 
 
664 aa  65.1  0.0000000004  Burkholderia pseudomallei 1106a  Bacteria  normal  n/a   
 
 
-
 
NC_008146  Mmcs_3202  carbamoyl-phosphate synthase L chain, ATP-binding protein  31.94 
 
 
677 aa  65.1  0.0000000004  Mycobacterium sp. MCS  Bacteria  normal  n/a   
 
 
-
 
NC_008148  Rxyl_2464  carbamoyl-phosphate synthase L chain, ATP-binding protein  46.27 
 
 
580 aa  65.5  0.0000000004  Rubrobacter xylanophilus DSM 9941  Bacteria  normal  n/a   
 
 
-
 
NC_009975  MmarC6_0612  pyruvate carboxylase subunit B  43.42 
 
 
569 aa  65.5  0.0000000004  Methanococcus maripaludis C6  Archaea  normal  0.86669  n/a   
 
 
-
 
NC_009616  Tmel_0583  biotin/lipoyl attachment domain-containing protein  44.71 
 
 
131 aa  65.1  0.0000000004  Thermosipho melanesiensis BI429  Bacteria  normal  n/a   
 
 
-
 
NC_008705  Mkms_3264  carbamoyl-phosphate synthase L chain, ATP-binding  31.94 
 
 
677 aa  65.1  0.0000000004  Mycobacterium sp. KMS  Bacteria  normal  0.079197  normal 
 
 
-
 
NC_010623  Bphy_3559  carbamoyl-phosphate synthase L chain ATP-binding  42.86 
 
 
670 aa  65.1  0.0000000005  Burkholderia phymatum STM815  Bacteria  normal  normal  0.733851 
 
 
-
 
NC_007650  BTH_II0950  biotin carboxylase  46.05 
 
 
666 aa  65.1  0.0000000005  Burkholderia thailandensis E264  Bacteria  normal  0.790249  n/a   
 
 
-
 
NC_007958  RPD_3093  carbamoyl-phosphate synthase L chain, ATP-binding  34.07 
 
 
691 aa  64.7  0.0000000005  Rhodopseudomonas palustris BisB5  Bacteria  normal  normal  0.0379768 
 
 
-
 
NC_011004  Rpal_3585  Carbamoyl-phosphate synthase L chain ATP-binding  33.58 
 
 
671 aa  65.1  0.0000000005  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.930093  n/a   
 
 
-
 
NC_008726  Mvan_0345  carbamoyl-phosphate synthase L chain, ATP-binding  44.93 
 
 
665 aa  64.7  0.0000000005  Mycobacterium vanbaalenii PYR-1  Bacteria  normal  normal  0.780411 
 
 
-
 
NC_008554  Sfum_0461  hypothetical protein  43.66 
 
 
661 aa  64.7  0.0000000005  Syntrophobacter fumaroxidans MPOB  Bacteria  hitchhiker  0.00676863  normal  0.0747191 
 
 
-
 
NC_010320  Teth514_0799  biotin/lipoyl attachment domain-containing protein  32.54 
 
 
132 aa  64.7  0.0000000006  Thermoanaerobacter sp. X514  Bacteria  hitchhiker  0.000233394  n/a   
 
 
-
 
NC_008699  Noca_4551  carbamoyl-phosphate synthase L chain, ATP-binding  47.06 
 
 
633 aa  64.7  0.0000000006  Nocardioides sp. JS614  Bacteria  normal  0.282138  n/a   
 
 
-
 
NC_011666  Msil_1360  pyruvate carboxylase  44.93 
 
 
1147 aa  64.3  0.0000000007  Methylocella silvestris BL2  Bacteria  n/a    normal  0.0615601 
 
 
-
 
NC_009075  BURPS668_A2053  putative acetyl-CoA carboxylase, biotin carboxylase  46.05 
 
 
666 aa  63.9  0.0000000009  Burkholderia pseudomallei 668  Bacteria  normal  0.698368  n/a   
 
 
-
 
NC_008835  BMA10229_0651  putative acetyl-CoA carboxylase, biotin carboxylase  46.05 
 
