More than 300 homologs were found in PanDaTox collection
for query gene RSc2566 on replicon NC_003295
Organism: Ralstonia solanacearum GMI1000



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_003295  RSc2566  putative methylated-DNA--protein-cysteine methyltransferase  100 
 
 
171 aa  333  7.999999999999999e-91  Ralstonia solanacearum GMI1000  Bacteria  normal  normal 
 
 
-
 
NC_007005  Psyr_3365  methylated-DNA-[protein]-cysteine S-methyltransferase  53.71 
 
 
384 aa  190  1e-47  Pseudomonas syringae pv. syringae B728a  Bacteria  normal  normal 
 
 
-
 
NC_009667  Oant_0476  methylated-DNA--protein-cysteine methyltransferase  54.6 
 
 
361 aa  188  2.9999999999999997e-47  Ochrobactrum anthropi ATCC 49188  Bacteria  normal  n/a   
 
 
-
 
NC_003295  RSc2570  bifunctional methylated-DNA--protein-cysteine methyltransferase/O-6-methylguanine-DNA transcription regulator  58.28 
 
 
360 aa  186  1e-46  Ralstonia solanacearum GMI1000  Bacteria  normal  normal 
 
 
-
 
NC_010682  Rpic_2856  transcriptional regulator, AraC family  55.49 
 
 
361 aa  185  2e-46  Ralstonia pickettii 12J  Bacteria  normal  normal 
 
 
-
 
NC_009708  YpsIP31758_0082  ada regulatory protein  56.25 
 
 
354 aa  186  2e-46  Yersinia pseudotuberculosis IP 31758  Bacteria  normal  n/a   
 
 
-
 
NC_004578  PSPTO_3595  Ada regulatory protein  52 
 
 
368 aa  185  3e-46  Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  n/a   
 
 
-
 
NC_012856  Rpic12D_2450  transcriptional regulator, AraC family  55.49 
 
 
361 aa  184  4e-46  Ralstonia pickettii 12D  Bacteria  normal  normal 
 
 
-
 
NC_002947  PP_0706  adaptive response regulator protein  56.52 
 
 
350 aa  184  5e-46  Pseudomonas putida KT2440  Bacteria  normal  0.998073  normal 
 
 
-
 
NC_010465  YPK_4134  AraC family transcriptional regulator  55.28 
 
 
354 aa  184  5e-46  Yersinia pseudotuberculosis YPIII  Bacteria  normal  0.0607807  n/a   
 
 
-
 
NC_007348  Reut_B4734  DNA-O6-methylguanine--protein-cysteine S-methyltransferase  55.49 
 
 
240 aa  182  1.0000000000000001e-45  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_007492  Pfl01_2938  AraC family transcriptional regulator  52.27 
 
 
357 aa  183  1.0000000000000001e-45  Pseudomonas fluorescens Pf0-1  Bacteria  normal  normal 
 
 
-
 
NC_009512  Pput_0739  methylated-DNA--protein-cysteine methyltransferase  55.9 
 
 
350 aa  183  1.0000000000000001e-45  Pseudomonas putida F1  Bacteria  normal  normal 
 
 
-
 
NC_010322  PputGB1_0740  AraC family transcriptional regulator  57.76 
 
 
350 aa  183  1.0000000000000001e-45  Pseudomonas putida GB-1  Bacteria  normal  normal 
 
 
-
 
NC_010511  M446_1042  AraC family transcriptional regulator  60.12 
 
 
370 aa  181  4.0000000000000006e-45  Methylobacterium sp. 4-46  Bacteria  normal  0.826547  normal 
 
 
-
 
NC_007510  Bcep18194_A4931  AraC family transcriptional regulator  54.32 
 
 
354 aa  181  5.0000000000000004e-45  Burkholderia sp. 383  Bacteria  normal  normal 
 
 
-
 
NC_012917  PC1_0793  transcriptional regulator, AraC family  54.66 
 
 
376 aa  181  6e-45  Pectobacterium carotovorum subsp. carotovorum PC1  Bacteria  normal  0.0138198  n/a   
 
