88 homologs were found in PanDaTox collection
for query gene Ssol_1384 on replicon CP001800
Organism: Sulfolobus solfataricus 98/2



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
CP001800  Ssol_1384  Cobalamin-independent synthase MetE domain protein  100 
 
 		 328 aa  652    Sulfolobus solfataricus 98/2  Archaea  normal  0.273814  n/a   
 
 
-
 
NC_009440  Msed_2249  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase  46.43 
 
 		 320 aa  283  3.0000000000000004e-75  Metallosphaera sedula DSM 5348  Archaea  normal  0.349375  normal  0.145883 
 
 
-
 
NC_011661  Dtur_1756  Cobalamin-independent synthase MetE domain protein  30.97 
 
 		 325 aa  101  2e-20  Dictyoglomus turgidum DSM 6724  Bacteria  normal  1  n/a   
 
 
-
 
NC_013202  Hmuk_2668  Cobalamin-independent synthase MetE domain protein  23.21 
 
 		 331 aa  72.4  0.000000000009  Halomicrobium mukohataei DSM 12286  Archaea  normal  1  normal  1 
 
 
-
 
CP001800  Ssol_1385  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.67 
 
 		 332 aa  68.2  0.0000000002  Sulfolobus solfataricus 98/2  Archaea  normal  0.25974  n/a   
 
 
-
 
NC_013922  Nmag_1090  Cobalamin-independent synthase MetE domain protein  20.99 
 
 		 348 aa  68.2  0.0000000002  Natrialba magadii ATCC 43099  Archaea  normal  1  n/a   
 
 
-
 
NC_013743  Htur_2395  Cobalamin-independent synthase MetE domain protein  21.84 
 
 		 347 aa  62.8  0.000000007  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_010483  TRQ2_1533  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  29.19 
 
 		 734 aa  61.6  0.00000002  Thermotoga sp. RQ2  Bacteria  normal  1  n/a   
 
 
-
 
NC_013158  Huta_0079  Cobalamin-independent synthase MetE domain protein  21.58 
 
 		 329 aa  60.1  0.00000006  Halorhabdus utahensis DSM 12940  Archaea  normal  0.0833926  n/a   
 
 
-
 
NC_013158  Huta_0080  methionine synthase  23.51 
 
 		 350 aa  58.5  0.0000001  Halorhabdus utahensis DSM 12940  Archaea  normal  0.0497366  n/a   
 
 
-
 
NC_004116  SAG2049  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  27.6 
 
 		 745 aa  58.5  0.0000001  Streptococcus agalactiae 2603V/R  Bacteria  normal  1  n/a   
 
 
-
 
NC_012029  Hlac_2107  Cobalamin-independent synthase MetE domain protein  21.09 
 
 		 333 aa  58.5  0.0000002  Halorubrum lacusprofundi ATCC 49239  Archaea  normal  0.133546  normal  0.0920246 
 
 
-
 
NC_007614  Nmul_A2634  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25 
 
 		 796 aa  58.5  0.0000002  Nitrosospira multiformis ATCC 25196  Bacteria  hitchhiker  0.00665323  n/a   
 
 
-
 
NC_008148  Rxyl_0842  cobalamin-independent synthase MetE-like protein  18.26 
 
 		 311 aa  56.6  0.0000006  Rubrobacter xylanophilus DSM 9941  Bacteria  normal  0.368488  n/a   
 
 
-
 
NC_009440  Msed_2248  methionine synthase  24.61 
 
 		 331 aa  56.2  0.0000008  Metallosphaera sedula DSM 5348  Archaea  normal  0.88722  normal  0.0178602 
 
 
-
 
NC_013385  Adeg_1122  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.37 
 
 		 755 aa  55.1  0.000002  Ammonifex degensii KC4  Bacteria  normal  0.0904662  n/a   
 
 
-
 
NC_007520  Tcr_2184  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.67 
 
 		 782 aa  55.1  0.000002  Thiomicrospira crunogena XCL-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_011080  SNSL254_A4244  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.08 
 
 		 754 aa  53.9  0.000004  Salmonella enterica subsp. enterica serovar Newport str. SL254  Bacteria  normal  1  normal  1 
 
 
-
 
NC_012029  Hlac_2108  methionine synthase  23.71 
 
 		 356 aa  53.5  0.000004  Halorubrum lacusprofundi ATCC 49239  Archaea  normal  0.112744  normal  0.0912449 
 
 
-
 
NC_011083  SeHA_C4291  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.08 
 
 		 754 aa  53.5  0.000005  Salmonella enterica subsp. enterica serovar Heidelberg str. SL476  Bacteria  normal  0.675603  normal  0.794614 
 
