83 homologs were found in PanDaTox collection
for query gene Sros_8985 on replicon NC_013595
Organism: Streptosporangium roseum DSM 43021



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_013595  Sros_8985  5 10-methylenetetrahydrofolate reductase-like protein  100 
 
 
259 aa  524  1e-148  Streptosporangium roseum DSM 43021  Bacteria  normal  normal 
 
 
-
 
NC_009921  Franean1_6374  methylenetetrahydrofolate reductase  76.17 
 
 
257 aa  407  1e-113  Frankia sp. EAN1pec  Bacteria  normal  normal 
 
 
-
 
NC_007777  Francci3_2313  methylenetetrahydrofolate reductase  73.83 
 
 
257 aa  400  1e-111  Frankia sp. CcI3  Bacteria  normal  0.383678  normal  0.0348047 
 
 
-
 
NC_013131  Caci_1041  methylenetetrahydrofolate reductase  68.34 
 
 
259 aa  368  1e-101  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.569103  normal  0.0517108 
 
 
-
 
NC_009921  Franean1_1472  putative methylenetetrahydrofolate reductase  54.33 
 
 
91 aa  128  1.0000000000000001e-28  Frankia sp. EAN1pec  Bacteria  normal  normal 
 
 
-
 
NC_011899  Hore_19580  methylenetetrahydrofolate reductase  25.95 
 
 
309 aa  90.5  2e-17  Halothermothrix orenii H 168  Bacteria  normal  n/a   
 
 
-
 
NC_012034  Athe_0325  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.97 
 
 
605 aa  86.7  3e-16  Anaerocellum thermophilum DSM 6725  Bacteria  normal  n/a   
 
 
-
 
NC_007513  Syncc9902_0288  hypothetical protein  30.3 
 
 
297 aa  83.6  0.000000000000003  Synechococcus sp. CC9902  Bacteria  normal  n/a   
 
 
-
 
NC_009483  Gura_1171  methylenetetrahydrofolate reductase  29.41 
 
 
297 aa  83.2  0.000000000000004  Geobacter uraniireducens Rf4  Bacteria  normal  0.173306  n/a   
 
 
-
 
NC_010320  Teth514_1210  methylenetetrahydrofolate reductase  27.88 
 
 
303 aa  82.8  0.000000000000005  Thermoanaerobacter sp. X514  Bacteria  hitchhiker  0.000000116637  n/a   
 
 
-
 
NC_009943  Dole_0458  methylenetetrahydrofolate reductase  24.72 
 
 
321 aa  82.4  0.000000000000006  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_007516  Syncc9605_2405  hypothetical protein  28.79 
 
 
301 aa  81.6  0.00000000000001  Synechococcus sp. CC9605  Bacteria  normal  normal 
 
 
-
 
NC_011884  Cyan7425_1687  methylenetetrahydrofolate reductase  26.87 
 
 
312 aa  77  0.0000000000003  Cyanothece sp. PCC 7425  Bacteria  normal  normal  0.634042 
 
 
-
 
NC_007644  Moth_1191  methylenetetrahydrofolate reductase  25.36 
 
 
306 aa  77  0.0000000000003  Moorella thermoacetica ATCC 39073  Bacteria  normal  0.211578  normal 
 
 
-
 
NC_007355  Mbar_A2312  methylenetetrahydrofolate reductase  25.98 
 
 
292 aa  76.3  0.0000000000005  Methanosarcina barkeri str. Fusaro  Archaea  normal  normal 
 
 
-
 
NC_010424  Daud_0880  methylenetetrahydrofolate reductase  27.94 
 
 
314 aa  75.5  0.0000000000008  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  0.958062  n/a   
 
 
-
 
NC_009976  P9211_01691  methylenetetrahydrofolate reductase  25.38 
 
 
309 aa  73.9  0.000000000003  Prochlorococcus marinus str. MIT 9211  Bacteria  normal  normal 
 
 
-
 
NC_007955  Mbur_1847  methylenetetrahydrofolate reductase  25.89 
 
 
294 aa  72.4  0.000000000006  Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_009972  Haur_3632  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.36 
 
