More than 300 homologs were found in PanDaTox collection
for query gene Pfl01_2649 on replicon NC_007492
Organism: Pseudomonas fluorescens Pf0-1



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_004578  PSPTO_2715  sensor histidine kinase/response regulator  80.41 
 
 
393 aa  643    Pseudomonas syringae pv. tomato str. DC3000  Bacteria  normal  0.615592  n/a   
 
 
-
 
NC_007005  Psyr_2448  response regulator receiver:ATP-binding region, ATPase-like:histidine kinase A, N-terminal  81.68 
 
 
393 aa  653    Pseudomonas syringae pv. syringae B728a  Bacteria  normal  0.760608  hitchhiker  0.00120668 
 
 
-
 
NC_007492  Pfl01_2649  response regulator receiver Signal transduction histidine kinase  100 
 
 
404 aa  819    Pseudomonas fluorescens Pf0-1  Bacteria  normal  normal  0.699737 
 
 
-
 
NC_002947  PP_3758  response regulator receiver sensor signal transduction histidine kinase  71.5 
 
 
408 aa  585  1e-166  Pseudomonas putida KT2440  Bacteria  normal  normal  0.734482 
 
 
-
 
NC_010322  PputGB1_2145  response regulator receiver sensor signal transduction histidine kinase  72.24 
 
 
408 aa  587  1e-166  Pseudomonas putida GB-1  Bacteria  normal  hitchhiker  0.001377 
 
 
-
 
NC_009512  Pput_2005  response regulator receiver sensor signal transduction histidine kinase  71.25 
 
 
408 aa  582  1.0000000000000001e-165  Pseudomonas putida F1  Bacteria  normal  normal  0.343751 
 
 
-
 
NC_010501  PputW619_2109  response regulator receiver sensor signal transduction histidine kinase  69.53 
 
 
408 aa  568  1e-161  Pseudomonas putida W619  Bacteria  normal  normal 
 
 
-
 
NC_009439  Pmen_0172  response regulator receiver sensor signal transduction histidine kinase  64.54 
 
 
395 aa  516  1.0000000000000001e-145  Pseudomonas mendocina ymp  Bacteria  normal  normal 
 
 
-
 
NC_012791  Vapar_2802  response regulator receiver sensor signal transduction histidine kinase  60 
 
 
406 aa  490  1e-137  Variovorax paradoxus S110  Bacteria  normal  n/a   
 
 
-
 
NC_008781  Pnap_1070  response regulator receiver sensor signal transduction histidine kinase  59.08 
 
 
402 aa  454  1.0000000000000001e-126  Polaromonas naphthalenivorans CJ2  Bacteria  normal  0.947697  normal  0.86399 
 
 
-
 
NC_007947  Mfla_2590  response regulator receiver sensor signal transduction histidine kinase  53.85 
 
 
405 aa  446  1.0000000000000001e-124  Methylobacillus flagellatus KT  Bacteria  normal  normal  0.413696 
 
 
-
 
NC_009507  Swit_5356  response regulator receiver sensor signal transduction histidine kinase  39.45 
 
 
377 aa  267  2e-70  Sphingomonas wittichii RW1  Bacteria  normal  normal  0.940445 
 
 
-
 
NC_011984  Avi_9098  bacteriophytochrome protein  40.15 
 
 
378 aa  259  4e-68  Agrobacterium vitis S4  Bacteria  normal  0.384054  n/a   
 
 
-
 
NC_013216  Dtox_3783  histidine kinase  38.33 
 
 
544 aa  256  5e-67  Desulfotomaculum acetoxidans DSM 771  Bacteria  normal  0.401083  normal 
 
 
-
 
NC_008752  Aave_3993  response regulator receiver sensor signal transduction histidine kinase  40.2 
 
 
390 aa  248  1e-64  Acidovorax citrulli AAC00-1  Bacteria  normal  0.967169  normal 
 
 
-
 
NC_010002  Daci_3828  response regulator receiver sensor signal transduction histidine kinase  39.11 
 
 
392 aa  240  4e-62  Delftia acidovorans SPH-1  Bacteria  normal  0.287383  normal  0.140943 
 
 
-
 
NC_013061  Phep_4249  ATP-binding region ATPase domain protein  38.66 
 
 
374 aa  239  5e-62  Pedobacter heparinus DSM 2366  Bacteria  normal  normal 
 
 
-
 
NC_011992  Dtpsy_0629  response regulator receiver sensor signal transduction histidine kinase  37.85 
 
