More than 300 homologs were found in PanDaTox collection
for query gene Slin_3102 on replicon NC_013730
Organism: Spirosoma linguale DSM 74



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_013730  Slin_1989  MCP methyltransferase, CheR-type with PAS/PAC sensor  51.03 
 
 
1110 aa  711    Spirosoma linguale DSM 74  Bacteria  normal  0.175442  normal  0.013335 
 
 
-
 
NC_013730  Slin_3102  signal transduction histidine kinase with CheB and CheR activity  100 
 
 
1418 aa  2918    Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_014248  Aazo_2376  signal transduction histidine kinase with CheB and CheR activity  42.89 
 
 
1407 aa  610  1e-173  'Nostoc azollae' 0708  Bacteria  normal  n/a   
 
 
-
 
NC_007413  Ava_0314  Signal transduction histidine kinase (STHK) with CheB and CheR activity  41.87 
 
 
1399 aa  608  9.999999999999999e-173  Anabaena variabilis ATCC 29413  Bacteria  normal  normal 
 
 
-
 
NC_008752  Aave_2417  signal transduction histidine kinase with CheB and CheR activity  29.72 
 
 
1535 aa  542  9.999999999999999e-153  Acidovorax citrulli AAC00-1  Bacteria  normal  0.117494  normal 
 
 
-
 
NC_009712  Mboo_0327  putative PAS/PAC sensor protein  39.43 
 
 
1008 aa  532  1e-149  Candidatus Methanoregula boonei 6A8  Archaea  normal  normal 
 
 
-
 
NC_013173  Dbac_2162  MCP methyltransferase/methylesterase, CheR/CheB  38.1 
 
 
879 aa  521  1e-146  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  n/a   
 
 
-
 
NC_007355  Mbar_A2183  hypothetical protein  34.69 
 
 
980 aa  510  1e-143  Methanosarcina barkeri str. Fusaro  Archaea  normal  normal  0.850093 
 
 
-
 
NC_011060  Ppha_1653  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  34.53 
 
 
993 aa  513  1e-143  Pelodictyon phaeoclathratiforme BU-1  Bacteria  normal  n/a   
 
 
-
 
NC_008639  Cpha266_1788  putative PAS/PAC sensor protein  34.6 
 
 
998 aa  512  1e-143  Chlorobium phaeobacteroides DSM 266  Bacteria  normal  n/a   
 
 
-
 
NC_010803  Clim_1600  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  35.05 
 
 
1000 aa  508  9.999999999999999e-143  Chlorobium limicola DSM 245  Bacteria  normal  n/a   
 
 
-
 
NC_008709  Ping_3128  MCP methyltransferase, CheR-type  38.59 
 
 
840 aa  506  1e-141  Psychromonas ingrahamii 37  Bacteria  normal  normal 
 
 
-
 
NC_011832  Mpal_2460  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  35.05 
 
 
971 aa  505  1e-141  Methanosphaerula palustris E1-9c  Archaea  normal  normal 
 
 
-
 
NC_007298  Daro_2045  CheB methylesterase:MCP methyltransferase, CheR-type  36.91 
 
 
868 aa  501  1e-140  Dechloromonas aromatica RCB  Bacteria  normal  normal 
 
 
-
 
NC_007908  Rfer_2355  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  37.74 
 
 
1008 aa  502  1e-140  Rhodoferax ferrireducens T118  Bacteria  normal  0.71741  n/a   
 
 
-
 
NC_008709  Ping_1840  MCP methyltransferase, CheR-type  38.79 
 
 
840 aa  498  1e-139  Psychromonas ingrahamii 37  Bacteria  normal  0.59391  normal  0.603716 
 
 
-
 
NC_008340  Mlg_1118  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  35.92 
 
 
852 aa  493  1e-137  Alkalilimnicola ehrlichii MLHE-1  Bacteria  normal  normal  0.742809 
 
 
-
 
NC_011060  Ppha_0229  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  33.93 
 
 
1138 aa  490  1e-137  Pelodictyon phaeoclathratiforme BU-1  Bacteria  normal  n/a   
 