 
-
 
NC_009505  BOV_0383  ada regulatory protein  52.15 
 
 
361 aa  179  2e-44  Brucella ovis ATCC 25840  Bacteria  normal  n/a   
 
 
-
 
NC_004310  BR0368  ada regulatory protein  51.53 
 
 
361 aa  177  4.999999999999999e-44  Brucella suis 1330  Bacteria  normal  n/a   
 
 
-
 
NC_008687  Pden_4239  methylated-DNA--protein-cysteine methyltransferase  55.62 
 
 
353 aa  177  5.999999999999999e-44  Paracoccus denitrificans PD1222  Bacteria  normal  0.577797  normal  0.120321 
 
 
-
 
NC_008463  PA14_37190  O6-methylguanine-DNA methyltransferase  51.85 
 
 
358 aa  176  2e-43  Pseudomonas aeruginosa UCBPP-PA14  Bacteria  normal  0.0320795  normal 
 
 
-
 
NC_010501  PputW619_4477  AraC family transcriptional regulator  55.28 
 
 
350 aa  175  3e-43  Pseudomonas putida W619  Bacteria  normal  normal 
 
 
-
 
NC_010581  Bind_2118  AraC family transcriptional regulator  54.37 
 
 
366 aa  174  6e-43  Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  0.0669009  normal 
 
 
-
 
NC_007974  Rmet_3765  bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase  51.53 
 
 
354 aa  172  1.9999999999999998e-42  Cupriavidus metallidurans CH34  Bacteria  normal  normal 
 
 
-
 
NC_013421  Pecwa_1027  transcriptional regulator, AraC family  51.55 
 
 
359 aa  172  2.9999999999999996e-42  Pectobacterium wasabiae WPP163  Bacteria  normal  n/a   
 
 
-
 
NC_010725  Mpop_4835  transcriptional regulator, AraC family  58.23 
 
 
360 aa  170  9e-42  Methylobacterium populi BJ001  Bacteria  normal  0.0179003  normal  0.379038 
 
 
-
 
NC_009656  PSPA7_3190  O6-methylguanine-DNA methyltransferase  50.62 
 
 
358 aa  168  4e-41  Pseudomonas aeruginosa PA7  Bacteria  normal  n/a   
 
 
-
 
NC_011365  Gdia_1536  transcriptional regulator, AraC family  52.5 
 
 
366 aa  168  4e-41  Gluconacetobacter diazotrophicus PAl 5  Bacteria  normal  normal  0.26366 
 
 
-
 
NC_010505  Mrad2831_3551  AraC family transcriptional regulator  53.37 
 
 
369 aa  167  7e-41  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  0.0783013  normal  0.874169 
 
 
-
 
NC_007484  Noc_2104  methylated-DNA-(protein)-cysteine S-methyltransferase  53.09 
 
 
211 aa  166  2e-40  Nitrosococcus oceani ATCC 19707  Bacteria  normal  n/a   
 
 
-
 
NC_011894  Mnod_0501  transcriptional regulator, AraC family  54.32 
 
 
374 aa  165  2.9999999999999998e-40  Methylobacterium nodulans ORS 2060  Bacteria  normal  0.399439  n/a   
 
 
-
 
NC_011666  Msil_1307  transcriptional regulator, AraC family  55.56 
 
 
357 aa  162  2.0000000000000002e-39  Methylocella silvestris BL2  Bacteria  n/a    normal 
 
 
-
 
NC_007510  Bcep18194_A4925  DNA-O6-methylguanine--protein-cysteine S-methyltransferase  53.42 
 
 
186 aa  161  4.0000000000000004e-39  Burkholderia sp. 383  Bacteria  normal  normal 
 
 
-
 
NC_009436  Ent638_2793  DNA-O6-methylguanine--protein-cysteine S-methyltransferase / transcriptional regulator Ada  50.6 
 
