80 homologs were found in PanDaTox collection
for query gene Franean1_6374 on replicon NC_009921
Organism: Frankia sp. EAN1pec



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_009921  Franean1_6374  methylenetetrahydrofolate reductase  100 
 
 
257 aa  514  1.0000000000000001e-145  Frankia sp. EAN1pec  Bacteria  normal  normal 
 
 
-
 
NC_007777  Francci3_2313  methylenetetrahydrofolate reductase  96.5 
 
 
257 aa  503  1e-141  Frankia sp. CcI3  Bacteria  normal  0.383678  normal  0.0348047 
 
 
-
 
NC_013595  Sros_8985  5 10-methylenetetrahydrofolate reductase-like protein  76.17 
 
 
259 aa  407  1e-113  Streptosporangium roseum DSM 43021  Bacteria  normal  normal 
 
 
-
 
NC_013131  Caci_1041  methylenetetrahydrofolate reductase  71.65 
 
 
259 aa  382  1e-105  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.569103  normal  0.0517108 
 
 
-
 
NC_009921  Franean1_1472  putative methylenetetrahydrofolate reductase  67.97 
 
 
91 aa  158  8e-38  Frankia sp. EAN1pec  Bacteria  normal  normal 
 
 
-
 
NC_007644  Moth_1191  methylenetetrahydrofolate reductase  28.2 
 
 
306 aa  94.7  1e-18  Moorella thermoacetica ATCC 39073  Bacteria  normal  0.211578  normal 
 
 
-
 
NC_007955  Mbur_1847  methylenetetrahydrofolate reductase  27.6 
 
 
294 aa  90.1  3e-17  Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_011899  Hore_19580  methylenetetrahydrofolate reductase  24.48 
 
 
309 aa  88.2  1e-16  Halothermothrix orenii H 168  Bacteria  normal  n/a   
 
 
-
 
NC_009943  Dole_0458  methylenetetrahydrofolate reductase  26.26 
 
 
321 aa  85.5  7e-16  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_008554  Sfum_3130  methylenetetrahydrofolate reductase  24.57 
 
 
310 aa  82.4  0.000000000000007  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_007355  Mbar_A2312  methylenetetrahydrofolate reductase  25.27 
 
 
292 aa  80.5  0.00000000000002  Methanosarcina barkeri str. Fusaro  Archaea  normal  normal 
 
 
-
 
NC_010320  Teth514_1210  methylenetetrahydrofolate reductase  26.69 
 
 
303 aa  80.5  0.00000000000002  Thermoanaerobacter sp. X514  Bacteria  hitchhiker  0.000000116637  n/a   
 
 
-
 
NC_012034  Athe_0325  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.45 
 
 
605 aa  80.1  0.00000000000003  Anaerocellum thermophilum DSM 6725  Bacteria  normal  n/a   
 
 
-
 
NC_010424  Daud_0880  methylenetetrahydrofolate reductase  29.41 
 
 
314 aa  80.5  0.00000000000003  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  0.958062  n/a   
 
 
-
 
NC_009943  Dole_1151  methylenetetrahydrofolate reductase  26.28 
 
 
309 aa  80.1  0.00000000000004  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_009483  Gura_1171  methylenetetrahydrofolate reductase  30.43 
 
 
297 aa  76.6  0.0000000000004  Geobacter uraniireducens Rf4  Bacteria  normal  0.173306  n/a   
 
 
-
 
NC_013216  Dtox_1285  methylenetetrahydrofolate reductase  25.35 
 
 
314 aa  73.9  0.000000000002  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  normal  0.354589 
 
 
-
 
NC_013385  Adeg_0345  methylenetetrahydrofolate reductase  25.83 
 
 
312 aa  73.6  0.000000000003  Ammonifex degensii KC4  Bacteria  normal  0.997494  n/a   
 
