More than 300 homologs were found in PanDaTox collection
for query gene Nham_4605 on replicon NC_007961
Organism: Nitrobacter hamburgensis X14



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Replicon accession

Locus tag

Product

% identity

Alignment on query gene

Alignment on homolog gene

Length

Bit score

E-value

Organism name

Kingdom

Plasmid clonability

Plasmid unclonability p-value

Fosmid clonability

Fosmid unclonability p-value

Coverage Plot

PanDaTox homologs

Experimental validation
NC_010511  M446_6211  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  41.64 
 
 
1061 aa  704    Methylobacterium sp. 4-46  Bacteria  normal  0.820077  normal  0.703655 
 
 
-
 
NC_007355  Mbar_A2183  hypothetical protein  42.73 
 
 
980 aa  639    Methanosarcina barkeri str. Fusaro  Archaea  normal  normal  0.850093 
 
 
-
 
NC_009620  Smed_4278  putative PAS/PAC sensor protein  39.88 
 
 
1027 aa  743    Sinorhizobium medicae WSM419  Bacteria  normal  normal 
 
 
-
 
NC_007961  Nham_4605  MCP methyltransferase, CheR-type  100 
 
 
1092 aa  2258    Nitrobacter hamburgensis X14  Bacteria  normal  0.315944  n/a   
 
 
-
 
NC_011004  Rpal_3739  MCP methyltransferase, CheR-type  64.54 
 
 
1045 aa  1362    Rhodopseudomonas palustris TIE-1  Bacteria  normal  n/a   
 
 
-
 
NC_011894  Mnod_3755  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  40.09 
 
 
1063 aa  697    Methylobacterium nodulans ORS 2060  Bacteria  normal  n/a   
 
 
-
 
NC_010581  Bind_0707  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  47.91 
 
 
1190 aa  763    Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  normal 
 
 
-
 
NC_007908  Rfer_2355  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  41.79 
 
 
1008 aa  634  1e-180  Rhodoferax ferrireducens T118  Bacteria  normal  0.71741  n/a   
 
 
-
 
NC_008639  Cpha266_1788  putative PAS/PAC sensor protein  40.87 
 
 
998 aa  621  1e-176  Chlorobium phaeobacteroides DSM 266  Bacteria  normal  n/a   
 
 
-
 
NC_007517  Gmet_0780  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  40.47 
 
 
887 aa  610  1e-173  Geobacter metallireducens GS-15  Bacteria  normal  normal 
 
 
-
 
NC_013173  Dbac_2162  MCP methyltransferase/methylesterase, CheR/CheB  40.35 
 
 
879 aa  607  9.999999999999999e-173  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  n/a   
 
 
-
 
NC_011368  Rleg2_5237  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  41.68 
 
 
1324 aa  608  9.999999999999999e-173  Rhizobium leguminosarum bv. trifolii WSM2304  Bacteria  normal  normal  0.395635 
 
 
-
 
NC_011145  AnaeK_0372  signal transduction histidine kinase with CheB and CheR activity  40.85 
 
 
1233 aa  603  1.0000000000000001e-171  Anaeromyxobacter sp. K  Bacteria  normal  n/a   
 
 
-
 
NC_011060  Ppha_1653  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  39.42 
 
 
993 aa  604  1.0000000000000001e-171  Pelodictyon phaeoclathratiforme BU-1  Bacteria  normal  n/a   
 
 
-
 
NC_010510  Mrad2831_6264  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  44.98 
 
 
1163 aa  603  1.0000000000000001e-171  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_011060  Ppha_0229  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  40.95 
 
 
1138 aa  597  1e-169  Pelodictyon phaeoclathratiforme BU-1  Bacteria  normal  n/a   
 
 
-
 
NC_010725  Mpop_1297  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  43.38 
 
 
1168 aa  599  1e-169  Methylobacterium populi BJ001  Bacteria  normal  normal 
 
 
-
 
NC_010803  Clim_1600  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  40.66 
 