 
354 aa  160  9e-39  Enterobacter sp. 638  Bacteria  normal  0.986339  normal 
 
 
-
 
NC_007510  Bcep18194_A4920  DNA-O6-methylguanine--protein-cysteine S-methyltransferase  50.31 
 
 
197 aa  159  1e-38  Burkholderia sp. 383  Bacteria  normal  normal 
 
 
-
 
NC_010002  Daci_2162  AraC family transcriptional regulator  52.76 
 
 
306 aa  158  3e-38  Delftia acidovorans SPH-1  Bacteria  normal  0.235913  normal 
 
 
-
 
NC_010172  Mext_4318  methylated-DNA--protein-cysteine methyltransferase  56.33 
 
 
380 aa  157  5e-38  Methylobacterium extorquens PA1  Bacteria  normal  0.155933  normal 
 
 
-
 
NC_008825  Mpe_A3753  transcriptional regulator Ada / DNA-O6-methylguanine--protein-cysteine S-methyltransferase  56.44 
 
 
363 aa  156  1e-37  Methylibium petroleiphilum PM1  Bacteria  normal  0.2777  normal  0.322377 
 
 
-
 
NC_011071  Smal_2772  transcriptional regulator, AraC family  50.31 
 
 
313 aa  155  3e-37  Stenotrophomonas maltophilia R551-3  Bacteria  normal  0.353019  normal 
 
 
-
 
NC_011757  Mchl_4687  transcriptional regulator, AraC family  55.7 
 
 
361 aa  155  3e-37  Methylobacterium chloromethanicum CM4  Bacteria  normal  normal 
 
 
-
 
NC_009511  Swit_1127  DNA-O6-methylguanine--protein-cysteine S-methyltransferase / transcriptional regulator Ada  53.09 
 
 
351 aa  152  2.9999999999999998e-36  Sphingomonas wittichii RW1  Bacteria  normal  0.836162  normal 
 
 
-
 
CP001509  ECD_02140  fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase  47.83 
 
 
354 aa  149  2e-35  Escherichia coli BL21(DE3)  Bacteria  normal  0.581837  n/a   
 
 
-
 
NC_010498  EcSMS35_2362  regulatory protein Ada  47.83 
 
 
354 aa  149  2e-35  Escherichia coli SMS-3-5  Bacteria  normal  0.960218  normal 
 
 
-
 
NC_012892  B21_02099  hypothetical protein  47.83 
 
 
354 aa  149  2e-35  Escherichia coli BL21  Bacteria  normal  0.592554  n/a   
 
 
-
 
NC_010658  SbBS512_E0727  regulatory protein Ada  47.83 
 
 
354 aa  149  2e-35  Shigella boydii CDC 3083-94  Bacteria  normal  0.166972  n/a   
 
 
-
 
NC_011353  ECH74115_3351  regulatory protein Ada  47.83 
 
 
354 aa  149  2e-35  Escherichia coli O157:H7 str. EC4115  Bacteria  normal  0.212963  normal 
 
 
-
 
NC_012560  Avin_46280  Methylated-DNA--(protein)-cysteine S-methyltransferase  55.62 
 
 
355 aa  149  2e-35  Azotobacter vinelandii DJ  Bacteria  normal  n/a   
 
 
-
 
NC_010338  Caul_4048  methylated-DNA--protein-cysteine methyltransferase  53.09 
 
 
241 aa  148  3e-35  Caulobacter sp. K31  Bacteria  normal  0.785924  normal  0.44527 
 
 
-
 
NC_009800  EcHS_A2352  regulatory protein Ada  47.83 
 
 
354 aa  148  3e-35  Escherichia coli HS  Bacteria  normal  0.970088  n/a   
 
 
-
 
CP001637  EcDH1_1445  transcriptional regulator, AraC family  47.83 
 
 
354 aa  148  4e-35  Escherichia coli DH1  Bacteria  normal  0.29559  n/a   
 
 
-
 
NC_009801  EcE24377A_2512  regulatory protein Ada  47.83 
 
 
354 aa  148  4e-35  Escherichia coli E24377A  Bacteria  normal  0.0107303  n/a   
 
 
-
 
NC_010468  EcolC_1437  AraC family transcriptional regulator  47.83 
 
 
354 aa  148  4e-35  Escherichia coli ATCC 8739  Bacteria  normal  normal  0.195699 
 