 
-
 
NC_007908  Rfer_3013  MCP methyltransferase, CheR-type  36.91 
 
 
877 aa  488  1e-136  Rhodoferax ferrireducens T118  Bacteria  normal  0.404945  n/a   
 
 
-
 
NC_007514  Cag_0563  putative PAS/PAC sensor protein  34.16 
 
 
1035 aa  486  1e-135  Chlorobium chlorochromatii CaD3  Bacteria  normal  n/a   
 
 
-
 
NC_007517  Gmet_0780  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  36.51 
 
 
887 aa  486  1e-135  Geobacter metallireducens GS-15  Bacteria  normal  normal 
 
 
-
 
NC_010581  Bind_0707  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  34.36 
 
 
1190 aa  485  1e-135  Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  normal 
 
 
-
 
NC_013205  Aaci_0673  signal transduction histidine kinase with CheB and CheR activity  32.34 
 
 
1215 aa  486  1e-135  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_010625  Bphy_6399  signal transduction histidine kinase with CheB and CheR activity  33.3 
 
 
1361 aa  481  1e-134  Burkholderia phymatum STM815  Bacteria  normal  0.191888  normal 
 
 
-
 
NC_008709  Ping_2549  fused CheR-type MCP methyltransferase and PAS sensor protein  34.93 
 
 
1006 aa  476  1e-133  Psychromonas ingrahamii 37  Bacteria  normal  normal 
 
 
-
 
NC_009620  Smed_4278  putative PAS/PAC sensor protein  36.36 
 
 
1027 aa  474  1e-132  Sinorhizobium medicae WSM419  Bacteria  normal  normal 
 
 
-
 
NC_013037  Dfer_5571  signal transduction histidine kinase with CheB and CheR activity  35.39 
 
 
1218 aa  473  1.0000000000000001e-131  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.273526  normal 
 
 
-
 
NC_007961  Nham_4605  MCP methyltransferase, CheR-type  36.68 
 
 
1092 aa  471  1.0000000000000001e-131  Nitrobacter hamburgensis X14  Bacteria  normal  0.315944  n/a   
 
 
-
 
NC_013037  Dfer_5176  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  33.64 
 
 
1404 aa  471  1.0000000000000001e-131  Dyadobacter fermentans DSM 18053  Bacteria  normal  normal  0.190634 
 
 
-
 
NC_007760  Adeh_3183  signal transduction histidine kinase  36.1 
 
 
1279 aa  467  9.999999999999999e-131  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_011891  A2cp1_3377  signal transduction histidine kinase with CheB and CheR activity  35.73 
 
 
1242 aa  466  1e-129  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_3640  MCP methyltransferase, CheR-type with PAS/PAC sensor  37 
 
 
1303 aa  466  1e-129  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal  0.581797 
 
 
-
 
NC_008781  Pnap_1703  signal transduction histidine kinase with CheB and CheR activity  32.56 
 
 
1408 aa  464  1e-129  Polaromonas naphthalenivorans CJ2  Bacteria  normal  0.433463  normal 
 
 
-
 
NC_009621  Smed_5776  putative PAS/PAC sensor protein  32.8 
 
 
1160 aa  462  9.999999999999999e-129  Sinorhizobium medicae WSM419  Bacteria  normal  0.491611  normal  0.0137055 
 
 
-
 
NC_013173  Dbac_1410  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  29.73 
 
 
1120 aa  461  9.999999999999999e-129  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.132886  n/a   
 
 
-
 
NC_010725  Mpop_0310  MCP methyltransferase, CheR-type  35.99 
 
 
1149 aa  459  1e-127  Methylobacterium populi BJ001  Bacteria  normal  0.512157  normal 
 
 
-
 
NC_013440  Hoch_4639  signal transduction histidine kinase with CheB and CheR activity  27.06 
 
 
1453 aa  459  1e-127  Haliangium ochraceum DSM 14365  Bacteria  normal  0.432269  normal 
 
 
-
 
NC_010510  Mrad2831_6264  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  32.76 
 
 
1163 aa  457  1e-127  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_010086  Bmul_3193  signal transduction histidine kinase with CheB and CheR activity  32.49 
 
 
1380 aa  456  1.0000000000000001e-126  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal  0.112764 
 