 
664 aa  63.5  0.000000001  Burkholderia mallei NCTC 10229  Bacteria  normal  0.547961  n/a   
 
 
-
 
NC_008784  BMASAVP1_0539  putative acetyl-CoA carboxylase, biotin carboxylase  46.05 
 
 
664 aa  63.5  0.000000001  Burkholderia mallei SAVP1  Bacteria  normal  n/a   
 
 
-
 
NC_009511  Swit_2889  carbamoyl-phosphate synthase L chain, ATP-binding  35.66 
 
 
660 aa  63.5  0.000000001  Sphingomonas wittichii RW1  Bacteria  normal  0.894613  normal  0.421393 
 
 
-
 
NC_006349  BMAA0805  putative acetyl-CoA carboxylase, biotin carboxylase  46.05 
 
 
664 aa  63.5  0.000000001  Burkholderia mallei ATCC 23344  Bacteria  normal  n/a   
 
 
-
 
NC_013739  Cwoe_5538  Carbamoyl-phosphate synthase L chain ATP- binding protein  45.31 
 
 
596 aa  63.5  0.000000001  Conexibacter woesei DSM 14684  Bacteria  normal  normal  0.0551401 
 
 
-
 
NC_009635  Maeo_1005  pyruvate carboxylase subunit B  33.06 
 
 
567 aa  63.2  0.000000001  Methanococcus aeolicus Nankai-3  Archaea  normal  n/a   
 
 
-
 
NC_009079  BMA10247_A1605  putative acetyl-CoA carboxylase, biotin carboxylase  46.05 
 
 
664 aa  63.5  0.000000001  Burkholderia mallei NCTC 10247  Bacteria  normal  0.585456  n/a   
 
 
-
 
NC_009802  CCC13826_1508  glyceraldehyde-3-phosphate dehydrogenase 2  38.74 
 
 
600 aa  63.5  0.000000001  Campylobacter concisus 13826  Bacteria  normal  n/a   
 
 
-
 
NC_008709  Ping_3376  oxaloacetate decarboxylase  42.65 
 
 
604 aa  63.5  0.000000001  Psychromonas ingrahamii 37  Bacteria  normal  0.709986  normal 
 
 
-
 
NC_010682  Rpic_0116  Carbamoyl-phosphate synthase L chain ATP-binding  37.89 
 
 
674 aa  63.5  0.000000001  Ralstonia pickettii 12J  Bacteria  normal  normal 
 
 
-
 
NC_009714  CHAB381_1620  biotin/lipoyl attachment  39.19 
 
 
609 aa  62.8  0.000000002  Campylobacter hominis ATCC BAA-381  Bacteria  normal  n/a   
 
 
-
 
NC_013441  Gbro_3828  Carbamoyl-phosphate synthase L chain ATP- binding protein  38 
 
 
672 aa  63.2  0.000000002  Gordonia bronchialis DSM 43247  Bacteria  normal  n/a   
 
 
-
 
NC_007512  Plut_1433  biotin carboxyl carrier protein  31.51 
 
 
139 aa  62.8  0.000000002  Chlorobium luteolum DSM 273  Bacteria  normal  normal  0.816153 
 
 
-
 
NC_007644  Moth_1155  biotin/lipoyl attachment  41.18 
 
 
128 aa  63.2  0.000000002  Moorella thermoacetica ATCC 39073  Bacteria  normal  0.849643  normal 
 
 
-
 
NC_007778  RPB_2367  carbamoyl-phosphate synthase L chain, ATP-binding  34.81 
 
 
671 aa  63.2  0.000000002  Rhodopseudomonas palustris HaA2  Bacteria  normal  normal  0.60166 
 
 
-
 
NC_007796  Mhun_3189  pyruvate carboxylase subunit B  32.09 
 
 
577 aa  63.2  0.000000002  Methanospirillum hungatei JF-1  Archaea  normal  normal 
 
 
-
 
NC_009565  TBFG_13314  bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha subunit accA3: biotin carboxylase + biotin carboxyl carrier protein  32.9 
 
