More than 300 homologs were found in PanDaTox collection
for query gene Acel_0031 on replicon NC_008578
Organism: Acidothermus cellulolyticus 11B



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_008578  Acel_0031  dehydrogenase catalytic domain-containing protein  100 
 
 
546 aa  1071  Acidothermus cellulolyticus 11B  Bacteria  normal  normal 
 
 
-
 
NC_013595  Sros_8972  pyruvate dehydrogenase E2  49.63 
 
 
482 aa  436  1e-121  Streptosporangium roseum DSM 43021  Bacteria  normal  normal 
 
 
-
 
NC_013159  Svir_38880  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component  47.82 
 
 
473 aa  421  1e-116  Saccharomonospora viridis DSM 43017  Bacteria  normal  normal  0.273888 
 
 
-
 
NC_009380  Strop_0107  dehydrogenase catalytic domain-containing protein  49.72 
 
 
487 aa  406  1e-112  Salinispora tropica CNB-440  Bacteria  normal  0.399626  normal 
 
 
-
 
NC_011886  Achl_1401  catalytic domain of components of various dehydrogenase complexes  46.61 
 
 
483 aa  395  1e-109  Arthrobacter chlorophenolicus A6  Bacteria  n/a    hitchhiker  2.24247e-11 
 
 
-
 
NC_013131  Caci_0091  catalytic domain of components of various dehydrogenase complexes  46.45 
 
 
497 aa  397  1e-109  Catenulispora acidiphila DSM 44928  Bacteria  normal  normal  0.0517108 
 
 
-
 
NC_009953  Sare_0107  dehydrogenase catalytic domain-containing protein  50.55 
 
 
490 aa  395  1e-108  Salinispora arenicola CNS-205  Bacteria  normal  0.390532  hitchhiker  0.000261598 
 
 
-
 
NC_013174  Jden_2466  catalytic domain of components of various dehydrogenase complexes  43.6 
 
 
516 aa  387  1e-106  Jonesia denitrificans DSM 20603  Bacteria  normal  0.606926  decreased coverage  0.005432 
 
 
-
 
NC_009664  Krad_4286  branched-chain alpha-keto acid dehydrogenase subunit E2  46.28 
 
 
450 aa  380  1e-104  Kineococcus radiotolerans SRS30216  Bacteria  normal  0.217662  normal  0.0798721 
 
 
-
 
NC_011886  Achl_3816  branched-chain alpha-keto acid dehydrogenase subunit E2  43.38 
 
 
513 aa  379  1e-104  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal 
 
 
-
 
NC_008541  Arth_4026  branched-chain alpha-keto acid dehydrogenase subunit E2  41.51 
 
 
527 aa  381  1e-104  Arthrobacter sp. FB24  Bacteria  normal  n/a   
 
 
-
 
NC_014151  Cfla_3380  Dihydrolipoyllysine-residue succinyltransferase  46.22 
 
 
479 aa  370  1e-101  Cellulomonas flavigena DSM 20109  Bacteria  normal  0.184535  hitchhiker  0.00514491 
 
 
-
 
NC_007777  Francci3_0056  dehydrogenase subunit  44.35 
 
 
524 aa  343  6e-93  Frankia sp. CcI3  Bacteria  normal  normal 
 
 
-
 
NC_008699  Noca_4507  dehydrogenase catalytic domain-containing protein  57.47 
 
 
474 aa  340  4e-92  Nocardioides sp. JS614  Bacteria  normal  n/a   
 
 
-
 
NC_013093  Amir_6981  catalytic domain of components of various dehydrogenase complexes  59.6 
 
 
450 aa  339  8e-92  Actinosynnema mirum DSM 43827  Bacteria  normal  n/a   
 
 
-
 
NC_013530  Xcel_3221  catalytic domain of components of various dehydrogenase complexes  57 
 
 
525 aa  337  4e-91  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  n/a   
 
 
-
 
NC_014165  Tbis_3330  hypothetical protein  58.86 
 
 
441 aa  334  2e-90  Thermobispora bispora DSM 43833  Bacteria  normal  normal  0.446215 
 
 
-
 
NC_013521  Sked_35850  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component  55.59 
 
 
551 aa  331  2e-89  Sanguibacter keddieii DSM 10542  Bacteria  normal  normal  0.459996 
 
 
-
 
NC_014211  Ndas_5419  catalytic domain of components of various dehydrogenase complexes  57.05 
 
 
467 aa  327  3e-88  Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111  Bacteria  normal  normal 
 
