71 homologs were found in PanDaTox collection
for query gene Msed_2249 on replicon NC_009440
Organism: Metallosphaera sedula DSM 5348



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_009440  Msed_2249  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase  100 
 
 		 320 aa  649    Metallosphaera sedula DSM 5348  Archaea  normal  0.349375  normal  0.145883 
 
 
-
 
CP001800  Ssol_1384  Cobalamin-independent synthase MetE domain protein  46.69 
 
 		 328 aa  276  3e-73  Sulfolobus solfataricus 98/2  Archaea  normal  0.273814  n/a   
 
 
-
 
NC_011661  Dtur_1756  Cobalamin-independent synthase MetE domain protein  30.86 
 
 		 325 aa  119  7e-26  Dictyoglomus turgidum DSM 6724  Bacteria  normal  1  n/a   
 
 
-
 
NC_013922  Nmag_1090  Cobalamin-independent synthase MetE domain protein  26.03 
 
 		 348 aa  85.5  0.000000000000001  Natrialba magadii ATCC 43099  Archaea  normal  1  n/a   
 
 
-
 
NC_013202  Hmuk_2668  Cobalamin-independent synthase MetE domain protein  26.17 
 
 		 331 aa  78.2  0.0000000000002  Halomicrobium mukohataei DSM 12286  Archaea  normal  1  normal  1 
 
 
-
 
CP001800  Ssol_1385  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  30.48 
 
 		 332 aa  75.1  0.000000000002  Sulfolobus solfataricus 98/2  Archaea  normal  0.25974  n/a   
 
 
-
 
NC_009440  Msed_2248  methionine synthase  27.14 
 
 		 331 aa  72.8  0.000000000008  Metallosphaera sedula DSM 5348  Archaea  normal  0.88722  normal  0.0178602 
 
 
-
 
NC_013743  Htur_2395  Cobalamin-independent synthase MetE domain protein  25.64 
 
 		 347 aa  71.6  0.00000000002  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_012029  Hlac_2107  Cobalamin-independent synthase MetE domain protein  23.94 
 
 		 333 aa  62.4  0.00000001  Halorubrum lacusprofundi ATCC 49239  Archaea  normal  0.133546  normal  0.0920246 
 
 
-
 
NC_010730  SYO3AOP1_1374  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.57 
 
 		 762 aa  57  0.0000004  Sulfurihydrogenibium sp. YO3AOP1  Bacteria  hitchhiker  0.00034181  n/a   
 
 
-
 
NC_008312  Tery_0847  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  28.4 
 
 		 744 aa  57  0.0000005  Trichodesmium erythraeum IMS101  Bacteria  normal  1  normal  0.601961 
 
 
-
 
NC_008148  Rxyl_0842  cobalamin-independent synthase MetE-like protein  27.96 
 
 		 311 aa  55.5  0.000001  Rubrobacter xylanophilus DSM 9941  Bacteria  normal  0.368488  n/a   
 
 
-
 
NC_013205  Aaci_0760  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.74 
 
 		 762 aa  54.3  0.000003  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  0.301473  n/a   
 
 
-
 
NC_008751  Dvul_0025  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.34 
 
 		 797 aa  53.9  0.000004  Desulfovibrio vulgaris DP4  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011661  Dtur_1757  methionine synthase  27.53 
 
 		 342 aa  53.5  0.000005  Dictyoglomus turgidum DSM 6724  Bacteria  normal  1  n/a   
 
 
-
 
NC_010483  TRQ2_1533  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.53 
 
 		 734 aa  52.4  0.00001  Thermotoga sp. RQ2  Bacteria  normal  1  n/a   
 
 
-
 
NC_013158  Huta_0079  Cobalamin-independent synthase MetE domain protein  24.56 
 
 		 329 aa  52  0.00001  Halorhabdus utahensis DSM 12940  Archaea  normal  0.0833926  n/a   
 
 
-
 
NC_010678  Rpic_4542  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.61 
 
 		 776 aa  51.2  0.00002  Ralstonia pickettii 12J  Bacteria  normal  0.449329  normal  0.404575 
 
 
-
 
NC_012857  Rpic12D_3470  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.61 
 
 		 776 aa  51.2  0.00002  Ralstonia pickettii 12D  Bacteria  normal  1  normal  0.0697271 
 
 
-
 
NC_008309  HS_0824  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.44 
 
 		 757 aa  50.8  0.00003  Haemophilus somnus 129PT  Bacteria  normal  1  n/a   
 
 
-
 
NC_011365  Gdia_0807  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25 
 
 		 785 aa  50.1  0.00005  Gluconacetobacter diazotrophicus PAl 5  Bacteria  normal  1  normal  0.205879 
 
 
-
 
NC_009486  Tpet_1489  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.47 
 
 		 735 aa  50.1  0.00005  Thermotoga petrophila RKU-1  Bacteria  hitchhiker  0.00335848  n/a   
 