 
382 aa  238  2e-61  Acidovorax ebreus TPSY  Bacteria  normal  0.67365  n/a   
 
 
-
 
NC_008782  Ajs_0650  response regulator receiver sensor signal transduction histidine kinase  37.6 
 
 
382 aa  233  6e-60  Acidovorax sp. JS42  Bacteria  normal  normal 
 
 
-
 
NC_013061  Phep_0585  ATP-binding region ATPase domain protein  35.29 
 
 
528 aa  227  2e-58  Pedobacter heparinus DSM 2366  Bacteria  normal  0.215545  normal 
 
 
-
 
NC_010676  Bphyt_5387  response regulator receiver sensor signal transduction histidine kinase  37.31 
 
 
375 aa  228  2e-58  Burkholderia phytofirmans PsJN  Bacteria  normal  normal  0.0971839 
 
 
-
 
NC_011071  Smal_1740  response regulator receiver sensor signal transduction histidine kinase  35.5 
 
 
377 aa  227  3e-58  Stenotrophomonas maltophilia R551-3  Bacteria  normal  normal  0.129887 
 
 
-
 
NC_007952  Bxe_B1219  response regulator receiver sensor signal transduction histidine kinase  37.06 
 
 
375 aa  227  3e-58  Burkholderia xenovorans LB400  Bacteria  normal  0.745377  normal  0.599724 
 
 
-
 
NC_010623  Bphy_4207  response regulator receiver sensor signal transduction histidine kinase  36.29 
 
 
370 aa  226  5.0000000000000005e-58  Burkholderia phymatum STM815  Bacteria  normal  normal  0.728065 
 
 
-
 
NC_011884  Cyan7425_3767  response regulator receiver sensor hybrid histidine kinase  34.79 
 
 
587 aa  207  2e-52  Cyanothece sp. PCC 7425  Bacteria  normal  0.634012  normal 
 
 
-
 
NC_007517  Gmet_2639  response regulator receiver sensor signal transduction histidine kinase  35.29 
 
 
396 aa  203  4e-51  Geobacter metallireducens GS-15  Bacteria  normal  0.136447  normal  0.717158 
 
 
-
 
NC_013440  Hoch_2075  response regulator receiver sensor hybrid histidine kinase  35.42 
 
 
572 aa  197  2.0000000000000003e-49  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_6238  histidine kinase  31.57 
 
 
519 aa  191  1e-47  Haliangium ochraceum DSM 14365  Bacteria  normal  0.547868  normal 
 
 
-
 
NC_009441  Fjoh_3355  response regulator receiver sensor signal transduction histidine kinase  31.25 
 
 
405 aa  187  4e-46  Flavobacterium johnsoniae UW101  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_0324  response regulator receiver sensor signal transduction histidine kinase  30.84 
 
 
424 aa  184  3e-45  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.046409  normal 
 
 
-
 
NC_009675  Anae109_2142  histidine kinase  40.98 
 
 
502 aa  183  5.0000000000000004e-45  Anaeromyxobacter sp. Fw109-5  Bacteria  decreased coverage  0.000590991  normal  0.0793761 
 
 
-
 
NC_009012  Cthe_0286  response regulator receiver sensor signal transduction histidine kinase  31.92 
 
 
424 aa  183  5.0000000000000004e-45  Clostridium thermocellum ATCC 27405  Bacteria  normal  0.136894  n/a   
 
 
-
 
NC_009675  Anae109_1722  GAF sensor signal transduction histidine kinase  39.84 
 
 
763 aa  181  2.9999999999999997e-44  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  normal  0.418059 
 
 
-
 
NC_011145  AnaeK_1788  GAF sensor signal transduction histidine kinase  34.78 
 
 
763 aa  175  9.999999999999999e-43  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_011891  A2cp1_1867  GAF sensor signal transduction histidine kinase  34.78 
 
 
763 aa  175  1.9999999999999998e-42  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_007760  Adeh_2090  GAF sensor signal transduction histidine kinase  39.22 
 
 
763 aa  174  1.9999999999999998e-42  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  0.163656  n/a   
 
 
-
 
NC_008576  Mmc1_3693  histidine kinase  29.04 
 
 
667 aa  174  1.9999999999999998e-42  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_009675  Anae109_1498  GAF sensor signal transduction histidine kinase  39.13 
 
 
1070 aa  173  3.9999999999999995e-42  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  0.308131  normal  0.537019 
 