 
-
 
NC_008541  Arth_1383  dehydrogenase catalytic domain-containing protein  49.49 
 
 
462 aa  321  2e-86  Arthrobacter sp. FB24  Bacteria  normal  0.0109581  n/a   
 
 
-
 
NC_007333  Tfu_0182  branched-chain alpha-keto acid dehydrogenase subunit E2  56.43 
 
 
446 aa  320  5e-86  Thermobifida fusca YX  Bacteria  normal  0.547004  n/a   
 
 
-
 
NC_013169  Ksed_02370  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component  48.11 
 
 
629 aa  314  3e-84  Kytococcus sedentarius DSM 20547  Bacteria  normal  normal 
 
 
-
 
NC_013530  Xcel_2099  catalytic domain of components of various dehydrogenase complexes  43.57 
 
 
537 aa  310  3e-83  Xylanimonas cellulosilytica DSM 15894  Bacteria  normal  n/a   
 
 
-
 
NC_013172  Bfae_25380  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component  41.09 
 
 
517 aa  305  1e-81  Brachybacterium faecium DSM 4810  Bacteria  normal  0.0347062  n/a   
 
 
-
 
NC_012803  Mlut_06820  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component  47.91 
 
 
479 aa  302  8e-81  Micrococcus luteus NCTC 2665  Bacteria  normal  n/a   
 
 
-
 
NC_013510  Tcur_0330  catalytic domain of components of various dehydrogenase complexes  63.88 
 
 
523 aa  291  2e-77  Thermomonospora curvata DSM 43183  Bacteria  normal  n/a   
 
 
-
 
NC_013235  Namu_5309  catalytic domain of components of various dehydrogenase complexes  57.95 
 
 
491 aa  277  3e-73  Nakamurella multipartita DSM 44233  Bacteria  normal  normal 
 
 
-
 
NC_013172  Bfae_00430  pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component  41.71 
 
 
447 aa  274  4e-72  Brachybacterium faecium DSM 4810  Bacteria  normal  n/a   
 
 
-
 
NC_009921  Franean1_7269  dehydrogenase catalytic domain-containing protein  48.24 
 
 
585 aa  273  7e-72  Frankia sp. EAN1pec  Bacteria  normal  normal  0.325123 
 
 
-
 
NC_012669  Bcav_3853  catalytic domain of components of various dehydrogenase complexes  51.56 
 
 
499 aa  261  2e-68  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal  0.132003 
 
 
-
 
NC_011886  Achl_2903  branched-chain alpha-keto acid dehydrogenase subunit E2  33.97 
 
 
518 aa  239  1e-61  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal 
 
 
-
 
NC_009376  Pars_1187  branched-chain alpha-keto acid dehydrogenase subunit E2  42.31 
 
 
408 aa  234  2e-60  Pyrobaculum arsenaticum DSM 13514  Archaea  normal  0.255358  normal  0.0273122 
 
 
-
 
NC_008541  Arth_3191  branched-chain alpha-keto acid dehydrogenase subunit E2  34.85 
 
 
518 aa  234  3e-60  Arthrobacter sp. FB24  Bacteria  normal  n/a   
 
 
-
 
NC_009831  Ssed_2327  dihydrolipoamide acetyltransferase  29.26 
 
 
544 aa  231  3e-59  Shewanella sediminis HAW-EB3  Bacteria  normal  hitchhiker  0.00355536 
 
 
-
 
NC_012029  Hlac_0141  branched-chain alpha-keto acid dehydrogenase subunit E2  32.86 
 
 
539 aa  229  8e-59  Halorubrum lacusprofundi ATCC 49239  Archaea  normal  0.652081  normal 
 
 
-
 
NC_008322  Shewmr7_1949  dihydrolipoamide acetyltransferase  32.01 
 
 
531 aa  223  6e-57  Shewanella sp. MR-7  Bacteria  normal  0.940274  decreased coverage  0.000367008 
 
 
-
 
NC_008577  Shewana3_2129  dihydrolipoamide acetyltransferase  31.83 
 
 
531 aa  221  3e-56  Shewanella sp. ANA-3  Bacteria  normal  hitchhiker  0.00053212 
 
 
-
 
NC_011663  Sbal223_2233  dihydrolipoamide acetyltransferase  30.3 
 
 
539 aa  219  1e-55  Shewanella baltica OS223  Bacteria  normal  0.324969  hitchhiker  0.000134211 
 
 
-
 
NC_010506  Swoo_2280  dihydrolipoamide acetyltransferase  29.45 
 
 
526 aa  219  1e-55  Shewanella woodyi ATCC 51908  Bacteria  normal  0.229971  normal  0.76505 
 