 
1000 aa  594  1e-168  Chlorobium limicola DSM 245  Bacteria  normal  n/a   
 
 
-
 
NC_007298  Daro_2045  CheB methylesterase:MCP methyltransferase, CheR-type  40.66 
 
 
868 aa  590  1e-167  Dechloromonas aromatica RCB  Bacteria  normal  normal 
 
 
-
 
NC_007908  Rfer_3013  MCP methyltransferase, CheR-type  40.63 
 
 
877 aa  591  1e-167  Rhodoferax ferrireducens T118  Bacteria  normal  0.404945  n/a   
 
 
-
 
NC_009712  Mboo_0327  putative PAS/PAC sensor protein  36.69 
 
 
1008 aa  588  1e-166  Candidatus Methanoregula boonei 6A8  Archaea  normal  normal 
 
 
-
 
NC_011832  Mpal_2460  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  38.97 
 
 
971 aa  585  1.0000000000000001e-165  Methanosphaerula palustris E1-9c  Archaea  normal  normal 
 
 
-
 
NC_011891  A2cp1_3377  signal transduction histidine kinase with CheB and CheR activity  38.69 
 
 
1242 aa  582  1e-164  Anaeromyxobacter dehalogenans 2CP-1  Bacteria  normal  n/a   
 
 
-
 
NC_007760  Adeh_3183  signal transduction histidine kinase  38.58 
 
 
1279 aa  581  1e-164  Anaeromyxobacter dehalogenans 2CP-C  Bacteria  normal  n/a   
 
 
-
 
NC_010625  Bphy_6399  signal transduction histidine kinase with CheB and CheR activity  38.89 
 
 
1361 aa  580  1e-164  Burkholderia phymatum STM815  Bacteria  normal  0.191888  normal 
 
 
-
 
NC_008781  Pnap_1703  signal transduction histidine kinase with CheB and CheR activity  38.57 
 
 
1408 aa  581  1e-164  Polaromonas naphthalenivorans CJ2  Bacteria  normal  0.433463  normal 
 
 
-
 
NC_009621  Smed_5776  putative PAS/PAC sensor protein  40.54 
 
 
1160 aa  575  1.0000000000000001e-162  Sinorhizobium medicae WSM419  Bacteria  normal  0.491611  normal  0.0137055 
 
 
-
 
NC_013037  Dfer_5571  signal transduction histidine kinase with CheB and CheR activity  38.58 
 
 
1218 aa  572  1e-161  Dyadobacter fermentans DSM 18053  Bacteria  normal  0.273526  normal 
 
 
-
 
NC_007348  Reut_B4915  PAS  39.03 
 
 
1384 aa  571  1e-161  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_008709  Ping_3128  MCP methyltransferase, CheR-type  39.57 
 
 
840 aa  572  1e-161  Psychromonas ingrahamii 37  Bacteria  normal  normal 
 
 
-
 
NC_007514  Cag_0563  putative PAS/PAC sensor protein  38.44 
 
 
1035 aa  569  1e-160  Chlorobium chlorochromatii CaD3  Bacteria  normal  n/a   
 
 
-
 
NC_008709  Ping_1840  MCP methyltransferase, CheR-type  38.98 
 
 
840 aa  568  1e-160  Psychromonas ingrahamii 37  Bacteria  normal  0.59391  normal  0.603716 
 
 
-
 
NC_008709  Ping_2549  fused CheR-type MCP methyltransferase and PAS sensor protein  40.88 
 
 
1006 aa  567  1e-160  Psychromonas ingrahamii 37  Bacteria  normal  normal 
 
 
-
 
NC_013132  Cpin_4422  signal transduction histidine kinase with CheB and CheR activity  38.3 
 
 
1274 aa  564  1.0000000000000001e-159  Chitinophaga pinensis DSM 2588  Bacteria  normal  0.381764  normal 
 