 
617 aa  71.2  0.00000000001  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_014248  Aazo_4669  methylenetetrahydrofolate reductase  24.63 
 
 
304 aa  69.7  0.00000000004  'Nostoc azollae' 0708  Bacteria  normal  n/a   
 
 
-
 
NC_013385  Adeg_0345  methylenetetrahydrofolate reductase  25.83 
 
 
312 aa  69.7  0.00000000004  Ammonifex degensii KC4  Bacteria  normal  0.997494  n/a   
 
 
-
 
NC_008819  NATL1_02251  methylenetetrahydrofolate reductase  25.56 
 
 
293 aa  68.6  0.00000000009  Prochlorococcus marinus str. NATL1A  Bacteria  normal  0.0232498  normal 
 
 
-
 
NC_013411  GYMC61_1524  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.19 
 
 
615 aa  67.4  0.0000000002  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_008312  Tery_4692  methylenetetrahydrofolate reductase  27.88 
 
 
296 aa  67.8  0.0000000002  Trichodesmium erythraeum IMS101  Bacteria  normal  0.575485  normal 
 
 
-
 
NC_013216  Dtox_1285  methylenetetrahydrofolate reductase  23 
 
 
314 aa  67.8  0.0000000002  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  normal  0.354589 
 
 
-
 
NC_008817  P9515_01811  methylenetetrahydrofolate reductase  25.51 
 
 
296 aa  67.8  0.0000000002  Prochlorococcus marinus str. MIT 9515  Bacteria  normal  n/a   
 
 
-
 
NC_011831  Cagg_1947  methylenetetrahydrofolate reductase  26.67 
 
 
307 aa  67  0.0000000003  Chloroflexus aggregans DSM 9485  Bacteria  normal  hitchhiker  0.00287398 
 
 
-
 
NC_007517  Gmet_1160  methylenetetrahydrofolate reductase  25.18 
 
 
299 aa  67  0.0000000003  Geobacter metallireducens GS-15  Bacteria  hitchhiker  0.0000209189  normal  0.0125682 
 
 
-
 
NC_009943  Dole_1151  methylenetetrahydrofolate reductase  22.68 
 
 
309 aa  67  0.0000000003  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_007335  PMN2A_1519  methylenetetrahydrofolate reductase  24.81 
 
 
293 aa  66.2  0.0000000005  Prochlorococcus marinus str. NATL2A  Bacteria  normal  n/a   
 
 
-
 
NC_009091  P9301_01721  methylenetetrahydrofolate reductase  23.55 
 
 
296 aa  65.9  0.0000000006  Prochlorococcus marinus str. MIT 9301  Bacteria  normal  n/a   
 
 
-
 
NC_007577  PMT9312_0155  methylenetetrahydrofolate reductase  23.97 
 
 
296 aa  65.9  0.0000000007  Prochlorococcus marinus str. MIT 9312  Bacteria  normal  n/a   
 
 
-
 
NC_007413  Ava_2992  methylenetetrahydrofolate reductase  24.63 
 
 
357 aa  65.9  0.0000000007  Anabaena variabilis ATCC 29413  Bacteria  normal  0.0109931  normal  0.735442 
 
 
-
 
NC_007604  Synpcc7942_1309  hypothetical protein  27.14 
 
 
310 aa  65.9  0.0000000007  Synechococcus elongatus PCC 7942  Bacteria  normal  0.401481  normal 
 
 
-
 
NC_009523  RoseRS_2032  methylenetetrahydrofolate reductase  22.93 
 
 
309 aa  64.7  0.000000001  Roseiflexus sp. RS-1  Bacteria  normal  normal  0.264771 
 
 
-
 
NC_008820  P9303_26821  methylenetetrahydrofolate reductase  27.65 
 
 
298 aa  64.3  0.000000002  Prochlorococcus marinus str. MIT 9303  Bacteria  n/a    normal 
 
 
-
 
NC_002939  GSU0860  methylenetetrahydrofolate reductase family protein  25.63 
 
 
301 aa  64.3  0.000000002  Geobacter sulfurreducens PCA  Bacteria  normal  0.0656354  n/a   
 