 
-
 
NC_009665  Shew185_2151  dihydrolipoamide acetyltransferase  30.14 
 
 
541 aa  218  2e-55  Shewanella baltica OS185  Bacteria  hitchhiker  8.43995e-05  n/a   
 
 
-
 
NC_009052  Sbal_2220  dihydrolipoamide acetyltransferase  30.4 
 
 
541 aa  218  3e-55  Shewanella baltica OS155  Bacteria  normal  0.0838687  n/a   
 
 
-
 
NC_009035  Sbal_4506  dihydrolipoamide acetyltransferase  30.4 
 
 
541 aa  218  3e-55  Shewanella baltica OS155  Bacteria  n/a    n/a   
 
 
-
 
NC_012803  Mlut_17790  branched-chain alpha-keto acid dehydrogenase subunit E2  36.41 
 
 
496 aa  217  4e-55  Micrococcus luteus NCTC 2665  Bacteria  normal  n/a   
 
 
-
 
NC_008025  Dgeo_2341  branched-chain alpha-keto acid dehydrogenase subunit E2  31.48 
 
 
516 aa  215  1e-54  Deinococcus geothermalis DSM 11300  Bacteria  normal  0.968697  normal 
 
 
-
 
NC_008321  Shewmr4_2026  dihydrolipoamide acetyltransferase  31.57 
 
 
531 aa  216  1e-54  Shewanella sp. MR-4  Bacteria  hitchhiker  0.00246701  hitchhiker  2.01314e-05 
 
 
-
 
NC_009997  Sbal195_2201  dihydrolipoamide acetyltransferase  30.3 
 
 
541 aa  215  1e-54  Shewanella baltica OS195  Bacteria  normal  normal  0.21404 
 
 
-
 
NC_008740  Maqu_1380  dihydrolipoamide acetyltransferase  31.75 
 
 
528 aa  215  2e-54  Marinobacter aquaeolei VT8  Bacteria  normal  0.60189  n/a   
 
 
-
 
NC_008009  Acid345_2791  dihydrolipoamide acetyltransferase  30.2 
 
 
615 aa  213  8e-54  Candidatus Koribacter versatilis Ellin345  Bacteria  normal  0.319819  normal 
 
 
-
 
NC_009438  Sputcn32_1887  dihydrolipoamide acetyltransferase  30.36 
 
 
540 aa  212  1e-53  Shewanella putrefaciens CN-32  Bacteria  normal  0.763867  n/a   
 
 
-
 
NC_007954  Sden_1788  dihydrolipoamide acetyltransferase  29.91 
 
 
541 aa  211  3e-53  Shewanella denitrificans OS217  Bacteria  normal  n/a   
 
 
-
 
NC_009901  Spea_2244  dihydrolipoamide acetyltransferase  30.62 
 
 
540 aa  210  4e-53  Shewanella pealeana ATCC 700345  Bacteria  normal  0.74319  n/a   
 
 
-
 
NC_008345  Sfri_1937  dihydrolipoamide acetyltransferase  30.52 
 
 
540 aa  210  5e-53  Shewanella frigidimarina NCIMB 400  Bacteria  normal  n/a   
 
 
-
 
NC_013743  Htur_3595  catalytic domain of components of various dehydrogenase complexes  40.51 
 
 
563 aa  210  5e-53  Haloterrigena turkmenica DSM 5511  Archaea  n/a    n/a   
 
 
-
 
NC_009073  Pcal_1403  branched-chain alpha-keto acid dehydrogenase subunit E2  41.91 
 
 
391 aa  209  7e-53  Pyrobaculum calidifontis JCM 11548  Archaea  n/a    normal  0.0133365 
 
 
-
 
NC_006368  lpp1460  dihydrolipoamide acetyltransferase  29.45 
 
 
544 aa  209  1e-52  Legionella pneumophila str. Paris  Bacteria  n/a    n/a   
 
 
-
 
NC_006369  lpl1523  dihydrolipoamide acetyltransferase  29.54 
 
 
544 aa  207  5e-52  Legionella pneumophila str. Lens  Bacteria  n/a    n/a   
 
 
-
 
NC_013411  GYMC61_3320  catalytic domain of components of various dehydrogenase complexes  39.69 
 
 
437 aa  204  5e-51  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_008228  Patl_2038  dihydrolipoamide acetyltransferase  29.35 
 
 
555 aa  201  2e-50  Pseudoalteromonas atlantica T6c  Bacteria  normal  0.878718  n/a   
 