 
-
 
NC_009675  Anae109_2560  PAS/PAC sensor signal transduction histidine kinase  39.92 
 
 
518 aa  173  5e-42  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  normal  0.315276 
 
 
-
 
NC_013132  Cpin_2260  response regulator receiver sensor signal transduction histidine kinase  31.99 
 
 
361 aa  173  5.999999999999999e-42  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.208609  normal 
 
 
-
 
NC_008576  Mmc1_3271  PAS/PAC sensor hybrid histidine kinase  30.52 
 
 
1691 aa  173  5.999999999999999e-42  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_007760  Adeh_3724  multi-sensor signal transduction histidine kinase  35.08 
 
 
592 aa  171  2e-41  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_011145  AnaeK_3781  multi-sensor signal transduction histidine kinase  39.57 
 
 
592 aa  170  3e-41  Anaeromyxobacter sp. K  Bacteria  normal  0.233259  n/a   
 
 
-
 
NC_011891  A2cp1_3864  multi-sensor signal transduction histidine kinase  39.57 
 
 
592 aa  171  3e-41  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  0.130733  n/a   
 
 
-
 
NC_009675  Anae109_3853  multi-sensor signal transduction histidine kinase  35.6 
 
 
591 aa  170  5e-41  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  normal 
 
 
-
 
NC_011145  AnaeK_0539  PAS/PAC sensor signal transduction histidine kinase  36.02 
 
 
383 aa  169  9e-41  Anaeromyxobacter sp. K  Bacteria  normal  0.143908  n/a   
 
 
-
 
NC_011891  A2cp1_0535  PAS/PAC sensor signal transduction histidine kinase  36.02 
 
 
383 aa  169  1e-40  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  0.175177  n/a   
 
 
-
 
NC_007760  Adeh_0506  PAS/PAC sensor signal transduction histidine kinase  37.71 
 
 
383 aa  167  2.9999999999999998e-40  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_009675  Anae109_2235  multi-sensor signal transduction histidine kinase  37.18 
 
 
716 aa  167  2.9999999999999998e-40  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  0.530022  normal  0.014643 
 
 
-
 
NC_013440  Hoch_5118  integral membrane sensor hybrid histidine kinase  31.85 
 
 
837 aa  166  8e-40  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.657918 
 
 
-
 
NC_009675  Anae109_0792  GAF sensor signal transduction histidine kinase  40.53 
 
 
592 aa  165  1.0000000000000001e-39  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  0.389456  hitchhiker  0.00398352 
 
 
-
 
NC_009972  Haur_3365  multi-sensor signal transduction histidine kinase  35.47 
 
 
733 aa  164  2.0000000000000002e-39  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_009675  Anae109_2823  histidine kinase  38.43 
 
 
501 aa  164  2.0000000000000002e-39  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  normal 
 
 
-
 
NC_010571  Oter_3856  response regulator receiver sensor signal transduction histidine kinase  29.95 
 
 
378 aa  163  7e-39  Opitutus terrae PB90-1  Bacteria  normal  normal  0.215089 
 
 
-
 
NC_009675  Anae109_4211  PAS/PAC sensor signal transduction histidine kinase  41.13 
 
 
403 aa  162  1e-38  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  0.108613  normal 
 
 
-
 
NC_009675  Anae109_2188  PAS/PAC sensor signal transduction histidine kinase  40 
 
 
413 aa  159  6e-38  Anaeromyxobacter sp. Fw109-5  Bacteria  normal  normal  0.925316 
 
 
-
 
NC_013440  Hoch_3251  response regulator receiver sensor signal transduction histidine kinase  32.87 
 
 
418 aa  159  1e-37  Haliangium ochraceum DSM 14365  Bacteria  normal  0.35487  normal  0.0265543 
 
 
-
 
NC_007760  Adeh_1623  PAS/PAC sensor signal transduction histidine kinase  38.43 
 
 
377 aa  158  1e-37  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  0.632325  n/a   
 
 
-
 
NC_011145  AnaeK_2237  PAS/PAC sensor signal transduction histidine kinase  38.89 
 
 
381 aa  155  8e-37  Anaeromyxobacter sp. K  Bacteria  normal  0.5102  n/a   
 
 
-
 
NC_011891  A2cp1_2325  PAS/PAC sensor signal transduction histidine kinase  38.89 
 
 
381 aa  155  9e-37  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  0.830525  n/a   
 