 
-
 
NC_009767  Rcas_3006  methylenetetrahydrofolate reductase  23.31 
 
 
309 aa  63.2  0.000000004  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_013161  Cyan8802_2074  methylenetetrahydrofolate reductase  25.55 
 
 
296 aa  63.2  0.000000004  Cyanothece sp. PCC 8802  Bacteria  hitchhiker  0.00402744  normal 
 
 
-
 
NC_011726  PCC8801_2050  methylenetetrahydrofolate reductase  25.55 
 
 
296 aa  62.8  0.000000005  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_011725  BCB4264_A4367  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.36 
 
 
610 aa  62.4  0.000000008  Bacillus cereus B4264  Bacteria  normal  n/a   
 
 
-
 
NC_011661  Dtur_1634  methylenetetrahydrofolate reductase  21.84 
 
 
288 aa  62  0.000000009  Dictyoglomus turgidum DSM 6724  Bacteria  normal  n/a   
 
 
-
 
NC_008816  A9601_01701  methylenetetrahydrofolate reductase  25.1 
 
 
296 aa  62  0.000000009  Prochlorococcus marinus str. AS9601  Bacteria  normal  0.982527  n/a   
 
 
-
 
NC_008554  Sfum_3130  methylenetetrahydrofolate reductase  20.79 
 
 
310 aa  61.2  0.00000001  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_013205  Aaci_1583  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.18 
 
 
637 aa  61.6  0.00000001  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_011772  BCG9842_B0867  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  60.8  0.00000002  Bacillus cereus G9842  Bacteria  normal  normal 
 
 
-
 
NC_005945  BAS4157  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  60.8  0.00000002  Bacillus anthracis str. Sterne  Bacteria  normal  n/a   
 
 
-
 
NC_005957  BT9727_3996  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  60.8  0.00000002  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  normal  n/a   
 
 
-
 
NC_006274  BCZK4006  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  60.8  0.00000002  Bacillus cereus E33L  Bacteria  normal  n/a   
 
 
-
 
NC_010184  BcerKBAB4_4109  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.36 
 
 
610 aa  60.5  0.00000002  Bacillus weihenstephanensis KBAB4  Bacteria  normal  n/a   
 
 
-
 
NC_007530  GBAA_4479  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  60.8  0.00000002  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  normal  n/a   
 
 
-
 
NC_010424  Daud_0117  methylenetetrahydrofolate reductase  26.01 
 
 
306 aa  60.1  0.00000003  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  n/a   
 
 
-
 
NC_003909  BCE_4333  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  60.5  0.00000003  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
NC_011773  BCAH820_4275  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.99 
 
 
610 aa  59.3  0.00000005  Bacillus cereus AH820  Bacteria  n/a    normal 
 
 
-
 
NC_011658  BCAH187_A4386  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.63 
 
 
610 aa  59.3  0.00000007  Bacillus cereus AH187  Bacteria  normal  n/a   
 
 
-
 
NC_009483  Gura_0708  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.99 
 
 
604 aa  58.5  0.00000009  Geobacter uraniireducens Rf4  Bacteria  normal  0.537957  n/a   
 
 
-
 
NC_012918  GM21_0627  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.22 
 
 
610 aa  58.5  0.0000001  Geobacter sp. M21  Bacteria  n/a    unclonable  1.07944e-34 
 
 
-
 
NC_012793  GWCH70_0708  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.44 
 
 
616 aa  58.5  0.0000001  Geobacillus sp. WCH70  Bacteria  normal  0.0266464  n/a   
 
 
-
 
NC_009636  Smed_1783  methylenetetrahydrofolate reductase  24.64 
 
 
367 aa  58.5  0.0000001  Sinorhizobium medicae WSM419  Bacteria  normal  0.182207  hitchhiker  0.00669682 
 
 
-
 
NC_007517  Gmet_0504  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.58 
 
 
605 aa  58.5  0.0000001  Geobacter metallireducens GS-15  Bacteria  normal  0.0120544  normal 
 