 
-
 
NC_007516  Syncc9605_2405  hypothetical protein  29.06 
 
 
301 aa  71.6  0.00000000001  Synechococcus sp. CC9605  Bacteria  normal  normal 
 
 
-
 
NC_011884  Cyan7425_1687  methylenetetrahydrofolate reductase  26.2 
 
 
312 aa  70.5  0.00000000002  Cyanothece sp. PCC 7425  Bacteria  normal  normal  0.634042 
 
 
-
 
NC_009976  P9211_01691  methylenetetrahydrofolate reductase  26.22 
 
 
309 aa  69.7  0.00000000004  Prochlorococcus marinus str. MIT 9211  Bacteria  normal  normal 
 
 
-
 
NC_007513  Syncc9902_0288  hypothetical protein  29.06 
 
 
297 aa  68.9  0.00000000008  Synechococcus sp. CC9902  Bacteria  normal  n/a   
 
 
-
 
NC_010424  Daud_0117  methylenetetrahydrofolate reductase  27.61 
 
 
306 aa  68.2  0.0000000001  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  n/a   
 
 
-
 
NC_008819  NATL1_02251  methylenetetrahydrofolate reductase  26.22 
 
 
293 aa  67.8  0.0000000002  Prochlorococcus marinus str. NATL1A  Bacteria  normal  0.0232498  normal 
 
 
-
 
NC_007517  Gmet_1160  methylenetetrahydrofolate reductase  26.09 
 
 
299 aa  67.4  0.0000000002  Geobacter metallireducens GS-15  Bacteria  hitchhiker  0.0000209189  normal  0.0125682 
 
 
-
 
NC_011831  Cagg_1947  methylenetetrahydrofolate reductase  26.94 
 
 
307 aa  67.8  0.0000000002  Chloroflexus aggregans DSM 9485  Bacteria  normal  hitchhiker  0.00287398 
 
 
-
 
NC_008312  Tery_4692  methylenetetrahydrofolate reductase  26.02 
 
 
296 aa  65.5  0.0000000007  Trichodesmium erythraeum IMS101  Bacteria  normal  0.575485  normal 
 
 
-
 
NC_011661  Dtur_1634  methylenetetrahydrofolate reductase  22.22 
 
 
288 aa  65.1  0.000000001  Dictyoglomus turgidum DSM 6724  Bacteria  normal  n/a   
 
 
-
 
NC_009523  RoseRS_2032  methylenetetrahydrofolate reductase  26.24 
 
 
309 aa  65.1  0.000000001  Roseiflexus sp. RS-1  Bacteria  normal  normal  0.264771 
 
 
-
 
NC_009767  Rcas_3006  methylenetetrahydrofolate reductase  25.63 
 
 
309 aa  63.9  0.000000002  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_009636  Smed_1783  methylenetetrahydrofolate reductase  25.55 
 
 
367 aa  63.5  0.000000003  Sinorhizobium medicae WSM419  Bacteria  normal  0.182207  hitchhiker  0.00669682 
 
 
-
 
NC_002939  GSU0860  methylenetetrahydrofolate reductase family protein  26.67 
 
 
301 aa  62.8  0.000000005  Geobacter sulfurreducens PCA  Bacteria  normal  0.0656354  n/a   
 
 
-
 
NC_014248  Aazo_4669  methylenetetrahydrofolate reductase  24.91 
 
 
304 aa  62  0.000000009  'Nostoc azollae' 0708  Bacteria  normal  n/a   
 
 
-
 
NC_007335  PMN2A_1519  methylenetetrahydrofolate reductase  25.09 
 
 
293 aa  61.6  0.00000001  Prochlorococcus marinus str. NATL2A  Bacteria  normal  n/a   
 
 
-
 
NC_013411  GYMC61_1524  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.45 
 
 
615 aa  60.5  0.00000002  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_009972  Haur_3632  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.91 
 
 
617 aa  60.8  0.00000002  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_010483  TRQ2_0678  methylenetetrahydrofolate reductase  22.32 
 