 
-
 
NC_010322  PputGB1_3018  signal transduction histidine kinase with CheB and CheR activity  31.37 
 
 
1371 aa  455  1.0000000000000001e-126  Pseudomonas putida GB-1  Bacteria  normal  normal  0.980757 
 
 
-
 
NC_007348  Reut_B4915  PAS  30.72 
 
 
1384 aa  452  1e-125  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_4422  signal transduction histidine kinase with CheB and CheR activity  33.64 
 
 
1274 aa  453  1e-125  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.381764  normal 
 
 
-
 
NC_011145  AnaeK_0372  signal transduction histidine kinase with CheB and CheR activity  35.42 
 
 
1233 aa  449  1.0000000000000001e-124  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_008751  Dvul_2487  signal transduction histidine kinase with CheB and CheR activity  35.12 
 
 
1535 aa  441  9.999999999999999e-123  Desulfovibrio vulgaris DP4  Bacteria  normal  0.162467  normal  0.455724 
 
 
-
 
NC_011004  Rpal_3739  MCP methyltransferase, CheR-type  36.15 
 
 
1045 aa  437  1e-121  Rhodopseudomonas palustris TIE-1  Bacteria  normal  n/a   
 
 
-
 
NC_010580  Bind_3835  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  32.27 
 
 
1167 aa  437  1e-121  Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  normal 
 
 
-
 
NC_010505  Mrad2831_4430  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  31.78 
 
 
1158 aa  432  1e-119  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_010505  Mrad2831_5709  MCP methyltransferase, CheR-type  35.93 
 
 
853 aa  427  1e-118  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal  0.729466 
 
 
-
 
NC_007955  Mbur_0399  MCP methyltransferase, CheR-type  33.13 
 
 
820 aa  426  1e-117  Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_010725  Mpop_1297  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  32.35 
 
 
1168 aa  424  1e-117  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_007484  Noc_1601  CheB methylesterase, CheR methyltransferase, hybrid histidine kinase  34.95 
 
 
1222 aa  422  1e-116  Nitrosococcus oceani ATCC 19707  Bacteria  normal  0.472526  n/a   
 
 
-
 
NC_013440  Hoch_3278  signal transduction histidine kinase with CheB and CheR activity  33.52 
 
 
2468 aa  420  1e-116  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0267066 
 
 
-
 
NC_007643  Rru_A1500  Signal transduction histidine kinase (STHK) with CheB and CheR activity  34.62 
 
 
1483 aa  422  1e-116  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  n/a   
 
 
-
 
NC_008609  Ppro_3165  signal transduction histidine kinase with CheB and CheR activity  32.82 
 
 
1306 aa  423  1e-116  Pelobacter propionicus DSM 2379  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_7206  signal transduction histidine kinase with CheB and CheR activity  30.75 
 
 
1499 aa  417  9.999999999999999e-116  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal 
 
 
-
 
NC_007802  Jann_2564  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  32 
 
 
1089 aa  414  1e-114  Jannaschia sp. CCS1  Bacteria  normal  normal 
 
 
-
 
NC_007953  Bxe_C0521  multi sensor hybrid histidine kinase  33.37 
 
 
1344 aa  414  1e-114  Burkholderia xenovorans LB400  Bacteria  normal  normal 
 
 
-
 
NC_008789  Hhal_1716  MCP methyltransferase, CheR-type  34.21 
 
 
856 aa  410  1e-113  Halorhodospira halophila SL1  Bacteria  normal  0.92135  n/a   
 
 
-
 
NC_007493  RSP_2229  methylesterase CheB/methylase CheR  31.84 
 
 
1170 aa  413  1e-113  Rhodobacter sphaeroides 2.4.1  Bacteria  normal  0.840236  n/a   
 
 
-
 
NC_009049  Rsph17029_0905  putative PAS/PAC sensor protein  31.84 
 
 
1170 aa  413  1e-113  Rhodobacter sphaeroides ATCC 17029  Bacteria  normal  normal  0.968727 
 
 
-
 
NC_007912  Sde_3046  hypothetical protein  33.5 
 
 
1010 aa  413  1e-113  Saccharophagus degradans 2-40  Bacteria  normal  hitchhiker  0.00164382 
 
