140 homologs were found in PanDaTox collection
for query gene Mthe_0988 on replicon NC_008553
Organism: Methanosaeta thermophila PT



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_008553  Mthe_0988  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  100 
 
 
392 aa  784    Methanosaeta thermophila PT  Archaea  normal  n/a   
 
 
-
 
NC_007955  Mbur_1994  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  65.66 
 
 
396 aa  543  1e-153  Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_007355  Mbar_A0935  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  66.07 
 
 
392 aa  532  1e-150  Methanosarcina barkeri str. Fusaro  Archaea  hitchhiker  0.0033619  normal 
 
 
-
 
NC_007796  Mhun_1628  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  64.63 
 
 
393 aa  516  1.0000000000000001e-145  Methanospirillum hungatei JF-1  Archaea  normal  normal 
 
 
-
 
NC_011832  Mpal_1036  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  63.87 
 
 
393 aa  515  1.0000000000000001e-145  Methanosphaerula palustris E1-9c  Archaea  normal  normal 
 
 
-
 
NC_009712  Mboo_0772  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  62.09 
 
 
393 aa  506  9.999999999999999e-143  Candidatus Methanoregula boonei 6A8  Archaea  normal  normal  0.58783 
 
 
-
 
NC_008942  Mlab_0996  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  59.31 
 
 
403 aa  499  1e-140  Methanocorpusculum labreanum Z  Archaea  normal  normal  0.566431 
 
 
-
 
NC_009051  Memar_1085  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  61.07 
 
 
393 aa  493  9.999999999999999e-139  Methanoculleus marisnigri JR1  Archaea  normal  0.136979  n/a   
 
 
-
 
NC_009635  Maeo_0614  bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase  38.69 
 
 
391 aa  262  8e-69  Methanococcus aeolicus Nankai-3  Archaea  normal  n/a   
 
 
-
 
NC_007355  Mbar_A2060  formaldehyde-activating enzyme  60.76 
 
 
178 aa  193  4e-48  Methanosarcina barkeri str. Fusaro  Archaea  normal  0.189028  normal  0.41416 
 
 
-
 
NC_014148  Plim_1285  formaldehyde-activating enzyme  58.02 
 
 
165 aa  192  9e-48  Planctomyces limnophilus DSM 3776  Bacteria  normal  n/a   
 
 
-
 
NC_007955  Mbur_0367  formaldehyde-activating enzyme  56.96 
 
 
160 aa  187  3e-46  Methanococcoides burtonii DSM 6242  Archaea  normal  0.203725  n/a   
 
 
-
 
NC_010505  Mrad2831_0533  formaldehyde-activating enzyme  52.87 
 
 
170 aa  161  2e-38  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_010725  Mpop_1785  formaldehyde-activating enzyme  52.23 
 
 
170 aa  160  5e-38  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_011894  Mnod_6007  formaldehyde-activating enzyme  51.27 
 
 
171 aa  159  1e-37  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.100814  n/a   
 
 
-
 
NC_011757  Mchl_2169  formaldehyde-activating enzyme  51.59 
 
 
170 aa  158  1e-37  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.783809  normal  0.178175 
 
 
-
 
NC_010172  Mext_1834  formaldehyde-activating enzyme  51.59 
 
 
170 aa  158  1e-37  Methylobacterium extorquens PA1  Bacteria  normal  normal 
 
 
-
 
NC_010511  M446_5783  formaldehyde-activating enzyme  51.9 
 
 
171 aa  159  1e-37  Methylobacterium sp. 4-46  Bacteria  normal  0.0971644  normal 
 
 
-
 
NC_011666  Msil_2390  formaldehyde-activating enzyme  52.83 
 
 
175 aa  157  3e-37  Methylocella silvestris BL2  Bacteria  n/a    normal 
 
 
-
 
NC_002977  MCA2866  formaldehyde-activating enzyme  50.61 
 
 
170 aa  157  3e-37  Methylococcus capsulatus str. Bath  Bacteria  normal  n/a   
 
 
-
 
NC_007952  Bxe_B2436  formaldehyde-activating protein  51.9 
 
 
169 aa  157  3e-37  Burkholderia xenovorans LB400  Bacteria  normal  normal  0.397979 
 
 
-
 
NC_010625  Bphy_6487  formaldehyde-activating enzyme  51.27 
 
 
169 aa  157  3e-37  Burkholderia phymatum STM815  Bacteria  normal  0.497311  normal  0.302319 
 
