92 homologs were found in PanDaTox collection
for query gene Fnod_1578 on replicon NC_009718
Organism: Fervidobacterium nodosum Rt17-B1



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_009718  Fnod_1578  methylenetetrahydrofolate reductase  100 
 
 
293 aa  597  1e-170  Fervidobacterium nodosum Rt17-B1  Bacteria  normal  n/a   
 
 
-
 
NC_009486  Tpet_0654  methylenetetrahydrofolate reductase  43.77 
 
 
281 aa  240  2e-62  Thermotoga petrophila RKU-1  Bacteria  normal  0.495611  n/a   
 
 
-
 
NC_010483  TRQ2_0678  methylenetetrahydrofolate reductase  44.33 
 
 
281 aa  237  2e-61  Thermotoga sp. RQ2  Bacteria  normal  0.431353  n/a   
 
 
-
 
NC_013525  Tter_1187  homocysteine S-methyltransferase  30.94 
 
 
629 aa  127  3e-28  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_012034  Athe_0325  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  30.04 
 
 
605 aa  126  4.0000000000000003e-28  Anaerocellum thermophilum DSM 6725  Bacteria  normal  n/a   
 
 
-
 
NC_008148  Rxyl_0843  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  28.36 
 
 
611 aa  116  3.9999999999999997e-25  Rubrobacter xylanophilus DSM 9941  Bacteria  normal  n/a   
 
 
-
 
NC_010184  BcerKBAB4_4109  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.98 
 
 
610 aa  116  5e-25  Bacillus weihenstephanensis KBAB4  Bacteria  normal  n/a   
 
 
-
 
NC_013205  Aaci_1583  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  28.57 
 
 
637 aa  115  1.0000000000000001e-24  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_011772  BCG9842_B0867  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.62 
 
 
610 aa  115  1.0000000000000001e-24  Bacillus cereus G9842  Bacteria  normal  normal 
 
 
-
 
NC_011725  BCB4264_A4367  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.98 
 
 
610 aa  115  1.0000000000000001e-24  Bacillus cereus B4264  Bacteria  normal  n/a   
 
 
-
 
NC_006274  BCZK4006  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  5e-24  Bacillus cereus E33L  Bacteria  normal  n/a   
 
 
-
 
NC_005957  BT9727_3996  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  5e-24  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  normal  n/a   
 
 
-
 
NC_005945  BAS4157  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  5e-24  Bacillus anthracis str. Sterne  Bacteria  normal  n/a   
 
 
-
 
NC_007530  GBAA_4479  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  5e-24  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  normal  n/a   
 
 
-
 
NC_009674  Bcer98_2984  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.91 
 
 
614 aa  112  5e-24  Bacillus cytotoxicus NVH 391-98  Bacteria  normal  n/a   
 
 
-
 
NC_011773  BCAH820_4275  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  6e-24  Bacillus cereus AH820  Bacteria  n/a    normal 
 
 
-
 
NC_011658  BCAH187_A4386  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  7.000000000000001e-24  Bacillus cereus AH187  Bacteria  normal  n/a   
 
 
-
 
NC_003909  BCE_4333  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.27 
 
 
610 aa  112  7.000000000000001e-24  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
NC_013411  GYMC61_1524  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  27.51 
 
 
615 aa  112  8.000000000000001e-24  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_010320  Teth514_1210  methylenetetrahydrofolate reductase  26.46 
 
 
303 aa  110  4.0000000000000004e-23  Thermoanaerobacter sp. X514  Bacteria  hitchhiker  0.000000116637  n/a   
 
 
-
 
NC_008009  Acid345_3426  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25 
 
 
617 aa  110  4.0000000000000004e-23  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  0.41819  normal 
 
 
-
 
NC_013440  Hoch_4784  homocysteine S-methyltransferase  29.2 
 
 
643 aa  108  7.000000000000001e-23  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_007498  Pcar_0238  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.37 
 
 
609 aa  108  7.000000000000001e-23  Pelobacter carbinolicus DSM 2380  Bacteria  normal  n/a   
 
 
-
 
NC_012793  GWCH70_0708  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  27 
 
 
616 aa  108  8.000000000000001e-23  Geobacillus sp. WCH70  Bacteria  normal  0.0266464  n/a   
 
 
-
 
NC_002939  GSU2974  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  26.62 
 
 
605 aa  102  5e-21  Geobacter sulfurreducens PCA  Bacteria  normal  n/a   
 
 
-
 
NC_009972  Haur_3632  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.82 
 
 
617 aa  100  2e-20  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_008609  Ppro_0283  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.79 
 