 
-
 
NC_010580  Bind_3835  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  39.45 
 
 
1167 aa  564  1.0000000000000001e-159  Beijerinckia indica subsp. indica ATCC 9039  Bacteria  normal  normal 
 
 
-
 
NC_008752  Aave_2417  signal transduction histidine kinase with CheB and CheR activity  38.67 
 
 
1535 aa  561  1e-158  Acidovorax citrulli AAC00-1  Bacteria  normal  0.117494  normal 
 
 
-
 
NC_014248  Aazo_2376  signal transduction histidine kinase with CheB and CheR activity  38.34 
 
 
1407 aa  559  1e-157  'Nostoc azollae' 0708  Bacteria  normal  n/a   
 
 
-
 
NC_007413  Ava_0314  Signal transduction histidine kinase (STHK) with CheB and CheR activity  38.99 
 
 
1399 aa  552  1e-155  Anabaena variabilis ATCC 29413  Bacteria  normal  normal 
 
 
-
 
NC_008340  Mlg_1118  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  38.74 
 
 
852 aa  551  1e-155  Alkalilimnicola ehrlichii MLHE-1  Bacteria  normal  normal  0.742809 
 
 
-
 
NC_013037  Dfer_5176  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  38.51 
 
 
1404 aa  549  1e-155  Dyadobacter fermentans DSM 18053  Bacteria  normal  normal  0.190634 
 
 
-
 
NC_007484  Noc_1601  CheB methylesterase, CheR methyltransferase, hybrid histidine kinase  37.6 
 
 
1222 aa  546  1e-153  Nitrosococcus oceani ATCC 19707  Bacteria  normal  0.472526  n/a   
 
 
-
 
NC_010725  Mpop_0310  MCP methyltransferase, CheR-type  38.11 
 
 
1149 aa  521  1e-146  Methylobacterium populi BJ001  Bacteria  normal  0.512157  normal 
 
 
-
 
NC_013205  Aaci_0673  signal transduction histidine kinase with CheB and CheR activity  37.3 
 
 
1215 aa  517  1.0000000000000001e-145  Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446  Bacteria  normal  n/a   
 
 
-
 
NC_010322  PputGB1_3018  signal transduction histidine kinase with CheB and CheR activity  36.28 
 
 
1371 aa  518  1.0000000000000001e-145  Pseudomonas putida GB-1  Bacteria  normal  normal  0.980757 
 
 
-
 
NC_010505  Mrad2831_5709  MCP methyltransferase, CheR-type  37.83 
 
 
853 aa  514  1e-144  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal  0.729466 
 
 
-
 
NC_009467  Acry_3169  signal transduction histidine kinase with CheB and CheR activity  35.72 
 
 
1445 aa  508  9.999999999999999e-143  Acidiphilium cryptum JF-5  Bacteria  normal  n/a   
 
 
-
 
NC_010086  Bmul_3193  signal transduction histidine kinase with CheB and CheR activity  36.91 
 
 
1380 aa  508  9.999999999999999e-143  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal  0.112764 
 
 
-
 
NC_007493  RSP_2229  methylesterase CheB/methylase CheR  36.85 
 
 
1170 aa  504  1e-141  Rhodobacter sphaeroides 2.4.1  Bacteria  normal  0.840236  n/a   
 
 
-
 
NC_007643  Rru_A1500  Signal transduction histidine kinase (STHK) with CheB and CheR activity  36.71 
 
 
1483 aa  504  1e-141  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  n/a   
 
 
-
 
NC_009049  Rsph17029_0905  putative PAS/PAC sensor protein  36.85 
 
 
1170 aa  503  1e-141  Rhodobacter sphaeroides ATCC 17029  Bacteria  normal  normal  0.968727 
 
 
-
 
NC_013173  Dbac_1410  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  34.79 
 
