More than 300 homologs were found in PanDaTox collection
for query gene Hore_20620 on replicon NC_011899
Organism: Halothermothrix orenii H 168



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_011899  Hore_20620  binding-protein-dependent transport systems inner membrane component  100 
 
 
299 aa  602  1.0000000000000001e-171  Halothermothrix orenii H 168  Bacteria  normal  n/a   
 
 
-
 
NC_014213  Mesil_3421  binding-protein-dependent transport systems inner membrane component  42.95 
 
 
307 aa  260  2e-68  Meiothermus silvanus DSM 9946  Bacteria  normal  0.556907  normal 
 
 
-
 
NC_014213  Mesil_3227  extracellular solute-binding protein family 1  42.95 
 
 
307 aa  260  2e-68  Meiothermus silvanus DSM 9946  Bacteria  decreased coverage  0.00159401  normal  0.987884 
 
 
-
 
NC_013131  Caci_4319  binding-protein-dependent transport systems inner membrane component  43.06 
 
 
312 aa  251  9.000000000000001e-66  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.778687  hitchhiker  0.00185272 
 
 
-
 
NC_011886  Achl_3567  binding-protein-dependent transport systems inner membrane component  44.95 
 
 
309 aa  248  1e-64  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal 
 
 
-
 
NC_013525  Tter_0830  binding-protein-dependent transport systems inner membrane component  42.66 
 
 
309 aa  248  1e-64  Thermobaculum terrenum ATCC BAA-798  Bacteria  n/a    n/a   
 
 
-
 
NC_009939  Dgeo_2918  ABC-type sugar transport system, permease component  41.28 
 
 
305 aa  243  1.9999999999999999e-63  Deinococcus geothermalis DSM 11300  Bacteria  n/a    n/a   
 
 
-
 
NC_012669  Bcav_1523  binding-protein-dependent transport systems inner membrane component  42.31 
 
 
321 aa  239  2.9999999999999997e-62  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal 
 
 
-
 
NC_009616  Tmel_0691  binding-protein-dependent transport systems inner membrane component  43.4 
 
 
295 aa  239  2.9999999999999997e-62  Thermosipho melanesiensis BI429  Bacteria  normal  n/a   
 
 
-
 
NC_010320  Teth514_2200  binding-protein-dependent transport systems inner membrane component  43.69 
 
 
299 aa  239  5e-62  Thermoanaerobacter sp. X514  Bacteria  normal  0.426381  n/a   
 
 
-
 
NC_013526  Tter_2208  binding-protein-dependent transport systems inner membrane component  40.82 
 
 
306 aa  238  8e-62  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  0.739705  n/a   
 
 
-
 
NC_011881  Achl_4622  binding-protein-dependent transport systems inner membrane component  43.11 
 
 
317 aa  236  3e-61  Arthrobacter chlorophenolicus A6  Bacteria  n/a    normal 
 
 
-
 
NC_010816  BLD_1549  MalF-type ABC sugar transport systems permease component  42.71 
 
 
317 aa  234  1.0000000000000001e-60  Bifidobacterium longum DJO10A  Bacteria  normal  0.649517  n/a   
 
 
-
 
NC_013526  Tter_2217  binding-protein-dependent transport systems inner membrane component  39.93 
 
 
305 aa  233  2.0000000000000002e-60  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_013526  Tter_2292  binding-protein-dependent transport systems inner membrane component  41.99 
 
 
306 aa  233  4.0000000000000004e-60  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_011368  Rleg2_5336  binding-protein-dependent transport systems inner membrane component  43.49 
 
 
318 aa  230  2e-59  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  0.949955  normal 
 
 
-
 
NC_012848  Rleg_5053  binding-protein-dependent transport systems inner membrane component  42.81 
 
 
318 aa  228  7e-59  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.0625824  normal 
 
 
-
 
NC_012669  Bcav_3990  binding-protein-dependent transport systems inner membrane component  40.27 
 