 
-
 
NC_013061  Phep_3913  PAS sensor protein  33.62 
 
 
1337 aa  413  1e-113  Pedobacter heparinus DSM 2366  Bacteria  normal  0.290527  normal  0.28306 
 
 
-
 
NC_013440  Hoch_3250  signal transduction histidine kinase with CheB and CheR activity  34.12 
 
 
1348 aa  407  1.0000000000000001e-112  Haliangium ochraceum DSM 14365  Bacteria  normal  0.534329  normal  0.0270765 
 
 
-
 
NC_009467  Acry_3169  signal transduction histidine kinase with CheB and CheR activity  34.76 
 
 
1445 aa  409  1.0000000000000001e-112  Acidiphilium cryptum JF-5  Bacteria  normal  n/a   
 
 
-
 
NC_013440  Hoch_5252  signal transduction histidine kinase with CheB and CheR activity  33.41 
 
 
1698 aa  407  1.0000000000000001e-112  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_011368  Rleg2_5237  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  31.93 
 
 
1324 aa  407  1.0000000000000001e-112  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.395635 
 
 
-
 
NC_007952  Bxe_B1520  signal transduction histidine kinase (STHK) with CheB and CheR activity  35.24 
 
 
1303 aa  405  1e-111  Burkholderia xenovorans LB400  Bacteria  normal  0.124967  normal 
 
 
-
 
NC_010814  Glov_2975  diguanylate cyclase with PAS/PAC sensor  33.47 
 
 
1084 aa  405  1e-111  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_010508  Bcenmc03_1302  signal transduction histidine kinase with CheB and CheR activity  34.57 
 
 
1220 aa  403  9.999999999999999e-111  Burkholderia cenocepacia MC0-3  Bacteria  normal  normal  0.772751 
 
 
-
 
NC_010511  M446_6211  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  36.52 
 
 
1061 aa  399  1e-109  Methylobacterium sp. 4-46  Bacteria  normal  0.820077  normal  0.703655 
 
 
-
 
NC_014230  CA2559_12648  Signal Transduction Histidine Kinase (STHK) with CheB and CheRactivity  31.79 
 
 
1200 aa  399  1e-109  Croceibacter atlanticus HTCC2559  Bacteria  normal  n/a   
 
 
-
 
NC_008044  TM1040_0460  MCP methyltransferase, CheR-type  33.96 
 
 
837 aa  399  1e-109  Ruegeria sp. TM1040  Bacteria  normal  0.604812  normal 
 
 
-
 
NC_008044  TM1040_2227  MCP methyltransferase, CheR-type  34.6 
 
 
824 aa  396  1e-108  Ruegeria sp. TM1040  Bacteria  normal  normal 
 
 
-
 
NC_011894  Mnod_3755  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  33.74 
 
 
1063 aa  390  1e-107  Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_009428  Rsph17025_2264  putative PAS/PAC sensor protein  32.57 
 
 
1165 aa  387  1e-106  Rhodobacter sphaeroides ATCC 17025  Bacteria  normal  0.620072  normal  0.0600346 
 
 
-
 
NC_010086  Bmul_4696  signal transduction histidine kinase with CheB and CheR activity  32.22 
 
 
1214 aa  390  1e-106  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal 
 
 
-
 
NC_008255  CHU_1237  chemotaxis response regulator (methyltransferase)  32.47 
 
 
1618 aa  382  1e-104  Cytophaga hutchinsonii ATCC 33406  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_1404  signal transduction histidine kinase with CheB and CheR activity  30.49 
 
 
1759 aa  377  1e-103  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_008576  Mmc1_3390  MCP methyltransferase, CheR-type  36.47 
 
 
617 aa  365  3e-99  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_008044  TM1040_1028  signal transduction histidine kinase with CheB and CheR activity  28.57 
 
 
1248 aa  355  2.9999999999999997e-96  Ruegeria sp. TM1040  Bacteria  normal  normal  0.507304 
 
 
-
 
NC_008789  Hhal_0370  protein-glutamate O-methyltransferase  36.16 
 
 
639 aa  327  1e-87  Halorhodospira halophila SL1  Bacteria  normal  0.181962  n/a   
 