 
-
 
NC_013440  Hoch_6249  methylated-DNA/protein- cysteinemethyltransferase  56.88 
 
 
388 aa  146  1.0000000000000001e-34  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_009439  Pmen_0834  DNA-O6-methylguanine--protein-cysteine S-methyltransferase / transcriptional regulator Ada  46.25 
 
 
340 aa  145  2.0000000000000003e-34  Pseudomonas mendocina ymp  Bacteria  normal  normal 
 
 
-
 
NC_007510  Bcep18194_A6508  bifunctional DNA-O6-methylguanine--protein-cysteine S-methyltransferase / transcriptional regulator Ada  46.91 
 
 
363 aa  143  1e-33  Burkholderia sp. 383  Bacteria  hitchhiker  0.000000013299  normal  0.0946299 
 
 
-
 
NC_011205  SeD_A2608  regulatory protein ada  47.06 
 
 
352 aa  141  4e-33  Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853  Bacteria  normal  normal  0.669578 
 
 
-
 
NC_011094  SeSA_A2491  regulatory protein ada  44.38 
 
 
353 aa  141  4e-33  Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633  Bacteria  normal  normal 
 
 
-
 
NC_008060  Bcen_2539  AraC family transcriptional regulator  47.53 
 
 
363 aa  141  4e-33  Burkholderia cenocepacia AU 1054  Bacteria  hitchhiker  0.0000057895  n/a   
 
 
-
 
NC_011149  SeAg_B2401  regulatory protein ada  47.06 
 
 
352 aa  141  4e-33  Salmonella enterica subsp. enterica serovar Agona str. SL483  Bacteria  hitchhiker  0.00982046  n/a   
 
 
-
 
NC_008542  Bcen2424_3152  AraC family transcriptional regulator  47.53 
 
 
363 aa  141  4e-33  Burkholderia cenocepacia HI2424  Bacteria  hitchhiker  0.00000475647  n/a   
 
 
-
 
NC_011080  SNSL254_A2449  regulatory protein ada  47.06 
 
 
352 aa  141  5e-33  Salmonella enterica subsp. enterica serovar Newport str. SL254  Bacteria  normal  normal  0.0458356 
 
 
-
 
NC_011083  SeHA_C2505  regulatory protein ada  47.06 
 
 
352 aa  141  5e-33  Salmonella enterica subsp. enterica serovar Heidelberg str. SL476  Bacteria  normal  0.899315  hitchhiker  0.000630655 
 
 
-
 
NC_007951  Bxe_A4482  AraC family transcriptional regulator  47.24 
 
 
401 aa  140  9e-33  Burkholderia xenovorans LB400  Bacteria  hitchhiker  0.00000000221745  unclonable  0.0000015212 
 
 
-
 
NC_010681  Bphyt_3955  transcriptional regulator, AraC family  46.91 
 
 
391 aa  139  1.9999999999999998e-32  Burkholderia phytofirmans PsJN  Bacteria  hitchhiker  0.0000156521  normal  0.830157 
 
 
-
 
NC_009767  Rcas_1325  methylated-DNA--protein-cysteine methyltransferase  44.44 
 
 
175 aa  139  1.9999999999999998e-32  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_010622  Bphy_3088  AraC family transcriptional regulator  46.91 
 
 
376 aa  138  3.9999999999999997e-32  Burkholderia phymatum STM815  Bacteria  hitchhiker  0.000000118536  hitchhiker  0.0000000000000798373 
 
 
-
 
NC_008390  Bamb_3205  AraC family transcriptional regulator  46.91 
 
 
380 aa  137  4.999999999999999e-32  Burkholderia ambifaria AMMD  Bacteria  hitchhiker  0.000040374  n/a   
 
