90 homologs were found in PanDaTox collection
for query gene TDE0389 on replicon NC_002967
Organism: Treponema denticola ATCC 35405



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Replicon accession
Locus tag
Product
% identity
Alignment on query gene
Alignment on homolog gene
Length
Bit score

E-value
Organism name
Kingdom
Plasmid clonability
Plasmid unclonability p-value
Fosmid clonability
Fosmid unclonability p-value
Coverage Plot
PanDaTox homologs
Experimental validation
NC_002967  TDE0389  (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative  100 
 
 		 412 aa  852    Treponema denticola ATCC 35405  Bacteria  normal  1  n/a   
 
 
-
 
NC_008346  Swol_0412  (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative  60.68 
 
 		 424 aa  553  1e-156  Syntrophomonas wolfei subsp. wolfei str. Goettingen  Bacteria  normal  1  n/a   
 
 
-
 
NC_013165  Shel_25470  Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB  63.59 
 
 		 425 aa  545  1e-154  Slackia heliotrinireducens DSM 20476  Bacteria  normal  1  normal  1 
 
 
-
 
NC_013204  Elen_1690  2-hydroxyglutaryl-CoA dehydratase D-component  61.31 
 
 		 424 aa  543  1e-153  Eggerthella lenta DSM 2243  Bacteria  normal  0.531982  normal  0.740952 
 
 
-
 
NC_013170  Ccur_11360  Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB  61.41 
 
 		 426 aa  530  1e-149  Cryptobacterium curtum DSM 15641  Bacteria  normal  0.390545  normal  0.8731 
 
 
-
 
NC_013522  Taci_0254  2-hydroxyglutaryl-CoA dehydratase D-component  50.85 
 
 		 423 aa  465  9.999999999999999e-131  Thermanaerovibrio acidaminovorans DSM 6589  Bacteria  normal  1  n/a   
 
 
-
 
NC_013216  Dtox_0119  2-hydroxyglutaryl-CoA dehydratase D-component  53.77 
 
 		 424 aa  461  1e-129  Desulfotomaculum acetoxidans DSM 771  Bacteria  hitchhiker  0.000350126  normal  0.0170821 
 
 
-
 
NC_013385  Adeg_0387  2-hydroxyglutaryl-CoA dehydratase D-component  53.4 
 
 		 426 aa  444  1e-123  Ammonifex degensii KC4  Bacteria  normal  1  n/a   
 
 
-
 
NC_007644  Moth_1418  2-hydroxyglutaryl-CoA dehydratase, D-component  48.91 
 
 		 436 aa  438  9.999999999999999e-123  Moorella thermoacetica ATCC 39073  Bacteria  hitchhiker  0.00133287  normal  0.906732 
 
 
-
 
NC_007519  Dde_0090  2-hydroxyglutaryl-CoA dehydratase, beta subunit-like  46.6 
 
 		 426 aa  434  1e-120  Desulfovibrio desulfuricans subsp. desulfuricans str. G20  Bacteria  normal  1  n/a   
 
 
-
 
NC_008554  Sfum_3256  2-hydroxyglutaryl-CoA dehydratase, D-component  47.69 
 
 		 423 aa  424  1e-117  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  1  normal  1 
 
 
-
 
NC_002939  GSU2944  (R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit, putative  47.82 
 
 		 431 aa  417  9.999999999999999e-116  Geobacter sulfurreducens PCA  Bacteria  normal  1  n/a   
 
 
-
 
NC_013173  Dbac_1927  2-hydroxyglutaryl-CoA dehydratase D-component  46.36 
 
 		 425 aa  413  1e-114  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.756388  n/a   
 
 
-
 
NC_010814  Glov_0091  2-hydroxyglutaryl-CoA dehydratase D-component  48.06 
 
 		 429 aa  398  9.999999999999999e-111  Geobacter lovleyi SZ  Bacteria  normal  1  n/a   
 