 
615 aa  96.7  4e-19  Pelobacter propionicus DSM 2379  Bacteria  normal  n/a   
 
 
-
 
NC_011899  Hore_19580  methylenetetrahydrofolate reductase  26.71 
 
 
309 aa  96.3  5e-19  Halothermothrix orenii H 168  Bacteria  normal  n/a   
 
 
-
 
NC_011661  Dtur_1634  methylenetetrahydrofolate reductase  27.11 
 
 
288 aa  95.9  7e-19  Dictyoglomus turgidum DSM 6724  Bacteria  normal  n/a   
 
 
-
 
NC_009943  Dole_0458  methylenetetrahydrofolate reductase  26.75 
 
 
321 aa  95.5  8e-19  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_007516  Syncc9605_2405  hypothetical protein  23.65 
 
 
301 aa  94.4  2e-18  Synechococcus sp. CC9605  Bacteria  normal  normal 
 
 
-
 
NC_007517  Gmet_0504  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.18 
 
 
605 aa  93.6  3e-18  Geobacter metallireducens GS-15  Bacteria  normal  0.0120544  normal 
 
 
-
 
NC_011831  Cagg_1947  methylenetetrahydrofolate reductase  25.11 
 
 
307 aa  92  1e-17  Chloroflexus aggregans DSM 9485  Bacteria  normal  hitchhiker  0.00287398 
 
 
-
 
NC_009632  SaurJH1_0415  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.44 
 
 
613 aa  91.7  1e-17  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  n/a   
 
 
-
 
NC_009487  SaurJH9_0405  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.44 
 
 
613 aa  91.7  1e-17  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  n/a   
 
 
-
 
NC_013216  Dtox_1285  methylenetetrahydrofolate reductase  25.55 
 
 
314 aa  91.7  1e-17  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  normal  0.354589 
 
 
-
 
NC_002976  SERP0035  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.34 
 
 
612 aa  90.9  2e-17  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_007513  Syncc9902_0288  hypothetical protein  24.04 
 
 
297 aa  90.5  3e-17  Synechococcus sp. CC9902  Bacteria  normal  n/a   
 
 
-
 
NC_009976  P9211_01691  methylenetetrahydrofolate reductase  26.41 
 
 
309 aa  89.7  5e-17  Prochlorococcus marinus str. MIT 9211  Bacteria  normal  normal 
 
 
-
 
NC_009483  Gura_0708  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.17 
 
 
604 aa  89.4  6e-17  Geobacter uraniireducens Rf4  Bacteria  normal  0.537957  n/a   
 
 
-
 
NC_012918  GM21_0627  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25.18 
 
 
610 aa  89  1e-16  Geobacter sp. M21  Bacteria  n/a    unclonable  1.07944e-34 
 
 
-
 
NC_009483  Gura_1171  methylenetetrahydrofolate reductase  27.08 
 
 
297 aa  88.2  1e-16  Geobacter uraniireducens Rf4  Bacteria  normal  0.173306  n/a   
 
 
-
 
NC_009523  RoseRS_2032  methylenetetrahydrofolate reductase  24.79 
 
 
309 aa  88.6  1e-16  Roseiflexus sp. RS-1  Bacteria  normal  normal  0.264771 
 
 
-
 
NC_009767  Rcas_3006  methylenetetrahydrofolate reductase  24.79 
 
 
309 aa  88.6  1e-16  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal 
 
 
-
 
NC_010424  Daud_0880  methylenetetrahydrofolate reductase  27.63 
 
 
314 aa  86.3  5e-16  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  0.958062  n/a   
 
 
-
 
NC_011146  Gbem_0613  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.46 
 
 
610 aa  86.3  6e-16  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_007517  Gmet_1160  methylenetetrahydrofolate reductase  27.9 
 
 
299 aa  85.9  8e-16  Geobacter metallireducens GS-15  Bacteria  hitchhiker  0.0000209189  normal  0.0125682 
 
 
-
 
NC_013385  Adeg_0345  methylenetetrahydrofolate reductase  26.4 
 
 
312 aa  85.1  0.000000000000001  Ammonifex degensii KC4  Bacteria  normal  0.997494  n/a   
 
 
-
 
NC_008820  P9303_26821  methylenetetrahydrofolate reductase  23.9 
 
 
298 aa  84.7  0.000000000000002  Prochlorococcus marinus str. MIT 9303  Bacteria  n/a    normal 
 
 
-
 
NC_007577  PMT9312_0155  methylenetetrahydrofolate reductase  24.49 
 
 
296 aa  84.7  0.000000000000002  Prochlorococcus marinus str. MIT 9312  Bacteria  normal  n/a   
 