 
600 aa  63.2  0.000000002  Mycobacterium tuberculosis F11  Bacteria  normal  normal 
 
 
-
 
NC_012856  Rpic12D_0123  Carbamoyl-phosphate synthase L chain ATP-binding  37.89 
 
 
674 aa  62.8  0.000000002  Ralstonia pickettii 12D  Bacteria  normal  normal 
 
 
-
 
NC_010803  Clim_0887  biotin/lipoyl attachment domain-containing protein  33.78 
 
 
138 aa  62.4  0.000000003  Chlorobium limicola DSM 245  Bacteria  normal  n/a   
 
 
-
 
NC_003295  RSc0265  acyl-CoA carboxylase subunit alpha  37.89 
 
 
712 aa  62  0.000000003  Ralstonia solanacearum GMI1000  Bacteria  normal  normal 
 
 
-
 
NC_006369  lpl0507  pyruvate carboxylase subunit B  36.59 
 
 
596 aa  62  0.000000003  Legionella pneumophila str. Lens  Bacteria  n/a    n/a   
 
 
-
 
NC_007802  Jann_1147  3-methylcrotonoyl-CoA carboxylase, alpha subunit  41.98 
 
 
667 aa  62.4  0.000000003  Jannaschia sp. CCS1  Bacteria  normal  normal  0.221564 
 
 
-
 
NC_013440  Hoch_1857  Carbamoyl-phosphate synthase L chain ATP- binding protein  36.63 
 
 
700 aa  62.4  0.000000003  Haliangium ochraceum DSM 14365  Bacteria  normal  0.737896  normal 
 
 
-
 
NC_013159  Svir_05850  acetyl/propionyl-CoA carboxylase, alpha subunit  36.09 
 
 
591 aa  62  0.000000004  Saccharomonospora viridis DSM 43017  Bacteria  normal  normal  0.79631 
 
 
-
 
NC_009439  Pmen_2030  3-methylcrotonoyl-CoA carboxylase, alpha subunit  38.1 
 
 
644 aa  62  0.000000004  Pseudomonas mendocina ymp  Bacteria  normal  0.0317693  normal  0.435789 
 
 
-
 
NC_009483  Gura_2907  pyruvate carboxylase  31.54 
 
 
1148 aa  61.6  0.000000005  Geobacter uraniireducens Rf4  Bacteria  unclonable  0.000167641  n/a   
 
 
-
 
NC_009012  Cthe_0700  biotin/lipoyl attachment protein  46.27 
 
 
132 aa  61.6  0.000000005  Clostridium thermocellum ATCC 27405  Bacteria  normal  n/a   
 
 
-
 
NC_008346  Swol_0519  pyruvate carboxylase  34.26 
 
 
1144 aa  61.6  0.000000005  Syntrophomonas wolfei subsp. wolfei str. Goettingen  Bacteria  normal  n/a   
 
 
-
 
NC_010676  Bphyt_4689  Carbamoyl-phosphate synthase L chain ATP-binding  30.95 
 
 
692 aa  61.2  0.000000006  Burkholderia phytofirmans PsJN  Bacteria  normal  normal 
 
 
-
 
NC_006368  lpp0531  pyruvate carboxylase subunit B  36.59 
 
 
596 aa  60.8  0.000000007  Legionella pneumophila str. Paris  Bacteria  n/a    n/a   
 
 
-
 
NC_013889  TK90_1606  oxaloacetate decarboxylase alpha subunit  42.86 
 
 
608 aa  61.2  0.000000007  Thioalkalivibrio sp. K90mix  Bacteria  normal  0.0818232  normal 
 
 
-
 
NC_009457  VC0395_A0085  oxaloacetate decarboxylase  39.47 
 
 
597 aa  60.8  0.000000008  Vibrio cholerae O395  Bacteria  normal  0.0260292  n/a   
 
 
-
 
NC_008228  Patl_3012  oxaloacetate decarboxylase  39.71 
 
 
596 aa  60.8  0.000000008  Pseudoalteromonas atlantica T6c  Bacteria  normal  0.930079  n/a   
 