 
-
 
NC_009712  Mboo_0863  2-hydroxyglutaryl-CoA dehydratase, D-component  46.75 
 
 		 426 aa  393  1e-108  Candidatus Methanoregula boonei 6A8  Archaea  normal  0.0455624  normal  1 
 
 
-
 
NC_013512  Sdel_2024  2-hydroxyglutaryl-CoA dehydratase D-component  44.2 
 
 		 439 aa  367  1e-100  Sulfurospirillum deleyianum DSM 6946  Bacteria  normal  1  n/a   
 
 
-
 
NC_011146  Gbem_2040  2-hydroxyglutaryl-CoA dehydratase D-component  41.37 
 
 		 401 aa  293  4e-78  Geobacter bemidjiensis Bem  Bacteria  normal  0.921137  n/a   
 
 
-
 
NC_009637  MmarC7_0081  2-hydroxyglutaryl-CoA dehydratase D-component  42.74 
 
 		 373 aa  284  2.0000000000000002e-75  Methanococcus maripaludis C7  Archaea  hitchhiker  0.00790728  hitchhiker  0.00027984 
 
 
-
 
NC_009975  MmarC6_1821  2-hydroxyglutaryl-CoA dehydratase D-component  42.2 
 
 		 373 aa  279  6e-74  Methanococcus maripaludis C6  Archaea  normal  1  n/a   
 
 
-
 
NC_009135  MmarC5_1329  2-hydroxyglutaryl-CoA dehydratase, D-component  42.59 
 
 		 373 aa  278  1e-73  Methanococcus maripaludis C5  Archaea  normal  0.360165  n/a   
 
 
-
 
NC_009135  MmarC5_0834  2-hydroxyglutaryl-CoA dehydratase, D-component  42.2 
 
 		 373 aa  278  2e-73  Methanococcus maripaludis C5  Archaea  normal  1  n/a   
 
 
-
 
NC_009975  MmarC6_0607  2-hydroxyglutaryl-CoA dehydratase D-component  42.05 
 
 		 373 aa  274  2.0000000000000002e-72  Methanococcus maripaludis C6  Archaea  normal  0.422107  n/a   
 
 
-
 
NC_011832  Mpal_1311  2-hydroxyglutaryl-CoA dehydratase D-component  40.53 
 
 		 388 aa  273  3e-72  Methanosphaerula palustris E1-9c  Archaea  normal  0.522959  normal  1 
 
 
-
 
NC_007644  Moth_1446  2-hydroxyglutaryl-CoA dehydratase, D-component  38.02 
 
 		 381 aa  271  1e-71  Moorella thermoacetica ATCC 39073  Bacteria  normal  0.629308  normal  0.054659 
 
 
-
 
NC_009634  Mevan_1356  2-hydroxyglutaryl-CoA dehydratase D-component  40.6 
 
 		 373 aa  270  2.9999999999999997e-71  Methanococcus vannielii SB  Archaea  normal  0.0888918  n/a   
 
 
-
 
NC_009637  MmarC7_1346  2-hydroxyglutaryl-CoA dehydratase D-component  41.24 
 
 		 373 aa  270  2.9999999999999997e-71  Methanococcus maripaludis C7  Archaea  normal  0.922776  normal  0.0249494 
 
 
-
 
NC_008554  Sfum_3161  2-hydroxyglutaryl-CoA dehydratase, D-component  38.8 
 
 		 382 aa  261  2e-68  Syntrophobacter fumaroxidans MPOB  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009635  Maeo_1346  2-hydroxyglutaryl-CoA dehydratase D-component  40.92 
 
 		 372 aa  261  2e-68  Methanococcus aeolicus Nankai-3  Archaea  normal  0.120946  n/a   
 
 
-
 
NC_002939  GSU2519  (R)-2-hydroxyglutaryl-CoA dehydratase beta-subunit, putative  37.3 
 