 
-
 
NC_007651  BTH_I0085  ADA regulatory protein  46.01 
 
 
364 aa  137  7.999999999999999e-32  Burkholderia thailandensis E264  Bacteria  hitchhiker  0.000000000911419  n/a   
 
 
-
 
NC_008009  Acid345_1283  transcriptional regulator Ada / DNA-O6-methylguanine--protein-cysteine S-methyltransferase  42.5 
 
 
344 aa  136  1e-31  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  normal 
 
 
-
 
NC_010508  Bcenmc03_3171  AraC family transcriptional regulator  46.58 
 
 
363 aa  136  2e-31  Burkholderia cenocepacia MC0-3  Bacteria  hitchhiker  0.0000000719173  decreased coverage  0.000000135353 
 
 
-
 
NC_007434  BURPS1710b_0322  O6-methylguanine-DNA methyltransferase  46.3 
 
 
364 aa  133  9.999999999999999e-31  Burkholderia pseudomallei 1710b  Bacteria  unclonable  0.00000000161378  n/a   
 
 
-
 
NC_008048  Sala_2282  AraC family transcriptional regulator  45.12 
 
 
345 aa  133  9.999999999999999e-31  Sphingopyxis alaskensis RB2256  Bacteria  normal  normal 
 
 
-
 
NC_010551  BamMC406_3089  AraC family transcriptional regulator  45.68 
 
 
363 aa  132  1.9999999999999998e-30  Burkholderia ambifaria MC40-6  Bacteria  hitchhiker  0.000000381417  hitchhiker  0.0021619 
 
 
-
 
NC_014212  Mesil_0991  methylated-DNA/protein- cysteinemethyltransferase  43.83 
 
 
295 aa  132  1.9999999999999998e-30  Meiothermus silvanus DSM 9946  Bacteria  normal  0.275505  normal  0.265908 
 
 
-
 
NC_010084  Bmul_3145  AraC family transcriptional regulator  46.3 
 
 
365 aa  132  1.9999999999999998e-30  Burkholderia multivorans ATCC 17616  Bacteria  hitchhiker  0.0000000198948  unclonable  0.00000000000612342 
 
 
-
 
NC_007794  Saro_2396  transcriptional regulator Ada / DNA-O6-methylguanine--protein-cysteine S-methyltransferase  45.96 
 
 
343 aa  132  3e-30  Novosphingobium aromaticivorans DSM 12444  Bacteria  normal  n/a   
 
 
-
 
NC_009074  BURPS668_0116  regulatory protein ada (regulatory protein of adaptative response)  45.68 
 
 
364 aa  131  5e-30  Burkholderia pseudomallei 668  Bacteria  hitchhiker  0.00000000327978  n/a   
 
 
-
 
NC_006348  BMA0115  ADA regulatory protein  45.68 
 
 
364 aa  130  6.999999999999999e-30  Burkholderia mallei ATCC 23344  Bacteria  hitchhiker  0.0000393468  n/a   
 
 
-
 
NC_008785  BMASAVP1_A2836  ADA regulatory protein  45.68 
 
 
364 aa  130  6.999999999999999e-30  Burkholderia mallei SAVP1  Bacteria  hitchhiker  0.00000000000994394  n/a   
 
 
-
 
NC_009080  BMA10247_2323  ADA regulatory protein  45.68 
 
 
364 aa  130  6.999999999999999e-30  Burkholderia mallei NCTC 10247  Bacteria  decreased coverage  0.00000161007  n/a   
 
 
-
 
NC_009076  BURPS1106A_0132  ADA regulatory protein  45.68 
 
 
364 aa  130  6.999999999999999e-30  Burkholderia pseudomallei 1106a  Bacteria  normal  0.0622499  n/a   
 
 
-
 
NC_008836  BMA10229_A2249  ADA regulatory protein  45.68 
 
 
364 aa  130  6.999999999999999e-30  Burkholderia mallei NCTC 10229  Bacteria  hitchhiker  0.000000255362  n/a   
 