 
281 aa  59.7  0.00000004  Thermotoga sp. RQ2  Bacteria  normal  0.431353  n/a   
 
 
-
 
NC_008817  P9515_01811  methylenetetrahydrofolate reductase  22.71 
 
 
296 aa  59.3  0.00000007  Prochlorococcus marinus str. MIT 9515  Bacteria  normal  n/a   
 
 
-
 
NC_002976  SERP0035  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.2 
 
 
612 aa  58.5  0.0000001  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_007413  Ava_2992  methylenetetrahydrofolate reductase  25.37 
 
 
357 aa  57.4  0.0000002  Anabaena variabilis ATCC 29413  Bacteria  normal  0.0109931  normal  0.735442 
 
 
-
 
NC_008820  P9303_26821  methylenetetrahydrofolate reductase  27.55 
 
 
298 aa  56.2  0.0000005  Prochlorococcus marinus str. MIT 9303  Bacteria  n/a    normal 
 
 
-
 
NC_009486  Tpet_0654  methylenetetrahydrofolate reductase  21.5 
 
 
281 aa  55.8  0.0000006  Thermotoga petrophila RKU-1  Bacteria  normal  0.495611  n/a   
 
 
-
 
NC_009483  Gura_0708  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.36 
 
 
604 aa  55.8  0.0000007  Geobacter uraniireducens Rf4  Bacteria  normal  0.537957  n/a   
 
 
-
 
NC_008816  A9601_01701  methylenetetrahydrofolate reductase  23.66 
 
 
296 aa  55.8  0.0000007  Prochlorococcus marinus str. AS9601  Bacteria  normal  0.982527  n/a   
 
 
-
 
NC_009091  P9301_01721  methylenetetrahydrofolate reductase  22.03 
 
 
296 aa  55.5  0.0000009  Prochlorococcus marinus str. MIT 9301  Bacteria  normal  n/a   
 
 
-
 
NC_007517  Gmet_0504  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.55 
 
 
605 aa  55.5  0.0000009  Geobacter metallireducens GS-15  Bacteria  normal  0.0120544  normal 
 
 
-
 
NC_013205  Aaci_1583  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.56 
 
 
637 aa  55.5  0.0000009  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_009632  SaurJH1_0415  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.83 
 
 
613 aa  55.1  0.000001  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  n/a   
 
 
-
 
NC_009487  SaurJH9_0405  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.83 
 
 
613 aa  55.1  0.000001  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  n/a   
 
 
-
 
NC_013440  Hoch_4784  homocysteine S-methyltransferase  27.38 
 
 
643 aa  53.9  0.000002  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_013525  Tter_1187  homocysteine S-methyltransferase  25.61 
 
 
629 aa  54.7  0.000002  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_010184  BcerKBAB4_4109  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.08 
 
 
610 aa  54.7  0.000002  Bacillus weihenstephanensis KBAB4  Bacteria  normal  n/a   
 
 
-
 
NC_012918  GM21_0627  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  27.23 
 
 
610 aa  53.5  0.000003  Geobacter sp. M21  Bacteria  n/a    unclonable  1.07944e-34 
 
 
-
 
NC_011725  BCB4264_A4367  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.95 
 
 
610 aa  53.1  0.000005  Bacillus cereus B4264  Bacteria  normal  n/a   
 
 
-
 
NC_013161  Cyan8802_2074  methylenetetrahydrofolate reductase  24.91 
 
 
296 aa  52.8  0.000005  Cyanothece sp. PCC 8802  Bacteria  hitchhiker  0.00402744  normal 
 
 
-
 
NC_004116  SAG2048  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.44 
 
 
614 aa  52.8  0.000006  Streptococcus agalactiae 2603V/R  Bacteria  normal  n/a   
 
 
-
 
NC_011726  PCC8801_2050  methylenetetrahydrofolate reductase  24.91 
 
 
296 aa  52.4  0.000007  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_011729  PCC7424_0350  methylenetetrahydrofolate reductase  26.34 
 