 
-
 
NC_010623  Bphy_5470  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.37 
 
 		 763 aa  50.1  0.00006  Burkholderia phymatum STM815  Bacteria  normal  1  normal  0.0137341 
 
 
-
 
NC_011769  DvMF_2035  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.32 
 
 		 780 aa  49.3  0.00009  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal  1 
 
 
-
 
NC_012560  Avin_13980  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.75 
 
 		 763 aa  48.5  0.0001  Azotobacter vinelandii DJ  Bacteria  normal  1  n/a   
 
 
-
 
NC_008254  Meso_2701  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  27.04 
 
 		 769 aa  48.5  0.0001  Chelativorans sp. BNC1  Bacteria  normal  1  n/a   
 
 
-
 
NC_007925  RPC_3508  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.9 
 
 		 790 aa  48.1  0.0002  Rhodopseudomonas palustris BisB18  Bacteria  normal  0.365583  normal  0.0696827 
 
 
-
 
NC_007519  Dde_2328  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.87 
 
 		 758 aa  47.4  0.0003  Desulfovibrio desulfuricans subsp. desulfuricans str. G20  Bacteria  normal  0.960773  n/a   
 
 
-
 
NC_010086  Bmul_3434  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.76 
 
 		 777 aa  47.4  0.0003  Burkholderia multivorans ATCC 17616  Bacteria  decreased coverage  0.0080658  normal  0.291084 
 
 
-
 
NC_008340  Mlg_2105  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.36 
 
 		 773 aa  47  0.0004  Alkalilimnicola ehrlichii MLHE-1  Bacteria  normal  0.695669  normal  0.267963 
 
 
-
 
NC_008255  CHU_3320  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.81 
 
 		 775 aa  47  0.0005  Cytophaga hutchinsonii ATCC 33406  Bacteria  normal  1  normal  1 
 
 
-
 
NC_010498  EcSMS35_4195  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25 
 
 		 753 aa  46.6  0.0005  Escherichia coli SMS-3-5  Bacteria  normal  1  hitchhiker  0.00351399 
 
 
-
 
NC_009708  YpsIP31758_0264  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.15 
 
 		 758 aa  46.6  0.0006  Yersinia pseudotuberculosis IP 31758  Bacteria  normal  1  n/a   
 
 
-
 
NC_013525  Tter_1188  5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase  22.82 
 
 		 767 aa  46.6  0.0006  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_008786  Veis_4447  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.76 
 
 		 789 aa  46.6  0.0006  Verminephrobacter eiseniae EF01-2  Bacteria  normal  1  normal  0.925235 
 
 
-
 
NC_007520  Tcr_2184  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.89 
 
 		 782 aa  46.2  0.0007  Thiomicrospira crunogena XCL-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_011004  Rpal_2650  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.41 
 
 		 788 aa  46.2  0.0007  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.521144  n/a   
 
 
-
 
CP001509  ECD_03708  5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase  24.54 
 
 		 753 aa  45.8  0.0009  Escherichia coli BL21(DE3)  Bacteria  normal  1  n/a   
 
 
-
 
NC_007406  Nwi_2890  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.83 
 
 		 771 aa  45.4  0.001  Nitrobacter winogradskyi Nb-255  Bacteria  normal  1  decreased coverage  0.00709608 
 
 
-
 
NC_007492  Pfl01_4545  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.93 
 
 		 789 aa  45.4  0.001  Pseudomonas fluorescens Pf0-1  Bacteria  normal  0.55406  normal  0.861577 
 
 
-
 
NC_007964  Nham_3661  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.23 
 
 		 778 aa  45.4  0.001  Nitrobacter hamburgensis X14  Bacteria  normal  1  n/a   
 
 
-
 
NC_013385  Adeg_1122  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  26.18 
 
 		 755 aa  44.7  0.002  Ammonifex degensii KC4  Bacteria  normal  0.0904662  n/a   
 
 
-
 
NC_010159  YpAngola_A3648  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.15 
 
 		 763 aa  44.7  0.002  Yersinia pestis Angola  Bacteria  normal  1  normal  0.670904 
 
 
-
 
NC_011205  SeD_A4351  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25 
 
 		 754 aa  44.7  0.002  Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011094  SeSA_A4172  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25 
 
 		 754 aa  44.3  0.002  Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011083  SeHA_C4291  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25 
 
 		 754 aa  44.3  0.002  Salmonella enterica subsp. enterica serovar Heidelberg str. SL476  Bacteria  normal  0.675603  normal  0.794614 
 
 
-
 
CP001637  EcDH1_4150  5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase  23.96 
 
 		 753 aa  44.7  0.002  Escherichia coli DH1  Bacteria  normal  1  n/a   
 
 
-
 
NC_010525  Tneu_0945  methionine synthase vitamin-B12 independent  25.38 
 
 		 384 aa  45.1  0.002  Thermoproteus neutrophilus V24Sta  Archaea  normal  0.8649  hitchhiker  0.000170069 
 