 
-
 
NC_012791  Vapar_3079  formaldehyde-activating enzyme  50.31 
 
 
170 aa  154  2e-36  Variovorax paradoxus S110  Bacteria  normal  n/a   
 
 
-
 
NC_009720  Xaut_0032  formaldehyde-activating protein  50 
 
 
169 aa  154  2.9999999999999998e-36  Xanthobacter autotrophicus Py2  Bacteria  normal  normal  0.848098 
 
 
-
 
NC_010524  Lcho_3147  formaldehyde-activating enzyme  53.16 
 
 
169 aa  153  4e-36  Leptothrix cholodnii SP-6  Bacteria  n/a    normal 
 
 
-
 
NC_009051  Memar_0975  formaldehyde-activating enzyme  56.33 
 
 
167 aa  152  8e-36  Methanoculleus marisnigri JR1  Archaea  normal  0.0927434  n/a   
 
 
-
 
NC_008825  Mpe_A2612  formaldehyde-activating enzyme  50.63 
 
 
169 aa  152  1e-35  Methylibium petroleiphilum PM1  Bacteria  normal  0.0416881  normal 
 
 
-
 
NC_009720  Xaut_1365  formaldehyde-activating protein  50.63 
 
 
191 aa  152  1e-35  Xanthobacter autotrophicus Py2  Bacteria  normal  0.745489  normal 
 
 
-
 
NC_007947  Mfla_1652  formaldehyde-activating enzyme  44.31 
 
 
178 aa  124  3e-27  Methylobacillus flagellatus KT  Bacteria  unclonable  0.000000000163018  normal  0.176505 
 
 
-
 
NC_007947  Mfla_2543  formaldehyde-activating enzyme  43.71 
 
 
178 aa  121  1.9999999999999998e-26  Methylobacillus flagellatus KT  Bacteria  normal  0.234356  normal 
 
 
-
 
NC_008553  Mthe_0455  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  38.5 
 
 
428 aa  118  1.9999999999999998e-25  Methanosaeta thermophila PT  Archaea  normal  n/a   
 
 
-
 
NC_010676  Bphyt_6933  formaldehyde-activating enzyme  37.75 
 
 
190 aa  118  1.9999999999999998e-25  Burkholderia phytofirmans PsJN  Bacteria  normal  0.587797  normal 
 
 
-
 
NC_012791  Vapar_3063  formaldehyde-activating enzyme  42.51 
 
 
177 aa  117  3e-25  Variovorax paradoxus S110  Bacteria  normal  n/a   
 
 
-
 
NC_010623  Bphy_5474  formaldehyde-activating enzyme  39.76 
 
 
177 aa  117  3.9999999999999997e-25  Burkholderia phymatum STM815  Bacteria  normal  0.0338658  normal  0.0655052 
 
 
-
 
NC_007511  Bcep18194_B2825  hypothetical protein  37.75 
 
 
174 aa  116  6.9999999999999995e-25  Burkholderia sp. 383  Bacteria  normal  normal 
 
 
-
 
NC_010524  Lcho_3132  formaldehyde-activating enzyme  44.3 
 
 
181 aa  115  2.0000000000000002e-24  Leptothrix cholodnii SP-6  Bacteria  n/a    normal 
 
 
-
 
NC_007947  Mfla_2364  putative formaldehyde-activating enzyme  38.65 
 
 
182 aa  114  4.0000000000000004e-24  Methylobacillus flagellatus KT  Bacteria  hitchhiker  0.000000204771  normal  0.719365 
 
 
-
 
NC_008825  Mpe_A2627  putative formaldehyde-activating enzyme  42.28 
 
 
177 aa  110  3e-23  Methylibium petroleiphilum PM1  Bacteria  normal  0.212894  normal 
 
 
-
 
NC_009051  Memar_0744  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  34.11 
 
 
429 aa  111  3e-23  Methanoculleus marisnigri JR1  Archaea  normal  0.225207  n/a   
 
 
-
 
NC_007947  Mfla_2524  putative formaldehyde-activating enzyme  38.82 
 
 
183 aa  109  8.000000000000001e-23  Methylobacillus flagellatus KT  Bacteria  normal  normal 
 
 
-
 
NC_009634  Mevan_0582  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  31.48 
 