 
-
 
NC_011094  SeSA_A4172  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.08 
 
 		 754 aa  53.5  0.000005  Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011149  SeAg_B4194  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.08 
 
 		 754 aa  53.5  0.000005  Salmonella enterica subsp. enterica serovar Agona str. SL483  Bacteria  normal  1  n/a   
 
 
-
 
NC_011205  SeD_A4351  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.08 
 
 		 754 aa  53.5  0.000005  Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853  Bacteria  normal  1  normal  1 
 
 
-
 
NC_008391  Bamb_4646  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.09 
 
 		 764 aa  52.8  0.000008  Burkholderia ambifaria AMMD  Bacteria  normal  1  normal  0.910139 
 
 
-
 
NC_011661  Dtur_1757  methionine synthase  22 
 
 		 342 aa  52  0.00001  Dictyoglomus turgidum DSM 6724  Bacteria  normal  1  n/a   
 
 
-
 
NC_010498  EcSMS35_4195  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.28 
 
 		 753 aa  52.4  0.00001  Escherichia coli SMS-3-5  Bacteria  normal  1  hitchhiker  0.00351399 
 
 
-
 
NC_010678  Rpic_4542  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  19.62 
 
 		 776 aa  51.6  0.00002  Ralstonia pickettii 12J  Bacteria  normal  0.449329  normal  0.404575 
 
 
-
 
NC_010730  SYO3AOP1_1374  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.76 
 
 		 762 aa  51.2  0.00002  Sulfurihydrogenibium sp. YO3AOP1  Bacteria  hitchhiker  0.00034181  n/a   
 
 
-
 
NC_012857  Rpic12D_3470  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  19.62 
 
 		 776 aa  51.6  0.00002  Ralstonia pickettii 12D  Bacteria  normal  1  normal  0.0697271 
 
 
-
 
NC_007964  Nham_3661  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.41 
 
 		 778 aa  51.6  0.00002  Nitrobacter hamburgensis X14  Bacteria  normal  1  n/a   
 
 
-
 
NC_009708  YpsIP31758_0264  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.29 
 
 		 758 aa  50.8  0.00003  Yersinia pseudotuberculosis IP 31758  Bacteria  normal  1  n/a   
 
 
-
 
NC_013525  Tter_1188  5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase  25.14 
 
 		 767 aa  51.2  0.00003  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_010086  Bmul_3434  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.12 
 
 		 777 aa  50.8  0.00003  Burkholderia multivorans ATCC 17616  Bacteria  decreased coverage  0.0080658  normal  0.291084 
 
 
-
 
NC_009486  Tpet_1489  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.95 
 
 		 735 aa  50.1  0.00005  Thermotoga petrophila RKU-1  Bacteria  hitchhiker  0.00335848  n/a   
 
 
-
 
CP001509  ECD_03708  5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase  23.89 
 
 		 753 aa  49.7  0.00007  Escherichia coli BL21(DE3)  Bacteria  normal  1  n/a   
 
 
-
 
NC_010552  BamMC406_5175  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.13 
 
 		 764 aa  49.7  0.00008  Burkholderia ambifaria MC40-6  Bacteria  normal  1  normal  0.188369 
 
 
-
 
NC_007492  Pfl01_4545  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.23 
 
 		 789 aa  49.3  0.00009  Pseudomonas fluorescens Pf0-1  Bacteria  normal  0.55406  normal  0.861577 
 
 
-
 
NC_008312  Tery_0847  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.53 
 
 		 744 aa  48.5  0.0001  Trichodesmium erythraeum IMS101  Bacteria  normal  1  normal  0.601961 
 
 
-
 
NC_013093  Amir_3078  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.43 
 
 		 744 aa  49.3  0.0001  Actinosynnema mirum DSM 43827  Bacteria  normal  1  n/a   
 
 
-
 
NC_007912  Sde_0638  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24 
 
 		 765 aa  49.3  0.0001  Saccharophagus degradans 2-40  Bacteria  normal  0.248233  normal  1 
 
 
-
 
NC_007519  Dde_2328  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.79 
 
 		 758 aa  48.9  0.0001  Desulfovibrio desulfuricans subsp. desulfuricans str. G20  Bacteria  normal  0.960773  n/a   
 
 
-
 
NC_010465  YPK_3952  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.29 
 
 		 763 aa  48.9  0.0001  Yersinia pseudotuberculosis YPIII  Bacteria  normal  1  n/a   
 
 
-
 
NC_010159  YpAngola_A3648  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.29 
 