 		 387 aa  259  5.0000000000000005e-68  Geobacter sulfurreducens PCA  Bacteria  normal  0.321633  n/a   
 
 
-
 
NC_011830  Dhaf_3912  2-hydroxyglutaryl-CoA dehydratase D-component  38.84 
 
 		 384 aa  259  6e-68  Desulfitobacterium hafniense DCB-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_009253  Dred_1278  2-hydroxyglutaryl-CoA dehydratase, D-component  35.73 
 
 		 385 aa  257  3e-67  Desulfotomaculum reducens MI-1  Bacteria  normal  1  n/a   
 
 
-
 
NC_011769  DvMF_0986  2-hydroxyglutaryl-CoA dehydratase D-component  36.36 
 
 		 379 aa  253  3e-66  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal  0.345407 
 
 
-
 
NC_013517  Sterm_1694  2-hydroxyglutaryl-CoA dehydratase D-component  38.12 
 
 		 382 aa  252  1e-65  Sebaldella termitidis ATCC 33386  Bacteria  normal  1  n/a   
 
 
-
 
NC_010718  Nther_0828  2-hydroxyglutaryl-CoA dehydratase D-component  36.93 
 
 		 393 aa  249  8e-65  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  1  hitchhiker  0.0000331904 
 
 
-
 
NC_009715  CCV52592_0873  2-hydroxyglutaryl-CoA dehydratase, D-component  39.89 
 
 		 385 aa  249  9e-65  Campylobacter curvus 525.92  Bacteria  normal  1  n/a   
 
 
-
 
NC_009802  CCC13826_1134  UDP-MurNac-pentapeptide presynthetase  36.89 
 
 		 385 aa  248  1e-64  Campylobacter concisus 13826  Bacteria  normal  0.207036  n/a   
 
 
-
 
NC_014150  Bmur_0617  2-hydroxyglutaryl-CoA dehydratase D-component  39.39 
 
 		 384 aa  248  1e-64  Brachyspira murdochii DSM 12563  Bacteria  normal  1  n/a   
 
 
-
 
NC_010468  EcolC_3728  2-hydroxyglutaryl-CoA dehydratase D-component  38.44 
 
 		 383 aa  246  4.9999999999999997e-64  Escherichia coli ATCC 8739  Bacteria  normal  1  normal  1 
 
 
-
 
NC_009801  EcE24377A_4937  putative 2-hydroxyglutaryl-CoA dehydratase, D-component  38.5 
 
 		 383 aa  246  6e-64  Escherichia coli E24377A  Bacteria  normal  1  n/a   
 
 
-
 
NC_009800  EcHS_A4563  putative 2-hydroxyglutaryl-CoA dehydratase, D-component  38.24 
 
 		 383 aa  246  6e-64  Escherichia coli HS  Bacteria  normal  1  n/a   
 
 
-
 
NC_010498  EcSMS35_4882  putative 2-hydroxyglutaryl-CoA dehydratase, D-component  38.17 
 
 		 383 aa  246  6.999999999999999e-64  Escherichia coli SMS-3-5  Bacteria  normal  0.30993  normal  0.992487 
 
 
-
 
CP001637  EcDH1_3660  2-hydroxyglutaryl-CoA dehydratase D-component  38.24 
 
 		 383 aa  245  9e-64  Escherichia coli DH1  Bacteria  normal  0.814301  n/a   
 
 
-
 
CP001509  ECD_04204  predicted 2-hydroxyglutaryl-CoA dehydratase  38.24 
 
 		 383 aa  245  9e-64  Escherichia coli BL21(DE3)  Bacteria  normal  0.0605066  n/a   
 
 
-
 
NC_012892  B21_04167  hypothetical protein  38.24 
 
 		 383 aa  245  9e-64  Escherichia coli BL21  Bacteria  normal  0.0394396  n/a   
 
 
-
 
NC_013216  Dtox_1465  2-hydroxyglutaryl-CoA dehydratase D-component  36.71 
 
 		 369 aa  244  1.9999999999999999e-63  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011883  Ddes_0545  2-hydroxyglutaryl-CoA dehydratase D-component  33.7 
 