 
1120 aa  502  1e-140  Desulfomicrobium baculatum DSM 4028  Bacteria  normal  0.132886  n/a   
 
 
-
 
NC_010505  Mrad2831_4430  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  37.11 
 
 
1158 aa  498  1e-139  Methylobacterium radiotolerans JCM 2831  Bacteria  normal  normal 
 
 
-
 
NC_009428  Rsph17025_2264  putative PAS/PAC sensor protein  37.64 
 
 
1165 aa  497  1e-139  Rhodobacter sphaeroides ATCC 17025  Bacteria  normal  0.620072  normal  0.0600346 
 
 
-
 
NC_008789  Hhal_1716  MCP methyltransferase, CheR-type  37.15 
 
 
856 aa  488  1e-136  Halorhodospira halophila SL1  Bacteria  normal  0.92135  n/a   
 
 
-
 
NC_013440  Hoch_5252  signal transduction histidine kinase with CheB and CheR activity  36.88 
 
 
1698 aa  482  1e-134  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_3250  signal transduction histidine kinase with CheB and CheR activity  35.26 
 
 
1348 aa  476  1e-133  Haliangium ochraceum DSM 14365  Bacteria  normal  0.534329  normal  0.0270765 
 
 
-
 
NC_007912  Sde_3046  hypothetical protein  36.35 
 
 
1010 aa  477  1e-133  Saccharophagus degradans 2-40  Bacteria  normal  hitchhiker  0.00164382 
 
 
-
 
NC_007955  Mbur_0399  MCP methyltransferase, CheR-type  35.01 
 
 
820 aa  476  1e-132  Methanococcoides burtonii DSM 6242  Archaea  normal  n/a   
 
 
-
 
NC_008609  Ppro_3165  signal transduction histidine kinase with CheB and CheR activity  34 
 
 
1306 aa  470  1.0000000000000001e-131  Pelobacter propionicus DSM 2379  Bacteria  normal  n/a   
 
 
-
 
NC_013440  Hoch_1404  signal transduction histidine kinase with CheB and CheR activity  35.95 
 
 
1759 aa  464  1e-129  Haliangium ochraceum DSM 14365  Bacteria  normal  normal 
 
 
-
 
NC_008255  CHU_1237  chemotaxis response regulator (methyltransferase)  34.25 
 
 
1618 aa  464  1e-129  Cytophaga hutchinsonii ATCC 33406  Bacteria  normal  normal 
 
 
-
 
NC_013061  Phep_3913  PAS sensor protein  33.66 
 
 
1337 aa  461  9.999999999999999e-129  Pedobacter heparinus DSM 2366  Bacteria  normal  0.290527  normal  0.28306 
 
 
-
 
NC_013132  Cpin_7206  signal transduction histidine kinase with CheB and CheR activity  33.84 
 
 
1499 aa  462  9.999999999999999e-129  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal 
 
 
-
 
NC_013730  Slin_3102  signal transduction histidine kinase with CheB and CheR activity  36.68 
 
 
1418 aa  458  1e-127  Spirosoma linguale DSM 74  Bacteria  normal  normal 
 
 
-
 
NC_013440  Hoch_4639  signal transduction histidine kinase with CheB and CheR activity  34.25 
 
 
1453 aa  457  1e-127  Haliangium ochraceum DSM 14365  Bacteria  normal  0.432269  normal 
 
 
-
 
NC_013440  Hoch_3278  signal transduction histidine kinase with CheB and CheR activity  36.59 
 
 
2468 aa  450  1e-125  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0267066 
 
 
-
 
NC_014230  CA2559_12648  Signal Transduction Histidine Kinase (STHK) with CheB and CheRactivity  32.98 
 