 
-
 
NC_014248  Aazo_4669  methylenetetrahydrofolate reductase  25 
 
 
304 aa  84  0.000000000000003  'Nostoc azollae' 0708  Bacteria  normal  n/a   
 
 
-
 
NC_009091  P9301_01721  methylenetetrahydrofolate reductase  22.82 
 
 
296 aa  83.2  0.000000000000004  Prochlorococcus marinus str. MIT 9301  Bacteria  normal  n/a   
 
 
-
 
NC_007413  Ava_2992  methylenetetrahydrofolate reductase  23.66 
 
 
357 aa  83.2  0.000000000000005  Anabaena variabilis ATCC 29413  Bacteria  normal  0.0109931  normal  0.735442 
 
 
-
 
NC_008817  P9515_01811  methylenetetrahydrofolate reductase  23.58 
 
 
296 aa  81.6  0.00000000000001  Prochlorococcus marinus str. MIT 9515  Bacteria  normal  n/a   
 
 
-
 
NC_013161  Cyan8802_2074  methylenetetrahydrofolate reductase  25.1 
 
 
296 aa  80.9  0.00000000000002  Cyanothece sp. PCC 8802  Bacteria  hitchhiker  0.00402744  normal 
 
 
-
 
NC_007335  PMN2A_1519  methylenetetrahydrofolate reductase  23.79 
 
 
293 aa  81.3  0.00000000000002  Prochlorococcus marinus str. NATL2A  Bacteria  normal  n/a   
 
 
-
 
NC_007355  Mbar_A2312  methylenetetrahydrofolate reductase  25.22 
 
 
292 aa  81.3  0.00000000000002  Methanosarcina barkeri str. Fusaro  Archaea  normal  normal 
 
 
-
 
NC_008819  NATL1_02251  methylenetetrahydrofolate reductase  23.79 
 
 
293 aa  80.9  0.00000000000002  Prochlorococcus marinus str. NATL1A  Bacteria  normal  0.0232498  normal 
 
 
-
 
NC_008816  A9601_01701  methylenetetrahydrofolate reductase  23.67 
 
 
296 aa  81.3  0.00000000000002  Prochlorococcus marinus str. AS9601  Bacteria  normal  0.982527  n/a   
 
 
-
 
NC_007644  Moth_1191  methylenetetrahydrofolate reductase  25.7 
 
 
306 aa  80.5  0.00000000000003  Moorella thermoacetica ATCC 39073  Bacteria  normal  0.211578  normal 
 
 
-
 
NC_004116  SAG2048  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  22.06 
 
 
614 aa  80.9  0.00000000000003  Streptococcus agalactiae 2603V/R  Bacteria  normal  n/a   
 
 
-
 
NC_011726  PCC8801_2050  methylenetetrahydrofolate reductase  25.1 
 
 
296 aa  80.5  0.00000000000003  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_011729  PCC7424_0350  methylenetetrahydrofolate reductase  24.38 
 
 
300 aa  78.6  0.0000000000001  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_013173  Dbac_0626  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  23.14 
 
 
599 aa  78.2  0.0000000000001  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.490063  n/a   
 
 
-
 
NC_011898  Ccel_2474  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  25 
 
 
615 aa  77.8  0.0000000000002  Clostridium cellulolyticum H10  Bacteria  normal  n/a   
 
 
-
 
NC_002939  GSU0860  methylenetetrahydrofolate reductase family protein  25.65 
 
 
301 aa  77  0.0000000000003  Geobacter sulfurreducens PCA  Bacteria  normal  0.0656354  n/a   
 
 
-
 
NC_007955  Mbur_1847  methylenetetrahydrofolate reductase  23.95 
 
 
294 aa  76.6  0.0000000000004  Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_010424  Daud_0117  methylenetetrahydrofolate reductase  26.13 
 
 
306 aa  76.6  0.0000000000005  Candidatus Desulforudis audaxviator MP104C  Bacteria  normal  n/a   
 
 
-
 
NC_009943  Dole_1151  methylenetetrahydrofolate reductase  23.88 
 
 
309 aa  76.3  0.0000000000006  Desulfococcus oleovorans Hxd3  Bacteria  normal  n/a   
 
 
-
 
NC_009636  Smed_1783  methylenetetrahydrofolate reductase  25 
 
 
367 aa  75.9  0.0000000000008  Sinorhizobium medicae WSM419  Bacteria  normal  0.182207  hitchhiker  0.00669682 
 
 
-
 
NC_007604  Synpcc7942_1309  hypothetical protein  24.12 
 
 
310 aa  75.1  0.000000000001  Synechococcus elongatus PCC 7942  Bacteria  normal  0.401481  normal 
 
 
-
 
NC_008554  Sfum_3130  methylenetetrahydrofolate reductase  24.89 
 
 
310 aa  72.8  0.000000000006  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  normal 
 