 
-
 
NC_013946  Mrub_2322  catalytic domain of components of various dehydrogenase complexes  37.7 
 
 
466 aa  200  7e-50  Meiothermus ruber DSM 1279  Bacteria  normal  normal 
 
 
-
 
NC_013411  GYMC61_1834  branched-chain alpha-keto acid dehydrogenase subunit E2  40.52 
 
 
434 aa  198  2e-49  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_011138  MADE_01956  dihydrolipoamide acetyltransferase  29.07 
 
 
553 aa  198  2e-49  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  0.202344  n/a   
 
 
-
 
NC_009092  Shew_1927  dihydrolipoamide acetyltransferase  30.2 
 
 
520 aa  198  2e-49  Shewanella loihica PV-4  Bacteria  normal  normal  0.0146136 
 
 
-
 
NC_011725  BCB4264_A4073  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
429 aa  198  3e-49  Bacillus cereus B4264  Bacteria  normal  0.497773  n/a   
 
 
-
 
NC_011772  BCG9842_B1167  branched-chain alpha-keto acid dehydrogenase subunit E2  39.17 
 
 
429 aa  196  8e-49  Bacillus cereus G9842  Bacteria  normal  normal 
 
 
-
 
NC_012793  GWCH70_0954  branched-chain alpha-keto acid dehydrogenase subunit E2  39.16 
 
 
437 aa  196  8e-49  Geobacillus sp. WCH70  Bacteria  normal  n/a   
 
 
-
 
NC_010184  BcerKBAB4_3797  branched-chain alpha-keto acid dehydrogenase subunit E2  39.17 
 
 
429 aa  196  1e-48  Bacillus weihenstephanensis KBAB4  Bacteria  normal  0.0892072  n/a   
 
 
-
 
NC_011658  BCAH187_A4089  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
429 aa  194  3e-48  Bacillus cereus AH187  Bacteria  hitchhiker  0.000114299  n/a   
 
 
-
 
NC_006274  BCZK3729  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
429 aa  194  3e-48  Bacillus cereus E33L  Bacteria  normal  n/a   
 
 
-
 
NC_011773  BCAH820_3985  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
429 aa  194  3e-48  Bacillus cereus AH820  Bacteria  n/a    normal 
 
 
-
 
NC_005957  BT9727_3713  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
429 aa  194  3e-48  Bacillus thuringiensis serovar konkukian str. 97-27  Bacteria  normal  n/a   
 
 
-
 
NC_003909  BCE_4019  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
429 aa  194  3e-48  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
NC_009632  SaurJH1_1177  branched-chain alpha-keto acid dehydrogenase subunit E2  36.87 
 
 
430 aa  194  4e-48  Staphylococcus aureus subsp. aureus JH1  Bacteria  normal  0.127762  n/a   
 
 
-
 
NC_009487  SaurJH9_1155  branched-chain alpha-keto acid dehydrogenase subunit E2  36.87 
 
 
430 aa  194  4e-48  Staphylococcus aureus subsp. aureus JH9  Bacteria  normal  0.106145  n/a   
 
 
-
 
NC_005945  BAS3881  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
419 aa  194  5e-48  Bacillus anthracis str. Sterne  Bacteria  normal  n/a   
 
 
-
 
NC_007530  GBAA_4182  branched-chain alpha-keto acid dehydrogenase subunit E2  39.49 
 
 
419 aa  194  5e-48  Bacillus anthracis str. 'Ames Ancestor'  Bacteria  normal  n/a   
 
 
-
 
NC_011146  Gbem_0461  branched-chain alpha-keto acid dehydrogenase subunit E2  38.94 
 
 
406 aa  193  8e-48  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_012918  GM21_0477  branched-chain alpha-keto acid dehydrogenase subunit E2  37.62 
 
 
405 aa  192  1e-47  Geobacter sp. M21  Bacteria  n/a    decreased coverage  1.78114e-15 
 
 
-
 
NC_013525  Tter_0095  catalytic domain of components of various dehydrogenase complexes  34.38 
 
 
420 aa  192  2e-47  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_014212  Mesil_1134  catalytic domain of components of various dehydrogenase complexes  35.91 
 
 
476 aa  191  3e-47  Meiothermus silvanus DSM 9946  Bacteria  normal  normal  0.73839 
 
 
-
 
NC_010320  Teth514_2030  dehydrogenase catalytic domain-containing protein  34.63 
 
 
382 aa  191  3e-47  Thermoanaerobacter sp. X514  Bacteria  normal  n/a   
 
 
-
 
NC_013205  Aaci_0455  catalytic domain of components of various dehydrogenase complexes  38.36 
 