 
-
 
NC_010483  TRQ2_0210  biotin/lipoyl attachment domain-containing protein  41.38 
 
 
134 aa  60.8  0.000000009  Thermotoga sp. RQ2  Bacteria  normal  n/a   
 
 
-
 
NC_009485  BBta_4902  putative acyl-CoA carboxylase biotin-carrying subunit  47.46 
 
 
671 aa  60.1  0.00000001  Bradyrhizobium sp. BTAi1  Bacteria  normal  0.928975  normal  0.0609126 
 
 
-
 
NC_009943  Dole_2178  biotin/lipoyl attachment domain-containing protein  32.14 
 
 
174 aa  60.5  0.00000001  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_011831  Cagg_2537  acetyl-CoA carboxylase, biotin carboxylase  43.28 
 
 
590 aa  60.5  0.00000001  Chloroflexus aggregans DSM 9485  Bacteria  normal  0.232961  normal 
 
 
-
 
NC_013926  Aboo_1365  biotin/lipoyl attachment domain-containing protein  36.56 
 
 
125 aa  60.5  0.00000001  Aciduliprofundum boonei T469  Archaea  normal  0.0208474  n/a   
 
 
-
 
NC_012034  Athe_1318  biotin/lipoyl attachment domain-containing protein  37.8 
 
 
127 aa  60.5  0.00000001  Anaerocellum thermophilum DSM 6725  Bacteria  normal  n/a   
 
 
-
 
NC_007517  Gmet_3292  3-methylcrotonoyl-CoA carboxylase, alpha subunit  31.5 
 
 
668 aa  60.1  0.00000001  Geobacter metallireducens GS-15  Bacteria  normal  normal 
 
 
-
 
NC_013595  Sros_6358  carbamoyl-phosphate synthase L chain ATP- binding protein  45.71 
 
 
667 aa  60.1  0.00000001  Streptosporangium roseum DSM 43021  Bacteria  normal  0.188022  normal 
 
 
-
 
NC_010552  BamMC406_5118  carbamoyl-phosphate synthase L chain ATP-binding  42.68 
 
 
666 aa  60.1  0.00000001  Burkholderia ambifaria MC40-6  Bacteria  normal  normal 
 
 
-
 
NC_007511  Bcep18194_B0426  3-methylcrotonoyl-CoA carboxylase, alpha subunit  41.46 
 
 
665 aa  59.7  0.00000002  Burkholderia sp. 383  Bacteria  normal  0.967801  normal 
 
 
-
 
NC_013159  Svir_16520  acetyl/propionyl-CoA carboxylase, alpha subunit  44.78 
 
 
666 aa  59.7  0.00000002  Saccharomonospora viridis DSM 43017  Bacteria  normal  normal 
 
 
-
 
NC_009486  Tpet_0212  biotin/lipoyl attachment domain-containing protein  48.44 
 
 
132 aa  59.7  0.00000002  Thermotoga petrophila RKU-1  Bacteria  normal  n/a   
 
 
-
 
NC_007958  RPD_0350  carbamoyl-phosphate synthase L chain, ATP-binding  27.67 
 
 
679 aa  59.7  0.00000002  Rhodopseudomonas palustris BisB5  Bacteria  normal  hitchhiker  0.000448558 
 
 
-
 
NC_011901  Tgr7_1916  pyruvate carboxylase subunit B  41.43 
 
 
609 aa  59.7  0.00000002  Thioalkalivibrio sp. HL-EbGR7  Bacteria  normal  0.566124  n/a   
 
 
-
 
NC_008347  Mmar10_1727  carbamoyl-phosphate synthase L chain, ATP-binding  42.31 
 
 
667 aa  59.3  0.00000002  Maricaulis maris MCS10  Bacteria  normal  0.807685  normal  0.290764 
 
 
-
 
NC_008391  Bamb_4585  carbamoyl-phosphate synthase L chain, ATP-binding  42.68 
 
 
666 aa  60.1  0.00000002  Burkholderia ambifaria AMMD  Bacteria  normal  normal  0.747689 
 
 
-
 
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