 
317 aa  226  3e-58  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal 
 
 
-
 
NC_008699  Noca_4634  binding-protein-dependent transport systems inner membrane component  39.93 
 
 
292 aa  226  4e-58  Nocardioides sp. JS614  Bacteria  normal  0.219562  n/a   
 
 
-
 
NC_013526  Tter_2523  binding-protein-dependent transport systems inner membrane component  38.16 
 
 
309 aa  224  2e-57  Thermobaculum terrenum ATCC BAA-798  Bacteria  hitchhiker  0.00000000325465  n/a   
 
 
-
 
NC_013526  Tter_2316  binding-protein-dependent transport systems inner membrane component  40.34 
 
 
313 aa  223  3e-57  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_010003  Pmob_0955  binding-protein-dependent transport systems inner membrane component  40.62 
 
 
291 aa  223  4e-57  Petrotoga mobilis SJ95  Bacteria  normal  0.0196347  n/a   
 
 
-
 
NC_011981  Avi_7347  ABC transporter membrane spanning protein (sugar)  41.81 
 
 
320 aa  222  4.9999999999999996e-57  Agrobacterium vitis S4  Bacteria  normal  n/a   
 
 
-
 
NC_002977  MCA1942  sugar ABC transporter, permease protein  42.49 
 
 
287 aa  221  9.999999999999999e-57  Methylococcus capsulatus str. Bath  Bacteria  normal  n/a   
 
 
-
 
NC_011368  Rleg2_5350  binding-protein-dependent transport systems inner membrane component  41.18 
 
 
308 aa  221  9.999999999999999e-57  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  0.84186  normal  0.48209 
 
 
-
 
NC_013093  Amir_2919  binding-protein-dependent transport systems inner membrane component  40.22 
 
 
310 aa  221  9.999999999999999e-57  Actinosynnema mirum DSM 43827  Bacteria  normal  n/a   
 
 
-
 
NC_013235  Namu_3848  binding-protein-dependent transport systems inner membrane component  40.89 
 
 
320 aa  220  1.9999999999999999e-56  Nakamurella multipartita DSM 44233  Bacteria  normal  0.0230008  normal  0.429544 
 
 
-
 
NC_011831  Cagg_2193  binding-protein-dependent transport systems inner membrane component  40.56 
 
 
306 aa  219  3e-56  Chloroflexus aggregans DSM 9485  Bacteria  normal  0.692762  normal 
 
 
-
 
NC_010001  Cphy_1390  binding-protein-dependent transport systems inner membrane component  40 
 
 
308 aa  219  3.9999999999999997e-56  Clostridium phytofermentans ISDg  Bacteria  normal  n/a   
 
 
-
 
NC_013526  Tter_2302  binding-protein-dependent transport systems inner membrane component  40.5 
 
 
320 aa  219  6e-56  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  0.253823  n/a   
 
 
-
 
NC_013172  Bfae_29330  permease component of ABC-type sugar transporter  40.44 
 
 
321 aa  219  6e-56  Brachybacterium faecium DSM 4810  Bacteria  normal  n/a   
 
 
-
 
NC_007778  RPB_0176  binding-protein dependent transport system inner membrane protein  43.78 
 
 
314 aa  218  7.999999999999999e-56  Rhodopseudomonas palustris HaA2  Bacteria  normal  normal 
 
 
-
 
NC_013526  Tter_2453  binding-protein-dependent transport systems inner membrane component  39.24 
 
 
314 aa  218  1e-55  Thermobaculum terrenum ATCC BAA-798  Bacteria  hitchhiker  0.000000200699  n/a   
 
 
-
 
NC_011661  Dtur_0382  binding-protein-dependent transport systems inner membrane component  41.01 
 
 
296 aa  218  1e-55  Dictyoglomus turgidum DSM 6724  Bacteria  normal  n/a   
 
 
-
 
NC_012669  Bcav_0647  binding-protein-dependent transport systems inner membrane component  38.11 
 