 		 763 aa  48.5  0.0001  Yersinia pestis Angola  Bacteria  normal  1  normal  0.670904 
 
 
-
 
NC_008740  Maqu_0809  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26 
 
 		 756 aa  48.1  0.0002  Marinobacter aquaeolei VT8  Bacteria  normal  0.134457  n/a   
 
 
-
 
NC_012560  Avin_13980  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.1 
 
 		 763 aa  48.5  0.0002  Azotobacter vinelandii DJ  Bacteria  normal  1  n/a   
 
 
-
 
NC_009800  EcHS_A4053  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.89 
 
 		 753 aa  48.1  0.0002  Escherichia coli HS  Bacteria  normal  1  n/a   
 
 
-
 
NC_009801  EcE24377A_4350  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.89 
 
 		 753 aa  48.1  0.0002  Escherichia coli E24377A  Bacteria  normal  1  n/a   
 
 
-
 
CP001637  EcDH1_4150  5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase  23.45 
 
 		 753 aa  47.8  0.0003  Escherichia coli DH1  Bacteria  normal  1  n/a   
 
 
-
 
NC_013421  Pecwa_4356  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.45 
 
 		 754 aa  47  0.0004  Pectobacterium wasabiae WPP163  Bacteria  normal  0.724806  n/a   
 
 
-
 
NC_010623  Bphy_5470  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  27.18 
 
 		 763 aa  47.4  0.0004  Burkholderia phymatum STM815  Bacteria  normal  1  normal  0.0137341 
 
 
-
 
NC_004578  PSPTO_4179  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.87 
 
 		 766 aa  47  0.0005  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  1  n/a   
 
 
-
 
NC_007952  Bxe_B1250  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.54 
 
 		 764 aa  47  0.0005  Burkholderia xenovorans LB400  Bacteria  normal  0.33578  normal  1 
 
 
-
 
NC_009436  Ent638_3967  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.45 
 
 		 753 aa  46.6  0.0005  Enterobacter sp. 638  Bacteria  normal  1  normal  0.57426 
 
 
-
 
NC_010468  EcolC_4179  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.89 
 
 		 753 aa  46.2  0.0007  Escherichia coli ATCC 8739  Bacteria  normal  1  normal  0.0336494 
 
 
-
 
NC_012917  PC1_4073  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.2 
 
 		 756 aa  46.6  0.0007  Pectobacterium carotovorum subsp. carotovorum PC1  Bacteria  normal  1  n/a   
 
 
-
 
NC_010658  SbBS512_E4295  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.45 
 
 		 753 aa  46.2  0.0008  Shigella boydii CDC 3083-94  Bacteria  normal  1  n/a   
 
 
-
 
NC_011353  ECH74115_5270  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.45 
 
 		 753 aa  46.2  0.0008  Escherichia coli O157:H7 str. EC4115  Bacteria  normal  1  normal  0.253105 
 
 
-
 
NC_008061  Bcen_3081  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.26 
 
 		 764 aa  45.8  0.0009  Burkholderia cenocepacia AU 1054  Bacteria  normal  1  n/a   
 
 
-
 
NC_008527  LACR_1368  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.28 
 
 		 757 aa  45.8  0.0009  Lactococcus lactis subsp. cremoris SK11  Bacteria  normal  1  n/a   
 
 
-
 
NC_011901  Tgr7_0616  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.79 
 
 		 765 aa  45.8  0.0009  Thioalkalivibrio sp. HL-EbGR7  Bacteria  normal  1  n/a   
 
 
-
 
NC_008543  Bcen2424_5286  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.26 
 
 		 764 aa  45.8  0.0009  Burkholderia cenocepacia HI2424  Bacteria  normal  1  normal  1 
 
 
-
 
NC_008532  STER_0831  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.23 
 
 		 749 aa  45.8  0.001  Streptococcus thermophilus LMD-9  Bacteria  normal  0.749949  n/a   
 
 
-
 
NC_008309  HS_0824  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.26 
 
 		 757 aa  45.8  0.001  Haemophilus somnus 129PT  Bacteria  normal  1  n/a   
 
 
-
 
NC_011761  AFE_0288  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.08 
 
 		 784 aa  45.8  0.001  Acidithiobacillus ferrooxidans ATCC 23270  Bacteria  normal  1  n/a   
 
 
-
 
NC_011206  Lferr_0465  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.08 
 
 		 784 aa  45.8  0.001  Acidithiobacillus ferrooxidans ATCC 53993  Bacteria  normal  1  hitchhiker  0.0070963 
 