 
-
 
NC_007348  Reut_B4539  response regulator receiver:ATP-binding region, ATPase-like:histidine kinase A, N-terminal  31.39 
 
 
1152 aa  155  1e-36  Ralstonia eutropha JMP134  Bacteria  normal  0.329946  n/a   
 
 
-
 
NC_011891  A2cp1_0806  GAF sensor signal transduction histidine kinase  37.29 
 
 
587 aa  152  1e-35  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_013173  Dbac_0019  response regulator receiver modulated diguanylate cyclase  47.8 
 
 
341 aa  152  1e-35  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.0416556  n/a   
 
 
-
 
NC_011145  AnaeK_0802  GAF sensor signal transduction histidine kinase  37.29 
 
 
587 aa  151  2e-35  Anaeromyxobacter sp. K  Bacteria  normal  0.773486  n/a   
 
 
-
 
NC_014248  Aazo_4229  response regulator receiver sensor signal transduction histidine kinase  26.7 
 
 
383 aa  150  3e-35  'Nostoc azollae' 0708  Bacteria  normal  0.599633  n/a   
 
 
-
 
NC_011729  PCC7424_0500  response regulator receiver sensor signal transduction histidine kinase  28.03 
 
 
373 aa  150  4e-35  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_011145  AnaeK_0395  multi-sensor signal transduction histidine kinase  37.83 
 
 
509 aa  149  6e-35  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_011729  PCC7424_2188  response regulator receiver sensor signal transduction histidine kinase  27.67 
 
 
384 aa  148  2.0000000000000003e-34  Cyanothece sp. PCC 7424  Bacteria  n/a    hitchhiker  0.00677544 
 
 
-
 
NC_010524  Lcho_1401  response regulator receiver sensor signal transduction histidine kinase  31.16 
 
 
384 aa  147  3e-34  Leptothrix cholodnii SP-6  Bacteria  n/a    normal 
 
 
-
 
NC_007760  Adeh_0755  GAF sensor signal transduction histidine kinase  38.56 
 
 
588 aa  147  4.0000000000000006e-34  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  0.452305  n/a   
 
 
-
 
NC_011891  A2cp1_2991  GAF sensor signal transduction histidine kinase  38.63 
 
 
1069 aa  145  1e-33  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_011769  DvMF_1131  response regulator receiver sensor signal transduction histidine kinase  30.68 
 
 
500 aa  145  1e-33  Desulfovibrio vulgaris str. 'Miyazaki F'  Bacteria  n/a    normal 
 
 
-
 
NC_010644  Emin_1198  response regulator receiver sensor signal transduction histidine kinase  29.62 
 
 
375 aa  145  1e-33  Elusimicrobium minutum Pei191  Bacteria  normal  hitchhiker  0.00328285 
 
 
-
 
NC_011884  Cyan7425_4608  multi-sensor signal transduction histidine kinase  31.2 
 
 
1645 aa  145  1e-33  Cyanothece sp. PCC 7425  Bacteria  normal  0.284957  normal  0.407853 
 
 
-
 
NC_007760  Adeh_2805  multi-sensor signal transduction histidine kinase  38.63 
 
 
1070 aa  145  2e-33  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_008254  Meso_1944  signal transduction histidine kinase  47.92 
 
 
507 aa  144  2e-33  Chelativorans sp. BNC1  Bacteria  normal  0.0183597  n/a   
 
 
-
 
NC_007760  Adeh_0367  multi-sensor signal transduction histidine kinase  32.47 
 
 
507 aa  143  5e-33  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_011145  AnaeK_2900  multi-sensor signal transduction histidine kinase  38.2 
 
 
1069 aa  143  6e-33  Anaeromyxobacter sp. K  Bacteria  normal  0.095908  n/a   
 
 
-
 
NC_012918  GM21_0975  response regulator receiver sensor signal transduction histidine kinase  28.46 
 
 
383 aa  142  9.999999999999999e-33  Geobacter sp. M21  Bacteria  n/a    normal 
 
 
-
 
NC_007413  Ava_3616  response regulator receiver Signal transduction histidine kinase  25.36 
 
 
393 aa  140  3e-32  Anabaena variabilis ATCC 29413  Bacteria  normal  0.159723  normal  0.789101 
 
 
-
 
NC_007413  Ava_1561  response regulator receiver Signal transduction histidine kinase  29.31 
 