 		 379 aa  243  6e-63  Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774  Bacteria  normal  1  n/a   
 
 
-
 
NC_011353  ECH74115_5849  putative 2-hydroxyglutaryl-CoA dehydratase, D-component  37.97 
 
 		 383 aa  241  1e-62  Escherichia coli O157:H7 str. EC4115  Bacteria  normal  1  normal  0.981774 
 
 
-
 
NC_009634  Mevan_1623  2-hydroxyglutaryl-CoA dehydratase D-component  40 
 
 		 373 aa  239  5e-62  Methanococcus vannielii SB  Archaea  decreased coverage  0.000208392  n/a   
 
 
-
 
NC_013165  Shel_25330  Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB  35.89 
 
 		 390 aa  234  2.0000000000000002e-60  Slackia heliotrinireducens DSM 20476  Bacteria  normal  1  normal  0.8257 
 
 
-
 
NC_008751  Dvul_0706  2-hydroxyglutaryl-CoA dehydratase, D-component  36.84 
 
 		 380 aa  233  4.0000000000000004e-60  Desulfovibrio vulgaris DP4  Bacteria  normal  0.255737  normal  0.505258 
 
 
-
 
NC_013165  Shel_26180  Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB  37.08 
 
 		 384 aa  231  2e-59  Slackia heliotrinireducens DSM 20476  Bacteria  normal  1  normal  1 
 
 
-
 
NC_008346  Swol_0410  (R)-2-hydroxyglutaryl-CoA dehydratase beta-subunit, putative  32.38 
 
 		 378 aa  229  9e-59  Syntrophomonas wolfei subsp. wolfei str. Goettingen  Bacteria  normal  0.732282  n/a   
 
 
-
 
NC_002967  TDE0392  (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative  34.79 
 
 		 392 aa  226  6e-58  Treponema denticola ATCC 35405  Bacteria  normal  1  n/a   
 
 
-
 
NC_009712  Mboo_0866  2-hydroxyglutaryl-CoA dehydratase, D-component  31.88 
 
 		 383 aa  214  1.9999999999999998e-54  Candidatus Methanoregula boonei 6A8  Archaea  normal  0.327302  normal  1 
 
 
-
 
NC_008346  Swol_0427  (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative  35.25 
 
 		 382 aa  207  2e-52  Syntrophomonas wolfei subsp. wolfei str. Goettingen  Bacteria  normal  1  n/a   
 
 
-
 
NC_013216  Dtox_2825  2-hydroxyglutaryl-CoA dehydratase D-component  34.34 
 
 		 368 aa  201  1.9999999999999998e-50  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  1  normal  1 
 
 
-
 
NC_007575  Suden_0273  2-hydroxyglutaryl-CoA dehydratase, D-component  31.36 
 
 		 422 aa  191  2e-47  Sulfurimonas denitrificans DSM 1251  Bacteria  normal  1  n/a   
 
 
-
 
NC_008340  Mlg_0785  2-hydroxyglutaryl-CoA dehydratase, D-component  31.2 
 
 		 420 aa  184  2.0000000000000003e-45  Alkalilimnicola ehrlichii MLHE-1  Bacteria  normal  0.237879  normal  1 
 
 
-
 
NC_011832  Mpal_1147  2-hydroxyglutaryl-CoA dehydratase D-component  27.69 
 
 		 393 aa  160  5e-38  Methanosphaerula palustris E1-9c  Archaea  normal  0.132933  normal  1 
 
 
-
 
NC_011830  Dhaf_1101  2-hydroxyglutaryl-CoA dehydratase D-component  27.58 
 
 		 379 aa  150  5e-35  Desulfitobacterium hafniense DCB-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_008609  Ppro_1278  2-hydroxyglutaryl-CoA dehydratase, D-component  27.34 
 