 
1200 aa  449  1e-125  Croceibacter atlanticus HTCC2559  Bacteria  normal  n/a   
 
 
-
 
NC_007953  Bxe_C0521  multi sensor hybrid histidine kinase  36.25 
 
 
1344 aa  451  1e-125  Burkholderia xenovorans LB400  Bacteria  normal  normal 
 
 
-
 
NC_009622  Smed_6341  putative PAS/PAC sensor protein  39.04 
 
 
629 aa  424  1e-117  Sinorhizobium medicae WSM419  Bacteria  normal  0.433344  normal  0.230755 
 
 
-
 
NC_007952  Bxe_B1520  signal transduction histidine kinase (STHK) with CheB and CheR activity  35.05 
 
 
1303 aa  423  1e-117  Burkholderia xenovorans LB400  Bacteria  normal  0.124967  normal 
 
 
-
 
NC_010508  Bcenmc03_1302  signal transduction histidine kinase with CheB and CheR activity  33.61 
 
 
1220 aa  400  9.999999999999999e-111  Burkholderia cenocepacia MC0-3  Bacteria  normal  normal  0.772751 
 
 
-
 
NC_010086  Bmul_4696  signal transduction histidine kinase with CheB and CheR activity  32.94 
 
 
1214 aa  394  1e-108  Burkholderia multivorans ATCC 17616  Bacteria  normal  normal 
 
 
-
 
NC_008751  Dvul_2487  signal transduction histidine kinase with CheB and CheR activity  32.96 
 
 
1535 aa  388  1e-106  Desulfovibrio vulgaris DP4  Bacteria  normal  0.162467  normal  0.455724 
 
 
-
 
NC_007802  Jann_2564  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor  33.18 
 
 
1089 aa  384  1e-105  Jannaschia sp. CCS1  Bacteria  normal  normal 
 
 
-
 
NC_002977  MCA1246  methyltransferase CheR, putative  32.63 
 
 
1378 aa  379  1e-103  Methylococcus capsulatus str. Bath  Bacteria  normal  0.271052  n/a   
 
 
-
 
NC_008044  TM1040_1028  signal transduction histidine kinase with CheB and CheR activity  31.59 
 
 
1248 aa  369  1e-100  Ruegeria sp. TM1040  Bacteria  normal  normal  0.507304 
 
 
-
 
NC_008789  Hhal_0370  protein-glutamate O-methyltransferase  37.05 
 
 
639 aa  369  1e-100  Halorhodospira halophila SL1  Bacteria  normal  0.181962  n/a   
 
 
-
 
NC_008576  Mmc1_3390  MCP methyltransferase, CheR-type  38.18 
 
 
617 aa  364  4e-99  Magnetococcus sp. MC-1  Bacteria  normal  normal 
 
 
-
 
NC_010717  PXO_03023  methyltransferase  37.61 
 
 
604 aa  360  8e-98  Xanthomonas oryzae pv. oryzae PXO99A  Bacteria  normal  0.361036  n/a   
 
 
-
 
NC_008044  TM1040_0460  MCP methyltransferase, CheR-type  32.48 
 
 
837 aa  349  2e-94  Ruegeria sp. TM1040  Bacteria  normal  0.604812  normal 
 
 
-
 
NC_013730  Slin_1989  MCP methyltransferase, CheR-type with PAS/PAC sensor  33.07 
 
 
1110 aa  347  8e-94  Spirosoma linguale DSM 74  Bacteria  normal  0.175442  normal  0.013335 
 
 
-
 
NC_008044  TM1040_2227  MCP methyltransferase, CheR-type  31.34 
 
 
824 aa  336  2e-90  Ruegeria sp. TM1040  Bacteria  normal  normal 
 
 
-
 
NC_010623  Bphy_5175  MCP methyltransferase, CheR-type  29.59 
 
 
823 aa  326  2e-87  Burkholderia phymatum STM815  Bacteria  normal  normal  0.367936 
 
 
-
 
NC_007348  Reut_B5191  CheB methylesterase:MCP methyltransferase, CheR-type  30.38 
 