 
443 aa  140  3.9999999999999997e-32  Anabaena variabilis ATCC 29413  Bacteria  normal  normal  0.414952 
 
 
-
 
NC_013061  Phep_3913  PAS sensor protein  37.39 
 
 
1337 aa  140  3.9999999999999997e-32  Pedobacter heparinus DSM 2366  Bacteria  normal  0.290527  normal  0.28306 
 
 
-
 
NC_013510  Tcur_2645  response regulator receiver protein  46.94 
 
 
215 aa  140  3.9999999999999997e-32  Thermomonospora curvata DSM 43183  Bacteria  normal  0.492308  n/a   
 
 
-
 
NC_009831  Ssed_1645  hypothetical protein  51.75 
 
 
344 aa  140  6e-32  Shewanella sediminis HAW-EB3  Bacteria  normal  0.176846  normal 
 
 
-
 
NC_011146  Gbem_3274  response regulator receiver sensor signal transduction histidine kinase  27.99 
 
 
383 aa  139  7e-32  Geobacter bemidjiensis Bem  Bacteria  normal  n/a   
 
 
-
 
NC_013730  Slin_1029  response regulator receiver sensor signal transduction histidine kinase  29.27 
 
 
371 aa  139  7e-32  Spirosoma linguale DSM 74  Bacteria  normal  0.040723  normal 
 
 
-
 
NC_011729  PCC7424_3765  multi-sensor signal transduction histidine kinase  41.62 
 
 
562 aa  139  8.999999999999999e-32  Cyanothece sp. PCC 7424  Bacteria  n/a    normal  0.13531 
 
 
-
 
NC_013132  Cpin_3745  response regulator receiver sensor signal transduction histidine kinase  28.26 
 
 
1010 aa  139  8.999999999999999e-32  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.412805  hitchhiker  0.00597184 
 
 
-
 
NC_009670  Oant_4781  signal transduction histidine kinase  41.43 
 
 
356 aa  138  1e-31  Ochrobactrum anthropi ATCC 49188  Bacteria  normal  0.252184  n/a   
 
 
-
 
NC_011726  PCC8801_1495  response regulator receiver sensor signal transduction histidine kinase  30.27 
 
 
389 aa  139  1e-31  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_007492  Pfl01_5255  diguanylate cyclase/phosphodiesterase  48.91 
 
 
707 aa  138  2e-31  Pseudomonas fluorescens Pf0-1  Bacteria  normal  0.864356  normal 
 
 
-
 
NC_011884  Cyan7425_2570  response regulator receiver sensor signal transduction histidine kinase  26.43 
 
 
381 aa  137  2e-31  Cyanothece sp. PCC 7425  Bacteria  normal  normal 
 
 
-
 
NC_013161  Cyan8802_1522  response regulator receiver sensor signal transduction histidine kinase  30.27 
 
 
389 aa  138  2e-31  Cyanothece sp. PCC 8802  Bacteria  normal  normal 
 
 
-
 
NC_011145  AnaeK_4252  multi-sensor signal transduction histidine kinase  34.18 
 
 
712 aa  137  5e-31  Anaeromyxobacter sp. K  Bacteria  normal  0.374039  n/a   
 
 
-
 
NC_011726  PCC8801_2743  response regulator receiver sensor signal transduction histidine kinase  27.12 
 
 
395 aa  136  5e-31  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_013161  Cyan8802_3359  response regulator receiver sensor signal transduction histidine kinase  27.12 
 
 
395 aa  136  5e-31  Cyanothece sp. PCC 8802  Bacteria  normal  0.361398  normal 
 
 
-
 
NC_011884  Cyan7425_4616  GAF sensor hybrid histidine kinase  34.77 
 
 
701 aa  136  7.000000000000001e-31  Cyanothece sp. PCC 7425  Bacteria  normal  normal  0.524944 
 
 
-
 
NC_007760  Adeh_4121  multi-sensor signal transduction histidine kinase  34.48 
 
 
712 aa  135  9e-31  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  0.6651  n/a   
 
 
-
 
NC_011729  PCC7424_1421  response regulator receiver sensor signal transduction histidine kinase  29.44 
 
 
404 aa  135  9.999999999999999e-31  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_010506  Swoo_1964  response regulator receiver sensor signal transduction histidine kinase  25.3 
 
 
427 aa  135  9.999999999999999e-31  Shewanella woodyi ATCC 51908  Bacteria  hitchhiker  0.00543356  normal  0.092514 
 
 
-
 
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