 
325 aa  217  2e-55  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal 
 
 
-
 
NC_011004  Rpal_0131  binding-protein-dependent transport systems inner membrane component  40.79 
 
 
319 aa  216  2.9999999999999998e-55  Rhodopseudomonas palustris TIE-1  Bacteria  normal  0.128042  n/a   
 
 
-
 
NC_012669  Bcav_0016  binding-protein-dependent transport systems inner membrane component  38.46 
 
 
311 aa  216  4e-55  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.17058  normal 
 
 
-
 
NC_013172  Bfae_29020  carbohydrate ABC transporter membrane protein  43.91 
 
 
275 aa  216  5e-55  Brachybacterium faecium DSM 4810  Bacteria  normal  n/a   
 
 
-
 
NC_013205  Aaci_2047  binding-protein-dependent transport systems inner membrane component  40.57 
 
 
294 aa  215  7e-55  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  0.550241  n/a   
 
 
-
 
NC_013526  Tter_2024  binding-protein-dependent transport systems inner membrane component  43.75 
 
 
303 aa  215  8e-55  Thermobaculum terrenum ATCC BAA-798  Bacteria  hitchhiker  0.000000249122  n/a   
 
 
-
 
NC_013739  Cwoe_3982  binding-protein-dependent transport systems inner membrane component  40.7 
 
 
316 aa  213  1.9999999999999998e-54  Conexibacter woesei DSM 14684  Bacteria  normal  normal 
 
 
-
 
NC_011884  Cyan7425_0944  binding-protein-dependent transport systems inner membrane component  41.72 
 
 
290 aa  213  2.9999999999999995e-54  Cyanothece sp. PCC 7425  Bacteria  normal  0.120711  normal  0.307929 
 
 
-
 
NC_013501  Rmar_0359  binding-protein-dependent transport systems inner membrane component  37.02 
 
 
300 aa  213  3.9999999999999995e-54  Rhodothermus marinus DSM 4252  Bacteria  normal  n/a   
 
 
-
 
NC_013521  Sked_03080  permease component of ABC-type sugar transporter  41.03 
 
 
322 aa  212  5.999999999999999e-54  Sanguibacter keddieii DSM 10542  Bacteria  normal  0.151535  normal 
 
 
-
 
NC_007958  RPD_3149  binding-protein-dependent transport systems inner membrane component  40.3 
 
 
315 aa  212  5.999999999999999e-54  Rhodopseudomonas palustris BisB5  Bacteria  normal  0.0566553  normal  0.330059 
 
 
-
 
NC_009523  RoseRS_1357  binding-protein-dependent transport systems inner membrane component  41.54 
 
 
316 aa  211  1e-53  Roseiflexus sp. RS-1  Bacteria  normal  normal 
 
 
-
 
NC_012669  Bcav_2264  binding-protein-dependent transport systems inner membrane component  36.3 
 
 
307 aa  211  1e-53  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.277747  normal 
 
 
-
 
NC_012669  Bcav_3573  binding-protein-dependent transport systems inner membrane component  37.5 
 
 
353 aa  211  1e-53  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.500594  normal 
 
 
-
 
NC_013526  Tter_2041  binding-protein-dependent transport systems inner membrane component  38.63 
 
 
305 aa  210  3e-53  Thermobaculum terrenum ATCC BAA-798  Bacteria  hitchhiker  0.00457854  n/a   
 
 
-
 
NC_007413  Ava_0461  binding-protein dependent transport system inner membrane protein  40.85 
 
 
301 aa  209  3e-53  Anabaena variabilis ATCC 29413  Bacteria  normal  normal  0.0667876 
 
 
-
 
NC_009523  RoseRS_2819  binding-protein-dependent transport systems inner membrane component  39.72 
 
 
315 aa  209  4e-53  Roseiflexus sp. RS-1  Bacteria  normal  0.0308401  normal 
 
 
-
 
NC_013526  Tter_2000  binding-protein-dependent transport systems inner membrane component  37.77 
 