 
300 aa  52.4  0.000007  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_011772  BCG9842_B0867  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  52.4  0.000007  Bacillus cereus G9842  Bacteria  normal  normal 
 
 
-
 
NC_011146  Gbem_0613  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  27.23 
 
 
610 aa  52.4  0.000008  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_013173  Dbac_0626  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.97 
 
 
599 aa  51.6  0.00001  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.490063  n/a   
 
 
-
 
NC_008609  Ppro_0283  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.36 
 
 
615 aa  51.2  0.00001  Pelobacter propionicus DSM 2379  Bacteria  normal  n/a   
 
 
-
 
NC_007498  Pcar_0238  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  28.36 
 
 
609 aa  50.8  0.00002  Pelobacter carbinolicus DSM 2380  Bacteria  normal  n/a   
 
 
-
 
NC_012793  GWCH70_0708  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.56 
 
 
616 aa  51.2  0.00002  Geobacillus sp. WCH70  Bacteria  normal  0.0266464  n/a   
 
 
-
 
NC_007577  PMT9312_0155  methylenetetrahydrofolate reductase  20.94 
 
 
296 aa  50.8  0.00002  Prochlorococcus marinus str. MIT 9312  Bacteria  normal  n/a   
 
 
-
 
NC_009674  Bcer98_2984  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.59 
 
 
614 aa  50.4  0.00003  Bacillus cytotoxicus NVH 391-98  Bacteria  normal  n/a   
 
 
-
 
NC_006670  CNA07390  methylenetetrahydrofolate reductase (NADPH), putative  26 
 
 
633 aa  50.4  0.00003  Cryptococcus neoformans var. neoformans JEC21  Eukaryota  normal  0.497264  n/a   
 
 
-
 
NC_011773  BCAH820_4275  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  50.1  0.00004  Bacillus cereus AH820  Bacteria  n/a    normal 
 
 
-
 
NC_008009  Acid345_3426  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  33.02 
 
 
617 aa  50.1  0.00004  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  0.41819  normal 
 
 
-
 
NC_007604  Synpcc7942_1309  hypothetical protein  24.91 
 
 
310 aa  50.1  0.00004  Synechococcus elongatus PCC 7942  Bacteria  normal  0.401481  normal 
 
 
-
 
NC_007530  GBAA_4479  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  50.1  0.00004  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  normal  n/a   
 
 
-
 
NC_006274  BCZK4006  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  50.1  0.00004  Bacillus cereus E33L  Bacteria  normal  n/a   
 
 
-
 
NC_005957  BT9727_3996  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  50.1  0.00004  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  normal  n/a   
 
 
-
 
NC_005945  BAS4157  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  50.1  0.00004  Bacillus anthracis str. Sterne  Bacteria  normal  n/a   
 
 
-
 
NC_003909  BCE_4333  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.86 
 
 
610 aa  49.7  0.00005  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
NC_002939  GSU2974  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  27.72 
 
 
605 aa  48.9  0.00007  Geobacter sulfurreducens PCA  Bacteria  normal  n/a   
 
 
-
 
NC_011658  BCAH187_A4386  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.45 
 
 
610 aa  48.1  0.0001  Bacillus cereus AH187  Bacteria  normal  n/a   
 
 
-
 
NC_011898  Ccel_2474  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  21.07 
 
 
615 aa  45.8  0.0008  Clostridium cellulolyticum H10  Bacteria  normal  n/a   
 
 
-
 
NC_014150  Bmur_0112  methylenetetrahydrofolate reductase  20.34 
 
 
306 aa  45.1  0.001  Brachyspira murdochii DSM 12563  Bacteria  normal  n/a   
 
 
-
 
NC_008701  Pisl_1726  hypothetical protein  26.72 
 
 
225 aa  43.5  0.003  Pyrobaculum islandicum DSM 4184  Archaea  normal  normal 
 
 
-
 
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