 
-
 
NC_004116  SAG2048  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.02 
 
 
614 aa  57.8  0.0000002  Streptococcus agalactiae 2603V/R  Bacteria  normal  n/a   
 
 
-
 
NC_011146  Gbem_0613  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.25 
 
 
610 aa  56.6  0.0000003  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_010483  TRQ2_0678  methylenetetrahydrofolate reductase  22.41 
 
 
281 aa  55.1  0.000001  Thermotoga sp. RQ2  Bacteria  normal  0.431353  n/a   
 
 
-
 
NC_013440  Hoch_4784  homocysteine S-methyltransferase  25.75 
 
 
643 aa  54.7  0.000001  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_011729  PCC7424_0350  methylenetetrahydrofolate reductase  23.27 
 
 
300 aa  54.3  0.000002  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_002976  SERP0035  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.94 
 
 
612 aa  54.3  0.000002  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_008609  Ppro_0283  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.97 
 
 
615 aa  52.4  0.000006  Pelobacter propionicus DSM 2379  Bacteria  normal  n/a   
 
 
-
 
NC_013525  Tter_1187  homocysteine S-methyltransferase  23.16 
 
 
629 aa  52.4  0.000007  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_009674  Bcer98_2984  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.55 
 
 
614 aa  52  0.00001  Bacillus cytotoxicus NVH 391-98  Bacteria  normal  n/a   
 
 
-
 
NC_007498  Pcar_0238  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.56 
 
 
609 aa  51.6  0.00001  Pelobacter carbinolicus DSM 2380  Bacteria  normal  n/a   
 
 
-
 
NC_008009  Acid345_3426  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.64 
 
 
617 aa  50.4  0.00002  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  0.41819  normal 
 
 
-
 
NC_009487  SaurJH9_0405  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  20.59 
 
 
613 aa  50.8  0.00002  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  n/a   
 
 
-
 
NC_009632  SaurJH1_0415  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  20.59 
 
 
613 aa  50.8  0.00002  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  n/a   
 
 
-
 
NC_009486  Tpet_0654  methylenetetrahydrofolate reductase  21.37 
 
 
281 aa  50.4  0.00003  Thermotoga petrophila RKU-1  Bacteria  normal  0.495611  n/a   
 
 
-
 
NC_002939  GSU2974  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.4 
 
 
605 aa  49.3  0.00006  Geobacter sulfurreducens PCA  Bacteria  normal  n/a   
 
 
-
 
NC_008578  Acel_0991  5,10-methylenetetrahydrofolate reductase  30.2 
 
 
331 aa  45.4  0.0008  Acidothermus cellulolyticus 11B  Bacteria  normal  0.232217  normal 
 
 
-
 
NC_009253  Dred_1750  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  21.72 
 
 
598 aa  45.4  0.0008  Desulfotomaculum reducens MI-1  Bacteria  normal  n/a   
 
 
-
 
NC_013173  Dbac_0626  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.16 
 
 
599 aa  45.1  0.001  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.490063  n/a   
 
 
-
 
NC_006670  CNA07390  methylenetetrahydrofolate reductase (NADPH), putative  24.38 
 
 
633 aa  44.7  0.002  Cryptococcus neoformans var. neoformans JEC21  Eukaryota  normal  0.497264  n/a   
 
 
-
 
NC_009707  JJD26997_0527  5,10-methylenetetrahydrofolate reductase  20.92 
 
 
282 aa  43.9  0.002  Campylobacter jejuni subsp. doylei 269.97  Bacteria  normal  n/a   
 
 
-
 
NC_008701  Pisl_1726  hypothetical protein  24.37 
 
 
225 aa  43.9  0.003  Pyrobaculum islandicum DSM 4184  Archaea  normal  normal 
 
 
-
 
NC_013947  Snas_5027  5,10-methylenetetrahydrofolate reductase  26.85 
 
 
298 aa  43.5  0.004  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.641097  normal  0.199479 
 
 
-
 
NC_014150  Bmur_0112  methylenetetrahydrofolate reductase  23.53 
 
 
306 aa  42.7  0.005  Brachyspira murdochii DSM 12563  Bacteria  normal  n/a   
 
 
-
 
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