 
319 aa  208  7e-53  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_012034  Athe_0400  binding-protein-dependent transport systems inner membrane component  36.82 
 
 
295 aa  208  8e-53  Anaerocellum thermophilum DSM 6725  Bacteria  unclonable  0.000000000506379  n/a   
 
 
-
 
NC_013526  Tter_2615  binding-protein-dependent transport systems inner membrane component  40.3 
 
 
307 aa  208  8e-53  Thermobaculum terrenum ATCC BAA-798  Bacteria  hitchhiker  0.0000296099  n/a   
 
 
-
 
NC_011884  Cyan7425_3980  binding-protein-dependent transport systems inner membrane component  39.8 
 
 
299 aa  208  8e-53  Cyanothece sp. PCC 7425  Bacteria  normal  hitchhiker  0.00655631 
 
 
-
 
NC_009972  Haur_1151  binding-protein-dependent transport systems inner membrane component  45.53 
 
 
314 aa  208  9e-53  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  0.59424  n/a   
 
 
-
 
NC_013947  Snas_0204  binding-protein-dependent transport systems inner membrane component  36.68 
 
 
299 aa  207  2e-52  Stackebrandtia nassauensis DSM 44728  Bacteria  normal  0.497209  normal  0.169553 
 
 
-
 
NC_009767  Rcas_2545  binding-protein-dependent transport systems inner membrane component  39.72 
 
 
316 aa  207  2e-52  Roseiflexus castenholzii DSM 13941  Bacteria  normal  0.637107  normal  0.115222 
 
 
-
 
NC_011661  Dtur_0377  binding-protein-dependent transport systems inner membrane component  39.51 
 
 
294 aa  206  3e-52  Dictyoglomus turgidum DSM 6724  Bacteria  normal  n/a   
 
 
-
 
NC_013595  Sros_2365  sugar ABC transporter, permease protein  37.86 
 
 
288 aa  206  4e-52  Streptosporangium roseum DSM 43021  Bacteria  normal  0.216835  normal 
 
 
-
 
NC_010001  Cphy_0290  binding-protein-dependent transport systems inner membrane component  41.96 
 
 
297 aa  206  4e-52  Clostridium phytofermentans ISDg  Bacteria  normal  n/a   
 
 
-
 
NC_010524  Lcho_3242  binding-protein-dependent transport systems inner membrane component  36.3 
 
 
317 aa  205  8e-52  Leptothrix cholodnii SP-6  Bacteria  n/a    normal 
 
 
-
 
NC_013745  Htur_4489  binding-protein-dependent transport systems inner membrane component  39.07 
 
 
308 aa  204  1e-51  Haloterrigena turkmenica DSM 5511  Archaea  normal  0.283214  n/a   
 
 
-
 
NC_009972  Haur_3640  binding-protein-dependent transport systems inner membrane component  34.23 
 
 
298 aa  204  1e-51  Herpetosiphon aurantiacus ATCC 23779  Bacteria  normal  n/a   
 
 
-
 
NC_013411  GYMC61_2730  binding-protein-dependent transport systems inner membrane component  39.78 
 
 
300 aa  204  1e-51  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_007604  Synpcc7942_0526  ABC-type sugar transport systems permease components-like  35.89 
 
 
293 aa  204  2e-51  Synechococcus elongatus PCC 7942  Bacteria  normal  normal 
 
 
-
 
NC_008262  CPR_0477  ABC tranporter, permease protein  40.48 
 
 
315 aa  203  2e-51  Clostridium perfringens SM101  Bacteria  normal  n/a   
 
 
-
 
NC_009523  RoseRS_4568  binding-protein-dependent transport systems inner membrane component  36.83 
 
 
352 aa  204  2e-51  Roseiflexus sp. RS-1  Bacteria  normal  normal 
 
 
-
 
NC_014248  Aazo_4983  binding-protein-dependent transporter inner membrane protein  38.46 
 