 
-
 
NC_009080  BMA10247_2300  regulatory protein ada (regulatory protein of adaptative response)  45.68 
 
 
364 aa  130  6.999999999999999e-30  Burkholderia mallei NCTC 10247  Bacteria  hitchhiker  0.000121844  n/a   
 
 
-
 
NC_009523  RoseRS_3679  methylated-DNA--protein-cysteine methyltransferase  47.24 
 
 
175 aa  130  6.999999999999999e-30  Roseiflexus sp. RS-1  Bacteria  normal  normal  0.0102541 
 
 
-
 
NC_011831  Cagg_2119  methylated-DNA/protein-cysteine methyltransferase  48.21 
 
 
172 aa  125  3e-28  Chloroflexus aggregans DSM 9485  Bacteria  normal  normal  0.025406 
 
 
-
 
NC_008740  Maqu_2956  methylated-DNA--protein-cysteine methyltransferase  43.79 
 
 
303 aa  125  3e-28  Marinobacter aquaeolei VT8  Bacteria  normal  n/a   
 
 
-
 
NC_014148  Plim_0950  methylated-DNA/protein-cysteine methyltransferase  41.21 
 
 
212 aa  123  1e-27  Planctomyces limnophilus DSM 3776  Bacteria  normal  0.267452  n/a   
 
 
-
 
NC_009511  Swit_0551  methylated-DNA--protein-cysteine methyltransferase  42.33 
 
 
169 aa  122  2e-27  Sphingomonas wittichii RW1  Bacteria  normal  normal 
 
 
-
 
NC_011769  DvMF_1950  transcriptional regulator, AraC family  46.58 
 
 
338 aa  121  4e-27  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal 
 
 
-
 
NC_011145  AnaeK_1031  methylated-DNA/protein-cysteine methyltransferase  47.85 
 
 
204 aa  109  2.0000000000000002e-23  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_007760  Adeh_0969  methylated-DNA--protein-cysteine methyltransferase  49.7 
 
 
193 aa  109  2.0000000000000002e-23  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_011891  A2cp1_1028  methylated-DNA/protein-cysteine methyltransferase  47.85 
 
 
204 aa  108  3e-23  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_010184  BcerKBAB4_3509  methylated-DNA--protein-cysteine methyltransferase  39.46 
 
 
176 aa  107  8.000000000000001e-23  Bacillus weihenstephanensis KBAB4  Bacteria  normal  0.0199748  n/a   
 
 
-
 
NC_011884  Cyan7425_4855  methylated-DNA/protein-cysteine methyltransferase  39.76 
 
 
207 aa  107  9.000000000000001e-23  Cyanothece sp. PCC 7425  Bacteria  normal  normal 
 
 
-
 
NC_011369  Rleg2_3439  methylated-DNA/protein-cysteine methyltransferase  39.52 
 
 
290 aa  106  1e-22  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal 
 
 
-
 
NC_003909  BCE_3773  methylated-DNA--protein-cysteine S-methyltransferase  39.46 
 
 
176 aa  105  2e-22  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
NC_007604  Synpcc7942_0149  methylated-DNA--protein-cysteine methyltransferase  41.86 
 
 
185 aa  106  2e-22  Synechococcus elongatus PCC 7942  Bacteria  normal  normal 
 
 
-
 
NC_012912  Dd1591_0948  transcriptional regulator, AraC family  35.85 
 
 
275 aa  105  4e-22  Dickeya zeae Ech1591  Bacteria  normal  n/a   
 
 
-
 
NC_008060  Bcen_2901  methylated-DNA--protein-cysteine methyltransferase  48.45 
 
 
104 aa  105  4e-22  Burkholderia cenocepacia AU 1054  Bacteria  normal  n/a   
 
 
-
 
NC_011772  BCG9842_B1458  methylated-DNA--protein-cysteine S-methyltransferase  40.58 
 
 
176 aa  104  6e-22  Bacillus cereus G9842  Bacteria  normal  hitchhiker  0.00000721585 
 
 
-
 
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