 
437 aa  107  3e-22  Methanococcus vannielii SB  Archaea  normal  0.062003  n/a   
 
 
-
 
NC_013926  Aboo_0457  Orotidine 5'-phosphate decarboxylase  34.6 
 
 
426 aa  106  7e-22  Aciduliprofundum boonei T469  Archaea  normal  n/a   
 
 
-
 
CP001800  Ssol_1184  Orotidine 5'-phosphate decarboxylase  29.82 
 
 
225 aa  106  7e-22  Sulfolobus solfataricus 98/2  Archaea  normal  0.0998927  n/a   
 
 
-
 
NC_009135  MmarC5_0321  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  30.95 
 
 
438 aa  105  1e-21  Methanococcus maripaludis C5  Archaea  normal  n/a   
 
 
-
 
NC_010172  Mext_1450  formaldehyde-activating enzyme  39.6 
 
 
179 aa  105  2e-21  Methylobacterium extorquens PA1  Bacteria  normal  normal  0.485811 
 
 
-
 
NC_010725  Mpop_1445  formaldehyde-activating enzyme  39.04 
 
 
179 aa  104  2e-21  Methylobacterium populi BJ001  Bacteria  normal  normal  0.318243 
 
 
-
 
NC_011757  Mchl_1725  formaldehyde-activating enzyme  39.6 
 
 
179 aa  105  2e-21  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.393787  normal  0.0143668 
 
 
-
 
NC_009637  MmarC7_0516  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  29.41 
 
 
438 aa  103  6e-21  Methanococcus maripaludis C7  Archaea  normal  0.35671  normal 
 
 
-
 
NC_014148  Plim_3519  formaldehyde-activating enzyme  37.04 
 
 
211 aa  102  1e-20  Planctomyces limnophilus DSM 3776  Bacteria  normal  n/a   
 
 
-
 
NC_008942  Mlab_1453  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  35.68 
 
 
427 aa  102  1e-20  Methanocorpusculum labreanum Z  Archaea  normal  normal  0.395706 
 
 
-
 
NC_009712  Mboo_0707  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  35.71 
 
 
428 aa  102  2e-20  Candidatus Methanoregula boonei 6A8  Archaea  normal  normal  0.172064 
 
 
-
 
NC_009975  MmarC6_1403  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  29.55 
 
 
438 aa  101  2e-20  Methanococcus maripaludis C6  Archaea  normal  0.175956  n/a   
 
 
-
 
NC_010505  Mrad2831_2016  formaldehyde-activating enzyme  36.99 
 
 
179 aa  100  3e-20  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.560353  normal  0.585828 
 
 
-
 
NC_010511  M446_4369  formaldehyde-activating enzyme  35.12 
 
 
181 aa  100  5e-20  Methylobacterium sp. 4-46  Bacteria  normal  0.279882  normal 
 
 
-
 
NC_011832  Mpal_2121  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  35.86 
 
 
428 aa  100  6e-20  Methanosphaerula palustris E1-9c  Archaea  normal  normal 
 
 
-
 
NC_011894  Mnod_4915  formaldehyde-activating enzyme  35.33 
 
 
181 aa  99.4  9e-20  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.090523  n/a   
 
 
-
 
NC_010525  Tneu_0708  orotidine 5'-phosphate decarboxylase  34.52 
 
 
222 aa  99  1e-19  Thermoproteus neutrophilus V24Sta  Archaea  normal  0.942951  normal 
 
 
-
 
NC_002977  MCA3043  hexulose-6-phosphate synthase  30.14 
 
 
215 aa  97.1  5e-19  Methylococcus capsulatus str. Bath  Bacteria  normal  0.146405  n/a   
 
 
-
 
NC_002977  MCA3049  hexulose-6-phosphate synthase  30.14 
 
 
215 aa  97.1  5e-19  Methylococcus capsulatus str. Bath  Bacteria  normal  n/a   
 
 
-
 
NC_009720  Xaut_1627  formaldehyde-activating protein  36.53 
 
 
179 aa  96.7  6e-19  Xanthobacter autotrophicus Py2  Bacteria  normal  0.67854  normal 
 
 
-
 
NC_007355  Mbar_A1170  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  34.09 
 
 
413 aa  96.3  7e-19  Methanosarcina barkeri str. Fusaro  Archaea  normal  normal 
 
 
-
 
NC_009440  Msed_0227  orotidine 5'-phosphate decarboxylase  30.59 
 
 
227 aa  96.7  7e-19  Metallosphaera sedula DSM 5348  Archaea  normal  decreased coverage  0.0096121 
 