 
310 aa  203  2e-51  'Nostoc azollae' 0708  Bacteria  normal  0.300856  n/a   
 
 
-
 
NC_011071  Smal_2682  binding-protein-dependent transport systems inner membrane component  37.76 
 
 
293 aa  203  3e-51  Stenotrophomonas maltophilia R551-3  Bacteria  normal  0.990678  normal 
 
 
-
 
NC_011899  Hore_15550  binding-protein-dependent transport systems inner membrane component  42.74 
 
 
294 aa  203  3e-51  Halothermothrix orenii H 168  Bacteria  normal  n/a   
 
 
-
 
NC_011831  Cagg_0728  binding-protein-dependent transport systems inner membrane component  36.08 
 
 
313 aa  202  4e-51  Chloroflexus aggregans DSM 9485  Bacteria  hitchhiker  0.000239391  normal 
 
 
-
 
NC_013131  Caci_3807  binding-protein-dependent transport systems inner membrane component  43.46 
 
 
316 aa  202  4e-51  Catenulispora acidiphila DSM 44928  Bacteria  normal  0.922708  normal  0.915782 
 
 
-
 
NC_009767  Rcas_3564  binding-protein-dependent transport systems inner membrane component  41.4 
 
 
316 aa  201  8e-51  Roseiflexus castenholzii DSM 13941  Bacteria  normal  normal  0.264329 
 
 
-
 
NC_012669  Bcav_2875  binding-protein-dependent transport systems inner membrane component  36.79 
 
 
318 aa  201  9e-51  Beutenbergia cavernae DSM 12333  Bacteria  normal  0.847542  normal  0.0272583 
 
 
-
 
NC_014212  Mesil_2465  binding-protein-dependent transport systems inner membrane component  39.32 
 
 
296 aa  201  9.999999999999999e-51  Meiothermus silvanus DSM 9946  Bacteria  normal  0.603266  normal  0.170133 
 
 
-
 
NC_010577  XfasM23_1549  binding-protein-dependent transport systems inner membrane component  37.23 
 
 
293 aa  201  9.999999999999999e-51  Xylella fastidiosa M23  Bacteria  normal  0.563461  n/a   
 
 
-
 
NC_013526  Tter_2511  binding-protein-dependent transport systems inner membrane component  40.98 
 
 
317 aa  201  9.999999999999999e-51  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  0.10809  n/a   
 
 
-
 
NC_013526  Tter_2573  binding-protein-dependent transport systems inner membrane component  39.44 
 
 
309 aa  200  1.9999999999999998e-50  Thermobaculum terrenum ATCC BAA-798  Bacteria  normal  n/a   
 
 
-
 
NC_013174  Jden_0512  binding-protein-dependent transport systems inner membrane component  39.02 
 
 
318 aa  201  1.9999999999999998e-50  Jonesia denitrificans DSM 20603  Bacteria  hitchhiker  0.000000473727  hitchhiker  0.00124128 
 
 
-
 
NC_013946  Mrub_0044  binding-protein-dependent transport systems inner membrane component  38.18 
 
 
304 aa  199  3e-50  Meiothermus ruber DSM 1279  Bacteria  normal  normal 
 
 
-
 
NC_010717  PXO_00881  ABC transporter sugar permease  37.41 
 
 
294 aa  199  3e-50  Xanthomonas oryzae pv. oryzae PXO99A  Bacteria  normal  0.0244413  n/a   
 
 
-
 
NC_010513  Xfasm12_1606  ABC transporter sugar permease  37.23 
 
 
293 aa  199  3.9999999999999996e-50  Xylella fastidiosa M12  Bacteria  normal  n/a   
 
 
-
 
NC_013526  Tter_2506  binding-protein-dependent transport systems inner membrane component  41.06 
 
 
306 aa  199  6e-50  Thermobaculum terrenum ATCC BAA-798  Bacteria  hitchhiker  0.000185658  n/a   
 