 		 413 aa  140  3e-32  Pelobacter propionicus DSM 2379  Bacteria  normal  1  n/a   
 
 
-
 
NC_009483  Gura_3877  2-hydroxyglutaryl-CoA dehydratase, D-component  25.6 
 
 		 395 aa  127  4.0000000000000003e-28  Geobacter uraniireducens Rf4  Bacteria  normal  1  n/a   
 
 
-
 
NC_009943  Dole_2769  2-hydroxyglutaryl-CoA dehydratase D-component  26.98 
 
 		 379 aa  119  7e-26  Desulfococcus oleovorans Hxd3  Bacteria  normal  1  n/a   
 
 
-
 
NC_007925  RPC_2055  2-hydroxyglutaryl-CoA dehydratase, D-component  23.1 
 
 		 376 aa  110  3e-23  Rhodopseudomonas palustris BisB18  Bacteria  normal  0.574959  normal  0.736744 
 
 
-
 
NC_009943  Dole_2774  2-hydroxyglutaryl-CoA dehydratase D-component  25.86 
 
 		 376 aa  97.1  5e-19  Desulfococcus oleovorans Hxd3  Bacteria  normal  1  n/a   
 
 
-
 
NC_009943  Dole_0891  2-hydroxyglutaryl-CoA dehydratase D-component  22.54 
 
 		 373 aa  85.5  0.000000000000001  Desulfococcus oleovorans Hxd3  Bacteria  normal  1  n/a   
 
 
-
 
NC_010718  Nther_1772  2-hydroxyglutaryl-CoA dehydratase D-component  25.33 
 
 		 358 aa  84.3  0.000000000000004  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  1  normal  0.39587 
 
 
-
 
NC_007644  Moth_1006  2-hydroxyglutaryl-CoA dehydratase, D-component  24.53 
 
 		 421 aa  80.1  0.00000000000007  Moorella thermoacetica ATCC 39073  Bacteria  normal  0.0695891  hitchhiker  0.000177823 
 
 
-
 
NC_011830  Dhaf_3454  2-hydroxyglutaryl-CoA dehydratase D-component  24.59 
 
 		 386 aa  75.5  0.000000000001  Desulfitobacterium hafniense DCB-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_011662  Tmz1t_2951  benzoyl-CoA reductase, subunit C  20.33 
 
 		 386 aa  72.8  0.00000000001  Thauera sp. MZ1T  Bacteria  normal  0.689086  n/a   
 
 
-
 
NC_007644  Moth_1007  2-hydroxyglutaryl-CoA dehydratase, D-component  23.16 
 
 		 349 aa  71.6  0.00000000002  Moorella thermoacetica ATCC 39073  Bacteria  decreased coverage  0.0000000530359  hitchhiker  0.000167288 
 
 
-
 
NC_007958  RPD_1538  benzoyl-CoA reductase, subunit C  20.8 
 
 		 394 aa  71.6  0.00000000003  Rhodopseudomonas palustris BisB5  Bacteria  normal  0.130058  normal  1 
 
 
-
 
NC_011899  Hore_16090  2-hydroxyglutaryl-CoA dehydratase D-component  23.61 
 
 		 355 aa  70.9  0.00000000004  Halothermothrix orenii H 168  Bacteria  normal  1  n/a   
 
 
-
 
NC_013385  Adeg_1708  2-hydroxyglutaryl-CoA dehydratase D-component  21.41 
 
 		 322 aa  69.3  0.0000000001  Ammonifex degensii KC4  Bacteria  normal  1  n/a   
 
 
-
 
NC_007925  RPC_1029  benzoyl-CoA reductase, subunit C  21.01 
 
 		 394 aa  69.3  0.0000000001  Rhodopseudomonas palustris BisB18  Bacteria  normal  1  normal  1 
 