 
-
 
NC_011757  Mchl_3465  Formaldehyde-activating enzyme (Fae)  33.33 
 
 
182 aa  95.9  1e-18  Methylobacterium chloromethanicum CM4  Bacteria  normal  0.719607  normal 
 
 
-
 
NC_010172  Mext_3143  formaldehyde-activating protein  33.33 
 
 
182 aa  95.9  1e-18  Methylobacterium extorquens PA1  Bacteria  normal  0.389753  normal  0.873661 
 
 
-
 
NC_011666  Msil_1799  formaldehyde-activating enzyme  39.19 
 
 
178 aa  95.1  2e-18  Methylocella silvestris BL2  Bacteria  n/a    normal 
 
 
-
 
NC_010725  Mpop_3340  Formaldehyde-activating enzyme (Fae)  33.33 
 
 
182 aa  95.1  2e-18  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_007796  Mhun_0647  bifunctional hexulose-6-phosphate synthase/ribonuclease regulator  31.58 
 
 
429 aa  94.4  3e-18  Methanospirillum hungatei JF-1  Archaea  normal  0.101947  normal  0.0867495 
 
 
-
 
NC_002977  MCA2738  hexulose-6-phosphate synthase/SIS domain-containing protein  30.3 
 
 
389 aa  94  4e-18  Methylococcus capsulatus str. Bath  Bacteria  normal  n/a   
 
 
-
 
NC_009832  Spro_2468  formaldehyde-activating protein  34.69 
 
 
167 aa  93.6  5e-18  Serratia proteamaculans 568  Bacteria  normal  normal 
 
 
-
 
NC_008698  Tpen_0372  orotidine 5'-phosphate decarboxylase  33.92 
 
 
231 aa  93.2  8e-18  Thermofilum pendens Hrk 5  Archaea  normal  n/a   
 
 
-
 
NC_009708  YpsIP31758_1542  hypothetical protein  36.48 
 
 
167 aa  93.2  8e-18  Yersinia pseudotuberculosis IP 31758  Bacteria  normal  n/a   
 
 
-
 
NC_010465  YPK_1651  formaldehyde-activating enzyme  36.48 
 
 
167 aa  93.2  8e-18  Yersinia pseudotuberculosis YPIII  Bacteria  normal  n/a   
 
 
-
 
NC_009073  Pcal_0568  hexulose-6-phosphate synthase  34.83 
 
 
217 aa  92.4  1e-17  Pyrobaculum calidifontis JCM 11548  Archaea  n/a    normal 
 
 
-
 
NC_011894  Mnod_3403  Formaldehyde-activating enzyme (Fae)  31.48 
 
 
182 aa  91.7  2e-17  Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_010159  YpAngola_A1721  hypothetical protein  36.48 
 
 
167 aa  92  2e-17  Yersinia pestis Angola  Bacteria  normal  0.054067  hitchhiker  0.00446803 
 
 
-
 
NC_008541  Arth_3708  hexulose-6-phosphate synthase  33.33 
 
 
207 aa  90.9  4e-17  Arthrobacter sp. FB24  Bacteria  normal  n/a   
 
 
-
 
NC_010505  Mrad2831_4467  formaldehyde-activating protein  32.72 
 
 
182 aa  90.1  6e-17  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal  0.164696 
 
 
-
 
NC_009954  Cmaq_1871  orotidine 5'-phosphate decarboxylase  35 
 
 
217 aa  87.8  3e-16  Caldivirga maquilingensis IC-167  Archaea  normal  0.563194  normal  0.356021 
 
 
-
 
NC_007947  Mfla_0250  hexulose-6-phosphate synthase  29.17 
 
 
228 aa  86.7  7e-16  Methylobacillus flagellatus KT  Bacteria  unclonable  0.00000000013709  normal  0.0274377 
 
 
-
 
NC_009376  Pars_1830  orotidine 5'-phosphate decarboxylase  36.88 
 
 
221 aa  86.7  8e-16  Pyrobaculum arsenaticum DSM 13514  Archaea  hitchhiker  0.000143542  normal  0.0955115 
 
 
-
 
NC_008701  Pisl_1686  orotidine 5'-phosphate decarboxylase  35 
 
 
221 aa  85.1  0.000000000000002  Pyrobaculum islandicum DSM 4184  Archaea  normal  normal  0.0279692 
 