 
-
 
NC_013172  Bfae_29410  carbohydrate ABC transporter membrane protein  37.73 
 
 
322 aa  199  6e-50  Brachybacterium faecium DSM 4810  Bacteria  normal  0.899558  n/a   
 
 
-
 
NC_012850  Rleg_3429  binding-protein-dependent transport systems inner membrane component  40.36 
 
 
307 aa  199  6e-50  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  normal 
 
 
-
 
NC_010001  Cphy_0527  binding-protein-dependent transport systems inner membrane component  41.04 
 
 
296 aa  198  1.0000000000000001e-49  Clostridium phytofermentans ISDg  Bacteria  hitchhiker  0.0000000283647  n/a   
 
 
-
 
NC_007413  Ava_0563  binding-protein dependent transport system inner membrane protein  39.86 
 
 
294 aa  197  2.0000000000000003e-49  Anabaena variabilis ATCC 29413  Bacteria  normal  0.22835  normal  0.0558608 
 
 
-
 
NC_012669  Bcav_0828  binding-protein-dependent transport systems inner membrane component  37.41 
 
 
316 aa  197  2.0000000000000003e-49  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal  0.194369 
 
 
-
 
NC_013205  Aaci_0796  binding-protein-dependent transport systems inner membrane component  42.76 
 
 
312 aa  197  2.0000000000000003e-49  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  0.633875  n/a   
 
 
-
 
NC_012669  Bcav_0311  binding-protein-dependent transport systems inner membrane component  32.51 
 
 
321 aa  197  3e-49  Beutenbergia cavernae DSM 12333  Bacteria  normal  normal 
 
 
-
 
NC_008541  Arth_3147  binding-protein-dependent transport systems inner membrane component  35.93 
 
 
319 aa  195  8.000000000000001e-49  Arthrobacter sp. FB24  Bacteria  hitchhiker  0.00382098  n/a   
 
 
-
 
NC_008781  Pnap_0229  binding-protein-dependent transport systems inner membrane component  37.1 
 
 
312 aa  194  1e-48  Polaromonas naphthalenivorans CJ2  Bacteria  normal  0.772545  normal  0.492978 
 
 
-
 
NC_009616  Tmel_1616  binding-protein-dependent transport systems inner membrane component  43.69 
 
 
429 aa  194  1e-48  Thermosipho melanesiensis BI429  Bacteria  normal  0.225919  n/a   
 
 
-
 
NC_013521  Sked_07100  carbohydrate ABC transporter membrane protein  36.69 
 
 
318 aa  194  1e-48  Sanguibacter keddieii DSM 10542  Bacteria  normal  0.790586  normal 
 
 
-
 
NC_011726  PCC8801_4236  binding-protein-dependent transport systems inner membrane component  39.93 
 
 
294 aa  194  2e-48  Cyanothece sp. PCC 8801  Bacteria  n/a    n/a   
 
 
-
 
NC_013161  Cyan8802_4298  binding-protein-dependent transport systems inner membrane component  39.93 
 
 
294 aa  194  2e-48  Cyanothece sp. PCC 8802  Bacteria  normal  normal  0.200183 
 
 
-
 
NC_009565  TBFG_12077  sugar ABC transporter membrane protein  36.86 
 
 
300 aa  194  2e-48  Mycobacterium tuberculosis F11  Bacteria  normal  normal 
 
 
-
 
NC_013411  GYMC61_1728  binding-protein-dependent transport systems inner membrane component  39.39 
 
 
299 aa  194  2e-48  Geobacillus sp. Y412MC61  Bacteria  n/a    n/a   
 
 
-
 
NC_003909  BCE_0630  glycerol-3-phosphate ABC transporter, permease protein, putative  37.45 
 
 
310 aa  193  3e-48  Bacillus cereus ATCC 10987  Bacteria  normal  n/a   
 
 
-
 
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