 
436 aa  191  4e-47  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_013205  Aaci_0827  catalytic domain of components of various dehydrogenase complexes  39 
 
 
438 aa  190  5e-47  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  0.64981  n/a   
 
 
-
 
NC_009674  Bcer98_2672  branched-chain alpha-keto acid dehydrogenase subunit E2  37.54 
 
 
421 aa  190  7e-47  Bacillus cytotoxicus NVH 391-98  Bacteria  hitchhiker  0.000161116  n/a   
 
 
-
 
NC_013922  Nmag_1666  catalytic domain of components of various dehydrogenase complexes  39 
 
 
545 aa  189  1e-46  Natrialba magadii ATCC 43099  Archaea  normal  n/a   
 
 
-
 
NC_008309  HS_1094  pyruvate dehydrogenase, E2 complex  29.68 
 
 
585 aa  188  2e-46  Haemophilus somnus 129PT  Bacteria  normal  n/a   
 
 
-
 
NC_012793  GWCH70_3162  catalytic domain of components of various dehydrogenase complexes  39.94 
 
 
398 aa  188  3e-46  Geobacillus sp. WCH70  Bacteria  normal  n/a   
 
 
-
 
NC_013411  GYMC61_1519  Dihydrolipoyllysine-residue succinyltransferase  34.21 
 
 
436 aa  186  7e-46  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_008784  BMASAVP1_1034  branched-chain alpha-keto acid dehydrogenase subunit E2  30.83 
 
 
483 aa  186  8e-46  Burkholderia mallei SAVP1  Bacteria  normal  n/a   
 
 
-
 
NC_008835  BMA10229_1320  branched-chain alpha-keto acid dehydrogenase subunit E2  30.83 
 
 
483 aa  186  8e-46  Burkholderia mallei NCTC 10229  Bacteria  normal  n/a   
 
 
-
 
NC_007435  BURPS1710b_A1409  branched-chain alpha-keto acid dehydrogenase subunit E2  30.94 
 
 
481 aa  186  8e-46  Burkholderia pseudomallei 1710b  Bacteria  normal  n/a   
 
 
-
 
NC_009079  BMA10247_A2300  branched-chain alpha-keto acid dehydrogenase subunit E2  30.83 
 
 
483 aa  186  8e-46  Burkholderia mallei NCTC 10247  Bacteria  normal  n/a   
 
 
-
 
NC_006349  BMAA2011  branched-chain alpha-keto acid dehydrogenase subunit E2  30.83 
 
 
483 aa  186  8e-46  Burkholderia mallei ATCC 23344  Bacteria  normal  n/a   
 
 
-
 
NC_006055  Mfl041  branched-chain alpha-keto acid dehydrogenase subunit E2  34.44 
 
 
422 aa  185  1e-45  Mesoplasma florum L1  Bacteria  normal  n/a   
 
 
-
 
NC_007493  RSP_0964  dihydrolipoamide acetyltransferase  29.51 
 
 
510 aa  184  3e-45  Rhodobacter sphaeroides 2.4.1  Bacteria  normal  0.0477505  n/a   
 
 
-
 
NC_002976  SERP0682  branched-chain alpha-keto acid dehydrogenase subunit E2  33.92 
 
 
433 aa  184  5e-45  Staphylococcus epidermidis RP62A  Bacteria  normal  n/a   
 
 
-
 
NC_011901  Tgr7_2455  Dihydrolipoyllysine-residue succinyltransferase  36.42 
 
 
435 aa  184  5e-45  Thioalkalivibrio sp. HL-EbGR7  Bacteria  normal  0.100049  n/a   
 
 
-
 
NC_011138  MADE_03224  pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase  35.76 
 
 
679 aa  183  7e-45  Alteromonas macleodii 'Deep ecotype'  Bacteria  normal  0.133104  n/a   
 
 
-
 
NC_013131  Caci_6169  catalytic domain of components of various dehydrogenase complexes  40.27 
 
 
596 aa  182  9e-45  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.166861  normal 
 
 
-
 
NC_002939  GSU2656  branched-chain alpha-keto acid dehydrogenase subunit E2  38.59 
 
 
392 aa  182  1e-44  Geobacter sulfurreducens PCA  Bacteria  normal  n/a   
 
 
-
 
NC_011138  MADE_01876  dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex  37.21 
 
 
503 aa  182  1e-44  Alteromonas macleodii 'Deep ecotype'  Bacteria  hitchhiker  0.0026892  n/a   
 
 
-
 
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