 
813 aa  316  9.999999999999999e-85  Ralstonia eutropha JMP134  Bacteria  normal  n/a   
 
 
-
 
NC_010814  Glov_0566  MCP methyltransferase, CheR-type with PAS/PAC sensor  33.76 
 
 
1193 aa  316  9.999999999999999e-85  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_010814  Glov_2975  diguanylate cyclase with PAS/PAC sensor  34.05 
 
 
1084 aa  311  5.9999999999999995e-83  Geobacter lovleyi SZ  Bacteria  normal  n/a   
 
 
-
 
NC_013132  Cpin_3640  MCP methyltransferase, CheR-type with PAS/PAC sensor  34.31 
 
 
1303 aa  304  5.000000000000001e-81  Chitinophaga pinensis DSM 2588  Bacteria  normal  normal  0.581797 
 
 
-
 
NC_007964  Nham_3990  MCP methyltransferase, CheR-type  38.14 
 
 
432 aa  284  5.000000000000001e-75  Nitrobacter hamburgensis X14  Bacteria  normal  n/a   
 
 
-
 
NC_013440  Hoch_3427  MCP methyltransferase, CheR-type with PAS/PAC sensor  28.1 
 
 
2031 aa  269  2.9999999999999995e-70  Haliangium ochraceum DSM 14365  Bacteria  normal  normal  0.0889636 
 
 
-
 
NC_009622  Smed_6342  CheB methylesterase  44.84 
 
 
336 aa  231  5e-59  Sinorhizobium medicae WSM419  Bacteria  normal  0.582664  normal  0.191496 
 
 
-
 
NC_011884  Cyan7425_3121  MCP methyltransferase, CheR-type with PAS/PAC sensor  30.19 
 
 
617 aa  224  9e-57  Cyanothece sp. PCC 7425  Bacteria  normal  0.0152355  normal  0.805919 
 
 
-
 
NC_011729  PCC7424_0433  MCP methyltransferase, CheR-type with PAS/PAC sensor  29.33 
 
 
618 aa  214  4.9999999999999996e-54  Cyanothece sp. PCC 7424  Bacteria  n/a    normal 
 
 
-
 
NC_014248  Aazo_0227  MCP methyltransferase  36.36 
 
 
631 aa  190  1e-46  'Nostoc azollae' 0708  Bacteria  normal  0.993793  n/a   
 
 
-
 
NC_007643  Rru_A0741  Signal transduction histidine kinase  40.95 
 
 
498 aa  182  2e-44  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  n/a   
 
 
-
 
NC_011666  Msil_0218  signal transduction histidine kinase  40.72 
 
 
867 aa  166  2.0000000000000002e-39  Methylocella silvestris BL2  Bacteria  n/a    normal  0.269004 
 
 
-
 
NC_009485  BBta_0678  two-component sensor histidine kinase  39.13 
 
 
460 aa  166  3e-39  Bradyrhizobium sp. BTAi1  Bacteria  normal  normal  0.320332 
 
 
-
 
NC_010511  M446_0827  signal transduction histidine kinase  40.74 
 
 
512 aa  163  2e-38  Methylobacterium sp. 4-46  Bacteria  normal  normal 
 
 
-
 
NC_007794  Saro_2666  signal transduction histidine kinase  39.11 
 
 
446 aa  161  5e-38  Novosphingobium aromaticivorans DSM 12444  Bacteria  normal  0.653198  n/a   
 
 
-
 
NC_007643  Rru_A2544  Signal transduction histidine kinase  35.5 
 
 
489 aa  160  2e-37  Rhodospirillum rubrum ATCC 11170  Bacteria  normal  n/a   
 
 
-
 
NC_012850  Rleg_3666  signal transduction histidine kinase  43.52 
 
 
550 aa  159  3e-37  Rhizobium leguminosarum bv. trifolii WSM1325  Bacteria  normal  0.0123232  normal  0.85719 
 
 
-
 
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