 
-
 
NC_010623  Bphy_5175  MCP methyltransferase, CheR-type  28.13 
 
 
823 aa  309  3e-82  Burkholderia phymatum STM815  Bacteria  normal  normal  0.367936 
 
 
-
 
NC_007348  Reut_B5191  CheB methylesterase:MCP methyltransferase, CheR-type  28.82 
 
 
813 aa  307  1.0000000000000001e-81  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_002977  MCA1246  methyltransferase CheR, putative  34.59 
 
 
1378 aa  301  7e-80  Methylococcus capsulatus str. Bath  Bacteria  normal  0.271052  n/a   
 
 
-
 
NC_007964  Nham_3990  MCP methyltransferase, CheR-type  38.1 
 
 
432 aa  294  7e-78  Nitrobacter hamburgensis X14  Bacteria  normal  n/a   
 
 
-
 
NC_010717  PXO_03023  methyltransferase  37.78 
 
 
604 aa  293  1e-77  Xanthomonas oryzae pv. oryzae PXO99A  Bacteria  normal  0.361036  n/a   
 
 
-
 
NC_009622  Smed_6341  putative PAS/PAC sensor protein  36 
 
 
629 aa  291  5.0000000000000004e-77  Sinorhizobium medicae WSM419  Bacteria  normal  0.433344  normal  0.230755 
 
 
-
 
NC_010814  Glov_0566  MCP methyltransferase, CheR-type with PAS/PAC sensor  32.42 
 
 
1193 aa  289  2.9999999999999996e-76  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_013037  Dfer_5175  histidine kinase  48.45 
 
 
291 aa  276  2.0000000000000002e-72  Dyadobacter fermentans DSM 18053  Bacteria  normal  normal  0.219996 
 
 
-
 
NC_014248  Aazo_0227  MCP methyltransferase  32.24 
 
 
631 aa  270  1e-70  'Nostoc azollae' 0708  Bacteria  normal  0.993793  n/a   
 
 
-
 
NC_011884  Cyan7425_3121  MCP methyltransferase, CheR-type with PAS/PAC sensor  30.8 
 
 
617 aa  250  1e-64  Cyanothece sp. PCC 7425  Bacteria  normal  0.0152355  normal  0.805919 
 
 
-
 
NC_011729  PCC7424_0433  MCP methyltransferase, CheR-type with PAS/PAC sensor  32.26 
 
 
618 aa  243  1e-62  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_013440  Hoch_3427  MCP methyltransferase, CheR-type with PAS/PAC sensor  27.44 
 
 
2031 aa  191  9e-47  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0889636 
 
 
-
 
NC_013037  Dfer_5603  histidine kinase  42.32 
 
 
401 aa  186  4.0000000000000006e-45  Dyadobacter fermentans DSM 18053  Bacteria  normal  normal  0.833057 
 
 
-
 
NC_013037  Dfer_5435  histidine kinase  41.73 
 
 
455 aa  184  9.000000000000001e-45  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.268395  normal  0.150207 
 
 
-
 
NC_013730  Slin_5220  histidine kinase  40.81 
 
 
438 aa  180  2e-43  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_010002  Daci_5074  histidine kinase  39.92 
 
 
432 aa  172  6e-41  Delftia acidovorans SPH-1  Bacteria  normal  0.299774  normal  0.0561141 
 
 
-
 
NC_007517  Gmet_3477  PAS/PAC sensor hybrid histidine kinase  24.38 
 
 
1465 aa  171  1e-40  Geobacter metallireducens GS-15  Bacteria  normal  normal 
 
 
-
 
NC_009712  Mboo_1581  protein-glutamate O-methyltransferase  35.88 
 
 
269 aa  165  5.0000000000000005e-39  Candidatus Methanoregula boonei 6A8  Archaea  normal  0.175681  normal  0.125652 
 
 
-
 
NC_009622  Smed_6342  CheB methylesterase  35.14 
 
 
336 aa  165  7e-39  Sinorhizobium medicae WSM419  Bacteria  normal  0.582664  normal  0.191496 
 
 
-
 
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