 
-
 
NC_007947  Mfla_1654  orotidine 5'-phosphate decarboxylase  31.22 
 
 
209 aa  84  0.000000000000004  Methylobacillus flagellatus KT  Bacteria  unclonable  0.000000000168104  normal  0.271517 
 
 
-
 
NC_011083  SeHA_C2929  3-hexulose-6-phosphate synthase  31.44 
 
 
211 aa  83.6  0.000000000000005  Salmonella enterica subsp. enterica serovar Heidelberg str. SL476  Bacteria  normal  hitchhiker  0.0000000015488 
 
 
-
 
NC_002976  SERP0216  hexulose-6-phosphate synthase, putative  29.21 
 
 
210 aa  83.2  0.000000000000007  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_5671  Orotidine 5'-phosphate decarboxylase  34.27 
 
 
211 aa  81.6  0.00000000000002  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal  0.587401 
 
 
-
 
NC_009477  SaurJH9_2736  orotidine 5'-phosphate decarboxylase  28.71 
 
 
210 aa  81.6  0.00000000000002  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  n/a   
 
 
-
 
NC_009619  SaurJH1_2812  orotidine 5'-phosphate decarboxylase  28.71 
 
 
210 aa  81.6  0.00000000000002  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  n/a   
 
 
-
 
NC_009487  SaurJH9_0593  orotidine 5'-phosphate decarboxylase  27.59 
 
 
210 aa  80.1  0.00000000000006  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  n/a   
 
 
-
 
NC_009632  SaurJH1_0607  orotidine 5'-phosphate decarboxylase  27.59 
 
 
210 aa  80.1  0.00000000000006  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  n/a   
 
 
-
 
NC_013517  Sterm_1849  3-hexulose-6-phosphate synthase  30.61 
 
 
212 aa  75.9  0.000000000001  Sebaldella termitidis ATCC 33386  Bacteria  normal  n/a   
 
 
-
 
NC_013517  Sterm_3212  3-hexulose-6-phosphate synthase  28.26 
 
 
211 aa  71.6  0.00000000002  Sebaldella termitidis ATCC 33386  Bacteria  normal  n/a   
 
 
-
 
NC_013526  Tter_2273  Orotidine 5'-phosphate decarboxylase  28.79 
 
 
240 aa  68.2  0.0000000003  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_013517  Sterm_0127  3-dehydro-L-gulonate-6-phosphate decarboxylase  28.12 
 
 
212 aa  61.2  0.00000003  Sebaldella termitidis ATCC 33386  Bacteria  normal  n/a   
 
 
-
 
NC_013517  Sterm_0145  3-dehydro-L-gulonate-6-phosphate decarboxylase  28.12 
 
 
212 aa  61.2  0.00000003  Sebaldella termitidis ATCC 33386  Bacteria  normal  n/a   
 
 
-
 
NC_008309  HS_0771  3-keto-L-gulonate-6-phosphate decarboxylase  26.2 
 
 
215 aa  60.8  0.00000004  Haemophilus somnus 129PT  Bacteria  normal  0.366407  n/a   
 
 
-
 
NC_010730  SYO3AOP1_1724  orotidine 5'-phosphate decarboxylase  30.09 
 
 
227 aa  57  0.0000005  Sulfurihydrogenibium sp. YO3AOP1  Bacteria  normal  0.297453  n/a   
 
 
-
 
NC_012880  Dd703_0115  3-keto-L-gulonate-6-phosphate decarboxylase  37.65 
 
 
215 aa  55.8  0.000001  Dickeya dadantii Ech703  Bacteria  normal  0.0197016  n/a   
 
 
-
 
NC_013926  Aboo_1139  orotidine 5'-phosphate decarboxylase  25.13 
 
 
209 aa  53.1  0.000008  Aciduliprofundum boonei T469  Archaea  hitchhiker  0.00457344  n/a   
 
 
-
 
NC_011205  SeD_A4783  3-keto-L-gulonate-6-phosphate decarboxylase  27.4 
 
 
216 aa  51.2  0.00003  Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853  Bacteria  normal  0.268129  normal 
 
 
-
 
NC_011149  SeAg_B4664  3-keto-L-gulonate-6-phosphate decarboxylase  27.4 
 
 
216 aa  51.2  0.00003  Salmonella enterica subsp. enterica serovar Agona str. SL483  Bacteria  normal  0.482194  n/a   
 
 
-
 
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