 
-
 
NC_010465  YPK_3952  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.15 
 
 		 763 aa  45.1  0.002  Yersinia pseudotuberculosis YPIII  Bacteria  normal  1  n/a   
 
 
-
 
NC_009801  EcE24377A_4350  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.54 
 
 		 753 aa  45.1  0.002  Escherichia coli E24377A  Bacteria  normal  1  n/a   
 
 
-
 
NC_009800  EcHS_A4053  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.54 
 
 		 753 aa  45.1  0.002  Escherichia coli HS  Bacteria  normal  1  n/a   
 
 
-
 
NC_009565  TBFG_11156  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.74 
 
 		 794 aa  44.7  0.002  Mycobacterium tuberculosis F11  Bacteria  hitchhiker  0.000000000816299  normal  1 
 
 
-
 
NC_013501  Rmar_0427  5-methyltetrahydropteroyltriglutamate/ homocystei neS-methyltransferase  24.05 
 
 		 774 aa  44.3  0.003  Rhodothermus marinus DSM 4252  Bacteria  normal  1  n/a   
 
 
-
 
NC_008463  PA14_39590  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.98 
 
 		 766 aa  44.3  0.003  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  0.823199  normal  0.952253 
 
 
-
 
NC_008740  Maqu_0809  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.38 
 
 		 756 aa  44.3  0.003  Marinobacter aquaeolei VT8  Bacteria  normal  0.134457  n/a   
 
 
-
 
NC_004578  PSPTO_4179  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  27.51 
 
 		 766 aa  43.9  0.004  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  1  n/a   
 
 
-
 
NC_010513  Xfasm12_1465  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.53 
 
 		 758 aa  43.5  0.004  Xylella fastidiosa M12  Bacteria  normal  0.93518  n/a   
 
 
-
 
NC_009045  PICST_78051  methionine-synthesizing 5- methyltetrahydropteroyltriglutamate--homocysteine methyltransferase  24.79 
 
 		 769 aa  43.9  0.004  Scheffersomyces stipitis CBS 6054  Eukaryota  normal  1  normal  1 
 
 
-
 
NC_009073  Pcal_0648  methionine synthase (B12-independent)  24.87 
 
 		 384 aa  43.5  0.005  Pyrobaculum calidifontis JCM 11548  Archaea  n/a    normal  1 
 
 
-
 
NC_008701  Pisl_0030  methionine synthase, vitamin-B12 independent  24.87 
 
 		 384 aa  43.5  0.005  Pyrobaculum islandicum DSM 4184  Archaea  normal  1  normal  1 
 
 
-
 
NC_011149  SeAg_B4194  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.87 
 
 		 754 aa  43.5  0.005  Salmonella enterica subsp. enterica serovar Agona str. SL483  Bacteria  normal  1  n/a   
 
 
-
 
NC_011080  SNSL254_A4244  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.53 
 
 		 754 aa  43.5  0.005  Salmonella enterica subsp. enterica serovar Newport str. SL254  Bacteria  normal  1  normal  1 
 
 
-
 
NC_010577  XfasM23_1392  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  22.71 
 
 		 758 aa  43.5  0.005  Xylella fastidiosa M23  Bacteria  normal  1  n/a   
 
 
-
 
NC_013037  Dfer_2814  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.65 
 
 		 773 aa  43.1  0.006  Dyadobacter fermentans DSM 18053  Bacteria  normal  1  normal  1 
 
 
-
 
NC_007348  Reut_B4245  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.71 
 
 		 800 aa  43.1  0.006  Ralstonia eutropha JMP134  Bacteria  normal  1  n/a   
 
 
-
 
NC_013132  Cpin_6481  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.28 
 
 		 769 aa  43.1  0.007  Chitinophaga pinensis DSM 2588  Bacteria  normal  1  normal  0.668969 
 
 
-
 
NC_004116  SAG2049  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  25.71 
 
 		 745 aa  42.7  0.007  Streptococcus agalactiae 2603V/R  Bacteria  normal  1  n/a   
 
 
-
 
NC_010468  EcolC_4179  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.07 
 
 		 753 aa  42.7  0.008  Escherichia coli ATCC 8739  Bacteria  normal  1  normal  0.0336494 
 
 
-
 
NC_011126  HY04AAS1_1502  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.74 
 
 		 755 aa  42.7  0.008  Hydrogenobaculum sp. Y04AAS1  Bacteria  normal  1  n/a   
 
 
-
 
NC_010658  SbBS512_E4295  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  23.5 
 
 		 753 aa  42.7  0.009  Shigella boydii CDC 3083-94  Bacteria  normal  1  n/a   
 
 
-
 
NC_008391  Bamb_4646  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase  24.04 
 
 		 764 aa  42.4  0.01  Burkholderia ambifaria AMMD  Bacteria  normal  1  normal  0.910139 
 
 
-
 
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