 
-
 
NC_013743  Htur_2396  Methionine synthase vitamin-B12 independent  25 
 
 		 358 aa  44.7  0.002  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_007511  Bcep18194_B0362  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.76 
 
 		 764 aa  45.1  0.002  Burkholderia sp. 383  Bacteria  normal  0.997242  normal  0.880013 
 
 
-
 
NC_009832  Spro_0242  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.98 
 
 		 758 aa  44.7  0.002  Serratia proteamaculans 568  Bacteria  normal  1  normal  0.167364 
 
 
-
 
NC_010515  Bcenmc03_4982  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.26 
 
 		 764 aa  44.7  0.002  Burkholderia cenocepacia MC0-3  Bacteria  normal  1  normal  1 
 
 
-
 
NC_010501  PputW619_0802  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  21.68 
 
 		 766 aa  45.1  0.002  Pseudomonas putida W619  Bacteria  normal  0.254178  normal  1 
 
 
-
 
NC_009045  PICST_78051  methionine-synthesizing 5- methyltetrahydropteroyltriglutamate--homocysteine methyltransferase  21.65 
 
 		 769 aa  44.3  0.003  Scheffersomyces stipitis CBS 6054  Eukaryota  normal  1  normal  1 
 
 
-
 
NC_009972  Haur_2573  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.75 
 
 		 748 aa  44.3  0.003  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  1  n/a   
 
 
-
 
NC_013922  Nmag_1089  Methionine synthase vitamin-B12 independent  23.43 
 
 		 366 aa  43.9  0.004  Natrialba magadii ATCC 43099  Archaea  normal  1  n/a   
 
 
-
 
NC_007406  Nwi_2890  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.58 
 
 		 771 aa  43.5  0.004  Nitrobacter winogradskyi Nb-255  Bacteria  normal  1  decreased coverage  0.00709608 
 
 
-
 
NC_011658  BCAH187_A4127  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  20.6 
 
 		 762 aa  43.5  0.005  Bacillus cereus AH187  Bacteria  normal  0.451313  n/a   
 
 
-
 
NC_009439  Pmen_1683  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.42 
 
 		 767 aa  43.5  0.005  Pseudomonas mendocina ymp  Bacteria  normal  1  normal  0.907749 
 
 
-
 
NC_009565  TBFG_11156  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.79 
 
 		 794 aa  43.5  0.005  Mycobacterium tuberculosis F11  Bacteria  hitchhiker  0.000000000816299  normal  1 
 
 
-
 
NC_003909  BCE_4053  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  20.17 
 
 		 762 aa  43.1  0.006  Bacillus cereus ATCC 10987  Bacteria  normal  1  n/a   
 
 
-
 
NC_008463  PA14_39590  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.67 
 
 		 766 aa  43.1  0.006  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  0.823199  normal  0.952253 
 
 
-
 
NC_009954  Cmaq_0981  methionine synthase vitamin-B12 independent  25.21 
 
 		 393 aa  43.1  0.007  Caldivirga maquilingensis IC-167  Archaea  normal  1  normal  1 
 
 
-
 
NC_009457  VC0395_A1308  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  21.54 
 
 		 761 aa  43.1  0.007  Vibrio cholerae O395  Bacteria  decreased coverage  0.00000166944  n/a   
 
 
-
 
NC_011769  DvMF_2035  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.59 
 
 		 780 aa  43.1  0.007  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal  1 
 
 
-
 
NC_007575  Suden_0899  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.65 
 
 		 759 aa  42.7  0.008  Sulfurimonas denitrificans DSM 1251  Bacteria  normal  1  n/a   
 
 
-
 
NC_009832  Spro_3176  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase  21.79 
 
 		 343 aa  42.7  0.008  Serratia proteamaculans 568  Bacteria  normal  0.364781  normal  1 
 
 
-
 
NC_009656  PSPA7_1556  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.62 
 
 		 763 aa  42.7  0.009  Pseudomonas aeruginosa PA7  Bacteria  normal  0.503379  n/a   
 
 
-
 
NC_007947  Mfla_2571  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.96 
 
 		 763 aa  42.4  0.01  Methylobacillus flagellatus KT  Bacteria  normal  1  normal  0.342945 
 
 
-
 
NC_007498  Pcar_0442  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  20.76 
 
 		 758 aa  42.4  0.01  Pelobacter carbinolicus DSM 2380  Bacteria  hitchhiker  0.0000063505  n/a   
 
 
-
 
NC_008709  Ping_3386  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.88 
 
 		 767 aa  42.4  0.01  Psychromonas ingrahamii 37  Bacteria  normal  1  normal  1 
 
 
-
 
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