 
-
 
NC_008312  Tery_4692  methylenetetrahydrofolate reductase  23.25 
 
 
296 aa  69.3  0.00000000008  Trichodesmium erythraeum IMS101  Bacteria  normal  0.575485  normal 
 
 
-
 
NC_011884  Cyan7425_1687  methylenetetrahydrofolate reductase  22.17 
 
 
312 aa  66.6  0.0000000005  Cyanothece sp. PCC 7425  Bacteria  normal  normal  0.634042 
 
 
-
 
NC_009253  Dred_1750  bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein  24.11 
 
 
598 aa  66.2  0.0000000007  Desulfotomaculum reducens MI-1  Bacteria  normal  n/a   
 
 
-
 
NC_007760  Adeh_2676  5,10-methylenetetrahydrofolate reductase  23.74 
 
 
300 aa  58.5  0.0000001  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_011145  AnaeK_2769  5,10-methylenetetrahydrofolate reductase  22.22 
 
 
300 aa  57.4  0.0000003  Anaeromyxobacter sp. K  Bacteria  normal  0.921353  n/a   
 
 
-
 
NC_011891  A2cp1_2862  5,10-methylenetetrahydrofolate reductase  22.22 
 
 
300 aa  57  0.0000003  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  0.662344  n/a   
 
 
-
 
NC_009675  Anae109_2667  5,10-methylenetetrahydrofolate reductase  23.74 
 
 
300 aa  56.2  0.0000005  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  0.167357  normal  0.059667 
 
 
-
 
NC_011680  PHATRDRAFT_28431  predicted protein  24.39 
 
 
634 aa  53.1  0.000005  Phaeodactylum tricornutum CCAP 1055/1  Eukaryota  normal  0.120876  n/a   
 
 
-
 
NC_007575  Suden_1666  methylenetetrahydrofolate reductase  22.27 
 
 
303 aa  52.8  0.000008  Sulfurimonas denitrificans DSM 1251  Bacteria  normal  n/a   
 
 
-
 
NC_011830  Dhaf_0077  methylenetetrahydrofolate reductase  24.62 
 
 
523 aa  49.7  0.00007  Desulfitobacterium hafniense DCB-2  Bacteria  normal  0.026551  n/a   
 
 
-
 
NC_013131  Caci_1572  5,10-methylenetetrahydrofolate reductase  19.32 
 
 
315 aa  46.2  0.0007  Catenulispora acidiphila DSM 44928  Bacteria  normal  normal  0.510874 
 
 
-
 
NC_014212  Mesil_0674  5,10-methylenetetrahydrofolate reductase  23.35 
 
 
294 aa  46.2  0.0007  Meiothermus silvanus DSM 9946  Bacteria  normal  0.363262  normal  0.312205 
 
 
-
 
NC_013172  Bfae_02690  5,10-methylenetetrahydrofolate reductase  23.4 
 
 
313 aa  45.4  0.001  Brachybacterium faecium DSM 4810  Bacteria  normal  n/a   
 
 
-
 
NC_010571  Oter_4335  methylenetetrahydrofolate reductase  23.08 
 
 
538 aa  45.4  0.001  Opitutus terrae PB90-1  Bacteria  normal  0.359645  normal 
 
 
-
 
NC_006681  CNL04820  methylenetetrahydrofolate reductase (NADPH), putative  19.63 
 
 
617 aa  44.3  0.003  Cryptococcus neoformans var. neoformans JEC21  Eukaryota  normal  0.999767  n/a   
 
 
-
 
NC_006670  CNA07390  methylenetetrahydrofolate reductase (NADPH), putative  23.58 
 
 
633 aa  43.9  0.003  Cryptococcus neoformans var. neoformans JEC21  Eukaryota  normal  0.497264  n/a   
 
 
-
 
NC_013512  Sdel_0207  methylenetetrahydrofolate reductase  20.54 
 
 
304 aa  43.5  0.004  Sulfurospirillum deleyianum DSM 6946  Bacteria  hitchhiker  0.00833446  n/a   
 
 
-
 
NC_012918  GM21_0946  Methylenetetrahydrofolate reductase (NAD(P)H)  20.26 
 
 
291 aa  43.1  0.005  Geobacter sp. M21  Bacteria  n/a    hitchhiker  0.000110385 
 
 
-
 
NC_009045  PICST_83803  predicted protein  21.89 
 
 
635 aa  43.1  0.006  Scheffersomyces stipitis CBS 6054  Eukaryota  normal  0.163002  decreased coverage  0.000293877 
 
 
-
 
NC_007498  Pcar_1732  5,10-methylenetetrahydrofolate reductase  23.87 
 
 
301 aa  42.4  0.009  Pelobacter carbinolicus DSM 2380  Bacteria  hitchhiker  0.000245457  n/a   
 
 
-
 
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