 
-
 
NC_011004  Rpal_0724  benzoyl-CoA reductase, subunit C  20.38 
 
 		 394 aa  67.4  0.0000000004  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.377082  n/a   
 
 
-
 
NC_011661  Dtur_1747  2-hydroxyglutaryl-CoA dehydratase D-component  22.37 
 
 		 339 aa  66.2  0.0000000009  Dictyoglomus turgidum DSM 6724  Bacteria  normal  1  n/a   
 
 
-
 
NC_009943  Dole_1686  2-hydroxyglutaryl-CoA dehydratase D-component  22 
 
 		 370 aa  65.5  0.000000002  Desulfococcus oleovorans Hxd3  Bacteria  normal  0.0274681  n/a   
 
 
-
 
NC_010718  Nther_1771  2-hydroxyglutaryl-CoA dehydratase D-component  23.6 
 
 		 419 aa  65.5  0.000000002  Natranaerobius thermophilus JW/NM-WN-LF  Bacteria  normal  1  normal  0.433973 
 
 
-
 
NC_010814  Glov_2401  2-hydroxyglutaryl-CoA dehydratase D-component  20.31 
 
 		 397 aa  64.7  0.000000003  Geobacter lovleyi SZ  Bacteria  normal  1  n/a   
 
 
-
 
NC_011832  Mpal_1146  2-hydroxyglutaryl-CoA dehydratase D-component  25.21 
 
 		 501 aa  62.8  0.00000001  Methanosphaerula palustris E1-9c  Archaea  normal  0.114062  normal  1 
 
 
-
 
NC_011899  Hore_16080  2-hydroxyglutaryl-CoA dehydratase D-component  24.24 
 
 		 426 aa  61.6  0.00000003  Halothermothrix orenii H 168  Bacteria  normal  1  n/a   
 
 
-
 
NC_011832  Mpal_1135  2-hydroxyglutaryl-CoA dehydratase D-component  23.88 
 
 		 494 aa  58.5  0.0000002  Methanosphaerula palustris E1-9c  Archaea  normal  1  normal  0.207631 
 
 
-
 
NC_011832  Mpal_1137  2-hydroxyglutaryl-CoA dehydratase D-component  25.5 
 
 		 494 aa  55.5  0.000002  Methanosphaerula palustris E1-9c  Archaea  normal  0.417243  normal  1 
 
 
-
 
NC_013385  Adeg_1707  2-hydroxyglutaryl-CoA dehydratase D-component  23.55 
 
 		 415 aa  53.9  0.000005  Ammonifex degensii KC4  Bacteria  normal  1  n/a   
 
 
-
 
NC_011661  Dtur_1746  2-hydroxyglutaryl-CoA dehydratase D-component  24.81 
 
 		 408 aa  52  0.00002  Dictyoglomus turgidum DSM 6724  Bacteria  normal  1  n/a   
 
 
-
 
NC_010320  Teth514_1898  putative CoA-substrate-specific enzyme activase  29.57 
 
 		 539 aa  49.3  0.0001  Thermoanaerobacter sp. X514  Bacteria  normal  1  n/a   
 
 
-
 
NC_011830  Dhaf_3453  2-hydroxyglutaryl-CoA dehydratase D-component  20.81 
 
 		 409 aa  48.1  0.0002  Desulfitobacterium hafniense DCB-2  Bacteria  normal  1  n/a   
 
 
-
 
NC_012034  Athe_0199  2-hydroxyglutaryl-CoA dehydratase D-component  22.51 
 
 		 416 aa  46.2  0.001  Anaerocellum thermophilum DSM 6725  Bacteria  hitchhiker  0.00000602439  n/a   
 
 
-
 
NC_012034  Athe_0200  CoA-substrate-specific enzyme activase  23.51 
 
 		 539 aa  45.4  0.002  Anaerocellum thermophilum DSM 6725  Bacteria  hitchhiker  0.00000427749  n/a   
 
 
-
 
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